PT84991B - Processo para a producao de actividador do plasminogenio biologicamente activo - Google Patents
Processo para a producao de actividador do plasminogenio biologicamente activo Download PDFInfo
- Publication number
- PT84991B PT84991B PT84991A PT8499187A PT84991B PT 84991 B PT84991 B PT 84991B PT 84991 A PT84991 A PT 84991A PT 8499187 A PT8499187 A PT 8499187A PT 84991 B PT84991 B PT 84991B
- Authority
- PT
- Portugal
- Prior art keywords
- tissue
- medium
- plasminogen activator
- culture
- components
- Prior art date
Links
- 230000000694 effects Effects 0.000 title claims abstract 6
- 238000004519 manufacturing process Methods 0.000 title claims abstract 3
- 238000000034 method Methods 0.000 title claims 15
- 238000004113 cell culture Methods 0.000 claims abstract 13
- 102000001938 Plasminogen Activators Human genes 0.000 claims abstract 7
- 229940127126 plasminogen activator Drugs 0.000 claims abstract 7
- 238000001914 filtration Methods 0.000 claims abstract 6
- 230000001627 detrimental effect Effects 0.000 claims abstract 5
- 238000011084 recovery Methods 0.000 claims abstract 5
- 101000801481 Homo sapiens Tissue-type plasminogen activator Proteins 0.000 claims abstract 3
- 210000004027 cell Anatomy 0.000 claims 10
- 239000002609 medium Substances 0.000 claims 8
- 101000605403 Homo sapiens Plasminogen Proteins 0.000 claims 6
- 210000004962 mammalian cell Anatomy 0.000 claims 5
- 230000010076 replication Effects 0.000 claims 4
- 239000012190 activator Substances 0.000 claims 2
- 210000004978 chinese hamster ovary cell Anatomy 0.000 claims 2
- 239000012528 membrane Substances 0.000 claims 2
- 102000003978 Tissue Plasminogen Activator Human genes 0.000 claims 1
- 108090000373 Tissue Plasminogen Activator Proteins 0.000 claims 1
- 239000008280 blood Substances 0.000 claims 1
- 210000004369 blood Anatomy 0.000 claims 1
- 230000001413 cellular effect Effects 0.000 claims 1
- 239000000835 fiber Substances 0.000 claims 1
- 239000001963 growth medium Substances 0.000 claims 1
- 238000003259 recombinant expression Methods 0.000 claims 1
- 238000004114 suspension culture Methods 0.000 claims 1
- 229960000187 tissue plasminogen activator Drugs 0.000 claims 1
- 108010001014 Plasminogen Activators Proteins 0.000 abstract 2
- 239000000306 component Substances 0.000 abstract 1
- 238000012258 culturing Methods 0.000 abstract 1
- 230000007717 exclusion Effects 0.000 abstract 1
- 239000012533 medium component Substances 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6424—Serine endopeptidases (3.4.21)
- C12N9/6456—Plasminogen activators
- C12N9/6459—Plasminogen activators t-plasminogen activator (3.4.21.68), i.e. tPA
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P1/00—Preparation of compounds or compositions, not provided for in groups C12P3/00 - C12P39/00, by using microorganisms or enzymes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/21—Serine endopeptidases (3.4.21)
- C12Y304/21069—Protein C activated (3.4.21.69)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Microbiology (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Mycology (AREA)
- Hematology (AREA)
- Physics & Mathematics (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Diabetes (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biophysics (AREA)
- Plant Pathology (AREA)
- Enzymes And Modification Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US87164286A | 1986-06-06 | 1986-06-06 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| PT84991A PT84991A (en) | 1987-07-01 |
| PT84991B true PT84991B (pt) | 1990-03-08 |
Family
ID=25357832
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT84991A PT84991B (pt) | 1986-06-06 | 1987-06-02 | Processo para a producao de actividador do plasminogenio biologicamente activo |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US5053334A (https=) |
| EP (1) | EP0248675B1 (https=) |
| JP (1) | JPS6332484A (https=) |
| KR (1) | KR930002888B1 (https=) |
| AT (1) | ATE75775T1 (https=) |
| AU (1) | AU601984B2 (https=) |
| DD (1) | DD257087A5 (https=) |
| DE (2) | DE3778758D1 (https=) |
| DK (1) | DK175366B1 (https=) |
| ES (1) | ES2032444T3 (https=) |
| FI (1) | FI91886C (https=) |
| FR (1) | FR2599625B1 (https=) |
| GB (1) | GB2191493B (https=) |
| GR (1) | GR3005245T3 (https=) |
| HU (1) | HU205171B (https=) |
| IE (1) | IE60485B1 (https=) |
| IL (1) | IL82746A (https=) |
| NO (1) | NO170595C (https=) |
| NZ (1) | NZ220547A (https=) |
| PT (1) | PT84991B (https=) |
| ZA (1) | ZA874054B (https=) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PT84991B (pt) * | 1986-06-06 | 1990-03-08 | Genentech Inc | Processo para a producao de actividador do plasminogenio biologicamente activo |
| JP2576200B2 (ja) * | 1988-03-09 | 1997-01-29 | 味の素株式会社 | 生理活性タンパク質の製造法 |
| EP0338716A3 (en) * | 1988-04-21 | 1990-04-11 | Berlex Laboratories, Inc. | Method and system for the production of non-degraded proteins from mammalian cells |
| DE3829244A1 (de) * | 1988-08-29 | 1990-03-01 | Boehringer Mannheim Gmbh | Verfahren zur herstellung von einkettigem t-pa |
| CA2011548A1 (en) * | 1989-03-07 | 1990-09-07 | Hubertus Stockinger | Process for the production of two-chain t-pa |
| GB2249099B (en) * | 1990-09-26 | 1995-05-03 | Squibb & Sons Inc | Squalene synthetase |
| US5677184A (en) * | 1994-04-19 | 1997-10-14 | Takeda Chemical Industries, Ltd. | CHO cells that express human LH-RH receptor |
| US6077940A (en) * | 1997-12-24 | 2000-06-20 | Genentech, Inc. | Free solution ligand interaction molecular separation method |
| WO2003087292A2 (en) | 2002-04-08 | 2003-10-23 | Millenium Biologix Inc. | Automated tissue engineering system |
| SI2041259T1 (sl) | 2006-07-14 | 2016-04-29 | Dpx Holdings B.V. | Izboljšan postopek kultiviranja celic |
| WO2009023562A2 (en) * | 2007-08-09 | 2009-02-19 | Wyeth | Use of perfusion to enhance production of fed-batch cell culture in bioreactors |
| JP2013517771A (ja) * | 2010-01-22 | 2013-05-20 | ロンザ ウォーカーズヴィル，インコーポレーテッド | タンジェンシャルフローフィルトレーションを用いた治療用細胞の容量減少および洗浄のための高収率法および装置 |
| US10934519B2 (en) | 2011-07-29 | 2021-03-02 | Global Life Sciences Solutions Usa Llc | Systems, methods and control laws for cell harvesting |
| CN104583386A (zh) * | 2012-08-20 | 2015-04-29 | 泰尔茂比司特公司 | 浓缩穿过细胞生长腔室循环的流体的组分 |
| CA3248436A1 (en) | 2017-09-01 | 2025-02-21 | Lonza Walkersville, Inc. | END-TO-END AUTOMATION OF CELL THERAPY |
| JP7396777B2 (ja) | 2018-09-28 | 2023-12-12 | オクタン バイオテック インコーポレーテッド | 磁気分離 |
| KR20210108406A (ko) | 2018-12-21 | 2021-09-02 | 론자 워커스빌 아이엔씨. | 바이러스 벡터의 자동화된 생산 |
| IL284214B2 (en) | 2018-12-21 | 2025-03-01 | Octane Biotech Inc | Carousel for modular biologic production units |
| SG11202106652WA (en) | 2018-12-28 | 2021-07-29 | Octane Biotech Inc | Cell culture and tissue engineering systems with controlled environmental zones |
| IL285288B2 (en) | 2019-02-08 | 2026-04-01 | Lonza Walkersville Inc | Cell concentration methods and devices for use in automated bioreactors |
| CN114729292A (zh) | 2019-10-24 | 2022-07-08 | 奥克泰生物科技股份有限公司 | 具有经改进的细胞接触表面的细胞培养室 |
| EP4058563A4 (en) | 2019-11-11 | 2023-12-06 | Lonza Walkersville, Inc. | QUALITY CONTROL PROCEDURES FOR AUTOMATED CELL PROCESSING |
| US12187784B2 (en) | 2021-07-02 | 2025-01-07 | Combangio, Inc. | Processes for making a cellular fibronectin composition |
Family Cites Families (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3904480A (en) * | 1972-10-24 | 1975-09-09 | Lilly Co Eli | Enhanced production of plasminogen activator |
| JPS5329985A (en) * | 1976-08-27 | 1978-03-20 | Kanegafuchi Chem Ind Co Ltd | High concentration culturing of yeast |
| JPS5571496A (en) * | 1978-11-24 | 1980-05-29 | Asahi Chem Ind Co Ltd | Preparation of living substance |
| US4409331A (en) * | 1979-03-28 | 1983-10-11 | Damon Corporation | Preparation of substances with encapsulated cells |
| US4232124A (en) * | 1979-04-23 | 1980-11-04 | Mann George F | Method of producing plasminogen activator |
| DE3015699C2 (de) * | 1979-04-26 | 1982-07-15 | Asahi Kasei Kogyo K.K., Osaka | Herstellung eines Plasminogen-Aktivators |
| JPS5642584A (en) * | 1979-09-18 | 1981-04-20 | Asahi Chem Ind Co Ltd | Cell cultivation method |
| US4420398A (en) * | 1981-08-13 | 1983-12-13 | American National Red Cross | Filteration method for cell produced antiviral substances |
| IL68561A (en) * | 1982-05-05 | 1991-01-31 | Genentech Inc | Preparation of polypeptide with human tissue plasminogen activator function,processes for making it,and dna and transformed cell intermediates thereof |
| JPS5951220A (ja) * | 1982-08-02 | 1984-03-24 | Asahi Chem Ind Co Ltd | 新規なプラスミノ−ゲン・アクチベ−タ−およびその製法ならびにこれを含有する薬剤 |
| US4537860A (en) * | 1982-12-08 | 1985-08-27 | Monsanto Company | Static cell culture maintenance system |
| NZ206699A (en) * | 1982-12-30 | 1989-08-29 | Bio Response Inc | Process for the production of serum independent cell lines |
| AU572108B2 (en) * | 1983-01-19 | 1988-05-05 | Genentech Inc. | Human tpa production using vectors coding for dhfr protein |
| JPS59121172U (ja) * | 1983-02-04 | 1984-08-15 | ミネソタ・マイニング・アンド・マニユフアクチユアリング・コンパニ− | ケーブル電線被覆の剥離部分のカバー装置 |
| US4546083A (en) * | 1983-04-22 | 1985-10-08 | Stolle Research & Development Corporation | Method and device for cell culture growth |
| PH22337A (en) * | 1983-11-21 | 1988-08-12 | Ciba Geigy Ag | Synthesis of fibrinolytic agents by yeast |
| US4740461A (en) * | 1983-12-27 | 1988-04-26 | Genetics Institute, Inc. | Vectors and methods for transformation of eucaryotic cells |
| US4888115A (en) * | 1983-12-29 | 1989-12-19 | Cuno, Incorporated | Cross-flow filtration |
| US4757005A (en) * | 1984-04-19 | 1988-07-12 | Miles Inc. | Method and cell line for obtaining plasminogen activators |
| DE3676604D1 (de) * | 1985-03-22 | 1991-02-07 | Chiron Corp | Expression von epa in saeugetierzellen. |
| AU593264B2 (en) * | 1985-07-10 | 1990-02-08 | Kanegafuchi Kagaku Kogyo Kabushiki Kaisha | Chromosomal DNA sequence, expression vector for human tissue plasminogen activating factor, cultured cells transfected with same and method of producing said activating factor |
| AU606582B2 (en) * | 1985-09-06 | 1991-02-14 | Codon | Methods for the recovery of tissue plasminogen activator |
| JPH07110232B2 (ja) * | 1985-10-14 | 1995-11-29 | 株式会社日立製作所 | 遺伝子組換え大腸菌の遺伝子生産物を採取する方法および装置 |
| PT84991B (pt) * | 1986-06-06 | 1990-03-08 | Genentech Inc | Processo para a producao de actividador do plasminogenio biologicamente activo |
-
1987
- 1987-06-02 PT PT84991A patent/PT84991B/pt unknown
- 1987-06-02 IL IL8274687A patent/IL82746A/en not_active IP Right Cessation
- 1987-06-03 HU HU872536A patent/HU205171B/hu unknown
- 1987-06-03 NZ NZ220547A patent/NZ220547A/en unknown
- 1987-06-04 KR KR1019870005638A patent/KR930002888B1/ko not_active Expired - Lifetime
- 1987-06-04 DK DK198702881A patent/DK175366B1/da not_active IP Right Cessation
- 1987-06-05 AU AU73872/87A patent/AU601984B2/en not_active Expired
- 1987-06-05 ES ES198787304995T patent/ES2032444T3/es not_active Expired - Lifetime
- 1987-06-05 FR FR878707905A patent/FR2599625B1/fr not_active Expired - Lifetime
- 1987-06-05 DE DE8787304995T patent/DE3778758D1/de not_active Expired - Lifetime
- 1987-06-05 FI FI872526A patent/FI91886C/fi not_active IP Right Cessation
- 1987-06-05 NO NO872395A patent/NO170595C/no unknown
- 1987-06-05 DE DE3718939A patent/DE3718939C2/de not_active Expired - Lifetime
- 1987-06-05 EP EP87304995A patent/EP0248675B1/en not_active Expired - Lifetime
- 1987-06-05 JP JP62142121A patent/JPS6332484A/ja active Granted
- 1987-06-05 GB GB8713267A patent/GB2191493B/en not_active Expired - Lifetime
- 1987-06-05 AT AT87304995T patent/ATE75775T1/de not_active IP Right Cessation
- 1987-06-05 IE IE150487A patent/IE60485B1/en not_active IP Right Cessation
- 1987-06-05 DD DD30357587A patent/DD257087A5/de unknown
- 1987-06-05 ZA ZA874054A patent/ZA874054B/xx unknown
-
1990
- 1990-05-09 US US07/522,073 patent/US5053334A/en not_active Expired - Lifetime
-
1992
- 1992-07-21 GR GR920401579T patent/GR3005245T3/el unknown
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