AR029442A1 - Un proceso para la produccion de derivados de dibenzo [b,f] azepina y compuestos intermediarios - Google Patents
Un proceso para la produccion de derivados de dibenzo [b,f] azepina y compuestos intermediariosInfo
- Publication number
- AR029442A1 AR029442A1 ARP010100515A ARP010100515A AR029442A1 AR 029442 A1 AR029442 A1 AR 029442A1 AR P010100515 A ARP010100515 A AR P010100515A AR P010100515 A ARP010100515 A AR P010100515A AR 029442 A1 AR029442 A1 AR 029442A1
- Authority
- AR
- Argentina
- Prior art keywords
- formula
- compound
- production
- reacting
- alkyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D223/18—Dibenzazepines; Hydrogenated dibenzazepines
- C07D223/22—Dibenz [b, f] azepines; Hydrogenated dibenz [b, f] azepines
- C07D223/24—Dibenz [b, f] azepines; Hydrogenated dibenz [b, f] azepines with hydrocarbon radicals, substituted by nitrogen atoms, attached to the ring nitrogen atom
- C07D223/26—Dibenz [b, f] azepines; Hydrogenated dibenz [b, f] azepines with hydrocarbon radicals, substituted by nitrogen atoms, attached to the ring nitrogen atom having a double bond between positions 10 and 11
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D223/18—Dibenzazepines; Hydrogenated dibenzazepines
- C07D223/22—Dibenz [b, f] azepines; Hydrogenated dibenz [b, f] azepines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
- C07C237/30—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having the nitrogen atom of the carboxamide group bound to hydrogen atoms or to acyclic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
- C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
- C07C271/26—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atom of at least one of the carbamate groups bound to a carbon atom of a six-membered aromatic ring
- C07C271/28—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atom of at least one of the carbamate groups bound to a carbon atom of a six-membered aromatic ring to a carbon atom of a non-condensed six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D223/18—Dibenzazepines; Hydrogenated dibenzazepines
- C07D223/22—Dibenz [b, f] azepines; Hydrogenated dibenz [b, f] azepines
- C07D223/24—Dibenz [b, f] azepines; Hydrogenated dibenz [b, f] azepines with hydrocarbon radicals, substituted by nitrogen atoms, attached to the ring nitrogen atom
- C07D223/28—Dibenz [b, f] azepines; Hydrogenated dibenz [b, f] azepines with hydrocarbon radicals, substituted by nitrogen atoms, attached to the ring nitrogen atom having a single bond between positions 10 and 11
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
- Epoxy Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
Un proceso para la produccion de un compuesto de formula (3), cuando R1 es alquilo (C1-4) mediante carbamoilacion de un compuesto de formula (2) con un cianato de metal; un proceso para la produccion de un compuesto de formula (5) en donde R2 es alquilo C1-4 o fenilo que comprende el cierre de anillo de un compuesto de formula (6), un proceso para la produccion de un compuesto de formula (5), que comprende el cierre de anillo de un compuesto de formula (7) en donde R3 y R4 independientemente son alquilo (C1-4); un proceso para la produccion de un compuesto de formula (1) que comprende reaccionar un compuesto de formula (5) con un compuesto de formula R1OH o (R1O)3CH; un proceso para la produccion de un compuesto de formula (6) que comprende reaccionar el compuesto de formula (8) bajo severas condiciones básicas con un compuesto de formula X-COOR2, en donde X es cloro o metoxilo; un procedimiento para la produccion de un compuesto de formula VII que comprende reaccionar un compuesto de formula (9) con un compuesto de formula CICOOR2, en donde R2 no es tert butilo, cuando R3 y R4 son ambos isopropilo y un proceso para la produccion de un compuesto de la formula (9) que comprende reaccionar el compuesto de formula (10) con un compuesto de formula R3-NH-R4. Los compuestos de formula (1), (5), (6), (7) y (9). Estos compuestos son utiles como intermediarios para la preparacion de oxcarbazepina.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB0002740.9A GB0002740D0 (en) | 2000-02-07 | 2000-02-07 | Organic compounds |
Publications (1)
Publication Number | Publication Date |
---|---|
AR029442A1 true AR029442A1 (es) | 2003-06-25 |
Family
ID=9885081
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP010100515A AR029442A1 (es) | 2000-02-07 | 2001-02-05 | Un proceso para la produccion de derivados de dibenzo [b,f] azepina y compuestos intermediarios |
ARP100104442A AR079237A2 (es) | 2000-02-07 | 2010-12-01 | Proceso para la preparacion de derivados de dibenzo(b,f) azepina |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP100104442A AR079237A2 (es) | 2000-02-07 | 2010-12-01 | Proceso para la preparacion de derivados de dibenzo(b,f) azepina |
Country Status (34)
Country | Link |
---|---|
US (1) | US7112673B2 (es) |
EP (2) | EP2067772B1 (es) |
JP (1) | JP4859322B2 (es) |
KR (5) | KR101216285B1 (es) |
CN (2) | CN100455572C (es) |
AR (2) | AR029442A1 (es) |
AT (2) | ATE505459T1 (es) |
AU (1) | AU767724B2 (es) |
BR (1) | BR0107922A (es) |
CA (3) | CA2724295C (es) |
CO (1) | CO5271705A1 (es) |
CY (1) | CY1111567T1 (es) |
CZ (1) | CZ301572B6 (es) |
DE (2) | DE60138271D1 (es) |
DK (1) | DK2067772T3 (es) |
ES (2) | ES2324900T3 (es) |
GB (1) | GB0002740D0 (es) |
HK (1) | HK1052501A1 (es) |
HU (1) | HU229420B1 (es) |
IL (3) | IL150613A0 (es) |
MX (1) | MXPA02007629A (es) |
MY (1) | MY136474A (es) |
NO (1) | NO324949B1 (es) |
NZ (1) | NZ520329A (es) |
PE (1) | PE20011078A1 (es) |
PL (2) | PL217225B1 (es) |
PT (2) | PT2067772E (es) |
RU (1) | RU2303591C2 (es) |
SI (1) | SI2067772T1 (es) |
SK (1) | SK287217B6 (es) |
TR (1) | TR200201655T2 (es) |
TW (1) | TWI284638B (es) |
WO (1) | WO2001056992A2 (es) |
ZA (1) | ZA200206219B (es) |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6670472B2 (en) | 2001-10-09 | 2003-12-30 | Max India Limited | Process for the preparation of 10-methoxycarbamazepine |
EP1302464A1 (en) * | 2001-10-09 | 2003-04-16 | Max India Limited | Process for preparation of 10-methoxycarbamazepine |
CA2486560A1 (en) | 2002-06-14 | 2003-12-24 | Taro Pharmaceuticals U.S.A., Inc. | Method of preparing a 5h-dibenz[b,f]azepine-5-carboxamide |
ITMI20040452A1 (it) | 2004-03-09 | 2004-06-09 | Clariant Lsm Italia Spa | Processo per la preparazione di oxcarbazepina |
ES2600460T3 (es) | 2005-05-10 | 2017-02-09 | Intermune, Inc. | Derivados de piridona-2-ona como moduladores del sistema de proteína cinasa activada por estrés |
EP2359830B1 (en) * | 2006-04-26 | 2012-09-19 | Supernus Pharmaceuticals, Inc. | Controlled released preparations of oxcarbazepine having sigmoidal release profile |
US20090082335A1 (en) * | 2007-09-26 | 2009-03-26 | Protia, Llc | Deuterium-enriched oxcarbazepine |
CA2726588C (en) | 2008-06-03 | 2019-04-16 | Karl Kossen | Compounds and methods for treating inflammatory and fibrotic disorders |
US20150232426A1 (en) | 2012-09-26 | 2015-08-20 | Ranbaxy Laboratories Limited | Process for the preparation of oxcarbazepine and its use as intermediate in the preparation of eslicarbazepine acetate |
AR092742A1 (es) | 2012-10-02 | 2015-04-29 | Intermune Inc | Piridinonas antifibroticas |
EP3043790B1 (en) | 2013-09-11 | 2021-05-26 | The Administrators of the Tulane Educational Fund | Novel anthranilic amides and the use thereof |
WO2015153683A1 (en) | 2014-04-02 | 2015-10-08 | Intermune, Inc. | Anti-fibrotic pyridinones |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4847374A (en) * | 1987-01-27 | 1989-07-11 | Ciba-Geigy Corporation | Process for the manufacture of N,N-(Dibenzohexatrienylene)ureas |
IT1272897B (it) * | 1995-01-13 | 1997-07-01 | I F C Iniziative Finanziaarie | Processo per la produzione di 10-oxo-10,11-diidro-sh- -dibenz(b,f) azepin-5-carbossiammide |
US6355680B1 (en) * | 1996-02-20 | 2002-03-12 | Exocell, Inc. | Albumin-binding compounds that prevent nonenzymatic glycation and that may be used for treatment of glycation-related pathologies |
IT1283594B1 (it) | 1996-04-12 | 1998-04-22 | Trifarma Srl | Derivati della 5h-dibenz- (b,f)-azepin-5-carbossiammide, loro preparazione e uso come sostanze ad azione medicinale |
DE69836378T2 (de) * | 1997-07-01 | 2007-10-11 | Warner-Lambert Co. Llc | Benzoesäure- und Benzamid-Derivate von Anthranilsäure und ihre Anwendung als MEK-Inhibitoren |
US6048856A (en) | 1997-12-17 | 2000-04-11 | Novo Nordisk A/S | Heterocyclic compounds |
-
2000
- 2000-02-07 GB GBGB0002740.9A patent/GB0002740D0/en not_active Ceased
-
2001
- 2001-02-05 PE PE2001000121A patent/PE20011078A1/es not_active Application Discontinuation
- 2001-02-05 AR ARP010100515A patent/AR029442A1/es not_active Application Discontinuation
- 2001-02-06 MY MYPI20010513A patent/MY136474A/en unknown
- 2001-02-06 CO CO01008602A patent/CO5271705A1/es active IP Right Grant
- 2001-02-07 KR KR1020107000738A patent/KR101216285B1/ko not_active IP Right Cessation
- 2001-02-07 SK SK1126-2002A patent/SK287217B6/sk not_active IP Right Cessation
- 2001-02-07 AU AU42373/01A patent/AU767724B2/en not_active Ceased
- 2001-02-07 PL PL392476A patent/PL217225B1/pl unknown
- 2001-02-07 WO PCT/EP2001/001330 patent/WO2001056992A2/en active Application Filing
- 2001-02-07 US US10/182,980 patent/US7112673B2/en not_active Expired - Lifetime
- 2001-02-07 ES ES01915203T patent/ES2324900T3/es not_active Expired - Lifetime
- 2001-02-07 SI SI200130996T patent/SI2067772T1/sl unknown
- 2001-02-07 DE DE60138271T patent/DE60138271D1/de not_active Expired - Lifetime
- 2001-02-07 PT PT09153375T patent/PT2067772E/pt unknown
- 2001-02-07 AT AT09153375T patent/ATE505459T1/de active
- 2001-02-07 KR KR1020097019039A patent/KR100966209B1/ko active IP Right Grant
- 2001-02-07 AT AT01915203T patent/ATE427938T1/de active
- 2001-02-07 KR KR1020027010123A patent/KR20020071033A/ko not_active Application Discontinuation
- 2001-02-07 KR KR1020077029687A patent/KR100931753B1/ko not_active IP Right Cessation
- 2001-02-07 PT PT01915203T patent/PT1265868E/pt unknown
- 2001-02-07 CA CA2724295A patent/CA2724295C/en not_active Expired - Fee Related
- 2001-02-07 DK DK09153375.2T patent/DK2067772T3/da active
- 2001-02-07 PL PL356404A patent/PL214039B1/pl unknown
- 2001-02-07 KR KR1020087027467A patent/KR20080103608A/ko not_active Application Discontinuation
- 2001-02-07 CN CNB2005100853024A patent/CN100455572C/zh not_active Expired - Lifetime
- 2001-02-07 CZ CZ20022676A patent/CZ301572B6/cs not_active IP Right Cessation
- 2001-02-07 IL IL15061301A patent/IL150613A0/xx unknown
- 2001-02-07 CN CNB018035302A patent/CN1244563C/zh not_active Expired - Lifetime
- 2001-02-07 EP EP09153375A patent/EP2067772B1/en not_active Expired - Lifetime
- 2001-02-07 EP EP01915203A patent/EP1265868B1/en not_active Expired - Lifetime
- 2001-02-07 TR TR2002/01655T patent/TR200201655T2/xx unknown
- 2001-02-07 JP JP2001556842A patent/JP4859322B2/ja not_active Expired - Lifetime
- 2001-02-07 ES ES09153375T patent/ES2363490T3/es not_active Expired - Lifetime
- 2001-02-07 BR BR0107922-0A patent/BR0107922A/pt not_active Application Discontinuation
- 2001-02-07 CA CA002395601A patent/CA2395601C/en not_active Expired - Fee Related
- 2001-02-07 HU HU0300243A patent/HU229420B1/hu unknown
- 2001-02-07 NZ NZ520329A patent/NZ520329A/en not_active IP Right Cessation
- 2001-02-07 RU RU2002123334/04A patent/RU2303591C2/ru not_active IP Right Cessation
- 2001-02-07 MX MXPA02007629A patent/MXPA02007629A/es active IP Right Grant
- 2001-02-07 DE DE60144456T patent/DE60144456D1/de not_active Expired - Lifetime
- 2001-02-07 CA CA2639210A patent/CA2639210C/en not_active Expired - Fee Related
- 2001-02-09 TW TW090102908A patent/TWI284638B/zh not_active IP Right Cessation
-
2002
- 2002-07-04 IL IL150613A patent/IL150613A/en not_active IP Right Cessation
- 2002-07-26 NO NO20023575A patent/NO324949B1/no not_active IP Right Cessation
- 2002-08-05 ZA ZA200206219A patent/ZA200206219B/en unknown
-
2003
- 2003-05-13 HK HK03103369.4A patent/HK1052501A1/xx not_active IP Right Cessation
-
2007
- 2007-12-17 IL IL188183A patent/IL188183A/en not_active IP Right Cessation
-
2010
- 2010-12-01 AR ARP100104442A patent/AR079237A2/es unknown
-
2011
- 2011-06-16 CY CY20111100572T patent/CY1111567T1/el unknown
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Legal Events
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FG | Grant, registration | ||
FD | Application declared void or lapsed, e.g., due to non-payment of fee |