AU2001287638A1 - 1,3-dioxolanes with antitussive activity - Google Patents

1,3-dioxolanes with antitussive activity

Info

Publication number
AU2001287638A1
AU2001287638A1 AU2001287638A AU8763801A AU2001287638A1 AU 2001287638 A1 AU2001287638 A1 AU 2001287638A1 AU 2001287638 A AU2001287638 A AU 2001287638A AU 8763801 A AU8763801 A AU 8763801A AU 2001287638 A1 AU2001287638 A1 AU 2001287638A1
Authority
AU
Australia
Prior art keywords
dioxolanes
antitussive activity
preparation
acetals
antitussive
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2001287638A
Inventor
Marcello Allegretti
Maria Candida Cesta
Roberto Curti
Gabriella Melillo
Luigi Pellegrini
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Dompe SpA
Original Assignee
Dompe SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dompe SpA filed Critical Dompe SpA
Publication of AU2001287638A1 publication Critical patent/AU2001287638A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
    • C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D317/28—Radicals substituted by nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/14—Antitussive agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pulmonology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Glass Compositions (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

(S)-3-(4-Phenyl-1-piperazinyl)-1,2-propanediol cyclic acetals useful as antitussive agents and as intermediates for the preparation of levodropropizine and the salts thereof, as well as a process for the preparation of said acetals, are disclosed.
AU2001287638A 2000-07-28 2001-07-18 1,3-dioxolanes with antitussive activity Abandoned AU2001287638A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
ITMI200A001734 2000-07-28
IT2000MI001734A IT1318650B1 (en) 2000-07-28 2000-07-28 1,3-DIOSSOLANS WITH ANTI-TOXIC ACTIVITY.
PCT/EP2001/008304 WO2002010149A1 (en) 2000-07-28 2001-07-18 1,3-dioxolanes with antitussive activity

Publications (1)

Publication Number Publication Date
AU2001287638A1 true AU2001287638A1 (en) 2002-02-13

Family

ID=11445591

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2001287638A Abandoned AU2001287638A1 (en) 2000-07-28 2001-07-18 1,3-dioxolanes with antitussive activity

Country Status (27)

Country Link
US (1) US6835734B2 (en)
EP (1) EP1307441B1 (en)
JP (1) JP5107497B2 (en)
KR (1) KR100781403B1 (en)
CN (1) CN1204135C (en)
AT (1) ATE266018T1 (en)
AU (1) AU2001287638A1 (en)
BR (1) BR0112765A (en)
CZ (1) CZ301087B6 (en)
DE (1) DE60103164T2 (en)
DK (1) DK1307441T3 (en)
EE (1) EE05178B1 (en)
ES (1) ES2219562T3 (en)
HK (1) HK1058797A1 (en)
HU (1) HUP0301497A3 (en)
IL (2) IL153515A0 (en)
IT (1) IT1318650B1 (en)
MX (1) MXPA02012920A (en)
PL (1) PL206307B1 (en)
PT (1) PT1307441E (en)
RS (1) RS50861B (en)
RU (1) RU2276149C2 (en)
SI (1) SI21040A (en)
SK (1) SK286794B6 (en)
TR (1) TR200401315T4 (en)
UA (1) UA73789C2 (en)
WO (1) WO2002010149A1 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1318651B1 (en) * 2000-07-28 2003-08-27 Dompe Spa SUMMARY OF (+ -) 1,3-DIOSSOLANS AND THEIR OPTICAL RESOLUTION.
TWI496776B (en) * 2007-11-15 2015-08-21 Astrazeneca Ab A process for preparing a diastereomerically pure dibenzoyl-l-tartrate salt of (3ar, 4s, 6r, 6as)-6-amino-2, 2-dimethyltetrahydro-3ah-cyclopenta(d)(1, 3)-dioxol-4-ol
EP2070915A1 (en) * 2007-12-03 2009-06-17 A.M.S.A. ANONIMA MATERIE SINTETICHE E AFFINI S.p.A. New process for the synthesis of moguisteine

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4049660A (en) * 1971-06-18 1977-09-20 Delalande S.A. N-substituted derivatives of 4 (N-piperazinylmethyl) spiro dibenzocycloheptadi- (or tri-) ene-5, 2-dioxolane (1,3) their method of preparation and their application in therapeutics
IT1203721B (en) * 1983-12-29 1989-02-23 Dompe Farmaceutici Spa OPTICALLY ACTIVE COMPOUNDS WITH ANTITOSSE AND CENTRAL SEDATIVE ACTIVITIES, PROCEDURE FOR PREPARATION AND COMPOSITIONS CONTAINING THEM
NL8801622A (en) * 1988-06-25 1990-01-16 Stamicarbon PREPARATION OF ENANTIOMERS OF DROPROPIZINE.
IT1226570B (en) * 1988-08-01 1991-01-24 Bidachem Spa LEVO- AND RIGHT-DROPROPIZINE PREPARATION PROCEDURE
IT1254452B (en) * 1992-02-14 1995-09-25 Dompe Farmaceutici Spa N-OXIDES AND N, N'-DIOXIDES OF 3- (PIPERAZIN-1-IL) -PROPAN-1,2-DIOLS
IT1254993B (en) * 1992-06-24 1995-10-11 PROCEDURE FOR THE PREPARATION OF THE ENANTIOMERS OF DROPROPIZINE
IL111730A (en) * 1993-11-29 1998-12-06 Fujisawa Pharmaceutical Co Piperazine derivatives processes for the preparation thereof and pharmaceutical compositions containing the same
IT1318651B1 (en) * 2000-07-28 2003-08-27 Dompe Spa SUMMARY OF (+ -) 1,3-DIOSSOLANS AND THEIR OPTICAL RESOLUTION.

Also Published As

Publication number Publication date
PL361172A1 (en) 2004-09-20
HK1058797A1 (en) 2004-06-04
JP2004505073A (en) 2004-02-19
IL153515A0 (en) 2003-07-06
IL153515A (en) 2006-12-10
WO2002010149A1 (en) 2002-02-07
DE60103164D1 (en) 2004-06-09
MXPA02012920A (en) 2004-04-20
SI21040A (en) 2003-04-30
RU2276149C2 (en) 2006-05-10
DE60103164T2 (en) 2005-05-04
EE05178B1 (en) 2009-06-15
YU3003A (en) 2006-05-25
CN1444578A (en) 2003-09-24
PT1307441E (en) 2004-09-30
KR20030016425A (en) 2003-02-26
CN1204135C (en) 2005-06-01
JP5107497B2 (en) 2012-12-26
US6835734B2 (en) 2004-12-28
ITMI20001734A0 (en) 2000-07-28
EE200300036A (en) 2004-10-15
SK892003A3 (en) 2003-09-11
CZ301087B6 (en) 2009-11-04
ATE266018T1 (en) 2004-05-15
KR100781403B1 (en) 2007-12-03
CZ2003268A3 (en) 2003-06-18
US20040038989A1 (en) 2004-02-26
TR200401315T4 (en) 2004-07-21
UA73789C2 (en) 2005-09-15
HUP0301497A2 (en) 2003-09-29
DK1307441T3 (en) 2004-08-09
HUP0301497A3 (en) 2005-08-29
PL206307B1 (en) 2010-07-30
EP1307441A1 (en) 2003-05-07
EP1307441B1 (en) 2004-05-06
RS50861B (en) 2010-08-31
BR0112765A (en) 2004-01-13
ES2219562T3 (en) 2004-12-01
IT1318650B1 (en) 2003-08-27
ITMI20001734A1 (en) 2002-01-28
SK286794B6 (en) 2009-05-07

Similar Documents

Publication Publication Date Title
DE69015650T2 (en) Manufacture of diamond-coated cutting tools.
MX9603050A (en) 1-h-3-arylpyrrolidine-2,4-dione derivatives as pest-control agents.
RS50218B (en) Crystalline monohydrate,method for producing the same and the use thereof in the production of a medicament
IT8719977A0 (en) PHARMACEUTICALLY ACCEPTABLE, IMPROVED AMLODIPE SALTS.
SV2002000356A (en) NEW DERIVATIVES OF PIPERAZINA REF. PC10770AIXN / BB
DK0923554T3 (en) N-Benzylpiperidine and tetrahydropyridine derivatives
MY114393A (en) 2-(2-amino-1,6-dihydro-6-oxo-purin-9-yl)methoxy-1, 3-propanediol derivatives
IT1320055B1 (en) GUIDE SLEEVE FOR THE AUCTION OF A HEADREST.
ATE288414T1 (en) PREPARATION OF 2-AMINO-2(2-(4-ALKYLPHENYL)ETHYL)PROPANE-1,3-DIOLS
SE9804002D0 (en) New manufacturing process
PL351145A1 (en) Salts of 2,2-dimethyl-1,3-dioxane intermediates and process for the preparation thereof
AU2001287638A1 (en) 1,3-dioxolanes with antitussive activity
BG105766A (en) New process for preparing pesticidal intermediates
IT1293777B1 (en) PROCESS FOR THE PREPARATION OF TETRAAZAMACROCYCLES
NO20032401D0 (en) Process for preparing taxane derivatives
AU2001281992A1 (en) 2,2-disubstituted 1,3-dioxolanes as antitussive agents
DK0840735T3 (en) Cleavage of 1-azabicyclo [2.2.2] octane-3-amine, 2- (diphenylmethyl) -N-2-methoxy-5- (1methylethyl) phenyl] methyl]
DK0438813T3 (en) New antibiotic, deoxymulundocandin, a process for its preparation and its use as a drug
UY26638A1 (en) NEW DERIVATIVES OF PIPERAZINE