RU2002120905A - Замещенные производные аминометилфенилциклогексана - Google Patents

Замещенные производные аминометилфенилциклогексана

Info

Publication number
RU2002120905A
RU2002120905A RU2002120905/04A RU2002120905A RU2002120905A RU 2002120905 A RU2002120905 A RU 2002120905A RU 2002120905/04 A RU2002120905/04 A RU 2002120905/04A RU 2002120905 A RU2002120905 A RU 2002120905A RU 2002120905 A RU2002120905 A RU 2002120905A
Authority
RU
Russia
Prior art keywords
dimethylaminomethyl
methoxyphenyl
benzoic acid
rac
cyclohexylidenemethyl
Prior art date
Application number
RU2002120905/04A
Other languages
English (en)
Russian (ru)
Inventor
Клаудиа ПЮТЦ (DE)
Клаудиа ПЮТЦ
Вольфганг ШТРАССБУРГЕР (DE)
Вольфганг ШТРАССБУРГЕР
Бабетте-Ивонне КЁГЕЛЬ (DE)
Бабетте-Ивонне КЁГЕЛЬ
Original Assignee
Грюненталь ГмбХ (DE)
Грюненталь Гмбх
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Грюненталь ГмбХ (DE), Грюненталь Гмбх filed Critical Грюненталь ГмбХ (DE)
Publication of RU2002120905A publication Critical patent/RU2002120905A/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
    • C07C215/46—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C215/64—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with rings other than six-membered aromatic rings being part of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12—Antidiarrhoeals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/04—Drugs for disorders of the respiratory system for throat disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/14—Antitussive agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/04—Antipruritics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/32—Alcohol-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/54—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C217/74—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with rings other than six-membered aromatic rings being part of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/38—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino groups bound to acyclic carbon atoms and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
    • C07C237/30—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having the nitrogen atom of the carboxamide group bound to hydrogen atoms or to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/16—Systems containing only non-condensed rings with a six-membered ring the ring being unsaturated

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pulmonology (AREA)
  • Addiction (AREA)
  • Psychiatry (AREA)
  • Urology & Nephrology (AREA)
  • Pain & Pain Management (AREA)
  • Cardiology (AREA)
  • Rheumatology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Dermatology (AREA)
  • Anesthesiology (AREA)
  • Immunology (AREA)
  • Otolaryngology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
RU2002120905/04A 2000-01-05 2000-12-27 Замещенные производные аминометилфенилциклогексана RU2002120905A (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10000312A DE10000312A1 (de) 2000-01-05 2000-01-05 Substituierte Aminomethyl-Phenyl-Cyclohexanderivate
DE10000312.5 2000-01-05

Publications (1)

Publication Number Publication Date
RU2002120905A true RU2002120905A (ru) 2004-01-10

Family

ID=7626853

Family Applications (1)

Application Number Title Priority Date Filing Date
RU2002120905/04A RU2002120905A (ru) 2000-01-05 2000-12-27 Замещенные производные аминометилфенилциклогексана

Country Status (27)

Country Link
US (1) US6673794B2 (zh)
EP (1) EP1246793B1 (zh)
JP (1) JP2003519210A (zh)
KR (1) KR20020063294A (zh)
CN (1) CN100379719C (zh)
AR (1) AR033506A1 (zh)
AT (1) ATE282021T1 (zh)
AU (1) AU780547B2 (zh)
BR (1) BR0016942A (zh)
CA (1) CA2396304A1 (zh)
CO (1) CO5251382A1 (zh)
CZ (1) CZ20022337A3 (zh)
DE (2) DE10000312A1 (zh)
ES (1) ES2231312T3 (zh)
HK (1) HK1050889A1 (zh)
HU (1) HU225102B1 (zh)
IL (2) IL150557A0 (zh)
MX (1) MXPA02006700A (zh)
NO (1) NO20022985L (zh)
NZ (1) NZ520467A (zh)
PE (1) PE20011044A1 (zh)
PL (1) PL364873A1 (zh)
PT (1) PT1246793E (zh)
RU (1) RU2002120905A (zh)
SK (1) SK286836B6 (zh)
WO (1) WO2001049654A2 (zh)
ZA (1) ZA200206151B (zh)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2470011C2 (ru) * 2007-05-31 2012-12-20 Сепракор Инк. Циклоалкиламины, содержащие в качестве заместителя фенил, как ингибиторы обратного захвата моноаминов

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10049483A1 (de) * 2000-09-29 2002-05-02 Gruenenthal Gmbh Substituierte 1-Aminobutan-3-ol-Derivate
DE10112198A1 (de) * 2001-03-14 2002-09-19 Gruenenthal Gmbh Substituierte Dimethyl-[1-(1-phenyl-cyclohexyl)-piperidin-3-ylmethyl]-amine
DE10224107A1 (de) * 2002-05-29 2003-12-11 Gruenenthal Gmbh Kombination ausgewählter Opioide mit anderen Wirkstoffen zur Therapie der Harninkontinenz
HUE033042T2 (en) 2002-11-22 2017-11-28 Gruenenthal Gmbh Combination of selected analgesics with COX II inhibitors
US20040248979A1 (en) * 2003-06-03 2004-12-09 Dynogen Pharmaceuticals, Inc. Method of treating lower urinary tract disorders
DE102005034973A1 (de) * 2005-07-22 2007-02-15 Grünenthal GmbH Salz von Dimethylaminomethyl-phenyl-cyclohexan und dessen kristalline Formen
KR100684436B1 (ko) * 2005-09-08 2007-02-16 주식회사 다원 항산화, 지질과산화 억제에 따른 항노화, 항염증 및 거담 활성을 갖는 단풍마 및 가시오가피 혼합추출물을 함유하는 조성물
DE102005061427A1 (de) * 2005-12-22 2007-06-28 Grünenthal GmbH Substituierte Oxadiazol-Derivate
DE102005061430A1 (de) * 2005-12-22 2007-07-05 Grünenthal GmbH Substituierte Imidazolin-Derivate
DE102005061428A1 (de) * 2005-12-22 2007-08-16 Grünenthal GmbH Substituierte Cyclohexylmethyl-Derivate
CN113197935B (zh) * 2021-04-13 2022-06-24 开平健之源保健食品有限公司 一种厚朴提取物的提取方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5223541A (en) * 1991-09-13 1993-06-29 Mcneilab, Inc. Tramadol n-oxide material, enantiomers and compositions thereof, and their use
IL112569A (en) * 1994-02-10 1999-12-22 Wyeth John & Brother Ltd Pharmaceutical compositions comprising cyclohexylamine derivatives certain such novel compounds and their preparation
DE4426245A1 (de) * 1994-07-23 1996-02-22 Gruenenthal Gmbh 1-Phenyl-3-dimethylamino-propanverbindungen mit pharmakologischer Wirkung
DE19525137C2 (de) * 1995-07-11 2003-02-27 Gruenenthal Gmbh 6-Dimethylaminomethyl-1-phenyl-cyclohexanverbin -dungen als Zwischenprodukte zur Herstellung pharmazeutischer Wirkstoffe
DE19547766A1 (de) * 1995-12-20 1997-06-26 Gruenenthal Gmbh 1-Phenyl-2-dimethylaminomethyl-cyclohexan-1-ol-verbindungen als pharmazeutische Wirkstoffe
DE19857475A1 (de) 1998-12-14 2000-06-15 Gruenenthal Gmbh Substituierte Cycloheptene, deren Herstellung und Verwendung

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2470011C2 (ru) * 2007-05-31 2012-12-20 Сепракор Инк. Циклоалкиламины, содержащие в качестве заместителя фенил, как ингибиторы обратного захвата моноаминов

Also Published As

Publication number Publication date
NO20022985L (no) 2002-08-28
HK1050889A1 (en) 2003-07-11
ES2231312T3 (es) 2005-05-16
CN1437576A (zh) 2003-08-20
MXPA02006700A (es) 2002-09-30
NO20022985D0 (no) 2002-06-20
EP1246793B1 (de) 2004-11-10
IL150557A0 (en) 2003-02-12
SK286836B6 (sk) 2009-06-05
ZA200206151B (en) 2003-11-03
BR0016942A (pt) 2003-06-10
PL364873A1 (en) 2004-12-27
HUP0204001A2 (hu) 2003-11-28
SK9812002A3 (en) 2003-02-04
WO2001049654A3 (de) 2002-05-16
CA2396304A1 (en) 2001-07-12
NZ520467A (en) 2004-02-27
IL150557A (en) 2007-03-08
US20030069288A1 (en) 2003-04-10
PE20011044A1 (es) 2001-11-24
US6673794B2 (en) 2004-01-06
AU2843801A (en) 2001-07-16
HUP0204001A3 (en) 2005-04-28
DE10000312A1 (de) 2001-07-12
KR20020063294A (ko) 2002-08-01
AU780547B2 (en) 2005-03-24
EP1246793A2 (de) 2002-10-09
DE50008626D1 (en) 2004-12-16
AR033506A1 (es) 2003-12-26
JP2003519210A (ja) 2003-06-17
ATE282021T1 (de) 2004-11-15
PT1246793E (pt) 2005-03-31
CZ20022337A3 (cs) 2002-11-13
WO2001049654A2 (de) 2001-07-12
CO5251382A1 (es) 2003-02-28
CN100379719C (zh) 2008-04-09
HU225102B1 (en) 2006-06-28

Similar Documents

Publication Publication Date Title
RU2002120905A (ru) Замещенные производные аминометилфенилциклогексана
JP5831835B2 (ja) ２―フェニル―１，２―エタンジオールのハロゲンで置換されたカルバメート化合物
JP2866744B2 (ja) 眼の炎症障害を処置するための３‐ベンゾイルフェニル酢酸誘導体を含む局所的に投与可能な組成物
RU2336267C2 (ru) Производные пирролидона в качестве ингибиторов маов
KR20000076314A (ko) 신규한 화합물, 그것의 용도 및 제조
SK11822003A3 (sk) N-fenpropylcyklopentylom substituované glutaramidové deriváty ako NEP inhibítory pre FSAD
NL1032046C2 (nl) Prostaglandinederivaten.
RU2005137175A (ru) Производные сложного эфира и амида 2-цианопропановой кислоты и способы их применения
JP2003506426A5 (zh)
US5648540A (en) Amine preparation
RU2007147344A (ru) Новые производные 2-азетидинона для лечения гиперлипидемических заболеваний
RU2002105496A (ru) Замещенные производные 2-диалкиламиноалкилбифенила
RU2004131201A (ru) Фосфатные пролекарства фтороксиндолов
KR890005052A (ko) 신규 피페리딘 유도체
BE897828A (nl) Piperazinederivaten met anti-cholinergische en/of anti-histamineactiviteit.
RU97117590A (ru) Пирролидинильные производные гидроксамовой кислоты и способ их получения
JP2002530378A5 (zh)
US20010034365A1 (en) Halogen substituted carbamate compounds from 2-phenyl-1,2-ethanediol
JP2007536318A5 (zh)
JP2005526795A5 (zh)
RU2222537C2 (ru) Новые производные морфолина, способ их получения и содержащие их фармацевтические композиции
RU2002120897A (ru) Производные аминометилфенилциклогексанона
JP3077047B2 (ja) 新規ピペラジン誘導体
JP2004504280A5 (zh)
JP2005533831A (ja) ＨＭＧＣｏＡ−リダクターゼインヒビター

Legal Events

Date Code Title Description
FA92 Acknowledgement of application withdrawn (lack of supplementary materials submitted)

Effective date: 20050426