RO101578B - Procedeu de obtinere a amidelor pe cale microbiologica - Google Patents

Procedeu de obtinere a amidelor pe cale microbiologica

Info

Publication number
RO101578B
RO101578B RO135188A RO13518888A RO101578B RO 101578 B RO101578 B RO 101578B RO 135188 A RO135188 A RO 135188A RO 13518888 A RO13518888 A RO 13518888A RO 101578 B RO101578 B RO 101578B
Authority
RO
Romania
Prior art keywords
culture
substrate
enzyme
cells
culture medium
Prior art date
Application number
RO135188A
Other languages
English (en)
Inventor
Yamada Hideaki
Nagasawa Toru
Original Assignee
Yamada Hideaki
Nitto Kagaku Kogyo Kabushiki Kaisha
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yamada Hideaki, Nitto Kagaku Kogyo Kabushiki Kaisha filed Critical Yamada Hideaki
Publication of RO101578B publication Critical patent/RO101578B/ro

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J9/00—Working-up of macromolecular substances to porous or cellular articles or materials; After-treatment thereof
    • C08J9/0014—Use of organic additives
    • C08J9/0023—Use of organic additives containing oxygen
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/78—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/02—Amides, e.g. chloramphenicol or polyamides; Imides or polyimides; Urethanes, i.e. compounds comprising N-C=O structural element or polyurethanes
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J2325/00—Characterised by the use of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by an aromatic carbocyclic ring; Derivatives of such polymers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Emergency Medicine (AREA)
  • Materials Engineering (AREA)
  • Polymers & Plastics (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)

Abstract

Procedeul, conform inventiei, consta în aceea ca prevede, cultivarea unui microorganism din speciile Rhodococcus rhodochrous, de preferinta R. rhodochrous FERM 1478, înregistrat în Depozitul International de Microorganisme, Japonia, într-un mediu de cultura ce contine 5...15 mg/l ioni de cobalt sub forma de clorura de cobalt si 2...6 g/l inductor de enzima reprezentat de crotonamida la temperatura de 15...50 degree C, de preferinta 20...45 degree C, pH=7...9, de preferinta 8, timp de 30...120 h, când are loc o reactie de hidratare a substratului selectat din cadrul nitrililor aromaticil cum ar fi 4-, 3- si 2- ciano-piridine, benzonitril, o-, m- si para- clorbenzonitril, o-m- si p-fluorobenzonitril, o- si m- nitrobenzonitril, p-aminobenzonitril, o-, m- si p- tolunitril, 4-cianofenol, anisonitril, ftalonitril, izoftalonitril, tereftalonitril, 2,6-ciclorbenzonitril, 2,4-diclorobenzonitril, 2,6-difluobenzonitril, alfa- si beta- naftonitril, 2-triofencarbonitril, 2-furonitril, 5-cianoindol, cianopirazina sau a nitriilor alifatici având 2...6 atomi de carbon, de preferinta acrilonitril si transformarea acestui substrat într-o amida corespunzatoare, aceasta în situatia când substratul este prezent într-o concentratie de 0,5...12 moli/l mediu de cultura, iar în varianta ca substratul este adaugat în cultura, în concentratie 0,5...12 moli/l mediu de cultura, iar în cultura exista enzima nitrilhidrataza acumulata sau substratul este contactat cu celulele numitului microorganism izolat din cultura în care au fost acumulate, cu enzima extrasa din celule sau cu celulele imobilzate sau extractul enzimatic al lor, cultura este efectuata la temperatura d
RO135188A 1987-09-18 1988-09-16 Procedeu de obtinere a amidelor pe cale microbiologica RO101578B (ro)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP23459787 1987-09-18
JP7276688 1988-03-26

Publications (1)

Publication Number Publication Date
RO101578B true RO101578B (ro) 1992-01-13

Family

ID=26413903

Family Applications (1)

Application Number Title Priority Date Filing Date
RO135188A RO101578B (ro) 1987-09-18 1988-09-16 Procedeu de obtinere a amidelor pe cale microbiologica

Country Status (21)

Country Link
US (1) US5334519A (ro)
EP (1) EP0307926B1 (ro)
JP (1) JPH0655148B2 (ro)
KR (1) KR0134094B1 (ro)
CN (1) CN1015473B (ro)
AT (1) ATE85082T1 (ro)
BG (1) BG48934A3 (ro)
BR (1) BR8804804A (ro)
CA (1) CA1298222C (ro)
DD (1) DD274631A5 (ro)
DE (1) DE3877869T2 (ro)
DK (1) DK174516B1 (ro)
ES (1) ES2043752T3 (ro)
FI (1) FI93858C (ro)
HU (1) HU204099B (ro)
MX (1) MX169933B (ro)
NO (1) NO175489C (ro)
PL (2) PL161959B1 (ro)
PT (1) PT88540B (ro)
RO (1) RO101578B (ro)
RU (1) RU1838416C (ro)

Families Citing this family (62)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU627648B2 (en) * 1990-02-28 1992-08-27 Teruhiko Beppu Dna fragment encoding a polypeptide having nitrile hydratase activity, a transformant containing the gene and a process for the production of amides using the transformant
US5648256A (en) * 1990-02-28 1997-07-15 Nitto Chemical Industry Co., Ltd. Gene encoding a polypeptide having nitrile hydratase activity, a transformant containing the gene and a process for the production of amides using the transformant
JP3009421B2 (ja) * 1990-02-28 2000-02-14 秀明 山田 有機酸の生物学的製造法
EP0486289B1 (en) * 1990-11-14 1997-07-09 Nitto Chemical Industry Co., Ltd. Biological process for producing alpha-hydroxyamide or alpha-hydroxy acid
US5753472A (en) * 1991-05-02 1998-05-19 Nitto Chemical Industry Co. Ltd. DNA fragment encoding a polypeptide having nitrile hydratase activity, a transformant containing the gene and a process for the production of amides using the transformant
JPH05244968A (ja) * 1991-08-16 1993-09-24 Mitsui Toatsu Chem Inc α−ヒドロキシイソブチルアミドの製造法
GEP20012441B (en) * 1993-04-02 2001-05-25 Lonza Ag Process for Preparing 3-Methylpiperidine and 3-Methylpyridine
RU2053300C1 (ru) * 1993-12-17 1996-01-27 Государственный научно-исследовательский институт генетики и селекции промышленных микроорганизмов Штамм бактерий rhodococcus rhodochrous - продуцент нитрилгидратазы
KR100339723B1 (ko) * 1994-02-01 2002-09-25 스미또모 가가꾸 고오교오 가부시끼가이샤 미생물을사용한아미드화합물의제조방법
JP3235934B2 (ja) 1994-08-04 2001-12-04 三菱レイヨン株式会社 ロドコッカス属細菌由来カナマイシン耐性遺伝子
JP3163224B2 (ja) * 1994-10-14 2001-05-08 三菱レイヨン株式会社 菌体または固定化菌体の懸濁液の保存方法
CH689831A5 (de) * 1995-11-07 1999-12-15 Eprova Ag Stabile kristalline Tetrahydrofolsaeure-Salze.
ZA968485B (en) * 1995-11-01 1997-05-20 Lonza Ag Process for preparing nicotinamide
GB9525372D0 (en) * 1995-12-12 1996-02-14 Allied Colloids Ltd Enzymes, their preparation and their use in the production of ammonium acrylate
CN1260363C (zh) 1996-02-14 2006-06-21 三井化学株式会社 由腈化合物生产酰胺的方法
US5728556A (en) * 1996-03-14 1998-03-17 E. I. Du Pont De Nemours And Company Production of ω-cyanocarboxamides from aliphatic α,ω-dinitriles using pseudomonas putida-derived biocatalysts
US5863750A (en) * 1996-12-18 1999-01-26 Cytec Tech Corp Methods for the detoxification of nitrile and/or amide compounds
US5866379A (en) * 1997-01-28 1999-02-02 Novus International Enzymatic conversion of α-hydroxynitriles to the corresponding .alpha.
CZ299166B6 (cs) 1997-07-22 2008-05-07 Lonza Ag Mikroorganismy rodu Amycolatopsis nebo Actinomadura, enzymy z nich získané a zpusob výroby amidu
JP3428404B2 (ja) * 1997-10-23 2003-07-22 三菱レイヨン株式会社 アミド化合物の製造方法
US6153415A (en) 1998-04-29 2000-11-28 Board Of Trustees Operating Michigan State University Method for producing amide compounds using a nitrile hydratase from a thermophilic bacillus
NL1011867C2 (nl) * 1999-04-22 2000-10-24 Dsm Nv Werkwijze voor de bereiding van een lineair, onverzadigd C3 - C8 carbonzuur.
WO2000064995A1 (fr) 1999-04-27 2000-11-02 Nok Corporation Joint d'etancheite
BR0109480B1 (pt) * 2000-03-21 2014-03-18 Mitsubishi Rayon Co Método de cultivo de microorganismo
US6562603B2 (en) 2000-08-04 2003-05-13 E. I. Du Pont De Nemours And Company 3-hydroxycarboxylic acid production and use in branched polymers
KR100407470B1 (ko) * 2000-08-08 2003-11-28 동서석유화학주식회사 로도코커스 로도크로스의 유가식 회분 배양방법 및 상기배양방법에 의해 배양된 로도코커스 로도크로스를이용하여 니트릴 화합물로부터 아미드 화합물을 제조하는방법
CN1296487C (zh) * 2000-12-20 2007-01-24 大野绿水株式会社 利用微生物催化剂生产酰胺化合物的方法
JP4307837B2 (ja) * 2001-01-09 2009-08-05 ロンザ ア−ゲ− アミド類を生成するための微生物学的方法
DE10120546A1 (de) * 2001-04-26 2002-10-31 Stockhausen Chem Fab Gmbh Verfahren zur Herstellung einer wässrigen Acrylamidlösung mit einem Biokatalysator
DE10120550A1 (de) * 2001-04-26 2002-10-31 Stockhausen Chem Fab Gmbh Verfahren zur Herstellung einer wässrigen Acrylamidlösung mit einem Biokatalysator
DE10120555A1 (de) * 2001-04-26 2002-10-31 Stockhausen Chem Fab Gmbh Verfahren zur Herstellung einer wässrigen Acrylamidlösung mit einem Biokataysator
WO2003033716A1 (en) * 2001-10-12 2003-04-24 Dia-Nitrix Co., Ltd. Process for producing acrylamide and/or methacrylamide with microorganism catalyst
JP2004194588A (ja) 2002-12-19 2004-07-15 Mitsui Chemicals Inc 新規なニトリルヒドラターゼ
EP1689861B1 (en) 2003-12-02 2011-11-09 Ciba Specialty Chemicals Water Treatments Limited Strain of rhodococcus rhodochrous ncimb 41164 and its use as producer of nitrile hydratase
GB0327901D0 (en) * 2003-12-02 2004-01-07 Ciba Spec Chem Water Treat Ltd Process for producing polymers
GB0327900D0 (en) 2003-12-02 2004-01-07 Ciba Spec Chem Water Treat Ltd Process for preparing unsaturated amides and carboxylic acids
US7816106B2 (en) 2003-12-02 2010-10-19 Ciba Specialty Chemicals Water Treatments Ltd. Manufacture of amides
GB0327906D0 (en) * 2003-12-02 2004-01-07 Ciba Spec Chem Water Treat Ltd Biocatalyst composition
JP2005328787A (ja) * 2004-05-21 2005-12-02 Mitsubishi Rayon Co Ltd ニトリルヒドラターゼ活性を有する新規な微生物、ニトリルヒドラターゼをコードする遺伝子及びアミド化合物の製造方法
JP4493011B2 (ja) * 2004-06-11 2010-06-30 三菱レイヨン株式会社 ロドコッカス属細菌由来トリメトプリム耐性ジヒドロ葉酸還元酵素及びその遺伝子
JP2008306928A (ja) * 2005-10-06 2008-12-25 Mitsui Chemicals Inc コバルト型ニトリルヒドラターゼ産生微生物の培養方法
NZ599631A (en) 2006-01-30 2013-08-30 Univ Georgia State Res Found Induction and stabilization of enzymatic activity in microorganisms
US7943549B2 (en) 2007-04-02 2011-05-17 Georgia State University Research Foundation, Inc. Biological-based catalyst to delay plant development processes
JP5132979B2 (ja) * 2007-04-27 2013-01-30 ダイヤニトリックス株式会社 ポリアクリルアミド及びその製造方法
WO2009009117A2 (en) * 2007-07-11 2009-01-15 Bioverdant, Inc. Chemoenzymatic processes for preparation of levetiracetam
EP2264003B1 (en) * 2008-03-14 2016-06-01 Dia-Nitrix Co., Ltd. Method for stabilization of aqueous acrylamide solution
CN101481713B (zh) * 2008-12-30 2011-12-21 浙江工业大学 生物催化2-氰基吡嗪生产吡嗪酰胺的方法及其菌株
KR101835160B1 (ko) 2010-02-22 2018-03-07 미쯔비시 케미컬 주식회사 안정된 아크릴아마이드 수용액
CN103687845A (zh) 2011-05-19 2014-03-26 三菱丽阳株式会社 丙烯酰胺水溶液、丙烯酰胺水溶液的稳定化剂、丙烯酰胺水溶液的稳定化方法
WO2012157777A1 (ja) 2011-05-19 2012-11-22 ダイヤニトリックス株式会社 アクリルアミド水溶液の製造方法
US9057084B2 (en) 2011-05-19 2015-06-16 Mitsubishi Rayon Co., Ltd. Method for producing aqueous acrylamide solution
BR112014020899A2 (pt) 2012-02-28 2018-05-02 Mitsubishi Rayon Co., Ltd. métodos para produzir, preservar, e ativar nitrila hidratase
FR3002542B1 (fr) * 2013-02-28 2016-01-22 Servier Lab Procede de synthese enzymatique de l'acide (7s) 3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-triene 7-carboxylique et application a la synthese de l'ivabradine et de ses sels
US9993005B2 (en) 2013-03-14 2018-06-12 Georgia State University Research Foundation, Inc. Preventing or delaying chill injury response in plants
WO2014160354A1 (en) 2013-03-14 2014-10-02 Georgia State University Research Foundation, Inc. Inhibiting or reducing fungal growth
EP3155089A4 (en) 2014-06-10 2017-11-22 Georgia State University Research Foundation, Inc. Inhibiting or reducing fungal infections
CN104762338A (zh) * 2015-03-17 2015-07-08 安徽国星生物化学有限公司 一种红球菌催化生产烟酰胺的方法
GB201601558D0 (en) * 2016-01-28 2016-03-16 Verdant Bioproducts Ltd Method for producing 3-hydroxypropionamide
CN111662938B (zh) * 2020-06-23 2021-05-04 浙江恒康药业股份有限公司 腈水合酶在催化氰基吡嗪类化合物水合反应生成酰胺吡嗪类化合物中的应用
CN112625065A (zh) * 2020-12-22 2021-04-09 北京师范大学 锝-99m标记含肼基尼古酰胺基的FAPI衍生物及制备方法和应用
KR20250156762A (ko) 2023-03-17 2025-11-03 미쯔비시 케미컬 주식회사 아미드 화합물의 제조 방법
KR20250138785A (ko) 2023-03-17 2025-09-22 미쯔비시 케미컬 주식회사 아미드 화합물의 제조 방법

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4629700A (en) * 1983-11-30 1986-12-16 Standard Oil Company (Indiana) Selective conversion of cyano compounds to amides and carboxylic acids
JPS61162193A (ja) * 1985-01-08 1986-07-22 Nitto Chem Ind Co Ltd 微生物によるアミド類の製造法
JPH0740948B2 (ja) * 1985-06-04 1995-05-10 旭化成工業株式会社 アミドの微生物学的製造法
JP3009421B2 (ja) * 1990-02-28 2000-02-14 秀明 山田 有機酸の生物学的製造法

Also Published As

Publication number Publication date
DE3877869D1 (de) 1993-03-11
CA1298222C (en) 1992-03-31
PT88540B (pt) 1992-11-30
DE3877869T2 (de) 1993-06-09
CN1032436A (zh) 1989-04-19
CN1015473B (zh) 1992-02-12
US5334519A (en) 1994-08-02
MX169933B (es) 1993-08-02
PL274710A1 (en) 1989-05-02
FI884279L (fi) 1989-03-19
NO884114D0 (no) 1988-09-16
EP0307926A3 (en) 1990-02-07
KR0134094B1 (ko) 1998-04-14
EP0307926A2 (en) 1989-03-22
NO884114L (no) 1989-03-20
PL160904B1 (pl) 1993-05-31
NO175489B (no) 1994-07-11
FI93858C (fi) 1995-06-12
FI93858B (fi) 1995-02-28
JPH02470A (ja) 1990-01-05
HUT50215A (en) 1989-12-28
EP0307926B1 (en) 1993-01-27
ATE85082T1 (de) 1993-02-15
DK516688A (da) 1989-03-19
KR890005274A (ko) 1989-05-13
FI884279A0 (fi) 1988-09-16
DD274631A5 (de) 1989-12-27
ES2043752T3 (es) 1994-01-01
PL161959B1 (pl) 1993-08-31
NO175489C (no) 1994-10-19
JPH0655148B2 (ja) 1994-07-27
DK516688D0 (da) 1988-09-16
DK174516B1 (da) 2003-05-05
BR8804804A (pt) 1989-04-25
BG48934A3 (bg) 1991-06-14
PT88540A (pt) 1988-10-01
HU204099B (en) 1991-11-28
RU1838416C (ru) 1993-08-30

Similar Documents

Publication Publication Date Title
RO101578B (ro) Procedeu de obtinere a amidelor pe cale microbiologica
Yamada et al. Nitrile hydratase and its application to industrial production of acrylamide
Bazylinski et al. Denitrification and assimilatory nitrate reduction in Aquaspirillum magnetotacticum
US8323942B2 (en) Method for stabilizing activity of enzymes or microorganisms producing the enzymes
US5296373A (en) Process for producing R(-)-mandelic acid or a derivative thereof from a mandelonitrile using rhodococcus
EP0610048A2 (en) Process for producing optically active alpha-hydrocarboxylic acid having phenyl group
JPS6083581A (ja) シユ−ドモナス属細菌の培養法
JPH03175984A (ja) 微生物により製造したｎ―アシル―ｌ―プロリン―アシラーゼ、その取得方法、ｌ―プロリン、ｌ―ピペコリン酸、ｌ―チアゾリジン―４―カルボン酸およびｌ―チアゾリジン―２―カルボン酸の取得方法、ならびにｎ―アセチル―ｌ―プロリン、ｎ―プロピオニル―ｌ―プロリンおよびｎ―ブチリル―ｌ―プロリンの製造方法
CN114480225A (zh) 一种生物强化处理高盐化工废水的方法
KR100421581B1 (ko) 광학활성아미노폴리카복실산의제조방법
FR2491086A1 (fr) Procede pour produire des bacteries ayant une forte activite nitrilasique
JPS63283580A (ja) シアン化物転換酵素及びその製造方法
Nawaz et al. Degradation of organic cyanides by Pseudomonas aeruginosa
JPS63273482A (ja) 廃棄物の微生物分解
US5238838A (en) L-carnitine amidase produced by a microorganism
Li et al. Heterotrophic nitrification and aerobic denitrification by four novel isolated bacteria
ATE42969T1 (de) Mikroorganismen des genus pseudomonas und verfahren zum abbau von methylgruppenhaltigen verbindungen in waessrigen loesungen.
EP0731171A2 (en) Method of producing optically active amino acid
EA009075B1 (ru) Штаммы микроорганизма rhodococcus, способные превращать нитрил в амид, и способ получения амидов
JP2001245655A (ja) シアン化合物の分解微生物
RU2196822C1 (ru) Штамм бактерий rhodococcus erythropolis - продуцент нитрилгидратазы
JPH03277292A (ja) 光学活性な２―ヒドロキシカルボン酸の製造法
SU1336454A1 (ru) Способ биологической очистки сточных вод от этиленгликол
SU1527184A1 (ru) Способ биохимической очистки сточных вод от органических соединений
Yongkang et al. Isolation and characterization of heterotrophic nitrifying strain W1