PT758651E - Cristal de derivado de pirrolidiltiocarbapenem formulacao liofilizada contendo o citado cristal e processo para a producao do mesmo - Google Patents

Cristal de derivado de pirrolidiltiocarbapenem formulacao liofilizada contendo o citado cristal e processo para a producao do mesmo

Info

Publication number
PT758651E
PT758651E PT95917497T PT95917497T PT758651E PT 758651 E PT758651 E PT 758651E PT 95917497 T PT95917497 T PT 95917497T PT 95917497 T PT95917497 T PT 95917497T PT 758651 E PT758651 E PT 758651E
Authority
PT
Portugal
Prior art keywords
crystal
same
pyrrolidyltocarbapenem
citation
production
Prior art date
Application number
PT95917497T
Other languages
English (en)
Inventor
Yoshinori Hamada
Masayoshi Inoue
Kazuichi Fujikane
Kenji Sugiyama
Hideaki Tai
Fumihiko Matsubara
Katsuo Oda
Takashi Oya
Original Assignee
Shionogi & Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shionogi & Co filed Critical Shionogi & Co
Publication of PT758651E publication Critical patent/PT758651E/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
    • C07D477/10—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D477/12—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6
    • C07D477/16—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6 with hetero atoms or carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 3
    • C07D477/20—Sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicinal Preparation (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
PT95917497T 1994-05-02 1995-04-28 Cristal de derivado de pirrolidiltiocarbapenem formulacao liofilizada contendo o citado cristal e processo para a producao do mesmo PT758651E (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP9353794 1994-05-02
JP10855494 1994-05-23

Publications (1)

Publication Number Publication Date
PT758651E true PT758651E (pt) 2002-12-31

Family

ID=26434878

Family Applications (1)

Application Number Title Priority Date Filing Date
PT95917497T PT758651E (pt) 1994-05-02 1995-04-28 Cristal de derivado de pirrolidiltiocarbapenem formulacao liofilizada contendo o citado cristal e processo para a producao do mesmo

Country Status (11)

Country Link
US (1) US6111098A (pt)
EP (1) EP0758651B1 (pt)
KR (1) KR100314558B1 (pt)
CN (1) CN1048248C (pt)
AT (1) ATE223916T1 (pt)
AU (1) AU700545B2 (pt)
DE (1) DE69528166T2 (pt)
ES (1) ES2183874T3 (pt)
PT (1) PT758651E (pt)
TW (1) TW387889B (pt)
WO (1) WO1995029913A1 (pt)

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Publication number Priority date Publication date Assignee Title
EP1138333B1 (en) * 1999-10-12 2004-02-25 Daiichi Suntory Pharma Co., Ltd. Medicinal compositions for oral use
WO2001072750A1 (fr) * 2000-03-31 2001-10-04 Shionogi & Co., Ltd. Nouvelle forme cristalline d'un derive de pyrrolidylthiocarbapenem
JP5004355B2 (ja) * 2001-05-10 2012-08-22 塩野義製薬株式会社 アセチルチオピロリジン誘導体の製法
US6727277B1 (en) 2002-11-12 2004-04-27 Kansas State University Research Foundation Compounds affecting cholesterol absorption
US20060121080A1 (en) * 2002-11-13 2006-06-08 Lye Whye K Medical devices having nanoporous layers and methods for making the same
TWI353855B (en) * 2005-05-26 2011-12-11 Shionogi & Co Method for preparing an aqueous solution of doripe
CN100582106C (zh) * 2006-01-27 2010-01-20 上海医药工业研究院 一种吡咯烷硫基碳青霉烯衍生物的制备方法及其中间体
WO2007142212A1 (ja) * 2006-06-08 2007-12-13 Dainippon Sumitomo Pharma Co., Ltd. 製剤組成物
WO2008006298A1 (fr) * 2006-07-03 2008-01-17 Chengdu Di'ao Jiuhong Pharmaceutical Factory Nouvelle forme cristalline de doripenem, préparation, procédé et utilisations de celle-ci
CN101333219B (zh) * 2007-06-26 2010-10-13 山东轩竹医药科技有限公司 含有巯基吡咯烷甲酰胺苯烷基杂环的培南衍生物
WO2009047604A1 (en) * 2007-10-08 2009-04-16 Orchid Chemicals & Pharmaceuticals Limited Process for the preparation of carbapenem antibiotic
EP2276762B1 (en) * 2008-03-24 2014-10-01 Ranbaxy Laboratories Limited Process for the preparation of sterile doripenem
WO2010097686A1 (en) * 2009-02-26 2010-09-02 Orchid Chemicals & Pharmaceuticals Ltd An improved process for the preparation of carbapenem antibiotic
US8691803B2 (en) * 2011-01-24 2014-04-08 Savior Lifetec Corporation Process for the preparation of antibiotic compounds
CN102285988B (zh) * 2011-09-08 2012-09-05 上海希迈医药科技有限公司 一种多尼培南水合物晶体及其制备方法
EP2776440A1 (en) 2011-11-08 2014-09-17 Ranbaxy Laboratories Limited Process for the preparation of polymorphs of doripenem
BR112014029368B1 (pt) 2012-05-30 2020-10-27 Meiji Seika Pharma Co., Ltd inibidor de beta-lactamase e processo para preparar o mesmo
CN104072497B (zh) * 2013-03-29 2017-10-03 石药集团中奇制药技术（石家庄）有限公司 一种多尼培南新结晶及其制备方法
EP3050883B1 (en) 2013-09-24 2020-04-22 Meiji Seika Pharma Co., Ltd. Production method for diazabicyclooctane derivatives and intermediates
BR122022016622B1 (pt) 2013-10-08 2023-11-07 Meiji Seika Pharma Co., Ltd. Formas cristalinas de derivado de diazabiciclo-octano, seus processos de produção e uso das mesmas
BR112016025281B8 (pt) * 2014-04-28 2023-10-03 Jw Pharmaceutical Corp Cristal de anidrido de doripenem, método para preparar um cristal de anidrido de doripenem e solvato de doripenem
ES2821826T3 (es) * 2014-12-05 2021-04-27 Meiji Seika Pharma Co Ltd Método para producir cristales de derivado de diazabiciclooctano y preparación liofilizada estable

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US4029655A (en) * 1975-04-11 1977-06-14 Eli Lilly And Company Method of preparing stable sterile crystalline cephalosporins for parenteral administration
JPS5294970A (en) * 1976-02-06 1977-08-10 Shimomura Seisakushiyo Kk Method of fixing parts
IL53427A0 (en) * 1976-11-24 1978-01-31 Lilly Co Eli Method of preparing a rapidly dissolving powder of sterile crystalline cefozolin sodium for parenteral administration
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JPS6143356A (ja) * 1984-08-07 1986-03-01 Nec Corp 共用フアイル管理装置
JPS61129123A (ja) * 1984-11-27 1986-06-17 Sankyo Co Ltd カルバペネム誘導体の安定な凍結乾燥製剤の製造法
JPS61172878A (ja) * 1985-01-28 1986-08-04 Sankyo Co Ltd カルバペネム誘導体の安定な凍結乾燥製剤の製法
JP2522671B2 (ja) * 1986-07-30 1996-08-07 住友製薬 株式会社 結晶態のカルバペネム化合物、その製造方法およびその化合物を含有する注射用抗菌剤
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US5317016A (en) * 1991-08-20 1994-05-31 Shionogi Seiyaku Kabushiki Kaisha Pyrrolidylthiocarbapenem derivative
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US5539102A (en) * 1992-02-21 1996-07-23 Shionogi Seiyaku Kabushiki Kaisha Production method for sulfamide

Also Published As

Publication number Publication date
DE69528166T2 (de) 2003-04-30
AU2353395A (en) 1995-11-29
TW387889B (en) 2000-04-21
CN1151162A (zh) 1997-06-04
EP0758651A1 (en) 1997-02-19
AU700545B2 (en) 1999-01-07
ATE223916T1 (de) 2002-09-15
US6111098A (en) 2000-08-29
EP0758651B1 (en) 2002-09-11
CN1048248C (zh) 2000-01-12
EP0758651A4 (en) 1997-05-02
ES2183874T3 (es) 2003-04-01
DE69528166D1 (de) 2002-10-17
KR100314558B1 (ko) 2002-02-28
WO1995029913A1 (fr) 1995-11-09

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