IT1318650B1 - 1,3-diossolani ad attivita' antitosse. - Google Patents
1,3-diossolani ad attivita' antitosse.Info
- Publication number
- IT1318650B1 IT1318650B1 IT2000MI001734A ITMI20001734A IT1318650B1 IT 1318650 B1 IT1318650 B1 IT 1318650B1 IT 2000MI001734 A IT2000MI001734 A IT 2000MI001734A IT MI20001734 A ITMI20001734 A IT MI20001734A IT 1318650 B1 IT1318650 B1 IT 1318650B1
- Authority
- IT
- Italy
- Prior art keywords
- diossolans
- toxic activity
- preparation
- acetals
- levodropropizine
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
- C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D317/28—Radicals substituted by nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/14—Antitussive agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pulmonology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Glass Compositions (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Hydrogenated Pyridines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Priority Applications (29)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT2000MI001734A IT1318650B1 (it) | 2000-07-28 | 2000-07-28 | 1,3-diossolani ad attivita' antitosse. |
HU0301497A HUP0301497A3 (en) | 2000-07-28 | 2001-07-18 | 1,3-dioxolanes with antitussive activity |
PL361172A PL206307B1 (pl) | 2000-07-28 | 2001-07-18 | 2,2-podstawione 1,3-dioksolany, sposób ich wytwarzania, kompozycja farmaceutyczna je zawierająca oraz ich zastosowanie |
EEP200300036A EE05178B1 (et) | 2000-07-28 | 2001-07-18 | 1,3-dioksolaanid, nende saamine ja kasutamine khavastaste ravimite valmistamiseks ning neid sisaldavad farmatseutilised kompositsioonid |
SI200130098T SI1307441T1 (en) | 2000-07-28 | 2001-07-18 | 1,3-dioxolanes with antitussive activity |
US10/333,979 US6835734B2 (en) | 2000-07-28 | 2001-07-18 | 1,3-dioxolanes with antitussive activity |
UA2003021767A UA73789C2 (en) | 2000-07-28 | 2001-07-18 | 1,3-dioxolans with antitussive activity |
DK01967203T DK1307441T3 (da) | 2000-07-28 | 2001-07-18 | 1,3-dioxolaner med en hostehæmmende virkning |
PT01967203T PT1307441E (pt) | 2000-07-28 | 2001-07-18 | 1,3-dioxolanos com actividade antitussica |
AT01967203T ATE266018T1 (de) | 2000-07-28 | 2001-07-18 | 1,3-dioxolanen mit hustenhemmender wirkung |
EP01967203A EP1307441B1 (en) | 2000-07-28 | 2001-07-18 | 1,3-dioxolanes with antitussive activity |
ES01967203T ES2219562T3 (es) | 2000-07-28 | 2001-07-18 | 1,3-dioxolanos con actividad antitusigena. |
IL15351501A IL153515A0 (en) | 2000-07-28 | 2001-07-18 | 1,3-dioxolanes with antitussive activity |
PCT/EP2001/008304 WO2002010149A1 (en) | 2000-07-28 | 2001-07-18 | 1,3-dioxolanes with antitussive activity |
CNB018134564A CN1204135C (zh) | 2000-07-28 | 2001-07-18 | 具有镇咳活性的1,3-二氧环戊烷 |
CZ20030268A CZ301087B6 (cs) | 2000-07-28 | 2001-07-18 | 1,3-dioxolany a farmaceutický prostredek |
RU2003105691/04A RU2276149C2 (ru) | 2000-07-28 | 2001-07-18 | 1,3-диоксоланы, способ их получения и фармацевтическая композиция |
JP2002515880A JP5107497B2 (ja) | 2000-07-28 | 2001-07-18 | 鎮咳活性を有する1,3−ジオキソラン |
MXPA02012920A MXPA02012920A (es) | 2000-07-28 | 2001-07-18 | 1,3 dioxolanos con actividad antitusigena.. |
SK89-2003A SK286794B6 (sk) | 2000-07-28 | 2001-07-18 | (S)-2,2-Substituované-1,3-dioxolány, spôsob ich prípravy, farmaceutický prostriedok s ich obsahom a ich použitie |
BR0112765-9A BR0112765A (pt) | 2000-07-28 | 2001-07-18 | l,3-dioxolanos com atividade antitussìgena |
AU2001287638A AU2001287638A1 (en) | 2000-07-28 | 2001-07-18 | 1,3-dioxolanes with antitussive activity |
SI200120036A SI21040A (sl) | 2000-07-28 | 2001-07-18 | 1,3-dioksolani z antitusičnim delovanjem |
YUP-30/03A RS50861B (sr) | 2000-07-28 | 2001-07-18 | 1,3-dioksolani kao sredstva protiv kašlja |
KR1020037000945A KR100781403B1 (ko) | 2000-07-28 | 2001-07-18 | 항해수성 1,3-디옥솔란 |
TR2004/01315T TR200401315T4 (tr) | 2000-07-28 | 2001-07-18 | Öksürük kesici etkiye sahip 1,3-dioksolanlar |
DE60103164T DE60103164T2 (de) | 2000-07-28 | 2001-07-18 | 1,3-dioxolanen mit hustenhemmender wirkung |
IL153515A IL153515A (en) | 2000-07-28 | 2002-12-18 | 1,3 - Dioxalenes with cough suppressant activity |
HK04101653A HK1058797A1 (en) | 2000-07-28 | 2004-03-05 | 1,3-Dioxolanes with antitussive activity. |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT2000MI001734A IT1318650B1 (it) | 2000-07-28 | 2000-07-28 | 1,3-diossolani ad attivita' antitosse. |
Publications (3)
Publication Number | Publication Date |
---|---|
ITMI20001734A0 ITMI20001734A0 (it) | 2000-07-28 |
ITMI20001734A1 ITMI20001734A1 (it) | 2002-01-28 |
IT1318650B1 true IT1318650B1 (it) | 2003-08-27 |
Family
ID=11445591
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IT2000MI001734A IT1318650B1 (it) | 2000-07-28 | 2000-07-28 | 1,3-diossolani ad attivita' antitosse. |
Country Status (27)
Country | Link |
---|---|
US (1) | US6835734B2 (it) |
EP (1) | EP1307441B1 (it) |
JP (1) | JP5107497B2 (it) |
KR (1) | KR100781403B1 (it) |
CN (1) | CN1204135C (it) |
AT (1) | ATE266018T1 (it) |
AU (1) | AU2001287638A1 (it) |
BR (1) | BR0112765A (it) |
CZ (1) | CZ301087B6 (it) |
DE (1) | DE60103164T2 (it) |
DK (1) | DK1307441T3 (it) |
EE (1) | EE05178B1 (it) |
ES (1) | ES2219562T3 (it) |
HK (1) | HK1058797A1 (it) |
HU (1) | HUP0301497A3 (it) |
IL (2) | IL153515A0 (it) |
IT (1) | IT1318650B1 (it) |
MX (1) | MXPA02012920A (it) |
PL (1) | PL206307B1 (it) |
PT (1) | PT1307441E (it) |
RS (1) | RS50861B (it) |
RU (1) | RU2276149C2 (it) |
SI (1) | SI21040A (it) |
SK (1) | SK286794B6 (it) |
TR (1) | TR200401315T4 (it) |
UA (1) | UA73789C2 (it) |
WO (1) | WO2002010149A1 (it) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IT1318651B1 (it) * | 2000-07-28 | 2003-08-27 | Dompe Spa | Sintesi di (+-)1,3-diossolani e loro risoluzione ottica. |
TWI496776B (zh) * | 2007-11-15 | 2015-08-21 | Astrazeneca Ab | 製備(3aR,4S,6R,6aS)-6-胺基-2,2-二甲基四氫-3aH-環戊并[d][1,3]二氧雜環戊烯-4-醇之純非對映異構性之二苯甲醯-L-酒石酸鹽之方法 |
EP2070915A1 (en) * | 2007-12-03 | 2009-06-17 | A.M.S.A. ANONIMA MATERIE SINTETICHE E AFFINI S.p.A. | New process for the synthesis of moguisteine |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4049660A (en) * | 1971-06-18 | 1977-09-20 | Delalande S.A. | N-substituted derivatives of 4 (N-piperazinylmethyl) spiro dibenzocycloheptadi- (or tri-) ene-5, 2-dioxolane (1,3) their method of preparation and their application in therapeutics |
IT1203721B (it) * | 1983-12-29 | 1989-02-23 | Dompe Farmaceutici Spa | Composti otticamente attivi ad attivita' antitosse e sedativa centrale,procedimento per la preparazione e composizioni che li contengono |
NL8801622A (nl) * | 1988-06-25 | 1990-01-16 | Stamicarbon | Bereiding van enantiomeren van dropropizine. |
IT1226570B (it) * | 1988-08-01 | 1991-01-24 | Bidachem Spa | Procedimento di preparazione della levo- e destro-dropropizina |
IT1254452B (it) * | 1992-02-14 | 1995-09-25 | Dompe Farmaceutici Spa | N-ossidi ed n,n'-diossidi di 3-(piperazin-1-il)-propan-1,2-dioli |
IT1254993B (it) * | 1992-06-24 | 1995-10-11 | Procedimento per la preparazione degli enantiomeri della dropropizina | |
IL111730A (en) * | 1993-11-29 | 1998-12-06 | Fujisawa Pharmaceutical Co | Piperazine derivatives, processes for their preparation and pharmaceutical preparations containing them |
IT1318651B1 (it) * | 2000-07-28 | 2003-08-27 | Dompe Spa | Sintesi di (+-)1,3-diossolani e loro risoluzione ottica. |
-
2000
- 2000-07-28 IT IT2000MI001734A patent/IT1318650B1/it active
-
2001
- 2001-07-18 MX MXPA02012920A patent/MXPA02012920A/es active IP Right Grant
- 2001-07-18 SK SK89-2003A patent/SK286794B6/sk not_active IP Right Cessation
- 2001-07-18 RS YUP-30/03A patent/RS50861B/sr unknown
- 2001-07-18 RU RU2003105691/04A patent/RU2276149C2/ru not_active IP Right Cessation
- 2001-07-18 IL IL15351501A patent/IL153515A0/xx active IP Right Grant
- 2001-07-18 ES ES01967203T patent/ES2219562T3/es not_active Expired - Lifetime
- 2001-07-18 EP EP01967203A patent/EP1307441B1/en not_active Expired - Lifetime
- 2001-07-18 AT AT01967203T patent/ATE266018T1/de active
- 2001-07-18 US US10/333,979 patent/US6835734B2/en not_active Expired - Fee Related
- 2001-07-18 BR BR0112765-9A patent/BR0112765A/pt not_active Application Discontinuation
- 2001-07-18 TR TR2004/01315T patent/TR200401315T4/xx unknown
- 2001-07-18 PT PT01967203T patent/PT1307441E/pt unknown
- 2001-07-18 AU AU2001287638A patent/AU2001287638A1/en not_active Abandoned
- 2001-07-18 PL PL361172A patent/PL206307B1/pl not_active IP Right Cessation
- 2001-07-18 SI SI200120036A patent/SI21040A/sl not_active IP Right Cessation
- 2001-07-18 WO PCT/EP2001/008304 patent/WO2002010149A1/en active IP Right Grant
- 2001-07-18 HU HU0301497A patent/HUP0301497A3/hu unknown
- 2001-07-18 DK DK01967203T patent/DK1307441T3/da active
- 2001-07-18 JP JP2002515880A patent/JP5107497B2/ja not_active Expired - Fee Related
- 2001-07-18 CZ CZ20030268A patent/CZ301087B6/cs not_active IP Right Cessation
- 2001-07-18 CN CNB018134564A patent/CN1204135C/zh not_active Expired - Fee Related
- 2001-07-18 EE EEP200300036A patent/EE05178B1/xx not_active IP Right Cessation
- 2001-07-18 UA UA2003021767A patent/UA73789C2/uk unknown
- 2001-07-18 DE DE60103164T patent/DE60103164T2/de not_active Expired - Lifetime
- 2001-07-18 KR KR1020037000945A patent/KR100781403B1/ko not_active IP Right Cessation
-
2002
- 2002-12-18 IL IL153515A patent/IL153515A/en not_active IP Right Cessation
-
2004
- 2004-03-05 HK HK04101653A patent/HK1058797A1/xx not_active IP Right Cessation
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