ATE223916T1 - Kristalline pyrrolidylthiocarbapenem derivate, lyophilisierste präparationen dieser kristalle und verfahren zu deren herstellung - Google Patents

Kristalline pyrrolidylthiocarbapenem derivate, lyophilisierste präparationen dieser kristalle und verfahren zu deren herstellung

Info

Publication number
ATE223916T1
ATE223916T1 AT95917497T AT95917497T ATE223916T1 AT E223916 T1 ATE223916 T1 AT E223916T1 AT 95917497 T AT95917497 T AT 95917497T AT 95917497 T AT95917497 T AT 95917497T AT E223916 T1 ATE223916 T1 AT E223916T1
Authority
AT
Austria
Prior art keywords
crystals
production
crystalline
lyophilized preparations
warming
Prior art date
Application number
AT95917497T
Other languages
English (en)
Inventor
Masayoshi Inoue
Kazuichi Fujikane
Kenji Sugiyama
Hideaki Tai
Fumihiko Matsubara
Katsuo Oda
Takashi Oya
Yoshinori Hamada
Original Assignee
Shionogi & Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shionogi & Co filed Critical Shionogi & Co
Application granted granted Critical
Publication of ATE223916T1 publication Critical patent/ATE223916T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
    • C07D477/10—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D477/12—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6
    • C07D477/16—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6 with hetero atoms or carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 3
    • C07D477/20—Sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
AT95917497T 1994-05-02 1995-04-28 Kristalline pyrrolidylthiocarbapenem derivate, lyophilisierste präparationen dieser kristalle und verfahren zu deren herstellung ATE223916T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP9353794 1994-05-02
JP10855494 1994-05-23
PCT/JP1995/000858 WO1995029913A1 (fr) 1994-05-02 1995-04-28 Cristal de derive de pyrrolidylthiocarbapeneme, preparation lyophilisee le contenant et son procede de production

Publications (1)

Publication Number Publication Date
ATE223916T1 true ATE223916T1 (de) 2002-09-15

Family

ID=26434878

Family Applications (1)

Application Number Title Priority Date Filing Date
AT95917497T ATE223916T1 (de) 1994-05-02 1995-04-28 Kristalline pyrrolidylthiocarbapenem derivate, lyophilisierste präparationen dieser kristalle und verfahren zu deren herstellung

Country Status (11)

Country Link
US (1) US6111098A (de)
EP (1) EP0758651B1 (de)
KR (1) KR100314558B1 (de)
CN (1) CN1048248C (de)
AT (1) ATE223916T1 (de)
AU (1) AU700545B2 (de)
DE (1) DE69528166T2 (de)
ES (1) ES2183874T3 (de)
PT (1) PT758651E (de)
TW (1) TW387889B (de)
WO (1) WO1995029913A1 (de)

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JP4731777B2 (ja) * 1999-10-12 2011-07-27 マルホ株式会社 経口医薬組成物
JP3375084B2 (ja) 2000-03-31 2003-02-10 塩野義製薬株式会社 ピロリジルチオカルバペネム誘導体の新型結晶
JP5004355B2 (ja) * 2001-05-10 2012-08-22 塩野義製薬株式会社 アセチルチオピロリジン誘導体の製法
US6727277B1 (en) 2002-11-12 2004-04-27 Kansas State University Research Foundation Compounds affecting cholesterol absorption
US20060121080A1 (en) * 2002-11-13 2006-06-08 Lye Whye K Medical devices having nanoporous layers and methods for making the same
TWI353855B (en) * 2005-05-26 2011-12-11 Shionogi & Co Method for preparing an aqueous solution of doripe
CN100582106C (zh) * 2006-01-27 2010-01-20 上海医药工业研究院 一种吡咯烷硫基碳青霉烯衍生物的制备方法及其中间体
WO2007142212A1 (ja) * 2006-06-08 2007-12-13 Dainippon Sumitomo Pharma Co., Ltd. 製剤組成物
CN101466713A (zh) * 2006-07-03 2009-06-24 成都地奥九泓制药厂 多尼培南的新结晶及其制备方法和用途
CN101333219B (zh) * 2007-06-26 2010-10-13 山东轩竹医药科技有限公司 含有巯基吡咯烷甲酰胺苯烷基杂环的培南衍生物
WO2009047604A1 (en) * 2007-10-08 2009-04-16 Orchid Chemicals & Pharmaceuticals Limited Process for the preparation of carbapenem antibiotic
EP2276762B1 (de) 2008-03-24 2014-10-01 Ranbaxy Laboratories Limited Verfahren zur herstellung von sterilem doripenem
EP2401278A4 (de) * 2009-02-26 2012-07-04 Orchid Chemicals & Pharm Ltd Verbessertes verfahren für die zubereitung eines carbapenem-antibiotikums
US8691803B2 (en) * 2011-01-24 2014-04-08 Savior Lifetec Corporation Process for the preparation of antibiotic compounds
CN102285988B (zh) * 2011-09-08 2012-09-05 上海希迈医药科技有限公司 一种多尼培南水合物晶体及其制备方法
WO2013068910A1 (en) * 2011-11-08 2013-05-16 Ranbaxy Laboratories Limited Process for the preparation of polymorphs of doripenem
AU2013268415B2 (en) 2012-05-30 2017-05-25 Meiji Seika Pharma Co., Ltd. Novel beta-lactamase inhibitor and method for producing same
CN104072497B (zh) * 2013-03-29 2017-10-03 石药集团中奇制药技术（石家庄）有限公司 一种多尼培南新结晶及其制备方法
CN105555787B (zh) 2013-09-24 2017-08-08 明治制果药业株式会社 二氮杂二环辛烷衍生物的制备方法及其中间体
CA2926071C (en) 2013-10-08 2021-11-09 Meiji Seika Pharma Co., Ltd. Crystalline forms of diazabicyclooctane derivative and production process thereof
CN106255694A (zh) 2014-04-28 2016-12-21 Jw制药公司 新型多尼培南晶体及其制备方法
AU2015355970B2 (en) * 2014-12-05 2020-05-21 Meiji Seika Pharma Co., Ltd. Method for producing crystals of diazabicyclooctane derivative and stable lyophilized preparation

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Also Published As

Publication number Publication date
AU2353395A (en) 1995-11-29
PT758651E (pt) 2002-12-31
WO1995029913A1 (fr) 1995-11-09
EP0758651A4 (de) 1997-05-02
US6111098A (en) 2000-08-29
TW387889B (en) 2000-04-21
AU700545B2 (en) 1999-01-07
ES2183874T3 (es) 2003-04-01
EP0758651B1 (de) 2002-09-11
KR100314558B1 (ko) 2002-02-28
EP0758651A1 (de) 1997-02-19
DE69528166D1 (de) 2002-10-17
CN1048248C (zh) 2000-01-12
CN1151162A (zh) 1997-06-04
DE69528166T2 (de) 2003-04-30

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