ES2138674T3 - Produccion de cristales de una sal monopotasica de diester-fosfato. - Google Patents
Produccion de cristales de una sal monopotasica de diester-fosfato.Info
- Publication number
- ES2138674T3 ES2138674T3 ES95104524T ES95104524T ES2138674T3 ES 2138674 T3 ES2138674 T3 ES 2138674T3 ES 95104524 T ES95104524 T ES 95104524T ES 95104524 T ES95104524 T ES 95104524T ES 2138674 T3 ES2138674 T3 ES 2138674T3
- Authority
- ES
- Spain
- Prior art keywords
- crystals
- diester
- phosphate
- production
- diester phosphate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000013078 crystal Substances 0.000 title abstract 5
- 238000004519 manufacturing process Methods 0.000 title abstract 3
- 229910019142 PO4 Inorganic materials 0.000 title abstract 2
- 239000010452 phosphate Substances 0.000 title abstract 2
- 150000003839 salts Chemical class 0.000 title 1
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 abstract 3
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 abstract 3
- KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 abstract 3
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 abstract 2
- 150000005690 diesters Chemical class 0.000 abstract 2
- GNSKLFRGEWLPPA-UHFFFAOYSA-M potassium dihydrogen phosphate Chemical compound [K+].OP(O)([O-])=O GNSKLFRGEWLPPA-UHFFFAOYSA-M 0.000 abstract 2
- -1 diester phosphate Chemical class 0.000 abstract 1
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 1
- VIHIKSJKXIMMLV-FZTHFCCHSA-M potassium;[(2r)-2-[(1s)-1,2-dihydroxyethyl]-3-hydroxy-5-oxo-2h-furan-4-yl] [(2r)-2,5,7,8-tetramethyl-2-[(4r,8r)-4,8,12-trimethyltridecyl]-3,4-dihydrochromen-6-yl] phosphate Chemical compound [K+].C([C@@](OC1=C(C)C=2C)(C)CCC[C@H](C)CCC[C@H](C)CCCC(C)C)CC1=C(C)C=2OP([O-])(=O)OC1=C(O)[C@@H]([C@@H](O)CO)OC1=O VIHIKSJKXIMMLV-FZTHFCCHSA-M 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
- C07F9/65586—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system at least one of the hetero rings does not contain nitrogen as ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/665—Phosphorus compounds having oxygen as a ring hetero atom, e.g. fosfomycin
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
Abstract
METODO PARA LA PRODUCCION DE CRISTALES DE SAL MONOPOTASICA FOSFATO DIESTER, QUE COMPRENDE (A) LA REACCION DE UN FOSFATO DIESTER DE FORMULA (I): CON UN HIDROXIDO POTASICO EN UN DISOLVENTE SELECCIONADO DE UN GRUPO QUE CONTENGA ALCOHOL ISOPROPIL, CLORURO DE METILENO Y CLOROFORMO Y (B) DEJAR QUE LOS CRISTALES DE LA SAL MONOPOTASICA DE FOSFATO DIESTER SE PRECIPITEN. LOS CRISTALES DE SAL MONOPOTASICA FOSFATO DIESTER PRODUCIDOS MEDIANTE EL METODO DE PRODUCCION DEL PRESENTE INVENTO TIENEN UNA PUREZA EXTREMADAMENTE REFINADA Y ASPECTO CRISTALINO. EN CONSECUENCIA, EL PRESENTE INVENTO ES VENTAJOSO EN QUE HA HECHO POSIBLE LA OBTENCION DE PREPARACIONES FARMACEUTICAS SUPERIORES EN EFICACIA, SEGURIDAD Y ESTABILIDAD.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP6513394 | 1994-04-01 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2138674T3 true ES2138674T3 (es) | 2000-01-16 |
Family
ID=13278080
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES95104524T Expired - Lifetime ES2138674T3 (es) | 1994-04-01 | 1995-03-28 | Produccion de cristales de una sal monopotasica de diester-fosfato. |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US5463976A (es) |
| EP (1) | EP0675132B1 (es) |
| KR (1) | KR950032246A (es) |
| AT (1) | ATE186730T1 (es) |
| CA (1) | CA2146072A1 (es) |
| DE (1) | DE69513318T2 (es) |
| ES (1) | ES2138674T3 (es) |
| TW (1) | TW266214B (es) |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3907689A (en) * | 1973-08-29 | 1975-09-23 | Eastman Kodak Co | Textile treating composition and textile yarn treated therewith |
| US4293305A (en) * | 1979-11-01 | 1981-10-06 | Northwestern Laboratories, Inc. | Diester composition and textile processing compositions therefrom |
| US4394126A (en) * | 1979-11-01 | 1983-07-19 | Wilson Robert B | Diester composition and textile processing compositions therefrom |
| US4426297A (en) * | 1979-11-01 | 1984-01-17 | Crucible Chemical Company | Diester composition and textile processing compositions therefrom |
| JPS59219295A (ja) * | 1983-05-30 | 1984-12-10 | Senjiyu Seiyaku Kk | リン酸ジエステルまたはその塩およびそれらの製造法 |
| JPS61225372A (ja) * | 1985-03-27 | 1986-10-07 | 三洋化成工業株式会社 | ポリエステル繊維用紡績油剤 |
| JP2546687B2 (ja) * | 1987-09-11 | 1996-10-23 | 千寿製薬株式会社 | リン酸ジエステルまたはその塩からなる抗酸化剤 |
-
1995
- 1995-03-28 KR KR1019950006794A patent/KR950032246A/ko not_active Application Discontinuation
- 1995-03-28 DE DE69513318T patent/DE69513318T2/de not_active Expired - Fee Related
- 1995-03-28 ES ES95104524T patent/ES2138674T3/es not_active Expired - Lifetime
- 1995-03-28 AT AT95104524T patent/ATE186730T1/de not_active IP Right Cessation
- 1995-03-28 EP EP95104524A patent/EP0675132B1/en not_active Expired - Lifetime
- 1995-03-28 TW TW084102983A patent/TW266214B/zh active
- 1995-03-29 US US08/412,886 patent/US5463976A/en not_active Expired - Fee Related
- 1995-03-31 CA CA002146072A patent/CA2146072A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| DE69513318T2 (de) | 2000-04-13 |
| ATE186730T1 (de) | 1999-12-15 |
| DE69513318D1 (de) | 1999-12-23 |
| CA2146072A1 (en) | 1995-10-02 |
| TW266214B (es) | 1995-12-21 |
| KR950032246A (ko) | 1995-12-20 |
| EP0675132A2 (en) | 1995-10-04 |
| EP0675132A3 (en) | 1995-12-13 |
| US5463976A (en) | 1995-11-07 |
| EP0675132B1 (en) | 1999-11-17 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG2A | Definitive protection |
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