BG51804A1 - Process for preparing 2-methyl-1,2,3,4,10,14b-hexahydro-dibenzo (c,f)-pyrazino - Google Patents

Process for preparing 2-methyl-1,2,3,4,10,14b-hexahydro-dibenzo (c,f)-pyrazino

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Publication number
BG51804A1
BG51804A1 BG9648592A BG9648592A BG51804A1 BG 51804 A1 BG51804 A1 BG 51804A1 BG 9648592 A BG9648592 A BG 9648592A BG 9648592 A BG9648592 A BG 9648592A BG 51804 A1 BG51804 A1 BG 51804A1
Authority
BG
Bulgaria
Prior art keywords
sulphate
pyrazino
dibenzo
hexahydro
methyl
Prior art date
Application number
BG9648592A
Inventor
Khristo P Daskalov
Marija Kh Gologanova
Tatjana S Zikolova
Kiril D Kirilov
Valentina K Sharkova
Ivan D Bogunski
Lidija V Mikhajlova
Ivan Kh Radoslavov
Veneta T Aneva
Evdokija A Ninova
Zoja T Ivanova
Dimitar E Katsarski
Original Assignee
Daskalov
Gologanova
Zikolova
Kirilov
Sharkova
Bogunski
Mikhajlova
Radoslavov
Aneva
Ninova
Ivanova
Katsarski
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Daskalov, Gologanova, Zikolova, Kirilov, Sharkova, Bogunski, Mikhajlova, Radoslavov, Aneva, Ninova, Ivanova, Katsarski filed Critical Daskalov
Priority to BG9648592A priority Critical patent/BG51804A1/en
Publication of BG51804A1 publication Critical patent/BG51804A1/en

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Abstract

This compound is known by the name of mianserine hydrochloride and finds application as an antidepressive and antihistamine agent in the medical practice. It is obtained at high yield rates and purity. The method comprises reacting 2-methyl-1,2,3,4,10,14b-hexahydro-dibenzo (c,f)-pyrazino (1,2-a)-azepine sulphate (mianserine sulphate) with calcium chloride at elevated temperatures in an aqueous medium, followed by hot isolation of the resulting calcium sulphate. This is followed by cooling the filtrate down to room temperature and isolating the crystallized mianserine hydrochloride.
BG9648592A 1992-06-16 1992-06-16 Process for preparing 2-methyl-1,2,3,4,10,14b-hexahydro-dibenzo (c,f)-pyrazino BG51804A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
BG9648592A BG51804A1 (en) 1992-06-16 1992-06-16 Process for preparing 2-methyl-1,2,3,4,10,14b-hexahydro-dibenzo (c,f)-pyrazino

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
BG9648592A BG51804A1 (en) 1992-06-16 1992-06-16 Process for preparing 2-methyl-1,2,3,4,10,14b-hexahydro-dibenzo (c,f)-pyrazino

Publications (1)

Publication Number Publication Date
BG51804A1 true BG51804A1 (en) 1993-09-15

Family

ID=3924474

Family Applications (1)

Application Number Title Priority Date Filing Date
BG9648592A BG51804A1 (en) 1992-06-16 1992-06-16 Process for preparing 2-methyl-1,2,3,4,10,14b-hexahydro-dibenzo (c,f)-pyrazino

Country Status (1)

Country Link
BG (1) BG51804A1 (en)

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