RU2012118620A - Множественное количественное определение в смеси индивидуальных рекомбинантных белков посредством сигнатурных пептидов и масс-спектрометрии - Google Patents
Множественное количественное определение в смеси индивидуальных рекомбинантных белков посредством сигнатурных пептидов и масс-спектрометрии Download PDFInfo
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- RU2012118620A RU2012118620A RU2012118620/15A RU2012118620A RU2012118620A RU 2012118620 A RU2012118620 A RU 2012118620A RU 2012118620/15 A RU2012118620/15 A RU 2012118620/15A RU 2012118620 A RU2012118620 A RU 2012118620A RU 2012118620 A RU2012118620 A RU 2012118620A
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- Prior art keywords
- recombinant
- peptides
- recombinant proteins
- polyclonal antibody
- signature
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Classifications
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
- G01N27/62—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating the ionisation of gases, e.g. aerosols; by investigating electric discharges, e.g. emission of cathode
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
- G01N33/6842—Proteomic analysis of subsets of protein mixtures with reduced complexity, e.g. membrane proteins, phosphoproteins, organelle proteins
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
- G01N33/6848—Methods of protein analysis involving mass spectrometry
- G01N33/6851—Methods of protein analysis involving laser desorption ionisation mass spectrometry
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Physics & Mathematics (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Bioinformatics & Computational Biology (AREA)
- Biochemistry (AREA)
- Analytical Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biophysics (AREA)
- Medicinal Chemistry (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Microbiology (AREA)
- Food Science & Technology (AREA)
- Cell Biology (AREA)
- Biotechnology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Spectroscopy & Molecular Physics (AREA)
- Optics & Photonics (AREA)
- Organic Chemistry (AREA)
- Electrochemistry (AREA)
- Genetics & Genomics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Peptides Or Proteins (AREA)
- Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DKPA200901112 | 2009-10-09 | ||
| DKPA200901112 | 2009-10-09 | ||
| US25623209P | 2009-10-29 | 2009-10-29 | |
| US61/256,232 | 2009-10-29 | ||
| PCT/DK2010/050258 WO2011042027A2 (en) | 2009-10-09 | 2010-10-07 | Multiplex quantitation of individual recombinant proteins in a mixture by signature peptides and mass spectrometry |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RU2012118620A true RU2012118620A (ru) | 2013-11-20 |
Family
ID=42166454
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2012118620/15A RU2012118620A (ru) | 2009-10-09 | 2010-10-07 | Множественное количественное определение в смеси индивидуальных рекомбинантных белков посредством сигнатурных пептидов и масс-спектрометрии |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US20120264155A1 (show.php) |
| EP (1) | EP2486411A2 (show.php) |
| JP (1) | JP2013507603A (show.php) |
| KR (1) | KR20120100982A (show.php) |
| CN (1) | CN102687020A (show.php) |
| AU (1) | AU2010305150A1 (show.php) |
| BR (1) | BR112012007815A2 (show.php) |
| CA (1) | CA2776508A1 (show.php) |
| IL (1) | IL218821A0 (show.php) |
| IN (1) | IN2012DN03911A (show.php) |
| MX (1) | MX2012003538A (show.php) |
| RU (1) | RU2012118620A (show.php) |
| WO (1) | WO2011042027A2 (show.php) |
| ZA (1) | ZA201202431B (show.php) |
Families Citing this family (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2241875A1 (en) * | 2009-04-14 | 2010-10-20 | Koninklijke Philips Electronics N.V. | Up-concentration of organic microobjects for microscopic imaging. |
| CN103608684B (zh) * | 2011-05-12 | 2016-05-04 | 基因泰克公司 | 利用框架签名肽检测动物样品中的治疗性抗体的多重反应监测lc-ms/ms方法 |
| WO2013019714A1 (en) | 2011-07-29 | 2013-02-07 | The Trustees Of Columbia University In The City Of New York | Mems affinity sensor for continuous monitoring of analytes |
| WO2016022696A1 (en) | 2014-08-05 | 2016-02-11 | The Trustees Of Columbia University In The City Of New York | Method of isolating aptamers for minimal residual disease detection |
| WO2016145390A1 (en) | 2015-03-12 | 2016-09-15 | Mars, Incorporated | Ultra high resolution mass spectrometry and methods of using the same |
| US10794916B2 (en) | 2015-05-06 | 2020-10-06 | Momenta Pharmaceuticals, Inc. | Methods of glycoprotein analysis |
| CN105242050A (zh) * | 2015-09-16 | 2016-01-13 | 同济大学 | 一种不同生理或病理条件下整体蛋白质的定量分析方法 |
| CN105218671A (zh) * | 2015-09-29 | 2016-01-06 | 李艳华 | 一种传染病病原体全人源化抗体的制备方法 |
| GB201603291D0 (en) | 2016-02-25 | 2016-04-13 | Binding Site Group The Ltd | Antibodies |
| JP6943872B2 (ja) * | 2016-03-25 | 2021-10-06 | ジェネンテック， インコーポレイテッド | 多重全抗体及び抗体複合体化薬物定量化アッセイ |
| EP3465221B1 (en) | 2016-05-27 | 2020-07-22 | H. Hoffnabb-La Roche Ag | Bioanalytical method for the characterization of site-specific antibody-drug conjugates |
| CN107525934A (zh) * | 2016-06-21 | 2017-12-29 | 张效龙 | 一种测定血液中抗体氨基酸序列的方法 |
| WO2018035350A1 (en) * | 2016-08-17 | 2018-02-22 | Momenta Pharmaceuticals, Inc. | Glycan oxonium ion profiling of glycosylated proteins |
| CN108072728A (zh) * | 2016-11-16 | 2018-05-25 | 中国科学院大连化学物理研究所 | 一种基于数据依赖性质谱扫描模式的谱图库建立方法及其应用 |
| CN108956789A (zh) * | 2017-05-17 | 2018-12-07 | 中国科学院大连化学物理研究所 | 一种血清中免疫球蛋白g糖肽的绝对定量分析方法 |
| AU2018309027B2 (en) * | 2017-08-01 | 2025-06-26 | Amgen Inc. | Systems and methods for real time preparation of a polypeptide sample for analysis with mass spectrometry |
| US10615016B2 (en) * | 2017-09-07 | 2020-04-07 | Thermo Fisher Scientific (Bremen) Gmbh | Determining isotope ratios using mass spectrometry |
| CN108226516B (zh) * | 2017-11-30 | 2020-05-19 | 中国农业科学院北京畜牧兽医研究所 | 一种相对定量分析肉鸡脂肪酸去饱和酶fads1的方法 |
| CN108169397B (zh) * | 2017-11-30 | 2019-11-15 | 中国农业科学院北京畜牧兽医研究所 | 一种相对定量分析肉鸡谷胱甘肽s转移酶gsta2的方法 |
| CN109900815B (zh) * | 2017-12-08 | 2021-06-29 | 中国科学院大连化学物理研究所 | 血清中IgG糖肽的绝对定量分析 |
| KR20200115467A (ko) * | 2018-01-31 | 2020-10-07 | 리제너론 파마슈티칼스 인코포레이티드 | 치료용 단클론 항체에 대한 새로운 산성 번역 후 변형으로서의 글루쿠로닐화 |
| JP7205077B2 (ja) * | 2018-05-10 | 2023-01-17 | 株式会社島津製作所 | 分析方法、処理装置、分析装置およびプログラム |
| CN110824096B (zh) * | 2018-08-13 | 2022-11-29 | 齐鲁制药有限公司 | 一种蛋白错配二硫键的分析方法 |
| CN110007019A (zh) * | 2019-03-29 | 2019-07-12 | 绿城农科检测技术有限公司 | 一种同时定量检测母乳中三种抗体含量的方法 |
| GB201910697D0 (en) * | 2019-07-26 | 2019-09-11 | Binding Site Group Ltd | Lonisation control |
| US20230089196A1 (en) | 2020-02-21 | 2023-03-23 | Genmab B.V. | Methods for the quantification of glycoproteins |
| CN111551739A (zh) * | 2020-04-27 | 2020-08-18 | 杭州璞湃科技有限公司 | 一种免疫球蛋白a和免疫球蛋白a1的检测方法及其试剂盒 |
| WO2021258114A1 (en) * | 2020-06-18 | 2021-12-23 | Northwestern University | Process for direct readout of immunoglobulins |
| JP7478040B2 (ja) | 2020-06-25 | 2024-05-02 | シスメックス株式会社 | Ａβペプチドの測定方法及びその方法に用いられる試薬組成物 |
| CN111766323B (zh) * | 2020-07-10 | 2022-06-14 | 中国检验检疫科学研究院 | 一种用于检测骆驼奶中掺入牛奶的特征肽组合及方法 |
| CN113933409B (zh) * | 2021-09-14 | 2023-11-14 | 上海中科新生命生物科技有限公司 | 基于液相色谱-质谱检测血清中特瑞普利单抗的方法 |
| DE102022115561B4 (de) * | 2022-06-22 | 2024-06-13 | Bruker Daltonics GmbH & Co. KG | Massenspektrometrische Bestimmung der Zelltoxizität |
| CN118221778A (zh) * | 2024-04-25 | 2024-06-21 | 烟台大学 | 拟穴青蟹Scyreprocin蛋白的特征肽段及其在雌雄鉴别方面的应用 |
| CN120399082B (zh) * | 2025-07-04 | 2025-08-26 | 北京溯本源和生物科技有限公司 | 一种用于检测猫Cys-C蛋白的单克隆抗体组合及应用 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2003087834A2 (en) * | 2002-04-08 | 2003-10-23 | Affinium Pharmaceuticals, Inc. | High throughput analysis of recombinant proteins in multi-well plates |
| EP1556478B1 (en) | 2002-10-03 | 2018-07-18 | Norman Leigh Anderson | High sensitivity quantitation of peptides by mass spectrometry |
| EP1766388A4 (en) * | 2004-06-09 | 2008-08-20 | Anderson Forschung Group Llc | STABLE ISOTOPES MARKED POLYPEPTIDE STANDARDS FOR PROTEIN QUANTIFICATION |
| MX2007000644A (es) | 2004-07-20 | 2007-03-28 | Symphogen As | Anticuerpo policlonal recombinante anti-rhesus d y metodos de fabricacion. |
| NZ552264A (en) * | 2004-07-20 | 2010-03-26 | Symphogen As | A procedure for structural characterization of a recombinant polyclonal protein or a polyclonal cell line |
| JP4683572B2 (ja) * | 2005-01-28 | 2011-05-18 | 塩野義製薬株式会社 | 組換え蛋白質の定量法 |
| JP2006300758A (ja) * | 2005-04-21 | 2006-11-02 | Apro Life Science Institute Inc | 内部標準ペプチドを用いて生体由来試料に含まれる標的タンパク質を定量する方法 |
| JP2009518320A (ja) | 2005-12-05 | 2009-05-07 | シュムフォウエン アクティーゼルスカブ | 抗オルトポックスウイルス組換えポリクローナル抗体 |
| WO2007101441A1 (en) | 2006-03-06 | 2007-09-13 | Symphogen A/S | Recombinant polyclonal antibody for treatment of respiratory syncytial virus infections |
| CN104151430A (zh) | 2007-03-01 | 2014-11-19 | 西福根有限公司 | 重组抗表皮生长因子受体抗体组合物 |
| KR20090127341A (ko) | 2007-03-06 | 2009-12-10 | 심포젠 에이/에스 | 호흡기세포 융합 바이러스 감염 치료용 재조합 항체 |
| US20090000419A1 (en) * | 2007-06-29 | 2009-01-01 | Harley-Davidson Motor Company Group, Inc. | Handlebar assembly with axial locking feature |
-
2010
- 2010-10-07 IN IN3911DEN2012 patent/IN2012DN03911A/en unknown
- 2010-10-07 BR BR112012007815A patent/BR112012007815A2/pt not_active IP Right Cessation
- 2010-10-07 CA CA2776508A patent/CA2776508A1/en not_active Abandoned
- 2010-10-07 RU RU2012118620/15A patent/RU2012118620A/ru unknown
- 2010-10-07 WO PCT/DK2010/050258 patent/WO2011042027A2/en not_active Ceased
- 2010-10-07 EP EP10774121A patent/EP2486411A2/en not_active Withdrawn
- 2010-10-07 CN CN2010800562278A patent/CN102687020A/zh active Pending
- 2010-10-07 AU AU2010305150A patent/AU2010305150A1/en not_active Abandoned
- 2010-10-07 KR KR1020127011934A patent/KR20120100982A/ko not_active Withdrawn
- 2010-10-07 US US13/501,051 patent/US20120264155A1/en not_active Abandoned
- 2010-10-07 JP JP2012532458A patent/JP2013507603A/ja active Pending
- 2010-10-07 MX MX2012003538A patent/MX2012003538A/es not_active Application Discontinuation
-
2012
- 2012-03-25 IL IL218821A patent/IL218821A0/en unknown
- 2012-04-03 ZA ZA2012/02431A patent/ZA201202431B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| MX2012003538A (es) | 2012-08-03 |
| IN2012DN03911A (show.php) | 2015-09-04 |
| AU2010305150A1 (en) | 2012-04-05 |
| EP2486411A2 (en) | 2012-08-15 |
| WO2011042027A2 (en) | 2011-04-14 |
| BR112012007815A2 (pt) | 2018-03-20 |
| CA2776508A1 (en) | 2011-04-14 |
| JP2013507603A (ja) | 2013-03-04 |
| IL218821A0 (en) | 2012-06-28 |
| WO2011042027A3 (en) | 2011-09-22 |
| ZA201202431B (en) | 2012-12-27 |
| KR20120100982A (ko) | 2012-09-12 |
| CN102687020A (zh) | 2012-09-19 |
| US20120264155A1 (en) | 2012-10-18 |
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