PT1335728E - Novas preparacoes farmaceuticas compostas com base em sais do tiotropio e sais do salmeterol - Google Patents
Novas preparacoes farmaceuticas compostas com base em sais do tiotropio e sais do salmeterolInfo
- Publication number
- PT1335728E PT1335728E PT01989446T PT01989446T PT1335728E PT 1335728 E PT1335728 E PT 1335728E PT 01989446 T PT01989446 T PT 01989446T PT 01989446 T PT01989446 T PT 01989446T PT 1335728 E PT1335728 E PT 1335728E
- Authority
- PT
- Portugal
- Prior art keywords
- salts
- salmeterol
- tiotropy
- pharmaceutical preparations
- new compound
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/46—8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, cocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
- A61K9/0078—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a nebulizer such as a jet nebulizer, ultrasonic nebulizer, e.g. in the form of aqueous drug solutions or dispersions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
- A61K9/0075—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
- A61K9/008—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy comprising drug dissolved or suspended in liquid propellant for inhalation via a pressurized metered dose inhaler [MDI]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Pulmonology (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Otolaryngology (AREA)
- Emergency Medicine (AREA)
- Dispersion Chemistry (AREA)
- Immunology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10056104A DE10056104A1 (de) | 2000-11-13 | 2000-11-13 | Neue Arzneimittelkompositionen auf der Basis von Tiotropiumsalzen und Salzen des Salmeterols |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PT1335728E true PT1335728E (pt) | 2005-05-31 |
Family
ID=7663071
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT04028508T PT1514546E (pt) | 2000-11-13 | 2001-11-09 | Composições medicamentosas à base de sais de tiotrópio e de sais de salmeterol |
| PT01989446T PT1335728E (pt) | 2000-11-13 | 2001-11-09 | Novas preparacoes farmaceuticas compostas com base em sais do tiotropio e sais do salmeterol |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT04028508T PT1514546E (pt) | 2000-11-13 | 2001-11-09 | Composições medicamentosas à base de sais de tiotrópio e de sais de salmeterol |
Country Status (32)
| Country | Link |
|---|---|
| EP (3) | EP1514546B1 (pt) |
| JP (2) | JP4282322B2 (pt) |
| KR (2) | KR100940752B1 (pt) |
| CN (1) | CN1678318A (pt) |
| AT (2) | ATE291428T1 (pt) |
| AU (3) | AU2002227910B2 (pt) |
| BG (1) | BG107781A (pt) |
| BR (1) | BR0115226A (pt) |
| CA (1) | CA2429012A1 (pt) |
| CY (1) | CY1106774T1 (pt) |
| CZ (1) | CZ20031444A3 (pt) |
| DE (3) | DE10056104A1 (pt) |
| DK (2) | DK1514546T3 (pt) |
| EA (1) | EA007904B1 (pt) |
| EC (1) | ECSP034571A (pt) |
| EE (1) | EE200300228A (pt) |
| ES (2) | ES2287629T3 (pt) |
| HR (1) | HRP20030378A2 (pt) |
| HU (1) | HUP0301447A3 (pt) |
| IL (2) | IL155718A0 (pt) |
| MX (1) | MXPA03004164A (pt) |
| NO (1) | NO20032111L (pt) |
| NZ (1) | NZ526400A (pt) |
| PL (1) | PL205330B1 (pt) |
| PT (2) | PT1514546E (pt) |
| RS (2) | RS50286B (pt) |
| SG (1) | SG167657A1 (pt) |
| SI (2) | SI1335728T1 (pt) |
| SK (2) | SK286939B6 (pt) |
| UA (1) | UA74853C2 (pt) |
| WO (1) | WO2002038154A1 (pt) |
| ZA (1) | ZA200302921B (pt) |
Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2165768B1 (es) | 1999-07-14 | 2003-04-01 | Almirall Prodesfarma Sa | Nuevos derivados de quinuclidina y composiciones farmaceuticas que los contienen. |
| US7214687B2 (en) | 1999-07-14 | 2007-05-08 | Almirall Ag | Quinuclidine derivatives and medicinal compositions containing the same |
| EP1231894B1 (en) * | 1999-11-23 | 2005-01-12 | Glaxo Group Limited | Pharmaceutical formulations of salmeterol |
| JP2005504076A (ja) * | 2001-09-14 | 2005-02-10 | ベーリンガー インゲルハイム ファルマ ゲゼルシャフト ミット ベシュレンクテル ハフツング ウント コンパニー コマンディトゲゼルシャフト | 新規な吸入用医薬組成物 |
| US7244415B2 (en) | 2002-03-28 | 2007-07-17 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | HFA suspension formulations of an anhydrate |
| DE10214263A1 (de) * | 2002-03-28 | 2003-10-16 | Boehringer Ingelheim Pharma | HFA-Suspensionsformulierungen enthaltend ein Anticholinergikum |
| US7311894B2 (en) | 2002-03-28 | 2007-12-25 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | HFA suspension formulations containing an anticholinergic |
| US7250426B2 (en) | 2002-11-29 | 2007-07-31 | Boehringer Ingelheim Pharma Gmbh & Co Kg | Tiotropium-containing pharmaceutical combination for inhalation |
| DE10256080A1 (de) * | 2002-11-29 | 2004-06-17 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Tiotropiumhaltige Arzneimittelkombination für die Inhalation |
| KR20050085650A (ko) * | 2002-12-16 | 2005-08-29 | 베링거 잉겔하임 파르마 게엠베하 운트 코 카게 | 타이오트로피움 함유 ｈｆｃ 용액 제형 |
| DE10351663A1 (de) * | 2002-12-20 | 2004-07-01 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Pulverförmige Arzneimittel enthaltend ein Tiotropiumsalz und Salmeterolxinafoat |
| DE10345065A1 (de) * | 2003-09-26 | 2005-04-14 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Aerosolformulierung für die Inhalation enthaltend ein Anticholinergikum |
| ATE478071T1 (de) * | 2003-11-03 | 2010-09-15 | Boehringer Ingelheim Int | Verfahren zur herstellung neuer tiotropiumsalze |
| PT1682541E (pt) | 2003-11-03 | 2010-04-14 | Boehringer Ingelheim Int | Processo para a preparação de sais de tiotrópio |
| ES2317245T3 (es) * | 2004-05-31 | 2009-04-16 | Laboratorios Almirall, S.A. | Combinaciones que comprenden agentes antimuscarinicos y agonistas beta-adrenergicos. |
| ES2257152B1 (es) | 2004-05-31 | 2007-07-01 | Laboratorios Almirall S.A. | Combinaciones que comprenden agentes antimuscarinicos y agonistas beta-adrenergicos. |
| CN101166738B (zh) | 2005-05-02 | 2011-06-01 | 贝林格尔·英格海姆国际有限公司 | 噻托溴铵的新晶型 |
| WO2007017437A1 (en) * | 2005-08-06 | 2007-02-15 | Boehringer Ingelheim International Gmbh | Method for the treatment of dyspnea comprising combined administration of tiotropium salts and salts of salmeterol |
| ES2298049B1 (es) | 2006-07-21 | 2009-10-20 | Laboratorios Almirall S.A. | Procedimiento para fabricar bromuro de 3(r)-(2-hidroxi-2,2-ditien-2-ilacetoxi)-1-(3-fenoxipropil)-1-azoniabiciclo (2.2.2) octano. |
| EP2100598A1 (en) | 2008-03-13 | 2009-09-16 | Laboratorios Almirall, S.A. | Inhalation composition containing aclidinium for treatment of asthma and chronic obstructive pulmonary disease |
| EP2100599A1 (en) | 2008-03-13 | 2009-09-16 | Laboratorios Almirall, S.A. | Inhalation composition containing aclidinium for treatment of asthma and chronic obstructive pulmonary disease |
| US20120220557A1 (en) * | 2011-02-17 | 2012-08-30 | Chiesi Farmaceutici S.P.A. | Liquid propellant-free formulation comprising an antimuscarinic drug |
| EP2510928A1 (en) | 2011-04-15 | 2012-10-17 | Almirall, S.A. | Aclidinium for use in improving the quality of sleep in respiratory patients |
| JP6335798B2 (ja) * | 2012-02-28 | 2018-05-30 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 新規噴射剤含有チオトロピウム製剤 |
| WO2015065222A1 (ru) * | 2013-10-28 | 2015-05-07 | Шолекс Девелопмент Гмбх | Фармацевтический ингаляционный препарат для лечения бронхиальной астмы и хронической обструктивной болезни легких, содержащий в качестве активного вещества микронизированный тиотропия бромид, и способ его получения |
| TW201835041A (zh) | 2017-02-17 | 2018-10-01 | 印度商托仁特生技有限公司 | 具β-腎上腺素促效劑及抗蕈毒活性化合物 |
| WO2019142214A1 (en) * | 2018-01-19 | 2019-07-25 | Cipla Limited | Pharmaceutical composition comprising tiotropium for inhalation |
| CN116173025A (zh) * | 2018-07-26 | 2023-05-30 | 四川海思科制药有限公司 | 一种含格隆铵盐及茚达特罗盐的气雾剂药物组合物及其制备方法与应用 |
| CN116196298A (zh) * | 2018-07-26 | 2023-06-02 | 四川海思科制药有限公司 | 一种含格隆铵盐的气雾剂药物组合物及其制备方法与应用 |
| US11642372B2 (en) | 2020-05-01 | 2023-05-09 | Tygrus, LLC | Therapeutic material with low pH and low toxicity active against at least one pathogen for addressing patients with respiratory illnesses |
| US11826382B2 (en) | 2020-05-01 | 2023-11-28 | Tygrus, LLC | Therapeutic material with low pH and low toxicity active against at least one pathogen for addressing patients with respiratory illnesses |
| WO2022119661A1 (en) * | 2020-12-04 | 2022-06-09 | Tygrus, LLC | THERAPEUTIC MATERIAL WITH LOW pH AND LOW TOXICITY ACTIVE AGAINST AT LEAST ONE PATHOGEN FOR ADDRESSING PATIENTS WITH RESPIRATORY ILLNESSES |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE283033T1 (de) * | 1998-07-24 | 2004-12-15 | Jago Res Ag | Medizinische aerosolformulierungen |
| DE19835346A1 (de) * | 1998-08-05 | 2000-02-10 | Boehringer Ingelheim Pharma | Zweiteilige Kapsel zur Aufnahme von pharmazeutischen Zubereitungen für Pulverinhalatoren |
| DE19847970A1 (de) * | 1998-10-17 | 2000-04-20 | Boehringer Ingelheim Pharma | Lagerfähige Wirkstoff-Formulierung |
| DE19847971A1 (de) * | 1998-10-17 | 1999-09-02 | Schiering | Verfahren und Einrichtung zur Verhinderung von Filterbränden (Staubfilter) |
| DE19921693A1 (de) * | 1999-05-12 | 2000-11-16 | Boehringer Ingelheim Pharma | Neuartige Arzneimittelkompositionen auf der Basis von anticholinergisch wirksamen Verbindungen und ß-Mimetika |
| DE19961300A1 (de) * | 1999-12-18 | 2001-06-21 | Asta Medica Ag | Vorratssystem für Arzneimittel in Pulverform und damit ausgestatteter Inhalator |
-
2000
- 2000-11-13 DE DE10056104A patent/DE10056104A1/de not_active Withdrawn
-
2001
- 2001-09-11 UA UA2003065486A patent/UA74853C2/uk unknown
- 2001-11-09 SK SK741-2003A patent/SK286939B6/sk not_active IP Right Cessation
- 2001-11-09 PL PL365989A patent/PL205330B1/pl not_active IP Right Cessation
- 2001-11-09 WO PCT/EP2001/012962 patent/WO2002038154A1/de active Application Filing
- 2001-11-09 EP EP04028508A patent/EP1514546B1/de not_active Expired - Lifetime
- 2001-11-09 RS YUP-355/03A patent/RS50286B/sr unknown
- 2001-11-09 SG SG200505149-5A patent/SG167657A1/en unknown
- 2001-11-09 KR KR1020087020177A patent/KR100940752B1/ko not_active IP Right Cessation
- 2001-11-09 EA EA200300503A patent/EA007904B1/ru not_active IP Right Cessation
- 2001-11-09 EP EP01989446A patent/EP1335728B1/de not_active Expired - Lifetime
- 2001-11-09 SK SK50015-2009A patent/SK286950B6/sk not_active IP Right Cessation
- 2001-11-09 PT PT04028508T patent/PT1514546E/pt unknown
- 2001-11-09 ES ES04028508T patent/ES2287629T3/es not_active Expired - Lifetime
- 2001-11-09 BR BR0115226-2A patent/BR0115226A/pt active Pending
- 2001-11-09 AU AU2002227910A patent/AU2002227910B2/en not_active Ceased
- 2001-11-09 SI SI200130347T patent/SI1335728T1/xx unknown
- 2001-11-09 AU AU2791002A patent/AU2791002A/xx active Pending
- 2001-11-09 IL IL15571801A patent/IL155718A0/xx unknown
- 2001-11-09 ES ES01989446T patent/ES2240549T3/es not_active Expired - Lifetime
- 2001-11-09 NZ NZ526400A patent/NZ526400A/en unknown
- 2001-11-09 AT AT01989446T patent/ATE291428T1/de active
- 2001-11-09 AT AT04028508T patent/ATE362761T1/de active
- 2001-11-09 CA CA002429012A patent/CA2429012A1/en not_active Abandoned
- 2001-11-09 HU HU0301447A patent/HUP0301447A3/hu unknown
- 2001-11-09 CZ CZ20031444A patent/CZ20031444A3/cs unknown
- 2001-11-09 DK DK04028508T patent/DK1514546T3/da active
- 2001-11-09 DK DK01989446T patent/DK1335728T3/da active
- 2001-11-09 DE DE50105729T patent/DE50105729D1/de not_active Expired - Lifetime
- 2001-11-09 MX MXPA03004164A patent/MXPA03004164A/es active IP Right Grant
- 2001-11-09 SI SI200130751T patent/SI1514546T1/sl unknown
- 2001-11-09 EP EP07104722A patent/EP1808174A1/de not_active Withdrawn
- 2001-11-09 CN CNA018187773A patent/CN1678318A/zh active Pending
- 2001-11-09 RS RSP-2009/0105A patent/RS20090105A/sr unknown
- 2001-11-09 KR KR1020037006434A patent/KR100886094B1/ko not_active IP Right Cessation
- 2001-11-09 JP JP2002540737A patent/JP4282322B2/ja not_active Expired - Lifetime
- 2001-11-09 PT PT01989446T patent/PT1335728E/pt unknown
- 2001-11-09 DE DE50112535T patent/DE50112535D1/de not_active Expired - Lifetime
- 2001-11-09 EE EEP200300228A patent/EE200300228A/xx unknown
-
2003
- 2003-04-14 ZA ZA200302921A patent/ZA200302921B/en unknown
- 2003-04-28 EC EC2003004571A patent/ECSP034571A/es unknown
- 2003-05-01 IL IL155718A patent/IL155718A/en not_active IP Right Cessation
- 2003-05-08 BG BG107781A patent/BG107781A/bg active Pending
- 2003-05-12 NO NO20032111A patent/NO20032111L/no not_active Application Discontinuation
- 2003-05-12 HR HR20030378A patent/HRP20030378A2/hr not_active Application Discontinuation
-
2004
- 2004-12-08 JP JP2004355226A patent/JP4282594B2/ja not_active Expired - Lifetime
-
2007
- 2007-05-22 AU AU2007202303A patent/AU2007202303B2/en not_active Ceased
- 2007-07-30 CY CY20071101011T patent/CY1106774T1/el unknown
Also Published As
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