YU3003A - 1,3-dioksolani kao sredstva protiv kašlja - Google Patents

1,3-dioksolani kao sredstva protiv kašlja

Info

Publication number
YU3003A
YU3003A YU3003A YUP3003A YU3003A YU 3003 A YU3003 A YU 3003A YU 3003 A YU3003 A YU 3003A YU P3003 A YUP3003 A YU P3003A YU 3003 A YU3003 A YU 3003A
Authority
YU
Yugoslavia
Prior art keywords
dioxolanes
antitussive activity
preparation
acetals
antitussive
Prior art date
Application number
YU3003A
Other languages
English (en)
Inventor
Marcello Allegretti
Maria Candida Cesta
Roberto Curti
Luigi Pellegrini
Gabriella Melillo
Original Assignee
Dompe S.P.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dompe S.P.A. filed Critical Dompe S.P.A.
Publication of YU3003A publication Critical patent/YU3003A/sh
Publication of RS50861B publication Critical patent/RS50861B/sr

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D317/00Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/10Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
    • C07D317/14Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D317/28Radicals substituted by nitrogen atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/14Antitussive agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pulmonology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Glass Compositions (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Hydrogenated Pyridines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Opisani su ciklični acetali (S)-3-(4-fenil-1-piperazinil)-1,2-propandiola koji se koriste kao sredstva protiv kašlja i kao intermedijeri za dobijanje levodroprizina i njegovih soli, kao i procesa za dobijanje pomenutih acetala.[(S)-3-(4-Phenyl-1-piperazinyl)-1,2-propanediol cyclic acetals useful as antitussive agents and as intermediates for the preparation of levodropropizine and the salts thereof, as well as a process for the preparation of said acetals, are disclosed.
YUP-30/03A 2000-07-28 2001-07-18 1,3-dioksolani kao sredstva protiv kašlja RS50861B (sr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT2000MI001734A IT1318650B1 (it) 2000-07-28 2000-07-28 1,3-diossolani ad attivita' antitosse.

Publications (2)

Publication Number Publication Date
YU3003A true YU3003A (sh) 2006-05-25
RS50861B RS50861B (sr) 2010-08-31

Family

ID=11445591

Country Status (27)

Country Link
US (1) US6835734B2 (sh)
EP (1) EP1307441B1 (sh)
JP (1) JP5107497B2 (sh)
KR (1) KR100781403B1 (sh)
CN (1) CN1204135C (sh)
AT (1) ATE266018T1 (sh)
AU (1) AU2001287638A1 (sh)
BR (1) BR0112765A (sh)
CZ (1) CZ301087B6 (sh)
DE (1) DE60103164T2 (sh)
DK (1) DK1307441T3 (sh)
EE (1) EE05178B1 (sh)
ES (1) ES2219562T3 (sh)
HK (1) HK1058797A1 (sh)
HU (1) HUP0301497A3 (sh)
IL (2) IL153515A0 (sh)
IT (1) IT1318650B1 (sh)
MX (1) MXPA02012920A (sh)
PL (1) PL206307B1 (sh)
PT (1) PT1307441E (sh)
RS (1) RS50861B (sh)
RU (1) RU2276149C2 (sh)
SI (1) SI21040A (sh)
SK (1) SK286794B6 (sh)
TR (1) TR200401315T4 (sh)
UA (1) UA73789C2 (sh)
WO (1) WO2002010149A1 (sh)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1318651B1 (it) * 2000-07-28 2003-08-27 Dompe Spa Sintesi di (+-)1,3-diossolani e loro risoluzione ottica.
TWI496776B (zh) * 2007-11-15 2015-08-21 Astrazeneca Ab 製備(3aR,4S,6R,6aS)-6-胺基-2,2-二甲基四氫-3aH-環戊并[d][1,3]二氧雜環戊烯-4-醇之純非對映異構性之二苯甲醯-L-酒石酸鹽之方法
EP2070915A1 (en) * 2007-12-03 2009-06-17 A.M.S.A. ANONIMA MATERIE SINTETICHE E AFFINI S.p.A. New process for the synthesis of moguisteine

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4049660A (en) * 1971-06-18 1977-09-20 Delalande S.A. N-substituted derivatives of 4 (N-piperazinylmethyl) spiro dibenzocycloheptadi- (or tri-) ene-5, 2-dioxolane (1,3) their method of preparation and their application in therapeutics
IT1203721B (it) * 1983-12-29 1989-02-23 Dompe Farmaceutici Spa Composti otticamente attivi ad attivita' antitosse e sedativa centrale,procedimento per la preparazione e composizioni che li contengono
NL8801622A (nl) * 1988-06-25 1990-01-16 Stamicarbon Bereiding van enantiomeren van dropropizine.
IT1226570B (it) * 1988-08-01 1991-01-24 Bidachem Spa Procedimento di preparazione della levo- e destro-dropropizina
IT1254452B (it) * 1992-02-14 1995-09-25 Dompe Farmaceutici Spa N-ossidi ed n,n'-diossidi di 3-(piperazin-1-il)-propan-1,2-dioli
IT1254993B (it) * 1992-06-24 1995-10-11 Procedimento per la preparazione degli enantiomeri della dropropizina
IL111730A (en) * 1993-11-29 1998-12-06 Fujisawa Pharmaceutical Co Piperazine derivatives, processes for their preparation and pharmaceutical preparations containing them
IT1318651B1 (it) * 2000-07-28 2003-08-27 Dompe Spa Sintesi di (+-)1,3-diossolani e loro risoluzione ottica.

Also Published As

Publication number Publication date
RS50861B (sr) 2010-08-31
IL153515A (en) 2006-12-10
SK286794B6 (sk) 2009-05-07
DE60103164T2 (de) 2005-05-04
MXPA02012920A (es) 2004-04-20
RU2276149C2 (ru) 2006-05-10
CZ2003268A3 (cs) 2003-06-18
CZ301087B6 (cs) 2009-11-04
TR200401315T4 (tr) 2004-07-21
UA73789C2 (en) 2005-09-15
EE05178B1 (et) 2009-06-15
WO2002010149A1 (en) 2002-02-07
US20040038989A1 (en) 2004-02-26
HUP0301497A2 (hu) 2003-09-29
IL153515A0 (en) 2003-07-06
EE200300036A (et) 2004-10-15
IT1318650B1 (it) 2003-08-27
AU2001287638A1 (en) 2002-02-13
KR20030016425A (ko) 2003-02-26
KR100781403B1 (ko) 2007-12-03
HK1058797A1 (en) 2004-06-04
BR0112765A (pt) 2004-01-13
PL361172A1 (en) 2004-09-20
SK892003A3 (en) 2003-09-11
DE60103164D1 (de) 2004-06-09
JP5107497B2 (ja) 2012-12-26
DK1307441T3 (da) 2004-08-09
EP1307441B1 (en) 2004-05-06
ITMI20001734A0 (it) 2000-07-28
PT1307441E (pt) 2004-09-30
HUP0301497A3 (en) 2005-08-29
EP1307441A1 (en) 2003-05-07
CN1204135C (zh) 2005-06-01
SI21040A (sl) 2003-04-30
ATE266018T1 (de) 2004-05-15
JP2004505073A (ja) 2004-02-19
ITMI20001734A1 (it) 2002-01-28
PL206307B1 (pl) 2010-07-30
ES2219562T3 (es) 2004-12-01
CN1444578A (zh) 2003-09-24
US6835734B2 (en) 2004-12-28

Similar Documents

Publication Publication Date Title
DE69015650T2 (de) Herstellung von diamantverbundbeschichteten Schneidwerkzeugen.
DE69022075D1 (de) Handwerkzeugmaschine zur Herstellung von kreisabschnittförmigen Nuten.
EE200300228A (et) Tiotroopium- ja salmeteroolsooladel põhinevad ravimkompositsioonid
IT8423292A0 (it) Forma delta cristallina, stabile, anidra di idrocloruro di prazosin e nuovo procedimento per lapreparazione di detta forma delta cristallina.
IT1320055B1 (it) Manicotto di guida per l'asta di un poggiatesta.
DE69923579D1 (de) Herstellung von 2-amino-2(2-(4-alkylphenyl)äthyl)propan-1,3-diolen
ATE202483T1 (de) Immuntolerante prothrombinkomplex-präparation
NL950021I2 (nl) 2-(Difluormethoxy)-1,1,1,2-tretrafluorethaan als anestheticum.
SE9804002D0 (sv) New manufacturing process
IL153515A0 (en) 1,3-dioxolanes with antitussive activity
EA199901098A1 (ru) Новый способ
IL153502A0 (en) 2,2-disubstituted 1,3-dioxolanes as antitussive agents
EA200200090A1 (ru) Способ получения замещенных бензизотиазоловых соединений
IT8722829A0 (it) Procedimento per la lavorazione precisa di pezzi tendenti ad inflettersi, nonche' tornio per attuarlo.
UY26638A1 (es) Nuevos derivados de piperazina
IT1317000B1 (it) Uso di composti di origine naturale ad attivita' antiangiogenica.
IT1309222B1 (it) Struttura di macchina utensile perfezionata.
IT7927929A0 (it) Macchina per la trivellazione particolarmente di terreni duri, specialmente per la formazione di diaframmi.