YU3003A - 1,3-dioksolani kao sredstva protiv kašlja - Google Patents
1,3-dioksolani kao sredstva protiv kašljaInfo
- Publication number
- YU3003A YU3003A YU3003A YUP3003A YU3003A YU 3003 A YU3003 A YU 3003A YU 3003 A YU3003 A YU 3003A YU P3003 A YUP3003 A YU P3003A YU 3003 A YU3003 A YU 3003A
- Authority
- YU
- Yugoslavia
- Prior art keywords
- dioxolanes
- antitussive activity
- preparation
- acetals
- antitussive
- Prior art date
Links
- 125000006091 1,3-dioxolane group Chemical class 0.000 title 1
- 230000000954 anitussive effect Effects 0.000 title 1
- -1 (S)-3-(4-Phenyl-1-piperazinyl)-1,2-propanediol cyclic acetals Chemical class 0.000 abstract 1
- 150000001241 acetals Chemical class 0.000 abstract 1
- 239000003434 antitussive agent Substances 0.000 abstract 1
- 229940124584 antitussives Drugs 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- PTVWPYVOOKLBCG-ZDUSSCGKSA-N levodropropizine Chemical compound C1CN(C[C@H](O)CO)CCN1C1=CC=CC=C1 PTVWPYVOOKLBCG-ZDUSSCGKSA-N 0.000 abstract 1
- 229960002265 levodropropizine Drugs 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
- C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D317/28—Radicals substituted by nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/14—Antitussive agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pulmonology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Glass Compositions (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Hydrogenated Pyridines (AREA)
Abstract
Opisani su ciklični acetali (S)-3-(4-fenil-1-piperazinil)-1,2-propandiola koji se koriste kao sredstva protiv kašlja i kao intermedijeri za dobijanje levodroprizina i njegovih soli, kao i procesa za dobijanje pomenutih acetala.[(S)-3-(4-Phenyl-1-piperazinyl)-1,2-propanediol cyclic acetals useful as antitussive agents and as intermediates for the preparation of levodropropizine and the salts thereof, as well as a process for the preparation of said acetals, are disclosed.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT2000MI001734A IT1318650B1 (it) | 2000-07-28 | 2000-07-28 | 1,3-diossolani ad attivita' antitosse. |
Publications (2)
Publication Number | Publication Date |
---|---|
YU3003A true YU3003A (sh) | 2006-05-25 |
RS50861B RS50861B (sr) | 2010-08-31 |
Family
ID=11445591
Country Status (27)
Country | Link |
---|---|
US (1) | US6835734B2 (sh) |
EP (1) | EP1307441B1 (sh) |
JP (1) | JP5107497B2 (sh) |
KR (1) | KR100781403B1 (sh) |
CN (1) | CN1204135C (sh) |
AT (1) | ATE266018T1 (sh) |
AU (1) | AU2001287638A1 (sh) |
BR (1) | BR0112765A (sh) |
CZ (1) | CZ301087B6 (sh) |
DE (1) | DE60103164T2 (sh) |
DK (1) | DK1307441T3 (sh) |
EE (1) | EE05178B1 (sh) |
ES (1) | ES2219562T3 (sh) |
HK (1) | HK1058797A1 (sh) |
HU (1) | HUP0301497A3 (sh) |
IL (2) | IL153515A0 (sh) |
IT (1) | IT1318650B1 (sh) |
MX (1) | MXPA02012920A (sh) |
PL (1) | PL206307B1 (sh) |
PT (1) | PT1307441E (sh) |
RS (1) | RS50861B (sh) |
RU (1) | RU2276149C2 (sh) |
SI (1) | SI21040A (sh) |
SK (1) | SK286794B6 (sh) |
TR (1) | TR200401315T4 (sh) |
UA (1) | UA73789C2 (sh) |
WO (1) | WO2002010149A1 (sh) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IT1318651B1 (it) * | 2000-07-28 | 2003-08-27 | Dompe Spa | Sintesi di (+-)1,3-diossolani e loro risoluzione ottica. |
TWI496776B (zh) * | 2007-11-15 | 2015-08-21 | Astrazeneca Ab | 製備(3aR,4S,6R,6aS)-6-胺基-2,2-二甲基四氫-3aH-環戊并[d][1,3]二氧雜環戊烯-4-醇之純非對映異構性之二苯甲醯-L-酒石酸鹽之方法 |
EP2070915A1 (en) * | 2007-12-03 | 2009-06-17 | A.M.S.A. ANONIMA MATERIE SINTETICHE E AFFINI S.p.A. | New process for the synthesis of moguisteine |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4049660A (en) * | 1971-06-18 | 1977-09-20 | Delalande S.A. | N-substituted derivatives of 4 (N-piperazinylmethyl) spiro dibenzocycloheptadi- (or tri-) ene-5, 2-dioxolane (1,3) their method of preparation and their application in therapeutics |
IT1203721B (it) * | 1983-12-29 | 1989-02-23 | Dompe Farmaceutici Spa | Composti otticamente attivi ad attivita' antitosse e sedativa centrale,procedimento per la preparazione e composizioni che li contengono |
NL8801622A (nl) * | 1988-06-25 | 1990-01-16 | Stamicarbon | Bereiding van enantiomeren van dropropizine. |
IT1226570B (it) | 1988-08-01 | 1991-01-24 | Bidachem Spa | Procedimento di preparazione della levo- e destro-dropropizina |
IT1254452B (it) | 1992-02-14 | 1995-09-25 | Dompe Farmaceutici Spa | N-ossidi ed n,n'-diossidi di 3-(piperazin-1-il)-propan-1,2-dioli |
IT1254993B (it) * | 1992-06-24 | 1995-10-11 | Procedimento per la preparazione degli enantiomeri della dropropizina | |
IL111730A (en) * | 1993-11-29 | 1998-12-06 | Fujisawa Pharmaceutical Co | Piperazine derivatives, processes for their preparation and pharmaceutical preparations containing them |
IT1318651B1 (it) * | 2000-07-28 | 2003-08-27 | Dompe Spa | Sintesi di (+-)1,3-diossolani e loro risoluzione ottica. |
-
2000
- 2000-07-28 IT IT2000MI001734A patent/IT1318650B1/it active
-
2001
- 2001-07-18 SI SI200120036A patent/SI21040A/sl not_active IP Right Cessation
- 2001-07-18 UA UA2003021767A patent/UA73789C2/uk unknown
- 2001-07-18 PT PT01967203T patent/PT1307441E/pt unknown
- 2001-07-18 TR TR2004/01315T patent/TR200401315T4/xx unknown
- 2001-07-18 EE EEP200300036A patent/EE05178B1/xx not_active IP Right Cessation
- 2001-07-18 AU AU2001287638A patent/AU2001287638A1/en not_active Abandoned
- 2001-07-18 RU RU2003105691/04A patent/RU2276149C2/ru not_active IP Right Cessation
- 2001-07-18 MX MXPA02012920A patent/MXPA02012920A/es active IP Right Grant
- 2001-07-18 CN CNB018134564A patent/CN1204135C/zh not_active Expired - Fee Related
- 2001-07-18 SK SK89-2003A patent/SK286794B6/sk not_active IP Right Cessation
- 2001-07-18 BR BR0112765-9A patent/BR0112765A/pt not_active Application Discontinuation
- 2001-07-18 ES ES01967203T patent/ES2219562T3/es not_active Expired - Lifetime
- 2001-07-18 US US10/333,979 patent/US6835734B2/en not_active Expired - Fee Related
- 2001-07-18 EP EP01967203A patent/EP1307441B1/en not_active Expired - Lifetime
- 2001-07-18 RS YUP-30/03A patent/RS50861B/sr unknown
- 2001-07-18 IL IL15351501A patent/IL153515A0/xx active IP Right Grant
- 2001-07-18 KR KR1020037000945A patent/KR100781403B1/ko not_active IP Right Cessation
- 2001-07-18 CZ CZ20030268A patent/CZ301087B6/cs not_active IP Right Cessation
- 2001-07-18 DE DE60103164T patent/DE60103164T2/de not_active Expired - Lifetime
- 2001-07-18 JP JP2002515880A patent/JP5107497B2/ja not_active Expired - Fee Related
- 2001-07-18 DK DK01967203T patent/DK1307441T3/da active
- 2001-07-18 WO PCT/EP2001/008304 patent/WO2002010149A1/en active IP Right Grant
- 2001-07-18 AT AT01967203T patent/ATE266018T1/de active
- 2001-07-18 HU HU0301497A patent/HUP0301497A3/hu unknown
- 2001-07-18 PL PL361172A patent/PL206307B1/pl not_active IP Right Cessation
-
2002
- 2002-12-18 IL IL153515A patent/IL153515A/en not_active IP Right Cessation
-
2004
- 2004-03-05 HK HK04101653A patent/HK1058797A1/xx not_active IP Right Cessation
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