ES2032444T3 - Procedimiento para producir un activador de plasminogeno biologicamente activo. - Google Patents
Procedimiento para producir un activador de plasminogeno biologicamente activo.Info
- Publication number
- ES2032444T3 ES2032444T3 ES198787304995T ES87304995T ES2032444T3 ES 2032444 T3 ES2032444 T3 ES 2032444T3 ES 198787304995 T ES198787304995 T ES 198787304995T ES 87304995 T ES87304995 T ES 87304995T ES 2032444 T3 ES2032444 T3 ES 2032444T3
- Authority
- ES
- Spain
- Prior art keywords
- plasminogen activator
- biologically active
- procedure
- producing
- medium
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6424—Serine endopeptidases (3.4.21)
- C12N9/6456—Plasminogen activators
- C12N9/6459—Plasminogen activators t-plasminogen activator (3.4.21.68), i.e. tPA
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P1/00—Preparation of compounds or compositions, not provided for in groups C12P3/00 - C12P39/00, by using microorganisms or enzymes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/21—Serine endopeptidases (3.4.21)
- C12Y304/21069—Protein C activated (3.4.21.69)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Abstract
SE PRODECE UN ACTIVADOR DE PLASMINOGENO DEL TIPO DE TEJIDO HUMANO, BIOLOGICAMENTE ACTIVO, EN EL CULTIVO DE CELULAS HUESPED, SEPARANDO DEL MEDIO DE CULTIVO TODOS LOS COMPONENTES QUE SON PERJUDICIALES PARA LA RECUPERACION Y LA ACTIVIDAD DEL ACTIVADOR DE PLASMINOGENO. POR EJEMPLO SE PUEDE EMPLEAR FILTRACION EN CONTRACORRIENTE PARA LLEVAR A CABO EL INTERCAMBIO DEL MEDIO DURANTE EL CULTIVO, O LOS COMPONENTES PERJUDICIALES SE PUEDEN SEPARAR ANTES DE LLEVAR A CABO EL CULTIVO. LAS CELULAS RETIENEN SU CAPACIDAD DE EXPRESION DESPUES DE LA EXCLUSION DE LAS SUSTANCIAS PERJUDICIALES CON LO QUE SE PUEDE EFECTUAR LA PRODUCCION DEL ACTIVADOR DE PLASMINOGENO ACTIVO.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US87164286A | 1986-06-06 | 1986-06-06 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2032444T3 true ES2032444T3 (es) | 1993-02-16 |
Family
ID=25357832
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES198787304995T Expired - Lifetime ES2032444T3 (es) | 1986-06-06 | 1987-06-05 | Procedimiento para producir un activador de plasminogeno biologicamente activo. |
Country Status (21)
Country | Link |
---|---|
US (1) | US5053334A (es) |
EP (1) | EP0248675B1 (es) |
JP (1) | JPS6332484A (es) |
KR (1) | KR930002888B1 (es) |
AT (1) | ATE75775T1 (es) |
AU (1) | AU601984B2 (es) |
DD (1) | DD257087A5 (es) |
DE (2) | DE3718939C2 (es) |
DK (1) | DK175366B1 (es) |
ES (1) | ES2032444T3 (es) |
FI (1) | FI91886C (es) |
FR (1) | FR2599625B1 (es) |
GB (1) | GB2191493B (es) |
GR (1) | GR3005245T3 (es) |
HU (1) | HU205171B (es) |
IE (1) | IE60485B1 (es) |
IL (1) | IL82746A (es) |
NO (1) | NO170595C (es) |
NZ (1) | NZ220547A (es) |
PT (1) | PT84991B (es) |
ZA (1) | ZA874054B (es) |
Families Citing this family (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
PT84991B (pt) * | 1986-06-06 | 1990-03-08 | Genentech Inc | Processo para a producao de actividador do plasminogenio biologicamente activo |
JP2576200B2 (ja) * | 1988-03-09 | 1997-01-29 | 味の素株式会社 | 生理活性タンパク質の製造法 |
EP0338716A3 (en) * | 1988-04-21 | 1990-04-11 | Berlex Laboratories, Inc. | Method and system for the production of non-degraded proteins from mammalian cells |
DE3829244A1 (de) * | 1988-08-29 | 1990-03-01 | Boehringer Mannheim Gmbh | Verfahren zur herstellung von einkettigem t-pa |
EP0391080A3 (de) * | 1989-03-07 | 1990-11-07 | Roche Diagnostics GmbH | Verfahren zur Herstellung von zweikettigem t-PA |
GB2249099B (en) * | 1990-09-26 | 1995-05-03 | Squibb & Sons Inc | Squalene synthetase |
US5677184A (en) * | 1994-04-19 | 1997-10-14 | Takeda Chemical Industries, Ltd. | CHO cells that express human LH-RH receptor |
US6077940A (en) * | 1997-12-24 | 2000-06-20 | Genentech, Inc. | Free solution ligand interaction molecular separation method |
AU2003218572B2 (en) * | 2002-04-08 | 2009-08-20 | Octane Biotech, Inc. | Automated tissue engineering system |
PL2343362T3 (pl) * | 2006-07-14 | 2016-11-30 | Udoskonalony sposób hodowania komórek | |
EP3327132A3 (en) * | 2007-08-09 | 2018-07-18 | Wyeth LLC | Use of perfusion to enhance production of fed-batch cell culture in bioreactors |
CA2787656A1 (en) * | 2010-01-22 | 2011-07-28 | Lonza Walkersville, Inc. | High yield method and apparatus for volume reduction and washing of therapeutic cells using tangential flow filtration |
US10934519B2 (en) * | 2011-07-29 | 2021-03-02 | Global Life Sciences Solutions Usa Llc | Systems, methods and control laws for cell harvesting |
CN104583386A (zh) * | 2012-08-20 | 2015-04-29 | 泰尔茂比司特公司 | 浓缩穿过细胞生长腔室循环的流体的组分 |
AU2018324180A1 (en) | 2017-09-01 | 2020-03-19 | Lonza Cologne Gmbh | End-to-end cell therapy automation |
SG11202106384YA (en) | 2018-12-21 | 2021-07-29 | Octane Biotech Inc | Carousel for modular biologic production units |
JP2022514761A (ja) | 2018-12-21 | 2022-02-15 | ロンザ ウォーカーズヴィル,インコーポレーテッド | ウイルスベクターの自動産生方法 |
WO2020132743A1 (en) | 2018-12-28 | 2020-07-02 | Octane Biotech Inc. | Cell culture and tissue engineering systems with controlled environmental zones |
CN113498432A (zh) | 2019-02-08 | 2021-10-12 | 隆萨沃克斯维尔股份有限公司 | 用于自动化生物反应器的细胞浓缩方法和装置 |
AU2022303345A1 (en) | 2021-07-02 | 2024-01-18 | Combangio, Inc. | Processes for making and using a cellular fibronectin composition |
Family Cites Families (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3904480A (en) * | 1972-10-24 | 1975-09-09 | Lilly Co Eli | Enhanced production of plasminogen activator |
JPS5329985A (en) * | 1976-08-27 | 1978-03-20 | Kanegafuchi Chem Ind Co Ltd | High concentration culturing of yeast |
JPS5571496A (en) * | 1978-11-24 | 1980-05-29 | Asahi Chem Ind Co Ltd | Preparation of living substance |
US4409331A (en) * | 1979-03-28 | 1983-10-11 | Damon Corporation | Preparation of substances with encapsulated cells |
US4232124A (en) * | 1979-04-23 | 1980-11-04 | Mann George F | Method of producing plasminogen activator |
DE3015699C2 (de) * | 1979-04-26 | 1982-07-15 | Asahi Kasei Kogyo K.K., Osaka | Herstellung eines Plasminogen-Aktivators |
JPS5642584A (en) * | 1979-09-18 | 1981-04-20 | Asahi Chem Ind Co Ltd | Cell cultivation method |
US4420398A (en) * | 1981-08-13 | 1983-12-13 | American National Red Cross | Filteration method for cell produced antiviral substances |
IL68561A (en) * | 1982-05-05 | 1991-01-31 | Genentech Inc | Preparation of polypeptide with human tissue plasminogen activator function,processes for making it,and dna and transformed cell intermediates thereof |
JPS5951220A (ja) * | 1982-08-02 | 1984-03-24 | Asahi Chem Ind Co Ltd | 新規なプラスミノ−ゲン・アクチベ−タ−およびその製法ならびにこれを含有する薬剤 |
US4537860A (en) * | 1982-12-08 | 1985-08-27 | Monsanto Company | Static cell culture maintenance system |
NZ206699A (en) * | 1982-12-30 | 1989-08-29 | Bio Response Inc | Process for the production of serum independent cell lines |
IE56716B1 (en) * | 1983-01-19 | 1991-11-20 | Genentech Inc | Method for producing human tpa and expression vectors therefor |
JPS59121172U (ja) * | 1983-02-04 | 1984-08-15 | ミネソタ・マイニング・アンド・マニユフアクチユアリング・コンパニ− | ケーブル電線被覆の剥離部分のカバー装置 |
US4546083A (en) * | 1983-04-22 | 1985-10-08 | Stolle Research & Development Corporation | Method and device for cell culture growth |
PH22337A (en) * | 1983-11-21 | 1988-08-12 | Ciba Geigy Ag | Synthesis of fibrinolytic agents by yeast |
US4740461A (en) * | 1983-12-27 | 1988-04-26 | Genetics Institute, Inc. | Vectors and methods for transformation of eucaryotic cells |
US4888115A (en) * | 1983-12-29 | 1989-12-19 | Cuno, Incorporated | Cross-flow filtration |
US4757005A (en) * | 1984-04-19 | 1988-07-12 | Miles Inc. | Method and cell line for obtaining plasminogen activators |
DE3676604D1 (de) * | 1985-03-22 | 1991-02-07 | Chiron Corp | Expression von epa in saeugetierzellen. |
AU593264B2 (en) * | 1985-07-10 | 1990-02-08 | Kanegafuchi Kagaku Kogyo Kabushiki Kaisha | Chromosomal DNA sequence, expression vector for human tissue plasminogen activating factor, cultured cells transfected with same and method of producing said activating factor |
WO1987001389A1 (en) * | 1985-09-06 | 1987-03-12 | Codon | Methods for the recovery of tissue plasminogen activator |
JPH07110232B2 (ja) * | 1985-10-14 | 1995-11-29 | 株式会社日立製作所 | 遺伝子組換え大腸菌の遺伝子生産物を採取する方法および装置 |
PT84991B (pt) * | 1986-06-06 | 1990-03-08 | Genentech Inc | Processo para a producao de actividador do plasminogenio biologicamente activo |
-
1987
- 1987-06-02 PT PT84991A patent/PT84991B/pt unknown
- 1987-06-02 IL IL8274687A patent/IL82746A/en not_active IP Right Cessation
- 1987-06-03 NZ NZ220547A patent/NZ220547A/en unknown
- 1987-06-03 HU HU872536A patent/HU205171B/hu unknown
- 1987-06-04 KR KR1019870005638A patent/KR930002888B1/ko not_active IP Right Cessation
- 1987-06-04 DK DK198702881A patent/DK175366B1/da not_active IP Right Cessation
- 1987-06-05 FI FI872526A patent/FI91886C/fi not_active IP Right Cessation
- 1987-06-05 FR FR878707905A patent/FR2599625B1/fr not_active Expired - Lifetime
- 1987-06-05 AU AU73872/87A patent/AU601984B2/en not_active Expired
- 1987-06-05 JP JP62142121A patent/JPS6332484A/ja active Granted
- 1987-06-05 IE IE150487A patent/IE60485B1/en not_active IP Right Cessation
- 1987-06-05 ES ES198787304995T patent/ES2032444T3/es not_active Expired - Lifetime
- 1987-06-05 NO NO872395A patent/NO170595C/no unknown
- 1987-06-05 GB GB8713267A patent/GB2191493B/en not_active Revoked
- 1987-06-05 DE DE3718939A patent/DE3718939C2/de not_active Expired - Lifetime
- 1987-06-05 DE DE8787304995T patent/DE3778758D1/de not_active Expired - Lifetime
- 1987-06-05 ZA ZA874054A patent/ZA874054B/xx unknown
- 1987-06-05 AT AT87304995T patent/ATE75775T1/de not_active IP Right Cessation
- 1987-06-05 DD DD30357587A patent/DD257087A5/de unknown
- 1987-06-05 EP EP87304995A patent/EP0248675B1/en not_active Expired - Lifetime
-
1990
- 1990-05-09 US US07/522,073 patent/US5053334A/en not_active Expired - Lifetime
-
1992
- 1992-07-21 GR GR920401579T patent/GR3005245T3/el unknown
Also Published As
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
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