EE200300035A - 2,2-asendatud-1,3-dioksolaanid, nende valmistamine, optiline lahutamine ning kasutamine vaheühenditena - Google Patents
2,2-asendatud-1,3-dioksolaanid, nende valmistamine, optiline lahutamine ning kasutamine vaheühenditenaInfo
- Publication number
- EE200300035A EE200300035A EEP200300035A EEP200300035A EE200300035A EE 200300035 A EE200300035 A EE 200300035A EE P200300035 A EEP200300035 A EE P200300035A EE P200300035 A EEP200300035 A EE P200300035A EE 200300035 A EE200300035 A EE 200300035A
- Authority
- EE
- Estonia
- Prior art keywords
- intermediates
- preparation
- optical resolution
- dioxolanes
- substituted
- Prior art date
Links
- 239000000543 intermediate Substances 0.000 title abstract 2
- 230000003287 optical effect Effects 0.000 title abstract 2
- -1 (±) 3-(4-Phenyl-1-piperazinyl)-1,2-propanediol cyclic acetals Chemical class 0.000 abstract 1
- PTVWPYVOOKLBCG-UHFFFAOYSA-N 3-(4-phenyl-1-piperazinyl)propane-1,2-diol Chemical compound C1CN(CC(O)CO)CCN1C1=CC=CC=C1 PTVWPYVOOKLBCG-UHFFFAOYSA-N 0.000 abstract 1
- PTVWPYVOOKLBCG-ZDUSSCGKSA-N levodropropizine Chemical compound C1CN(C[C@H](O)CO)CCN1C1=CC=CC=C1 PTVWPYVOOKLBCG-ZDUSSCGKSA-N 0.000 abstract 1
- 229960002265 levodropropizine Drugs 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
- C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D317/28—Radicals substituted by nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/14—Antitussive agents
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Pulmonology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Hydrogenated Pyridines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Holo Graphy (AREA)
- Fats And Perfumes (AREA)
- Glass Compositions (AREA)
- Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
- Compounds Of Alkaline-Earth Elements, Aluminum Or Rare-Earth Metals (AREA)
- Liquid Crystal Substances (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Electrochromic Elements, Electrophoresis, Or Variable Reflection Or Absorption Elements (AREA)
- Secondary Cells (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT2000MI001735A IT1318651B1 (it) | 2000-07-28 | 2000-07-28 | Sintesi di (+-)1,3-diossolani e loro risoluzione ottica. |
PCT/EP2001/008305 WO2002010150A1 (en) | 2000-07-28 | 2001-07-18 | 2,2-disubstituted 1,3-dioxolanes as antitussive agents |
Publications (2)
Publication Number | Publication Date |
---|---|
EE200300035A true EE200300035A (et) | 2004-10-15 |
EE05159B1 EE05159B1 (et) | 2009-04-15 |
Family
ID=11445592
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EEP200300035A EE05159B1 (et) | 2000-07-28 | 2001-07-18 | 2,2-asendatud-1,3-dioksolaanid, nende valmistamine, optiline lahutamine ning kasutamine vahehenditena |
Country Status (25)
Country | Link |
---|---|
US (1) | US6916926B2 (et) |
EP (1) | EP1307440B1 (et) |
JP (1) | JP5015403B2 (et) |
KR (1) | KR100788532B1 (et) |
CN (1) | CN1216053C (et) |
AT (1) | ATE290533T1 (et) |
AU (1) | AU2001281992A1 (et) |
BR (1) | BR0112802A (et) |
CZ (1) | CZ301039B6 (et) |
DE (1) | DE60109299T2 (et) |
EE (1) | EE05159B1 (et) |
ES (1) | ES2237589T3 (et) |
HK (1) | HK1058798A1 (et) |
HU (1) | HU229801B1 (et) |
IL (2) | IL153502A0 (et) |
IT (1) | IT1318651B1 (et) |
MX (1) | MXPA02012922A (et) |
PL (1) | PL206308B1 (et) |
PT (1) | PT1307440E (et) |
RS (1) | RS50862B (et) |
RU (1) | RU2269522C2 (et) |
SI (1) | SI21041B (et) |
SK (1) | SK286795B6 (et) |
UA (1) | UA73790C2 (et) |
WO (1) | WO2002010150A1 (et) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IT1318650B1 (it) * | 2000-07-28 | 2003-08-27 | Dompe Spa | 1,3-diossolani ad attivita' antitosse. |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4049660A (en) * | 1971-06-18 | 1977-09-20 | Delalande S.A. | N-substituted derivatives of 4 (N-piperazinylmethyl) spiro dibenzocycloheptadi- (or tri-) ene-5, 2-dioxolane (1,3) their method of preparation and their application in therapeutics |
IT1210639B (it) * | 1981-02-25 | 1989-09-14 | Menarini Sas | Prodotto: 3(4-fenil1piperazinio-1-il)-1,2-propandiolo 3(teofillin-7-il)-1propansolfonato,utilizzabile in terapia,e relativo procedimento di fabbricazione |
IT1203721B (it) * | 1983-12-29 | 1989-02-23 | Dompe Farmaceutici Spa | Composti otticamente attivi ad attivita' antitosse e sedativa centrale,procedimento per la preparazione e composizioni che li contengono |
SE449516B (sv) * | 1984-10-16 | 1987-05-04 | Skf Nova Ab | Klemring med reglerbar halomkrets |
IT1254452B (it) * | 1992-02-14 | 1995-09-25 | Dompe Farmaceutici Spa | N-ossidi ed n,n'-diossidi di 3-(piperazin-1-il)-propan-1,2-dioli |
IL111730A (en) * | 1993-11-29 | 1998-12-06 | Fujisawa Pharmaceutical Co | Piperazine derivatives, processes for their preparation and pharmaceutical preparations containing them |
IT1318650B1 (it) * | 2000-07-28 | 2003-08-27 | Dompe Spa | 1,3-diossolani ad attivita' antitosse. |
-
2000
- 2000-07-28 IT IT2000MI001735A patent/IT1318651B1/it active
-
2001
- 2001-07-18 AU AU2001281992A patent/AU2001281992A1/en not_active Abandoned
- 2001-07-18 MX MXPA02012922A patent/MXPA02012922A/es active IP Right Grant
- 2001-07-18 PT PT01960513T patent/PT1307440E/pt unknown
- 2001-07-18 IL IL15350201A patent/IL153502A0/xx active IP Right Grant
- 2001-07-18 AT AT01960513T patent/ATE290533T1/de active
- 2001-07-18 BR BR0112802-7A patent/BR0112802A/pt not_active Application Discontinuation
- 2001-07-18 RU RU2003105692/04A patent/RU2269522C2/ru not_active IP Right Cessation
- 2001-07-18 RS YUP-31/03A patent/RS50862B/sr unknown
- 2001-07-18 KR KR1020037000943A patent/KR100788532B1/ko not_active IP Right Cessation
- 2001-07-18 JP JP2002515881A patent/JP5015403B2/ja not_active Expired - Fee Related
- 2001-07-18 PL PL361173A patent/PL206308B1/pl unknown
- 2001-07-18 EE EEP200300035A patent/EE05159B1/et not_active IP Right Cessation
- 2001-07-18 CN CN018134572A patent/CN1216053C/zh not_active Expired - Fee Related
- 2001-07-18 US US10/312,290 patent/US6916926B2/en not_active Expired - Fee Related
- 2001-07-18 CZ CZ20030269A patent/CZ301039B6/cs not_active IP Right Cessation
- 2001-07-18 SK SK90-2003A patent/SK286795B6/sk not_active IP Right Cessation
- 2001-07-18 HU HU0301473A patent/HU229801B1/hu not_active IP Right Cessation
- 2001-07-18 DE DE60109299T patent/DE60109299T2/de not_active Expired - Lifetime
- 2001-07-18 WO PCT/EP2001/008305 patent/WO2002010150A1/en active IP Right Grant
- 2001-07-18 UA UA2003021768A patent/UA73790C2/uk unknown
- 2001-07-18 EP EP01960513A patent/EP1307440B1/en not_active Expired - Lifetime
- 2001-07-18 SI SI200120037A patent/SI21041B/sl not_active IP Right Cessation
- 2001-07-18 ES ES01960513T patent/ES2237589T3/es not_active Expired - Lifetime
-
2002
- 2002-12-17 IL IL153502A patent/IL153502A/en not_active IP Right Cessation
-
2004
- 2004-03-05 HK HK04101654A patent/HK1058798A1/xx not_active IP Right Cessation
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
GB1A | Change in the ownership or in the address of the owner | ||
KB4A | Valid patent at the end of a year |
Effective date: 20101231 |
|
GB1A | Change in the ownership or in the address of the owner | ||
MM4A | Lapsed by not paying the annual fees |
Effective date: 20160718 |