AR033506A1 - Derivados de aminometil-fenil-ciclohexano sustituidos,procedimiento para su preparacion, su uso para la preparacion de medicamentos y medicamentos que contienen estos compuestos - Google Patents

Derivados de aminometil-fenil-ciclohexano sustituidos,procedimiento para su preparacion, su uso para la preparacion de medicamentos y medicamentos que contienen estos compuestos

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Publication number
AR033506A1
AR033506A1 ARP010100009A ARP010100009A AR033506A1 AR 033506 A1 AR033506 A1 AR 033506A1 AR P010100009 A ARP010100009 A AR P010100009A AR P010100009 A ARP010100009 A AR P010100009A AR 033506 A1 AR033506 A1 AR 033506A1
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Argentina
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polysubstituted
mono
unsubstituted
saturated
unsaturated
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ARP010100009A
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Gruenenthal Gmbh
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    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
    • C07C215/46—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C215/64—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with rings other than six-membered aromatic rings being part of the carbon skeleton
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    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/04—Antipruritics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/32—Alcohol-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/54—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C217/74—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with rings other than six-membered aromatic rings being part of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/38—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino groups bound to acyclic carbon atoms and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
    • C07C237/30—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having the nitrogen atom of the carboxamide group bound to hydrogen atoms or to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/16—Systems containing only non-condensed rings with a six-membered ring the ring being unsaturated

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Life Sciences & Earth Sciences (AREA)
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  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pulmonology (AREA)
  • Addiction (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Urology & Nephrology (AREA)
  • Cardiology (AREA)
  • Rheumatology (AREA)
  • Dermatology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Anesthesiology (AREA)
  • Immunology (AREA)
  • Otolaryngology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Derivados de aminometil-fenil-ciclohexano sustituidos de la formula general (1) o (1a), en las cuales R1 y R1' representan independientemente entre sí, H, C1-10-alquilo, C2-10-alquenilo o C2-10 alquinilo, ramificados o no ramificados, no sustituidos o mono o polisustituidos, F, Cl, Br, I, NR6R6', NO2, CN, OR6, SR6, OC(O)R6, C(O)OR6, C(O)R6 o C(O)NR6R6', estando elegidos R6 y R6' del grupo que comprende: H; C1-10-alquilo, C2-10-alquenilo o C1-10-alquinilo, ramificados o no ramificados, no sustituidos o mono o polisustituidos, C3-7-cicloalquilo, saturado o mono o polisustituido o mono o polisustituido o un heterociclo correspondiente en donde un átomo de carbono en el ciclo está sustituido por N, S u O, alquilarilo, saturado o insaturado, no sustituido o mono o polisustituido, arilo o heteroarilo, no sustituido o mono o polisustituido o, R1 y R1' en conjunto forman el radical -CH=CH-CH=CH-, y el sistema de naftilo resultante puede estar mono o polisustituido, X representa H; F; Cl, Br, CF3, OS(O2)C6H4-pCH3, OR7 u OC(O)R7, estando elegido R7 del grupo que comprende H, C1-10-alquilo, C2-10-alquenilo o C2-10-alquinilo, ramificados o no ramificados, no sustituidos o mono o polisustituidos, C3-7-cicloalquilo, saturado o insaturado, no sustituido o poli o monosustituido o un heterociclo correspondiente en un átomo de carbono en el ciclo está sustituido por N, S u O, alquilarilo saturado o insaturado, no sustituido o mono o polisustituido, arilo, o heteroarilo no sustituido o mono o polisustituido, o cuando el compuesto carece de X en la formula 1a existe una doble ligadura entre el átomo de carbono A y el átomo de carbono B o entre el átomo de carbono B y el átomo de carbono C, R4 y R5 independientemente entre sí representan H, C1-10-alquilo, C2-10-alquenilo o C2-10-alquinilo, ramificados o no ramificados, no sustituidos o mono o polisustituidos; C3-7-cicloalquilo, saturado o insaturado, no sustituido o mono o polisustituido o un heterociclo correspondiente, en que un átomo de carbono en el ciclo está sustituido por N, S u O, alquilarilo saturado o insaturado, no sustituido o mono o polisustituido, arilo o heteroarilo, no sustituido o mono o polisustituido, o R4 y R5 conjuntamente forman C3-7-cicloalquilo, saturado o insaturado y no sustituido o mono o polisustituido o un heterociclo correspondiente en donde un átomo de carbono en el ciclo está sustituido por S, O o NR8, estando elegido R8 del grupo que comprende H, C1-10-alquilo, C2-10-alquenilo o C2-10-alquinilo, ramificado o no ramificado y no sustituidos o mono o polisustituidos, y R2 y R3 independientemente entre sí representan R9 o YR9 en donde Y representa C1-10-alquilo, C2-10-alquenilo o C2-10-alquinilo ramificado o no ramificado, no sustituido o mono o polisustituido, estando elegido R9 del grupo que comprende H, F, Cl, Br, I, CN, NO2, C1-18-alquilo, C2-18-alquenilo o C2-18-alqluinilo, ramificado o no ramificado, no sustituido o mono o polisustituido, C3-7-cicloalquilo, saturado o insaturado, no sustituido o mono o polisustituido, o un heterociclo correspondiente en un átomo de carbono en el ciclo está sustituido por S, O o NR10, OR11, OC(O)R11, OC(O)OR11, OC(S)R11, C(O)R11, C(O)OR11, C(S)R11, C(S)OR11, SR11, S(O)R11 o S(O2)R11, estando elegido R11 del grupo que comprende H, C1-18-alquilo, C2-18-alquenilo o C2-18-alquinilo, ramificado o no ramificado, no sustituido o mono o polisustituido, C3-7-cicloalquilo, saturado o insaturado, no sustituido o mono o polisustituido o un heterociclo correspondiente en donde un átomo de carbono en el ciclo está sustituido por S, O o NR12, alquilarilo, saturado o insaturado, no sustituido o mono o polisustituido; arilo o heteroarilo, no sustituido o mono o polisustituido; NR13R14, NR13C(O)R14, C(O)NR13R14 o S(O2)NR13R14, estando elegidos R13 y R14 independientemente entre sí del grupo que comprende H, O, C1-18-alquilo, C2-18-alquenilo, C2-18-alquinilo ramificados o no ramificados, no sustituidos o mono o polisustituidos; C3-7-cicloalquilo, saturado o insaturado, no sustituido, o mono o polisustituido o un heterociclo correspondiente en un átomo de carbono en el ciclo está sustituido por S, O o NR15, alquilarilo, saturado o insaturado, no sustituido o mono o polisustituido; arilo o heteroarilo, no sustituido o mono o polisustituido, o R13 y R14 en conjunto forman un C3-7-cicloalquilo, saturado o insaturado, no sustituido o mono o polisustituido o un heterociclo correspondiente en un átomo de carbono en el ciclo está sustituido por S, O, o NR16, alquilarilo, arilo o heteroarilo no sustituidos, o mono o polisustituidos particularmente formula (2) o (2a) estando elegidos R17, R18, R19 y R20 independientemente entre sí del grupo que comprende R21 o ZR21 en donde Z representa C1-10-alquilo, C2-10-alquinilo, ramificado o no ramificado, no sustituido o mono o polisustituido y estando elegido R21 del grupo que comprende H, F, Cl, Br, I, CN, NO2, C1-18-alquilo, C2-18-alquenilo, o C2-18-alquinilo, ramificado o no ramificado, no sustituido o mono o polisustituido; C3-7-cicloalquilo, saturado o insaturado, no sustituido o mono o polisustituido, o un heterociclo correspondiente, en un átomo de carbono en el ciclo está sustituido por S, O o NR22, alquilarilo, arilo o heteroarilo, no sustituido o mono o polisustituido; OR23, OC(O)R23, OC(O)OR23, OC(S)R23, C(O)R23, C(O)R23, C(S)R23, C(S)OR23, SR23, S(O)R23 o S(O2)R23, estando elegido R23 del grupo que comprende H, C1-18-alquilo, C2-18-alquenilo, o C2-18-alquinilo, ramificado o no ramificado, no sustituido o mono o polisustituido, C3-7-cicloalquilo, saturado o no saturado, no sustituido o mono o polisustituido, o un heterociclo correspondiente en donde un átomo de carbono en el ciclo está sustituido por S, O o NR24, alquilarilo, saturado o insaturado, no sustituido o mono o polisustituido, arilo o heteroarilo no sustituido o mono o polisustituido; NR25R26, NR25C(O)R26, C(O)NR25R26 o S(O2)NR25R26, estando elegido R25 y R26 independientemente entre si del grupo que comprende H, C1-18-alquilo, C2-18-alquenilo o C2-18-alquinilo, ramificado o no ramificado, o no sustituido o mono o polisustituidos, C3-7-cicloalquilo, saturado o insaturado, no sustituido o mono o polisustituido o un heterociclo correspondiente en donde un átomo de carbono en el ciclo está sustituido por S, O o NR27, estando elegido R27 del grupo que comprende H, C1-10-alquilo, C2-10-alquenilo, o C2-10-alquinilo, ramificado o no ramificado, no sustituido o mono o polisustituido; alquilarilo, saturado o insaturado, no sustituido o mono o polisustituido; arilo o heteroarilo, no sustituido o mono o polisustituido; R25 y R26 conjuntamente forman un C3-7-cicloalquilo saturado o insaturado, no sustituido o mono o polisustituido, o un heterociclo correspondiente en que un átomo de carbono en el ciclo está sustituido por S, O o NR28, procedimientos para su preparacion, medicamentos que contienen estos compuestos y su uso para la preparacion de medicamentos para combatir el dolor, para el tratamiento de la incontinencia urinaria, prurito y/o diarrea, o para el tratamiento de reacciones inflamatorias y alérgicas, depresiones, abuso de drogas y/o alcohol, gastritis, enfermedades cardiovasculares, enfermedades de las vías respiratorias, tos, enfermedades psíquicas y/o epilepsia.
ARP010100009A 2000-01-05 2001-01-02 Derivados de aminometil-fenil-ciclohexano sustituidos,procedimiento para su preparacion, su uso para la preparacion de medicamentos y medicamentos que contienen estos compuestos AR033506A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE10000312A DE10000312A1 (de) 2000-01-05 2000-01-05 Substituierte Aminomethyl-Phenyl-Cyclohexanderivate

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AR033506A1 true AR033506A1 (es) 2003-12-26

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US (1) US6673794B2 (es)
EP (1) EP1246793B1 (es)
JP (1) JP2003519210A (es)
KR (1) KR20020063294A (es)
CN (1) CN100379719C (es)
AR (1) AR033506A1 (es)
AT (1) ATE282021T1 (es)
AU (1) AU780547B2 (es)
BR (1) BR0016942A (es)
CA (1) CA2396304A1 (es)
CO (1) CO5251382A1 (es)
CZ (1) CZ20022337A3 (es)
DE (2) DE10000312A1 (es)
ES (1) ES2231312T3 (es)
HK (1) HK1050889A1 (es)
HU (1) HU225102B1 (es)
IL (2) IL150557A0 (es)
MX (1) MXPA02006700A (es)
NO (1) NO20022985L (es)
NZ (1) NZ520467A (es)
PE (1) PE20011044A1 (es)
PL (1) PL364873A1 (es)
PT (1) PT1246793E (es)
RU (1) RU2002120905A (es)
SK (1) SK286836B6 (es)
WO (1) WO2001049654A2 (es)
ZA (1) ZA200206151B (es)

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DE10112198A1 (de) * 2001-03-14 2002-09-19 Gruenenthal Gmbh Substituierte Dimethyl-[1-(1-phenyl-cyclohexyl)-piperidin-3-ylmethyl]-amine
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KR100684436B1 (ko) * 2005-09-08 2007-02-16 주식회사 다원 항산화, 지질과산화 억제에 따른 항노화, 항염증 및 거담 활성을 갖는 단풍마 및 가시오가피 혼합추출물을 함유하는 조성물
DE102005061430A1 (de) * 2005-12-22 2007-07-05 Grünenthal GmbH Substituierte Imidazolin-Derivate
DE102005061427A1 (de) * 2005-12-22 2007-06-28 Grünenthal GmbH Substituierte Oxadiazol-Derivate
DE102005061428A1 (de) * 2005-12-22 2007-08-16 Grünenthal GmbH Substituierte Cyclohexylmethyl-Derivate
JP5420534B2 (ja) 2007-05-31 2014-02-19 サノビオン ファーマシューティカルズ インク モノアミン再取り込み阻害薬としてのフェニル置換シクロアルキルアミン
CN113197935B (zh) * 2021-04-13 2022-06-24 开平健之源保健食品有限公司 一种厚朴提取物的提取方法

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HUP0204001A2 (hu) 2003-11-28
CN1437576A (zh) 2003-08-20
ZA200206151B (en) 2003-11-03
EP1246793A2 (de) 2002-10-09
PL364873A1 (en) 2004-12-27
MXPA02006700A (es) 2002-09-30
US6673794B2 (en) 2004-01-06
DE10000312A1 (de) 2001-07-12
CA2396304A1 (en) 2001-07-12
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EP1246793B1 (de) 2004-11-10
KR20020063294A (ko) 2002-08-01
AU2843801A (en) 2001-07-16
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US20030069288A1 (en) 2003-04-10
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PT1246793E (pt) 2005-03-31
NO20022985L (no) 2002-08-28
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HU225102B1 (en) 2006-06-28
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