RU2002123334A - Производные дибензол (B, F) азепина и их получение - Google Patents

Производные дибензол (B, F) азепина и их получение

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Publication number
RU2002123334A
RU2002123334A RU2002123334/04A RU2002123334A RU2002123334A RU 2002123334 A RU2002123334 A RU 2002123334A RU 2002123334/04 A RU2002123334/04 A RU 2002123334/04A RU 2002123334 A RU2002123334 A RU 2002123334A RU 2002123334 A RU2002123334 A RU 2002123334A
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Russia
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formula
compound
compounds
meanings
obtaining
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RU2002123334/04A
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RU2303591C2 (ru
Inventor
Петер ФЮНФШИЛЛИНГ (CH)
Петер ФЮНФШИЛЛИНГ
Даниель КАУФМАНН (CH)
Даниель КАУФМАНН
Оливье ЛОЗ (FR)
Оливье ЛОЗ
Ульрих БОЙТЛЕР (CH)
Ульрих БОЙТЛЕР
Вернер ЦАУГГ (CH)
Вернер ЦАУГГ
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Новартис АГ (CH)
Новартис Аг
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Application filed by Новартис АГ (CH), Новартис Аг filed Critical Новартис АГ (CH)
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/18—Dibenzazepines; Hydrogenated dibenzazepines
    • C07D223/22—Dibenz [b, f] azepines; Hydrogenated dibenz [b, f] azepines
    • C07D223/24—Dibenz [b, f] azepines; Hydrogenated dibenz [b, f] azepines with hydrocarbon radicals, substituted by nitrogen atoms, attached to the ring nitrogen atom
    • C07D223/26—Dibenz [b, f] azepines; Hydrogenated dibenz [b, f] azepines with hydrocarbon radicals, substituted by nitrogen atoms, attached to the ring nitrogen atom having a double bond between positions 10 and 11
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/18—Dibenzazepines; Hydrogenated dibenzazepines
    • C07D223/22—Dibenz [b, f] azepines; Hydrogenated dibenz [b, f] azepines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
    • C07C237/30—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having the nitrogen atom of the carboxamide group bound to hydrogen atoms or to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/26—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atom of at least one of the carbamate groups bound to a carbon atom of a six-membered aromatic ring
    • C07C271/28—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atom of at least one of the carbamate groups bound to a carbon atom of a six-membered aromatic ring to a carbon atom of a non-condensed six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/18—Dibenzazepines; Hydrogenated dibenzazepines
    • C07D223/22—Dibenz [b, f] azepines; Hydrogenated dibenz [b, f] azepines
    • C07D223/24—Dibenz [b, f] azepines; Hydrogenated dibenz [b, f] azepines with hydrocarbon radicals, substituted by nitrogen atoms, attached to the ring nitrogen atom
    • C07D223/28—Dibenz [b, f] azepines; Hydrogenated dibenz [b, f] azepines with hydrocarbon radicals, substituted by nitrogen atoms, attached to the ring nitrogen atom having a single bond between positions 10 and 11

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Epoxy Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Claims (12)

1. Способ получения соединения формулы III
Figure 00000001
где R1 означает С1-С4алкил, карбамоилированием соединения формулы II
Figure 00000002
где R1 имеет значения, указанные выше, цианатом металла, причем реакцию проводят с использованием уксусной кислоты в присутствии большого избытка цианата металла и в отсутствии дополнительного растворителя.
2. Способ получения соединения формулы V
Figure 00000003
где R2 означает С1-С4алкил или фенил, включающий замыкание цикла в соединении формулы VI
Figure 00000004
где R2 имеет значения, указанные выше.
3. Способ получения соединения формулы V по п.2, включающий замыкание цикла в соединении формулы VII
Figure 00000005
где R2 имеет значения, указанные в п.2, а R3 и R4 независимо означают С1-С4алкил.
4. Соединение формулы V, указанное в п.2.
5. Соединение формулы I
Figure 00000006
где R1 имеет значения, указанные в п.1, a R1 имеет значения, указанные в п.2.
6. Способ получения соединения формулы I по п.5, который включает взаимодействие соединения формулы V по п.2 с соединением формулы R1OH или (R1O)3СН, где R± имеет значения, указанные в п.1.
7. Соединение формулы VI
Figure 00000007
где R1 имеет значения, указанные в п.2.
8. Способ получения соединения формулы VI, указанного в п.7, который включает взаимодействие соединения формулы VIII
Figure 00000008
в сильно щелочных условиях с соединением формулы X-COOR2, где R2 имеет значения, указанные в п.2, а Х означает хлор или метокси.
9. Соединение формулы VII
Figure 00000009
где R2 имеет значения, указанные в п.2, а R3 и R4 имеют значения, указанные в п.3, при условии, что R2 не означает трет-бутил, если R3 и R4 оба означают изопропил.
10. Способ получения соединения формулы VII по п.9, который включает взаимодействие соединения формулы IX
Figure 00000010
где R3 и R4 имеют значения, указанные в п.9, с соединением формулы ClCOOR2, где R2 имеет значения, указанные в п.2, причем R2 не означает трет-бутил, если R3 и R4 оба означают изопропил.
11. Соединение формулы IX
Figure 00000011
где R3 и R4 имеют значения, указанные в п.9.
12. Способ получения соединения формулы IX по п.11, который включает взаимодействие соединения формулы Х
Figure 00000012
с соединением формулы R3-NH-R4, где R3 и R4 имеют значения, указанные в п.9.
RU2002123334/04A 2000-02-07 2001-02-07 ПРОИЗВОДНЫЕ ДИБЕНЗО(b,f)АЗЕПИНА И ИХ ПОЛУЧЕНИЕ RU2303591C2 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0002740.9A GB0002740D0 (en) 2000-02-07 2000-02-07 Organic compounds
GB0002740.9 2000-02-07

Publications (2)

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RU2002123334A true RU2002123334A (ru) 2004-01-10
RU2303591C2 RU2303591C2 (ru) 2007-07-27

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Country Status (34)

Country Link
US (1) US7112673B2 (ru)
EP (2) EP2067772B1 (ru)
JP (1) JP4859322B2 (ru)
KR (5) KR101216285B1 (ru)
CN (2) CN100455572C (ru)
AR (2) AR029442A1 (ru)
AT (2) ATE427938T1 (ru)
AU (1) AU767724B2 (ru)
BR (1) BR0107922A (ru)
CA (3) CA2639210C (ru)
CO (1) CO5271705A1 (ru)
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CZ (1) CZ301572B6 (ru)
DE (2) DE60138271D1 (ru)
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GB (1) GB0002740D0 (ru)
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IL (3) IL150613A0 (ru)
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MY (1) MY136474A (ru)
NO (1) NO324949B1 (ru)
NZ (1) NZ520329A (ru)
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Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1302464A1 (en) * 2001-10-09 2003-04-16 Max India Limited Process for preparation of 10-methoxycarbamazepine
US6670472B2 (en) 2001-10-09 2003-12-30 Max India Limited Process for the preparation of 10-methoxycarbamazepine
CA2486560A1 (en) * 2002-06-14 2003-12-24 Taro Pharmaceuticals U.S.A., Inc. Method of preparing a 5h-dibenz[b,f]azepine-5-carboxamide
ITMI20040452A1 (it) 2004-03-09 2004-06-09 Clariant Lsm Italia Spa Processo per la preparazione di oxcarbazepina
RS53599B1 (en) 2005-05-10 2015-02-27 Intermune, Inc. PIRIDON DERIVATIVES FOR STRESS MODULATION OF ACTIVATED PROTEIN KINASE SYSTEMS
MX2008013675A (es) * 2006-04-26 2009-03-06 Supernus Pharmaceuticals Inc Preparaciones de liberacion controlada de oxcarbacepina que tienen perfil de liberacion sigmoidal.
US20090082335A1 (en) * 2007-09-26 2009-03-26 Protia, Llc Deuterium-enriched oxcarbazepine
CA2726588C (en) 2008-06-03 2019-04-16 Karl Kossen Compounds and methods for treating inflammatory and fibrotic disorders
WO2014049550A1 (en) 2012-09-26 2014-04-03 Ranbaxy Laboratories Limited Process for the preparation of oxcarbazepine and its use as intermediate in the preparation of eslicarbazepine acetate
AR092742A1 (es) 2012-10-02 2015-04-29 Intermune Inc Piridinonas antifibroticas
AU2014318748B2 (en) * 2013-09-11 2019-02-28 Duquesne University Of The Holy Ghost Novel anthranilic amides and the use thereof
KR102373700B1 (ko) 2014-04-02 2022-03-11 인터뮨, 인크. 항섬유성 피리디논

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US4847374A (en) * 1987-01-27 1989-07-11 Ciba-Geigy Corporation Process for the manufacture of N,N-(Dibenzohexatrienylene)ureas
IT1272897B (it) * 1995-01-13 1997-07-01 I F C Iniziative Finanziaarie Processo per la produzione di 10-oxo-10,11-diidro-sh- -dibenz(b,f) azepin-5-carbossiammide
US6355680B1 (en) * 1996-02-20 2002-03-12 Exocell, Inc. Albumin-binding compounds that prevent nonenzymatic glycation and that may be used for treatment of glycation-related pathologies
IT1283594B1 (it) * 1996-04-12 1998-04-22 Trifarma Srl Derivati della 5h-dibenz- (b,f)-azepin-5-carbossiammide, loro preparazione e uso come sostanze ad azione medicinale
ATE344791T1 (de) * 1997-07-01 2006-11-15 Warner Lambert Co 2-(4-brom or 4-iod phenylamino)benzoesäurederivate und ihre anwendung als mek-inhibitoren
US6048856A (en) * 1997-12-17 2000-04-11 Novo Nordisk A/S Heterocyclic compounds

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US20030032800A1 (en) 2003-02-13
CA2639210A1 (en) 2001-08-09
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AU4237301A (en) 2001-08-14
CZ301572B6 (cs) 2010-04-21
EP1265868B1 (en) 2009-04-08
SK287217B6 (sk) 2010-03-08
CA2724295A1 (en) 2001-08-09
CA2639210C (en) 2011-05-03
ES2324900T3 (es) 2009-08-19
ZA200206219B (en) 2003-04-04
PT2067772E (pt) 2011-07-13
BR0107922A (pt) 2002-10-22
US7112673B2 (en) 2006-09-26
DE60138271D1 (de) 2009-05-20
KR20080003016A (ko) 2008-01-04
AU767724B2 (en) 2003-11-20
KR100931753B1 (ko) 2009-12-14
ATE427938T1 (de) 2009-04-15
PL217225B1 (pl) 2014-06-30
IL188183A (en) 2011-02-28
PL392476A1 (pl) 2010-11-22
HUP0300243A2 (hu) 2003-06-28
EP2067772A2 (en) 2009-06-10
HU229420B1 (en) 2013-12-30
GB0002740D0 (en) 2000-03-29
HK1052501A1 (en) 2003-09-19
AR029442A1 (es) 2003-06-25
SI2067772T1 (sl) 2011-08-31
EP2067772B1 (en) 2011-04-13
CO5271705A1 (es) 2003-04-30
ES2363490T3 (es) 2011-08-05
CY1111567T1 (el) 2015-10-07
WO2001056992A2 (en) 2001-08-09
RU2303591C2 (ru) 2007-07-27
HUP0300243A3 (en) 2005-07-28
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NO20023575D0 (no) 2002-07-26
AR079237A2 (es) 2012-01-04
WO2001056992A3 (en) 2002-01-24
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CN1244563C (zh) 2006-03-08
CZ20022676A3 (cs) 2002-11-13
DE60144456D1 (de) 2011-05-26
PE20011078A1 (es) 2001-11-16
MXPA02007629A (es) 2002-12-13
KR20090102882A (ko) 2009-09-30
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EP2067772A3 (en) 2009-08-19
NO324949B1 (no) 2008-01-14
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IL150613A (en) 2010-05-17
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TR200201655T2 (tr) 2002-11-21
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CA2395601A1 (en) 2001-08-09
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IL150613A0 (en) 2003-02-12
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MY136474A (en) 2008-10-31
CN1721409A (zh) 2006-01-18
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DK2067772T3 (da) 2011-07-18
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NZ520329A (en) 2003-11-28

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