RO101578B - Procedeu de obtinere a amidelor pe cale microbiologica - Google Patents
Procedeu de obtinere a amidelor pe cale microbiologicaInfo
- Publication number
- RO101578B RO101578B RO135188A RO13518888A RO101578B RO 101578 B RO101578 B RO 101578B RO 135188 A RO135188 A RO 135188A RO 13518888 A RO13518888 A RO 13518888A RO 101578 B RO101578 B RO 101578B
- Authority
- RO
- Romania
- Prior art keywords
- culture
- substrate
- enzyme
- cells
- culture medium
- Prior art date
Links
- 150000001408 amides Chemical class 0.000 title abstract 2
- 238000004519 manufacturing process Methods 0.000 title 1
- 230000002906 microbiologic effect Effects 0.000 title 1
- 239000000758 substrate Substances 0.000 abstract 5
- 102000004190 Enzymes Human genes 0.000 abstract 4
- 108090000790 Enzymes Proteins 0.000 abstract 4
- JFDZBHWFFUWGJE-UHFFFAOYSA-N benzonitrile Chemical compound N#CC1=CC=CC=C1 JFDZBHWFFUWGJE-UHFFFAOYSA-N 0.000 abstract 3
- 239000001963 growth medium Substances 0.000 abstract 3
- 244000005700 microbiome Species 0.000 abstract 3
- 241000187693 Rhodococcus rhodochrous Species 0.000 abstract 2
- -1 aromatic nitriles Chemical class 0.000 abstract 2
- 210000004027 cell Anatomy 0.000 abstract 2
- VMJNTFXCTXAXTC-UHFFFAOYSA-N 2,2-difluoro-1,3-benzodioxole-5-carbonitrile Chemical group C1=C(C#N)C=C2OC(F)(F)OC2=C1 VMJNTFXCTXAXTC-UHFFFAOYSA-N 0.000 abstract 1
- GRUHREVRSOOQJG-UHFFFAOYSA-N 2,4-dichlorobenzonitrile Chemical compound ClC1=CC=C(C#N)C(Cl)=C1 GRUHREVRSOOQJG-UHFFFAOYSA-N 0.000 abstract 1
- BNBRIFIJRKJGEI-UHFFFAOYSA-N 2,6-difluorobenzonitrile Chemical compound FC1=CC=CC(F)=C1C#N BNBRIFIJRKJGEI-UHFFFAOYSA-N 0.000 abstract 1
- FFNVQNRYTPFDDP-UHFFFAOYSA-N 2-cyanopyridine Chemical class N#CC1=CC=CC=N1 FFNVQNRYTPFDDP-UHFFFAOYSA-N 0.000 abstract 1
- YXDXXGXWFJCXEB-UHFFFAOYSA-N 2-furonitrile Chemical compound N#CC1=CC=CO1 YXDXXGXWFJCXEB-UHFFFAOYSA-N 0.000 abstract 1
- NWPNXBQSRGKSJB-UHFFFAOYSA-N 2-methylbenzonitrile Chemical compound CC1=CC=CC=C1C#N NWPNXBQSRGKSJB-UHFFFAOYSA-N 0.000 abstract 1
- SWBDKCMOLSUXRH-UHFFFAOYSA-N 2-nitrobenzonitrile Chemical compound [O-][N+](=O)C1=CC=CC=C1C#N SWBDKCMOLSUXRH-UHFFFAOYSA-N 0.000 abstract 1
- BOHCMQZJWOGWTA-UHFFFAOYSA-N 3-methylbenzonitrile Chemical compound CC1=CC=CC(C#N)=C1 BOHCMQZJWOGWTA-UHFFFAOYSA-N 0.000 abstract 1
- RUSAWEHOGCWOPG-UHFFFAOYSA-N 3-nitrobenzonitrile Chemical compound [O-][N+](=O)C1=CC=CC(C#N)=C1 RUSAWEHOGCWOPG-UHFFFAOYSA-N 0.000 abstract 1
- YBAZINRZQSAIAY-UHFFFAOYSA-N 4-aminobenzonitrile Chemical compound NC1=CC=C(C#N)C=C1 YBAZINRZQSAIAY-UHFFFAOYSA-N 0.000 abstract 1
- CVNOWLNNPYYEOH-UHFFFAOYSA-N 4-cyanophenol Chemical compound OC1=CC=C(C#N)C=C1 CVNOWLNNPYYEOH-UHFFFAOYSA-N 0.000 abstract 1
- AEKVBBNGWBBYLL-UHFFFAOYSA-N 4-fluorobenzonitrile Chemical compound FC1=CC=C(C#N)C=C1 AEKVBBNGWBBYLL-UHFFFAOYSA-N 0.000 abstract 1
- XDJAAZYHCCRJOK-UHFFFAOYSA-N 4-methoxybenzonitrile Chemical compound COC1=CC=C(C#N)C=C1 XDJAAZYHCCRJOK-UHFFFAOYSA-N 0.000 abstract 1
- VCZNNAKNUVJVGX-UHFFFAOYSA-N 4-methylbenzonitrile Chemical compound CC1=CC=C(C#N)C=C1 VCZNNAKNUVJVGX-UHFFFAOYSA-N 0.000 abstract 1
- NLHHRLWOUZZQLW-UHFFFAOYSA-N Acrylonitrile Chemical compound C=CC#N NLHHRLWOUZZQLW-UHFFFAOYSA-N 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- GVPFVAHMJGGAJG-UHFFFAOYSA-L cobalt dichloride Chemical compound [Cl-].[Cl-].[Co+2] GVPFVAHMJGGAJG-UHFFFAOYSA-L 0.000 abstract 1
- 229910001429 cobalt ion Inorganic materials 0.000 abstract 1
- XLJKHNWPARRRJB-UHFFFAOYSA-N cobalt(2+) Chemical compound [Co+2] XLJKHNWPARRRJB-UHFFFAOYSA-N 0.000 abstract 1
- PMSVVUSIPKHUMT-UHFFFAOYSA-N cyanopyrazine Chemical compound N#CC1=CN=CC=N1 PMSVVUSIPKHUMT-UHFFFAOYSA-N 0.000 abstract 1
- 238000006703 hydration reaction Methods 0.000 abstract 1
- 210000001822 immobilized cell Anatomy 0.000 abstract 1
- 239000000411 inducer Substances 0.000 abstract 1
- LAQPNDIUHRHNCV-UHFFFAOYSA-N isophthalonitrile Chemical compound N#CC1=CC=CC(C#N)=C1 LAQPNDIUHRHNCV-UHFFFAOYSA-N 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 150000002825 nitriles Chemical class 0.000 abstract 1
- XQZYPMVTSDWCCE-UHFFFAOYSA-N phthalonitrile Chemical compound N#CC1=CC=CC=C1C#N XQZYPMVTSDWCCE-UHFFFAOYSA-N 0.000 abstract 1
- 229920006391 phthalonitrile polymer Polymers 0.000 abstract 1
- CUPOOAWTRIURFT-UHFFFAOYSA-N thiophene-2-carbonitrile Chemical compound N#CC1=CC=CS1 CUPOOAWTRIURFT-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
- C08J9/00—Working-up of macromolecular substances to porous or cellular articles or materials; After-treatment thereof
- C08J9/0014—Use of organic additives
- C08J9/0023—Use of organic additives containing oxygen
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/78—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P13/00—Preparation of nitrogen-containing organic compounds
- C12P13/02—Amides, e.g. chloramphenicol or polyamides; Imides or polyimides; Urethanes, i.e. compounds comprising N-C=O structural element or polyurethanes
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
- C08J2325/00—Characterised by the use of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by an aromatic carbocyclic ring; Derivatives of such polymers
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- General Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Emergency Medicine (AREA)
- Materials Engineering (AREA)
- Polymers & Plastics (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Enzymes And Modification Thereof (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
Abstract
Procedeul, conform inventiei, consta în aceea ca prevede, cultivarea unui microorganism din speciile Rhodococcus rhodochrous, de preferinta R. rhodochrous FERM 1478, înregistrat în Depozitul International de Microorganisme, Japonia, într-un mediu de cultura ce contine 5...15 mg/l ioni de cobalt sub forma de clorura de cobalt si 2...6 g/l inductor de enzima reprezentat de crotonamida la temperatura de 15...50 degree C, de preferinta 20...45 degree C, pH=7...9, de preferinta 8, timp de 30...120 h, când are loc o reactie de hidratare a substratului selectat din cadrul nitrililor aromaticil cum ar fi 4-, 3- si 2- ciano-piridine, benzonitril, o-, m- si para- clorbenzonitril, o-m- si p-fluorobenzonitril, o- si m- nitrobenzonitril, p-aminobenzonitril, o-, m- si p- tolunitril, 4-cianofenol, anisonitril, ftalonitril, izoftalonitril, tereftalonitril, 2,6-ciclorbenzonitril, 2,4-diclorobenzonitril, 2,6-difluobenzonitril, alfa- si beta- naftonitril, 2-triofencarbonitril, 2-furonitril, 5-cianoindol, cianopirazina sau a nitriilor alifatici având 2...6 atomi de carbon, de preferinta acrilonitril si transformarea acestui substrat într-o amida corespunzatoare, aceasta în situatia când substratul este prezent într-o concentratie de 0,5...12 moli/l mediu de cultura, iar în varianta ca substratul este adaugat în cultura, în concentratie 0,5...12 moli/l mediu de cultura, iar în cultura exista enzima nitrilhidrataza acumulata sau substratul este contactat cu celulele numitului microorganism izolat din cultura în care au fost acumulate, cu enzima extrasa din celule sau cu celulele imobilzate sau extractul enzimatic al lor, cultura este efectuata la temperatura d
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP23459787 | 1987-09-18 | ||
| JP7276688 | 1988-03-26 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RO101578B true RO101578B (ro) | 1992-01-13 |
Family
ID=26413903
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RO135188A RO101578B (ro) | 1987-09-18 | 1988-09-16 | Procedeu de obtinere a amidelor pe cale microbiologica |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US5334519A (ro) |
| EP (1) | EP0307926B1 (ro) |
| JP (1) | JPH0655148B2 (ro) |
| KR (1) | KR0134094B1 (ro) |
| CN (1) | CN1015473B (ro) |
| AT (1) | ATE85082T1 (ro) |
| BG (1) | BG48934A3 (ro) |
| BR (1) | BR8804804A (ro) |
| CA (1) | CA1298222C (ro) |
| DD (1) | DD274631A5 (ro) |
| DE (1) | DE3877869T2 (ro) |
| DK (1) | DK174516B1 (ro) |
| ES (1) | ES2043752T3 (ro) |
| FI (1) | FI93858C (ro) |
| HU (1) | HU204099B (ro) |
| MX (1) | MX169933B (ro) |
| NO (1) | NO175489C (ro) |
| PL (2) | PL161959B1 (ro) |
| PT (1) | PT88540B (ro) |
| RO (1) | RO101578B (ro) |
| RU (1) | RU1838416C (ro) |
Families Citing this family (60)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP3009421B2 (ja) * | 1990-02-28 | 2000-02-14 | 秀明 山田 | 有機酸の生物学的製造法 |
| US5648256A (en) * | 1990-02-28 | 1997-07-15 | Nitto Chemical Industry Co., Ltd. | Gene encoding a polypeptide having nitrile hydratase activity, a transformant containing the gene and a process for the production of amides using the transformant |
| AU627648B2 (en) * | 1990-02-28 | 1992-08-27 | Teruhiko Beppu | Dna fragment encoding a polypeptide having nitrile hydratase activity, a transformant containing the gene and a process for the production of amides using the transformant |
| SG48037A1 (en) * | 1990-11-14 | 1998-04-17 | Nitto Chemical Industry Co Ltd | Biology process for production-alpha-hydroxyamide or alpha-hydroxy acid |
| US5753472A (en) * | 1991-05-02 | 1998-05-19 | Nitto Chemical Industry Co. Ltd. | DNA fragment encoding a polypeptide having nitrile hydratase activity, a transformant containing the gene and a process for the production of amides using the transformant |
| JPH05244968A (ja) * | 1991-08-16 | 1993-09-24 | Mitsui Toatsu Chem Inc | α−ヒドロキシイソブチルアミドの製造法 |
| GEP20012441B (en) * | 1993-04-02 | 2001-05-25 | Lonza Ag | Process for Preparing 3-Methylpiperidine and 3-Methylpyridine |
| RU2053300C1 (ru) * | 1993-12-17 | 1996-01-27 | Государственный научно-исследовательский институт генетики и селекции промышленных микроорганизмов | Штамм бактерий rhodococcus rhodochrous - продуцент нитрилгидратазы |
| KR100339723B1 (ko) * | 1994-02-01 | 2002-09-25 | 스미또모 가가꾸 고오교오 가부시끼가이샤 | 미생물을사용한아미드화합물의제조방법 |
| JP3235934B2 (ja) | 1994-08-04 | 2001-12-04 | 三菱レイヨン株式会社 | ロドコッカス属細菌由来カナマイシン耐性遺伝子 |
| JP3163224B2 (ja) * | 1994-10-14 | 2001-05-08 | 三菱レイヨン株式会社 | 菌体または固定化菌体の懸濁液の保存方法 |
| ZA968485B (en) * | 1995-11-01 | 1997-05-20 | Lonza Ag | Process for preparing nicotinamide |
| CH689831A5 (de) * | 1995-11-07 | 1999-12-15 | Eprova Ag | Stabile kristalline Tetrahydrofolsaeure-Salze. |
| GB9525372D0 (en) * | 1995-12-12 | 1996-02-14 | Allied Colloids Ltd | Enzymes, their preparation and their use in the production of ammonium acrylate |
| DE69739026D1 (de) | 1996-02-14 | 2008-11-20 | Mitsui Chemicals Inc | Nitril-Hydratase, ihre Derivate und Verfahren zur Herstellung von Verbindungen |
| US5728556A (en) * | 1996-03-14 | 1998-03-17 | E. I. Du Pont De Nemours And Company | Production of ω-cyanocarboxamides from aliphatic α,ω-dinitriles using pseudomonas putida-derived biocatalysts |
| US5863750A (en) * | 1996-12-18 | 1999-01-26 | Cytec Tech Corp | Methods for the detoxification of nitrile and/or amide compounds |
| US5866379A (en) * | 1997-01-28 | 1999-02-02 | Novus International | Enzymatic conversion of α-hydroxynitriles to the corresponding .alpha. |
| EA006444B1 (ru) | 1997-07-22 | 2005-12-29 | Лонца Аг | Микроорганизмы amycolatopsis, способные превращать нитрил в амид, фермент с нитрилгидратазной активностью, полученный из указанных микроорганизмов, и способы их использования |
| JP3428404B2 (ja) * | 1997-10-23 | 2003-07-22 | 三菱レイヨン株式会社 | アミド化合物の製造方法 |
| US6153415A (en) | 1998-04-29 | 2000-11-28 | Board Of Trustees Operating Michigan State University | Method for producing amide compounds using a nitrile hydratase from a thermophilic bacillus |
| NL1011867C2 (nl) * | 1999-04-22 | 2000-10-24 | Dsm Nv | Werkwijze voor de bereiding van een lineair, onverzadigd C3 - C8 carbonzuur. |
| AU4314200A (en) | 1999-04-27 | 2000-11-10 | Nok Corporation | Gasket |
| JP3467264B2 (ja) * | 2000-03-21 | 2003-11-17 | 三菱レイヨン株式会社 | 微生物の培養法 |
| US6562603B2 (en) * | 2000-08-04 | 2003-05-13 | E. I. Du Pont De Nemours And Company | 3-hydroxycarboxylic acid production and use in branched polymers |
| KR100407470B1 (ko) * | 2000-08-08 | 2003-11-28 | 동서석유화학주식회사 | 로도코커스 로도크로스의 유가식 회분 배양방법 및 상기배양방법에 의해 배양된 로도코커스 로도크로스를이용하여 니트릴 화합물로부터 아미드 화합물을 제조하는방법 |
| JP4708677B2 (ja) | 2000-12-20 | 2011-06-22 | ダイヤニトリックス株式会社 | 微生物触媒を用いたアミド化合物の製造方法 |
| SK288061B6 (sk) | 2001-01-09 | 2013-04-03 | Lonza Ag | Microbiological method for producing amides |
| DE10120546A1 (de) | 2001-04-26 | 2002-10-31 | Stockhausen Chem Fab Gmbh | Verfahren zur Herstellung einer wässrigen Acrylamidlösung mit einem Biokatalysator |
| DE10120550A1 (de) | 2001-04-26 | 2002-10-31 | Stockhausen Chem Fab Gmbh | Verfahren zur Herstellung einer wässrigen Acrylamidlösung mit einem Biokatalysator |
| DE10120555A1 (de) * | 2001-04-26 | 2002-10-31 | Stockhausen Chem Fab Gmbh | Verfahren zur Herstellung einer wässrigen Acrylamidlösung mit einem Biokataysator |
| WO2003033716A1 (fr) * | 2001-10-12 | 2003-04-24 | Dia-Nitrix Co., Ltd. | Procede de production d'acrylamide et/ou de methacrylamide au moyen d'un catalyseur de micro-organismes |
| JP2004194588A (ja) | 2002-12-19 | 2004-07-15 | Mitsui Chemicals Inc | 新規なニトリルヒドラターゼ |
| GB0327900D0 (en) | 2003-12-02 | 2004-01-07 | Ciba Spec Chem Water Treat Ltd | Process for preparing unsaturated amides and carboxylic acids |
| GB0327906D0 (en) * | 2003-12-02 | 2004-01-07 | Ciba Spec Chem Water Treat Ltd | Biocatalyst composition |
| GB0327901D0 (en) | 2003-12-02 | 2004-01-07 | Ciba Spec Chem Water Treat Ltd | Process for producing polymers |
| SG148992A1 (en) | 2003-12-02 | 2009-01-29 | Ciba Spec Chem Water Treat Ltd | Strain of rhodococcus rhodochrous ncimb 41164 and its use as producer of nitrile hydratase |
| WO2005054489A1 (en) | 2003-12-02 | 2005-06-16 | Ciba Specialty Chemicals Water Treatments Limited | Manufacture of amides |
| JP2005328787A (ja) * | 2004-05-21 | 2005-12-02 | Mitsubishi Rayon Co Ltd | ニトリルヒドラターゼ活性を有する新規な微生物、ニトリルヒドラターゼをコードする遺伝子及びアミド化合物の製造方法 |
| JP4493011B2 (ja) * | 2004-06-11 | 2010-06-30 | 三菱レイヨン株式会社 | ロドコッカス属細菌由来トリメトプリム耐性ジヒドロ葉酸還元酵素及びその遺伝子 |
| JP2008306928A (ja) * | 2005-10-06 | 2008-12-25 | Mitsui Chemicals Inc | コバルト型ニトリルヒドラターゼ産生微生物の培養方法 |
| WO2007090122A2 (en) | 2006-01-30 | 2007-08-09 | Georgia State University Research Foundation, Inc. | Induction and stabilization of enzymatic activity in microorganisms |
| US7943549B2 (en) | 2007-04-02 | 2011-05-17 | Georgia State University Research Foundation, Inc. | Biological-based catalyst to delay plant development processes |
| JP5132979B2 (ja) * | 2007-04-27 | 2013-01-30 | ダイヤニトリックス株式会社 | ポリアクリルアミド及びその製造方法 |
| WO2009009117A2 (en) * | 2007-07-11 | 2009-01-15 | Bioverdant, Inc. | Chemoenzymatic processes for preparation of levetiracetam |
| US8569012B2 (en) * | 2008-03-14 | 2013-10-29 | Mitsubishi Rayon Co., Ltd. | Method for stabilization of aqueous acrylamide solution |
| CN101481713B (zh) * | 2008-12-30 | 2011-12-21 | 浙江工业大学 | 生物催化2-氰基吡嗪生产吡嗪酰胺的方法及其菌株 |
| KR101835160B1 (ko) | 2010-02-22 | 2018-03-07 | 미쯔비시 케미컬 주식회사 | 안정된 아크릴아마이드 수용액 |
| CN103687844B (zh) | 2011-05-19 | 2015-06-10 | 三菱丽阳株式会社 | 丙烯酰胺水溶液的制造方法 |
| US9370571B2 (en) | 2011-05-19 | 2016-06-21 | Mitsubishi Rayon Co., Ltd. | Aqueous acrylamide solution, stabilizer for aqueous acrylamide solution, and stabilization method for aqueous acrylamide solution |
| EP2711429B1 (en) | 2011-05-19 | 2018-12-26 | Mitsubishi Chemical Corporation | Method for producing aqueous acrylamide solution |
| AU2013227585B2 (en) | 2012-02-28 | 2016-02-25 | Mitsubishi Chemical Corporation | Method for preserving enzyme |
| FR3002542B1 (fr) * | 2013-02-28 | 2016-01-22 | Servier Lab | Procede de synthese enzymatique de l'acide (7s) 3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-triene 7-carboxylique et application a la synthese de l'ivabradine et de ses sels |
| EP2970889A4 (en) | 2013-03-14 | 2016-10-19 | Univ Georgia State Res Found | PREVENTING OR DELAYING RESPONSE TO COLD-DAMAGE IN PLANTS |
| MX361278B (es) | 2013-03-14 | 2018-12-03 | Univ Georgia State Res Found | Inhibición o reducción del crecimiento de hongos. |
| WO2015191744A1 (en) | 2014-06-10 | 2015-12-17 | Georgia State University And Research Foundation, Inc. | Inhibiting or reducing fungal infections |
| CN104762338A (zh) * | 2015-03-17 | 2015-07-08 | 安徽国星生物化学有限公司 | 一种红球菌催化生产烟酰胺的方法 |
| GB201601558D0 (en) | 2016-01-28 | 2016-03-16 | Verdant Bioproducts Ltd | Method for producing 3-hydroxypropionamide |
| CN111662938B (zh) * | 2020-06-23 | 2021-05-04 | 浙江恒康药业股份有限公司 | 腈水合酶在催化氰基吡嗪类化合物水合反应生成酰胺吡嗪类化合物中的应用 |
| CN112625065A (zh) * | 2020-12-22 | 2021-04-09 | 北京师范大学 | 锝-99m标记含肼基尼古酰胺基的FAPI衍生物及制备方法和应用 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4629700A (en) * | 1983-11-30 | 1986-12-16 | Standard Oil Company (Indiana) | Selective conversion of cyano compounds to amides and carboxylic acids |
| JPS61162193A (ja) * | 1985-01-08 | 1986-07-22 | Nitto Chem Ind Co Ltd | 微生物によるアミド類の製造法 |
| JPH0740948B2 (ja) * | 1985-06-04 | 1995-05-10 | 旭化成工業株式会社 | アミドの微生物学的製造法 |
| JP3009421B2 (ja) * | 1990-02-28 | 2000-02-14 | 秀明 山田 | 有機酸の生物学的製造法 |
-
1988
- 1988-09-14 MX MX013025A patent/MX169933B/es unknown
- 1988-09-14 DD DD88319783A patent/DD274631A5/de unknown
- 1988-09-15 CA CA000577427A patent/CA1298222C/en not_active Expired - Lifetime
- 1988-09-16 AT AT88115182T patent/ATE85082T1/de not_active IP Right Cessation
- 1988-09-16 NO NO884114A patent/NO175489C/no not_active IP Right Cessation
- 1988-09-16 JP JP63231744A patent/JPH0655148B2/ja not_active Expired - Lifetime
- 1988-09-16 BG BG85446A patent/BG48934A3/xx unknown
- 1988-09-16 PL PL88293521A patent/PL161959B1/pl unknown
- 1988-09-16 PT PT88540A patent/PT88540B/pt not_active IP Right Cessation
- 1988-09-16 EP EP88115182A patent/EP0307926B1/en not_active Expired - Lifetime
- 1988-09-16 FI FI884279A patent/FI93858C/fi not_active IP Right Cessation
- 1988-09-16 DK DK198805166A patent/DK174516B1/da active
- 1988-09-16 RO RO135188A patent/RO101578B/ro unknown
- 1988-09-16 PL PL1988274710A patent/PL160904B1/pl unknown
- 1988-09-16 BR BR8804804A patent/BR8804804A/pt not_active IP Right Cessation
- 1988-09-16 RU SU884356476A patent/RU1838416C/ru active
- 1988-09-16 ES ES88115182T patent/ES2043752T3/es not_active Expired - Lifetime
- 1988-09-16 KR KR1019880011974A patent/KR0134094B1/ko not_active IP Right Cessation
- 1988-09-16 DE DE8888115182T patent/DE3877869T2/de not_active Expired - Lifetime
- 1988-09-16 HU HU884887A patent/HU204099B/hu unknown
- 1988-09-17 CN CN88106735A patent/CN1015473B/zh not_active Expired
-
1991
- 1991-10-15 US US07/777,641 patent/US5334519A/en not_active Expired - Lifetime
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| RO101578B (ro) | Procedeu de obtinere a amidelor pe cale microbiologica | |
| Yamada et al. | Nitrile hydratase and its application to industrial production of acrylamide | |
| Bazylinski et al. | Denitrification and assimilatory nitrate reduction in Aquaspirillum magnetotacticum | |
| US8323942B2 (en) | Method for stabilizing activity of enzymes or microorganisms producing the enzymes | |
| Yanase et al. | Degradation of the metal-cyano complex tetracyanonickelate (II) by Fusarium oxysporum N-10 | |
| EP0610048A2 (en) | Process for producing optically active alpha-hydrocarboxylic acid having phenyl group | |
| EP0527553A1 (en) | Process for producing r(-)-mandelic acid and derivative thereof | |
| JPS6083581A (ja) | シユ−ドモナス属細菌の培養法 | |
| CN114480225A (zh) | 一种生物强化处理高盐化工废水的方法 | |
| Nawaz et al. | Degradation of organic cyanides by Pseudomonas aeruginosa | |
| KR100421581B1 (ko) | 광학활성아미노폴리카복실산의제조방법 | |
| FR2491086A1 (fr) | Procede pour produire des bacteries ayant une forte activite nitrilasique | |
| JPS63283580A (ja) | シアン化物転換酵素及びその製造方法 | |
| JPH03175984A (ja) | 微生物により製造したｎ―アシル―ｌ―プロリン―アシラーゼ、その取得方法、ｌ―プロリン、ｌ―ピペコリン酸、ｌ―チアゾリジン―４―カルボン酸およびｌ―チアゾリジン―２―カルボン酸の取得方法、ならびにｎ―アセチル―ｌ―プロリン、ｎ―プロピオニル―ｌ―プロリンおよびｎ―ブチリル―ｌ―プロリンの製造方法 | |
| US5238838A (en) | L-carnitine amidase produced by a microorganism | |
| EP0731171A2 (en) | Method of producing optically active amino acid | |
| JPS63273482A (ja) | 廃棄物の微生物分解 | |
| Li et al. | Heterotrophic nitrification and aerobic denitrification by four novel isolated bacteria | |
| EA009075B1 (ru) | Штаммы микроорганизма rhodococcus, способные превращать нитрил в амид, и способ получения амидов | |
| CN101410506B (zh) | 微生物中酶活性的诱导和稳定 | |
| RU2196822C1 (ru) | Штамм бактерий rhodococcus erythropolis - продуцент нитрилгидратазы | |
| Yongkang et al. | Isolation and characterization of heterotrophic nitrifying strain W1 | |
| SU1336454A1 (ru) | Способ биологической очистки сточных вод от этиленгликол | |
| JP3450663B2 (ja) | Ｓ，ｓ−エチレンジアミン−ｎ，ｎ’−ジコハク酸の製造法 | |
| AU2015203784B2 (en) | Induction and stabilization of enzymatic activity in microorganisms |