IT1318651B1 - Sintesi di (+-)1,3-diossolani e loro risoluzione ottica. - Google Patents

Sintesi di (+-)1,3-diossolani e loro risoluzione ottica.

Info

Publication number
IT1318651B1
IT1318651B1 IT2000MI001735A ITMI20001735A IT1318651B1 IT 1318651 B1 IT1318651 B1 IT 1318651B1 IT 2000MI001735 A IT2000MI001735 A IT 2000MI001735A IT MI20001735 A ITMI20001735 A IT MI20001735A IT 1318651 B1 IT1318651 B1 IT 1318651B1
Authority
IT
Italy
Prior art keywords
optical resolution
diossolans
piperazinyl
phenyl
propanediol
Prior art date
Application number
IT2000MI001735A
Other languages
English (en)
Inventor
Marcello Allegretti
Maria Candida Cesta
Roberto Curti
Luca Nicolini
Original Assignee
Dompe Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dompe Spa filed Critical Dompe Spa
Publication of ITMI20001735A0 publication Critical patent/ITMI20001735A0/it
Priority to IT2000MI001735A priority Critical patent/IT1318651B1/it
Priority to AU2001281992A priority patent/AU2001281992A1/en
Priority to PCT/EP2001/008305 priority patent/WO2002010150A1/en
Priority to KR1020037000943A priority patent/KR100788532B1/ko
Priority to IL15350201A priority patent/IL153502A0/xx
Priority to EP01960513A priority patent/EP1307440B1/en
Priority to BR0112802-7A priority patent/BR0112802A/pt
Priority to RU2003105692/04A priority patent/RU2269522C2/ru
Priority to DK01960513T priority patent/DK1307440T3/da
Priority to US10/312,290 priority patent/US6916926B2/en
Priority to UA2003021768A priority patent/UA73790C2/uk
Priority to PL361173A priority patent/PL206308B1/pl
Priority to SK90-2003A priority patent/SK286795B6/sk
Priority to YUP-31/03A priority patent/RS50862B/sr
Priority to SI200130321T priority patent/SI1307440T1/xx
Priority to SI200120037A priority patent/SI21041B/sl
Priority to ES01960513T priority patent/ES2237589T3/es
Priority to CN018134572A priority patent/CN1216053C/zh
Priority to DE60109299T priority patent/DE60109299T2/de
Priority to HU0301473A priority patent/HU229801B1/hu
Priority to AT01960513T priority patent/ATE290533T1/de
Priority to MXPA02012922A priority patent/MXPA02012922A/es
Priority to CZ20030269A priority patent/CZ301039B6/cs
Priority to EEP200300035A priority patent/EE05159B1/xx
Priority to JP2002515881A priority patent/JP5015403B2/ja
Priority to PT01960513T priority patent/PT1307440E/pt
Publication of ITMI20001735A1 publication Critical patent/ITMI20001735A1/it
Priority to IL153502A priority patent/IL153502A/en
Application granted granted Critical
Publication of IT1318651B1 publication Critical patent/IT1318651B1/it
Priority to HK04101654A priority patent/HK1058798A1/xx

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D317/00Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/10Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
    • C07D317/14Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D317/28Radicals substituted by nitrogen atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/14Antitussive agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pulmonology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Hydrogenated Pyridines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Holo Graphy (AREA)
  • Secondary Cells (AREA)
  • Electrochromic Elements, Electrophoresis, Or Variable Reflection Or Absorption Elements (AREA)
  • Glass Compositions (AREA)
  • Compounds Of Alkaline-Earth Elements, Aluminum Or Rare-Earth Metals (AREA)
  • Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
  • Fats And Perfumes (AREA)
  • Liquid Crystal Substances (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
IT2000MI001735A 2000-07-28 2000-07-28 Sintesi di (+-)1,3-diossolani e loro risoluzione ottica. IT1318651B1 (it)

Priority Applications (28)

Application Number Priority Date Filing Date Title
IT2000MI001735A IT1318651B1 (it) 2000-07-28 2000-07-28 Sintesi di (+-)1,3-diossolani e loro risoluzione ottica.
SI200130321T SI1307440T1 (it) 2000-07-28 2001-07-18
ES01960513T ES2237589T3 (es) 2000-07-28 2001-07-18 1,3-dioxolanos 2,2-disustituidos como agentes antitusigenos.
PCT/EP2001/008305 WO2002010150A1 (en) 2000-07-28 2001-07-18 2,2-disubstituted 1,3-dioxolanes as antitussive agents
IL15350201A IL153502A0 (en) 2000-07-28 2001-07-18 2,2-disubstituted 1,3-dioxolanes as antitussive agents
EP01960513A EP1307440B1 (en) 2000-07-28 2001-07-18 2,2-disubstituted 1,3-dioxolanes as antitussive agents
BR0112802-7A BR0112802A (pt) 2000-07-28 2001-07-18 l,3-dioxolanos 2,2-dissubstituìdos como agentes antitussivos
RU2003105692/04A RU2269522C2 (ru) 2000-07-28 2001-07-18 1,3-диоксоланы и способ их получения
DK01960513T DK1307440T3 (da) 2000-07-28 2001-07-18 2,2-disubstituerede 1,3-dioxolaner som antihostemidler
US10/312,290 US6916926B2 (en) 2000-07-28 2001-07-18 Process for the preparation of (±) 1-3-dioxolanes and the optical resolution thereof
UA2003021768A UA73790C2 (uk) 2000-07-28 2001-07-18 2,2-дизаміщені 1,3-діоксолани, спосіб одержання та застосування як проміжних продуктів для синтезу відповідних (s)-енантіомерів та (-)3-(4-феніл-1-піперазиніл)-1,2-пропандіолу
PL361173A PL206308B1 (pl) 2000-07-28 2001-07-18 2,2-dipodstawione 1,3-dioksolany, sposób ich wytwarzania, sposób ich rozdzielania optycznego i ich zastosowanie oraz sposób syntezy lewodropropizyny
SK90-2003A SK286795B6 (sk) 2000-07-28 2001-07-18 2,2-Disubstituované 1,3-dioxolány, spôsob ich prípravy a ich použitie
YUP-31/03A RS50862B (sr) 2000-07-28 2001-07-18 2,2-disupstituisani 1,3-dioksolani kao sredstva protiv kašlja
AU2001281992A AU2001281992A1 (en) 2000-07-28 2001-07-18 2,2-disubstituted 1,3-dioxolanes as antitussive agents
SI200120037A SI21041B (en) 2000-07-28 2001-07-18 2,2-disubstituted 1,3-dioxolanes as antitussive agents
KR1020037000943A KR100788532B1 (ko) 2000-07-28 2001-07-18 항해수성 2,2-이중치환된 1,3-디옥솔란
CN018134572A CN1216053C (zh) 2000-07-28 2001-07-18 用作镇咳药的2,2-二取代的1,3-二氧环戊烷
DE60109299T DE60109299T2 (de) 2000-07-28 2001-07-18 2,2-disubstituierte 1,3-dioxolane als hustenmittel
HU0301473A HU229801B1 (en) 2000-07-28 2001-07-18 2,2-disubstituted 1,3-dioxolanes as antitussive agents
AT01960513T ATE290533T1 (de) 2000-07-28 2001-07-18 2,2-disubstituierte 1,3-dioxolane als hustenmittel
MXPA02012922A MXPA02012922A (es) 2000-07-28 2001-07-18 1,3 dioxolanos 2,2-disubstituidos como agentes antitusigenos.
CZ20030269A CZ301039B6 (cs) 2000-07-28 2001-07-18 2,2-disubstituované 1,3-dioxolany
EEP200300035A EE05159B1 (et) 2000-07-28 2001-07-18 2,2-asendatud-1,3-dioksolaanid, nende valmistamine, optiline lahutamine ning kasutamine vahehenditena
JP2002515881A JP5015403B2 (ja) 2000-07-28 2001-07-18 (−)3−(4−フェニル−1−ピペラジニル)−1,2−プロパンジオール及びその中間体の製造方法
PT01960513T PT1307440E (pt) 2000-07-28 2001-07-18 1,3-dioxolanos dissubstituidos em 2,2 como agentes antitussicos
IL153502A IL153502A (en) 2000-07-28 2002-12-17 1,3 - Dioxolanes - 2,2 - Imaging as cough suppressants
HK04101654A HK1058798A1 (en) 2000-07-28 2004-03-05 2,2-Disubstituted 1,3-dioxolanes as antitussive agents.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT2000MI001735A IT1318651B1 (it) 2000-07-28 2000-07-28 Sintesi di (+-)1,3-diossolani e loro risoluzione ottica.

Publications (3)

Publication Number Publication Date
ITMI20001735A0 ITMI20001735A0 (it) 2000-07-28
ITMI20001735A1 ITMI20001735A1 (it) 2002-01-28
IT1318651B1 true IT1318651B1 (it) 2003-08-27

Family

ID=11445592

Family Applications (1)

Application Number Title Priority Date Filing Date
IT2000MI001735A IT1318651B1 (it) 2000-07-28 2000-07-28 Sintesi di (+-)1,3-diossolani e loro risoluzione ottica.

Country Status (25)

Country Link
US (1) US6916926B2 (it)
EP (1) EP1307440B1 (it)
JP (1) JP5015403B2 (it)
KR (1) KR100788532B1 (it)
CN (1) CN1216053C (it)
AT (1) ATE290533T1 (it)
AU (1) AU2001281992A1 (it)
BR (1) BR0112802A (it)
CZ (1) CZ301039B6 (it)
DE (1) DE60109299T2 (it)
EE (1) EE05159B1 (it)
ES (1) ES2237589T3 (it)
HK (1) HK1058798A1 (it)
HU (1) HU229801B1 (it)
IL (2) IL153502A0 (it)
IT (1) IT1318651B1 (it)
MX (1) MXPA02012922A (it)
PL (1) PL206308B1 (it)
PT (1) PT1307440E (it)
RS (1) RS50862B (it)
RU (1) RU2269522C2 (it)
SI (1) SI21041B (it)
SK (1) SK286795B6 (it)
UA (1) UA73790C2 (it)
WO (1) WO2002010150A1 (it)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1318650B1 (it) * 2000-07-28 2003-08-27 Dompe Spa 1,3-diossolani ad attivita' antitosse.

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4049660A (en) * 1971-06-18 1977-09-20 Delalande S.A. N-substituted derivatives of 4 (N-piperazinylmethyl) spiro dibenzocycloheptadi- (or tri-) ene-5, 2-dioxolane (1,3) their method of preparation and their application in therapeutics
IT1210639B (it) * 1981-02-25 1989-09-14 Menarini Sas Prodotto: 3(4-fenil1piperazinio-1-il)-1,2-propandiolo 3(teofillin-7-il)-1propansolfonato,utilizzabile in terapia,e relativo procedimento di fabbricazione
IT1203721B (it) * 1983-12-29 1989-02-23 Dompe Farmaceutici Spa Composti otticamente attivi ad attivita' antitosse e sedativa centrale,procedimento per la preparazione e composizioni che li contengono
SE449516B (sv) * 1984-10-16 1987-05-04 Skf Nova Ab Klemring med reglerbar halomkrets
IT1254452B (it) * 1992-02-14 1995-09-25 Dompe Farmaceutici Spa N-ossidi ed n,n'-diossidi di 3-(piperazin-1-il)-propan-1,2-dioli
IL111730A (en) * 1993-11-29 1998-12-06 Fujisawa Pharmaceutical Co Piperazine derivatives, processes for their preparation and pharmaceutical preparations containing them
IT1318650B1 (it) * 2000-07-28 2003-08-27 Dompe Spa 1,3-diossolani ad attivita' antitosse.

Also Published As

Publication number Publication date
RU2269522C2 (ru) 2006-02-10
AU2001281992A1 (en) 2002-02-13
HU229801B1 (en) 2014-07-28
PL361173A1 (en) 2004-09-20
IL153502A0 (en) 2003-07-06
CN1216053C (zh) 2005-08-24
YU3103A (sh) 2006-05-25
ITMI20001735A0 (it) 2000-07-28
WO2002010150A1 (en) 2002-02-07
SK286795B6 (sk) 2009-05-07
PT1307440E (pt) 2005-05-31
CZ301039B6 (cs) 2009-10-21
EE05159B1 (et) 2009-04-15
HUP0301473A2 (hu) 2003-08-28
MXPA02012922A (es) 2003-10-06
SI21041B (en) 2005-08-31
EE200300035A (et) 2004-10-15
KR100788532B1 (ko) 2007-12-24
UA73790C2 (uk) 2005-09-15
EP1307440B1 (en) 2005-03-09
SI21041A (sl) 2003-04-30
PL206308B1 (pl) 2010-07-30
JP5015403B2 (ja) 2012-08-29
RS50862B (sr) 2010-08-31
SK902003A3 (en) 2003-09-11
DE60109299T2 (de) 2005-07-21
DE60109299D1 (de) 2005-04-14
HK1058798A1 (en) 2004-06-04
BR0112802A (pt) 2003-07-01
US20030176446A1 (en) 2003-09-18
JP2004505074A (ja) 2004-02-19
KR20030016424A (ko) 2003-02-26
US6916926B2 (en) 2005-07-12
ITMI20001735A1 (it) 2002-01-28
EP1307440A1 (en) 2003-05-07
CZ2003269A3 (cs) 2003-06-18
ES2237589T3 (es) 2005-08-01
IL153502A (en) 2006-12-10
CN1444579A (zh) 2003-09-24
ATE290533T1 (de) 2005-03-15

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