AR079237A2 - Proceso para la preparacion de derivados de dibenzo(b,f) azepina - Google Patents

Proceso para la preparacion de derivados de dibenzo(b,f) azepina

Info

Publication number
AR079237A2
AR079237A2 ARP100104442A ARP100104442A AR079237A2 AR 079237 A2 AR079237 A2 AR 079237A2 AR P100104442 A ARP100104442 A AR P100104442A AR P100104442 A ARP100104442 A AR P100104442A AR 079237 A2 AR079237 A2 AR 079237A2
Authority
AR
Argentina
Prior art keywords
formula
preparation
compound
azepina
dibenze
Prior art date
Application number
ARP100104442A
Other languages
English (en)
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=9885081&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AR079237(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of AR079237A2 publication Critical patent/AR079237A2/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/18—Dibenzazepines; Hydrogenated dibenzazepines
    • C07D223/22—Dibenz [b, f] azepines; Hydrogenated dibenz [b, f] azepines
    • C07D223/24—Dibenz [b, f] azepines; Hydrogenated dibenz [b, f] azepines with hydrocarbon radicals, substituted by nitrogen atoms, attached to the ring nitrogen atom
    • C07D223/26—Dibenz [b, f] azepines; Hydrogenated dibenz [b, f] azepines with hydrocarbon radicals, substituted by nitrogen atoms, attached to the ring nitrogen atom having a double bond between positions 10 and 11
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/18—Dibenzazepines; Hydrogenated dibenzazepines
    • C07D223/22—Dibenz [b, f] azepines; Hydrogenated dibenz [b, f] azepines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
    • C07C237/30—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having the nitrogen atom of the carboxamide group bound to hydrogen atoms or to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/26—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atom of at least one of the carbamate groups bound to a carbon atom of a six-membered aromatic ring
    • C07C271/28—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atom of at least one of the carbamate groups bound to a carbon atom of a six-membered aromatic ring to a carbon atom of a non-condensed six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/18—Dibenzazepines; Hydrogenated dibenzazepines
    • C07D223/22—Dibenz [b, f] azepines; Hydrogenated dibenz [b, f] azepines
    • C07D223/24—Dibenz [b, f] azepines; Hydrogenated dibenz [b, f] azepines with hydrocarbon radicals, substituted by nitrogen atoms, attached to the ring nitrogen atom
    • C07D223/28—Dibenz [b, f] azepines; Hydrogenated dibenz [b, f] azepines with hydrocarbon radicals, substituted by nitrogen atoms, attached to the ring nitrogen atom having a single bond between positions 10 and 11

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Epoxy Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

Un proceso para la preparacion de un compuesto de la formula (4) mediante hidrolisis de un compuesto de la formula (3) donde R1 es alquilo C1-4, donde el compuesto de la formula (3) se prepara mediante carbamoilacion de un compuesto de la formula (2) donde R1 es como se define para la formula (3), con un cianato de metal, donde la reaccion se efectua utilizando ácido acético, en presencia de un exceso sustancial de cianato de metal y en ausencia de un solvente adicional, donde dicho exceso substancial de cianato de metal es un exceso de por lo menos 0,2 equivalentes.
ARP100104442A 2000-02-07 2010-12-01 Proceso para la preparacion de derivados de dibenzo(b,f) azepina AR079237A2 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB0002740.9A GB0002740D0 (en) 2000-02-07 2000-02-07 Organic compounds

Publications (1)

Publication Number Publication Date
AR079237A2 true AR079237A2 (es) 2012-01-04

Family

ID=9885081

Family Applications (2)

Application Number Title Priority Date Filing Date
ARP010100515A AR029442A1 (es) 2000-02-07 2001-02-05 Un proceso para la produccion de derivados de dibenzo [b,f] azepina y compuestos intermediarios
ARP100104442A AR079237A2 (es) 2000-02-07 2010-12-01 Proceso para la preparacion de derivados de dibenzo(b,f) azepina

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ARP010100515A AR029442A1 (es) 2000-02-07 2001-02-05 Un proceso para la produccion de derivados de dibenzo [b,f] azepina y compuestos intermediarios

Country Status (33)

Country Link
US (1) US7112673B2 (es)
EP (2) EP1265868B1 (es)
JP (1) JP4859322B2 (es)
KR (5) KR20020071033A (es)
CN (2) CN100455572C (es)
AR (2) AR029442A1 (es)
AT (2) ATE505459T1 (es)
AU (1) AU767724B2 (es)
BR (1) BR0107922A (es)
CA (3) CA2724295C (es)
CO (1) CO5271705A1 (es)
CY (1) CY1111567T1 (es)
CZ (1) CZ301572B6 (es)
DE (2) DE60144456D1 (es)
DK (1) DK2067772T3 (es)
ES (2) ES2363490T3 (es)
GB (1) GB0002740D0 (es)
HU (1) HU229420B1 (es)
IL (3) IL150613A0 (es)
MX (1) MXPA02007629A (es)
MY (1) MY136474A (es)
NO (1) NO324949B1 (es)
NZ (1) NZ520329A (es)
PE (1) PE20011078A1 (es)
PL (2) PL214039B1 (es)
PT (2) PT2067772E (es)
RU (1) RU2303591C2 (es)
SI (1) SI2067772T1 (es)
SK (1) SK287217B6 (es)
TR (1) TR200201655T2 (es)
TW (1) TWI284638B (es)
WO (1) WO2001056992A2 (es)
ZA (1) ZA200206219B (es)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1302464A1 (en) * 2001-10-09 2003-04-16 Max India Limited Process for preparation of 10-methoxycarbamazepine
CA2407173C (en) 2001-10-09 2009-09-29 Max India Limited Process for the preparation of 10-methoxycarbamazepine
US7091339B2 (en) 2002-06-14 2006-08-15 Taro Pharmaceuticals Usa, Inc. Method of preparing a 5H-dibenz(b,f)azepine-5-carboxamide
ITMI20040452A1 (it) 2004-03-09 2004-06-09 Clariant Lsm Italia Spa Processo per la preparazione di oxcarbazepina
JP2008544743A (ja) 2005-05-10 2008-12-11 インターミューン インコーポレイテッド ストレス活性化蛋白質キナーゼ系をモジュレートするためのピリドン誘導体
MX2008013675A (es) * 2006-04-26 2009-03-06 Supernus Pharmaceuticals Inc Preparaciones de liberacion controlada de oxcarbacepina que tienen perfil de liberacion sigmoidal.
US20090082335A1 (en) * 2007-09-26 2009-03-26 Protia, Llc Deuterium-enriched oxcarbazepine
MX2010012848A (es) 2008-06-03 2011-03-01 Intermune Inc Compuestos y metodos para tratar trastornos inflamatorios y fibroticos.
US20150232426A1 (en) 2012-09-26 2015-08-20 Ranbaxy Laboratories Limited Process for the preparation of oxcarbazepine and its use as intermediate in the preparation of eslicarbazepine acetate
AR092742A1 (es) 2012-10-02 2015-04-29 Intermune Inc Piridinonas antifibroticas
CA2923835C (en) * 2013-09-11 2022-11-29 The Administrators Of The Tulane Educational Fund Novel anthranilic amides and the use thereof
JP6525437B2 (ja) 2014-04-02 2019-06-05 インターミューン， インコーポレイテッド 抗線維性ピリジノン

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4847374A (en) * 1987-01-27 1989-07-11 Ciba-Geigy Corporation Process for the manufacture of N,N-(Dibenzohexatrienylene)ureas
DE4305502A1 (de) * 1993-02-23 1994-08-25 Basf Ag Ortho-substituierte 2-Methoxyiminophenylessigsäuremethylamide
IT1272897B (it) * 1995-01-13 1997-07-01 I F C Iniziative Finanziaarie Processo per la produzione di 10-oxo-10,11-diidro-sh- -dibenz(b,f) azepin-5-carbossiammide
US6355680B1 (en) * 1996-02-20 2002-03-12 Exocell, Inc. Albumin-binding compounds that prevent nonenzymatic glycation and that may be used for treatment of glycation-related pathologies
IT1283594B1 (it) 1996-04-12 1998-04-22 Trifarma Srl Derivati della 5h-dibenz- (b,f)-azepin-5-carbossiammide, loro preparazione e uso come sostanze ad azione medicinale
ES2274572T3 (es) * 1997-07-01 2007-05-16 Warner-Lambert Company Llc Derivados de acido 2-(4-bromo- o 4-yodo-fenilamino) benzoico y su uso como inhibidor de mek.
US6048856A (en) * 1997-12-17 2000-04-11 Novo Nordisk A/S Heterocyclic compounds

Also Published As

Publication number Publication date
EP2067772A3 (en) 2009-08-19
PT1265868E (pt) 2009-07-15
CY1111567T1 (el) 2015-10-07
PL217225B1 (pl) 2014-06-30
EP1265868B1 (en) 2009-04-08
TWI284638B (en) 2007-08-01
CZ301572B6 (cs) 2010-04-21
KR100966209B1 (ko) 2010-06-25
KR20080103608A (ko) 2008-11-27
EP2067772B1 (en) 2011-04-13
KR100931753B1 (ko) 2009-12-14
KR20080003016A (ko) 2008-01-04
CZ20022676A3 (cs) 2002-11-13
DE60144456D1 (de) 2011-05-26
AU767724B2 (en) 2003-11-20
WO2001056992A3 (en) 2002-01-24
CN1394204A (zh) 2003-01-29
PL214039B1 (pl) 2013-06-28
WO2001056992A2 (en) 2001-08-09
DE60138271D1 (de) 2009-05-20
CA2395601C (en) 2010-01-05
CA2395601A1 (en) 2001-08-09
IL188183A (en) 2011-02-28
US20030032800A1 (en) 2003-02-13
HU229420B1 (en) 2013-12-30
SK11262002A3 (sk) 2003-02-04
MY136474A (en) 2008-10-31
MXPA02007629A (es) 2002-12-13
NO20023575D0 (no) 2002-07-26
ES2324900T3 (es) 2009-08-19
PL392476A1 (pl) 2010-11-22
CA2639210C (en) 2011-05-03
IL150613A (en) 2010-05-17
GB0002740D0 (en) 2000-03-29
HK1052501A1 (en) 2003-09-19
CA2724295C (en) 2011-07-26
ATE505459T1 (de) 2011-04-15
DK2067772T3 (da) 2011-07-18
KR20090102882A (ko) 2009-09-30
PT2067772E (pt) 2011-07-13
HUP0300243A2 (hu) 2003-06-28
IL150613A0 (en) 2003-02-12
ZA200206219B (en) 2003-04-04
JP2003521536A (ja) 2003-07-15
CO5271705A1 (es) 2003-04-30
CN100455572C (zh) 2009-01-28
JP4859322B2 (ja) 2012-01-25
CN1721409A (zh) 2006-01-18
NO20023575L (no) 2002-07-26
EP1265868A2 (en) 2002-12-18
PL356404A1 (en) 2004-06-28
RU2303591C2 (ru) 2007-07-27
NZ520329A (en) 2003-11-28
ATE427938T1 (de) 2009-04-15
AR029442A1 (es) 2003-06-25
AU4237301A (en) 2001-08-14
HUP0300243A3 (en) 2005-07-28
RU2002123334A (ru) 2004-01-10
NO324949B1 (no) 2008-01-14
TR200201655T2 (tr) 2002-11-21
KR101216285B1 (ko) 2012-12-28
CN1244563C (zh) 2006-03-08
CA2639210A1 (en) 2001-08-09
EP2067772A2 (en) 2009-06-10
KR20020071033A (ko) 2002-09-11
CA2724295A1 (en) 2001-08-09
SI2067772T1 (sl) 2011-08-31
KR20100018069A (ko) 2010-02-16
US7112673B2 (en) 2006-09-26
PE20011078A1 (es) 2001-11-16
ES2363490T3 (es) 2011-08-05
BR0107922A (pt) 2002-10-22
SK287217B6 (sk) 2010-03-08

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