RU2006115558A - Ингибиторы сериновых протеаз, особенно hcv ns3-ns4a протеазы - Google Patents

Ингибиторы сериновых протеаз, особенно hcv ns3-ns4a протеазы Download PDF

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Publication number
RU2006115558A
RU2006115558A RU2006115558/04A RU2006115558A RU2006115558A RU 2006115558 A RU2006115558 A RU 2006115558A RU 2006115558/04 A RU2006115558/04 A RU 2006115558/04A RU 2006115558 A RU2006115558 A RU 2006115558A RU 2006115558 A RU2006115558 A RU 2006115558A
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Russia
Prior art keywords
ring
aliphatic group
cycloalkyl
heteroaryl
aryl
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RU2006115558/04A
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English (en)
Russian (ru)
Inventor
Кевин М. КОТТРЕЛЛ (US)
Кевин М. Коттрелл
Роберт Б. Перни (US)
Роберт Б. Перни
Янош ПИТЛИК (US)
Янош ПИТЛИК
Original Assignee
Вертекс Фармасьютикалз Инкорпорейтед (Us)
Вертекс Фармасьютикалз Инкорпорейтед
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Publication of RU2006115558A publication Critical patent/RU2006115558A/ru

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/08—Peptides having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Virology (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Hydrogenated Pyridines (AREA)
RU2006115558/04A 2003-10-10 2004-10-08 Ингибиторы сериновых протеаз, особенно hcv ns3-ns4a протеазы RU2006115558A (ru)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US51015603P 2003-10-10 2003-10-10
US60/510,156 2003-10-10
US51376803P 2003-10-23 2003-10-23
US60/513,768 2003-10-23

Publications (1)

Publication Number Publication Date
RU2006115558A true RU2006115558A (ru) 2007-11-20

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RU2006115558/04A RU2006115558A (ru) 2003-10-10 2004-10-08 Ингибиторы сериновых протеаз, особенно hcv ns3-ns4a протеазы

Country Status (14)

Country Link
US (2) US7208600B2 (US08039623-20111018-C00115.png)
EP (2) EP2361925A1 (US08039623-20111018-C00115.png)
JP (2) JP2007532474A (US08039623-20111018-C00115.png)
KR (2) KR20120010278A (US08039623-20111018-C00115.png)
CN (1) CN101857631A (US08039623-20111018-C00115.png)
AU (1) AU2004282148A1 (US08039623-20111018-C00115.png)
CA (1) CA2541634A1 (US08039623-20111018-C00115.png)
IL (1) IL174863A0 (US08039623-20111018-C00115.png)
MX (1) MXPA06004006A (US08039623-20111018-C00115.png)
NO (1) NO20062101L (US08039623-20111018-C00115.png)
NZ (1) NZ546663A (US08039623-20111018-C00115.png)
RU (1) RU2006115558A (US08039623-20111018-C00115.png)
TW (1) TW200528472A (US08039623-20111018-C00115.png)
WO (1) WO2005037860A2 (US08039623-20111018-C00115.png)

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EP1692157B1 (en) 2013-04-17
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JP2011246487A (ja) 2011-12-08
US7208600B2 (en) 2007-04-24
MXPA06004006A (es) 2006-06-28
US20050137140A1 (en) 2005-06-23
IL174863A0 (en) 2008-02-09
WO2005037860A2 (en) 2005-04-28
CA2541634A1 (en) 2005-04-28
KR20060130027A (ko) 2006-12-18
US20070161789A1 (en) 2007-07-12
CN101857631A (zh) 2010-10-13
NZ546663A (en) 2010-01-29
EP2361925A1 (en) 2011-08-31
TW200528472A (en) 2005-09-01
KR20120010278A (ko) 2012-02-02
AU2004282148A1 (en) 2005-04-28
WO2005037860A3 (en) 2005-11-10
EP1692157A2 (en) 2006-08-23
US8039623B2 (en) 2011-10-18

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