EE200300228A - Tiotroopium- ja salmeteroolsooladel põhinevad ravimkompositsioonid - Google Patents

Tiotroopium- ja salmeteroolsooladel põhinevad ravimkompositsioonid

Info

Publication number
EE200300228A
EE200300228A EEP200300228A EEP200300228A EE200300228A EE 200300228 A EE200300228 A EE 200300228A EE P200300228 A EEP200300228 A EE P200300228A EE P200300228 A EEP200300228 A EE P200300228A EE 200300228 A EE200300228 A EE 200300228A
Authority
EE
Estonia
Prior art keywords
salts
tiotropium
pharmaceutical compositions
compositions based
salmeterol
Prior art date
Application number
EEP200300228A
Other languages
English (en)
Inventor
Schmelzer Christel
Nagel Juergen
Original Assignee
Boehringer Ingelheim Pharma Gmbh & Co. Kg
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Pharma Gmbh & Co. Kg filed Critical Boehringer Ingelheim Pharma Gmbh & Co. Kg
Publication of EE200300228A publication Critical patent/EE200300228A/et

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/46—8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0078—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a nebulizer such as a jet nebulizer, ultrasonic nebulizer, e.g. in the form of aqueous drug solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0075—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/008—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy comprising drug dissolved or suspended in liquid propellant for inhalation via a pressurized metered dose inhaler [MDI]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
EEP200300228A 2000-11-13 2001-11-09 Tiotroopium- ja salmeteroolsooladel põhinevad ravimkompositsioonid EE200300228A (et)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10056104A DE10056104A1 (de) 2000-11-13 2000-11-13 Neue Arzneimittelkompositionen auf der Basis von Tiotropiumsalzen und Salzen des Salmeterols
PCT/EP2001/012962 WO2002038154A1 (de) 2000-11-13 2001-11-09 Neue arzneimittelkompositionen auf der basis von tiotropiumsalzen und salzen des salmeterols

Publications (1)

Publication Number Publication Date
EE200300228A true EE200300228A (et) 2003-10-15

Family

ID=7663071

Family Applications (1)

Application Number Title Priority Date Filing Date
EEP200300228A EE200300228A (et) 2000-11-13 2001-11-09 Tiotroopium- ja salmeteroolsooladel põhinevad ravimkompositsioonid

Country Status (32)

Country Link
EP (3) EP1514546B1 (et)
JP (2) JP4282322B2 (et)
KR (2) KR100940752B1 (et)
CN (1) CN1678318A (et)
AT (2) ATE362761T1 (et)
AU (3) AU2002227910B2 (et)
BG (1) BG107781A (et)
BR (1) BR0115226A (et)
CA (1) CA2429012A1 (et)
CY (1) CY1106774T1 (et)
CZ (1) CZ20031444A3 (et)
DE (3) DE10056104A1 (et)
DK (2) DK1514546T3 (et)
EA (1) EA007904B1 (et)
EC (1) ECSP034571A (et)
EE (1) EE200300228A (et)
ES (2) ES2240549T3 (et)
HR (1) HRP20030378A2 (et)
HU (1) HUP0301447A3 (et)
IL (2) IL155718A0 (et)
MX (1) MXPA03004164A (et)
NO (1) NO20032111L (et)
NZ (1) NZ526400A (et)
PL (1) PL205330B1 (et)
PT (2) PT1335728E (et)
RS (2) RS50286B (et)
SG (1) SG167657A1 (et)
SI (2) SI1335728T1 (et)
SK (2) SK286950B6 (et)
UA (1) UA74853C2 (et)
WO (1) WO2002038154A1 (et)
ZA (1) ZA200302921B (et)

Families Citing this family (32)

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ES2165768B1 (es) 1999-07-14 2003-04-01 Almirall Prodesfarma Sa Nuevos derivados de quinuclidina y composiciones farmaceuticas que los contienen.
US7214687B2 (en) 1999-07-14 2007-05-08 Almirall Ag Quinuclidine derivatives and medicinal compositions containing the same
AU1534501A (en) * 1999-11-23 2001-06-04 Glaxo Group Limited Pharmaceutical formulations of salmeterol
EP1429768B1 (de) * 2001-09-14 2016-11-16 Boehringer Ingelheim Pharma GmbH & Co.KG Neue arzneimittel zur inhalation
DE10214263A1 (de) * 2002-03-28 2003-10-16 Boehringer Ingelheim Pharma HFA-Suspensionsformulierungen enthaltend ein Anticholinergikum
US7244415B2 (en) 2002-03-28 2007-07-17 Boehringer Ingelheim Pharma Gmbh & Co. Kg HFA suspension formulations of an anhydrate
US7311894B2 (en) 2002-03-28 2007-12-25 Boehringer Ingelheim Pharma Gmbh & Co. Kg HFA suspension formulations containing an anticholinergic
DE10256080A1 (de) * 2002-11-29 2004-06-17 Boehringer Ingelheim Pharma Gmbh & Co. Kg Tiotropiumhaltige Arzneimittelkombination für die Inhalation
US7250426B2 (en) 2002-11-29 2007-07-31 Boehringer Ingelheim Pharma Gmbh & Co Kg Tiotropium-containing pharmaceutical combination for inhalation
WO2004054580A1 (en) * 2002-12-16 2004-07-01 Boehringer Ingelheim Pharma Gmbh & Co. Kg Tiotropium containing hfc solution formulations
DE10351663A1 (de) * 2002-12-20 2004-07-01 Boehringer Ingelheim Pharma Gmbh & Co. Kg Pulverförmige Arzneimittel enthaltend ein Tiotropiumsalz und Salmeterolxinafoat
DE10345065A1 (de) * 2003-09-26 2005-04-14 Boehringer Ingelheim Pharma Gmbh & Co. Kg Aerosolformulierung für die Inhalation enthaltend ein Anticholinergikum
EP2067779B9 (de) * 2003-11-03 2013-10-16 Boehringer Ingelheim International GmbH Tiotropiumsalze, Verfahren zu deren Herstellung und Arzneimittelformulierungen diese enthaltend
EP2336127A1 (de) * 2003-11-03 2011-06-22 Boehringer Ingelheim International GmbH Tiotropiumsalze, Verfahren zu deren Herstellung sowie diese enthaltende Arzneimittelformulierungen
ES2257152B1 (es) 2004-05-31 2007-07-01 Laboratorios Almirall S.A. Combinaciones que comprenden agentes antimuscarinicos y agonistas beta-adrenergicos.
DE602005022499D1 (de) * 2004-05-31 2010-09-02 Almirall Sa Kombinationen mit Antimuskarin-Wirkstoffen und PDE4-Hemmern
WO2006117299A2 (en) 2005-05-02 2006-11-09 Boehringer Ingelheim International Gmbh Novel crystalline forms of tiotropium bromide
JP2009504603A (ja) * 2005-08-06 2009-02-05 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング チオトロピウム塩とサルメテロールの塩とを組合せて投与する呼吸困難の治療方法
ES2298049B1 (es) 2006-07-21 2009-10-20 Laboratorios Almirall S.A. Procedimiento para fabricar bromuro de 3(r)-(2-hidroxi-2,2-ditien-2-ilacetoxi)-1-(3-fenoxipropil)-1-azoniabiciclo (2.2.2) octano.
EP2100598A1 (en) 2008-03-13 2009-09-16 Laboratorios Almirall, S.A. Inhalation composition containing aclidinium for treatment of asthma and chronic obstructive pulmonary disease
EP2100599A1 (en) 2008-03-13 2009-09-16 Laboratorios Almirall, S.A. Inhalation composition containing aclidinium for treatment of asthma and chronic obstructive pulmonary disease
US20120220557A1 (en) * 2011-02-17 2012-08-30 Chiesi Farmaceutici S.P.A. Liquid propellant-free formulation comprising an antimuscarinic drug
EP2510928A1 (en) 2011-04-15 2012-10-17 Almirall, S.A. Aclidinium for use in improving the quality of sleep in respiratory patients
JP6335798B2 (ja) * 2012-02-28 2018-05-30 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 新規噴射剤含有チオトロピウム製剤
WO2015065222A1 (ru) * 2013-10-28 2015-05-07 Шолекс Девелопмент Гмбх Фармацевтический ингаляционный препарат для лечения бронхиальной астмы и хронической обструктивной болезни легких, содержащий в качестве активного вещества микронизированный тиотропия бромид, и способ его получения
TW201835041A (zh) 2017-02-17 2018-10-01 印度商托仁特生技有限公司 具β-腎上腺素促效劑及抗蕈毒活性化合物
WO2019142214A1 (en) * 2018-01-19 2019-07-25 Cipla Limited Pharmaceutical composition comprising tiotropium for inhalation
CN111936124A (zh) * 2018-07-26 2020-11-13 四川海思科制药有限公司 一种含格隆铵盐及茚达特罗盐的气雾剂药物组合物及其制备方法与应用
CN116196298A (zh) * 2018-07-26 2023-06-02 四川海思科制药有限公司 一种含格隆铵盐的气雾剂药物组合物及其制备方法与应用
WO2022119661A1 (en) * 2020-12-04 2022-06-09 Tygrus, LLC THERAPEUTIC MATERIAL WITH LOW pH AND LOW TOXICITY ACTIVE AGAINST AT LEAST ONE PATHOGEN FOR ADDRESSING PATIENTS WITH RESPIRATORY ILLNESSES
US11642372B2 (en) 2020-05-01 2023-05-09 Tygrus, LLC Therapeutic material with low pH and low toxicity active against at least one pathogen for addressing patients with respiratory illnesses
US11826382B2 (en) 2020-05-01 2023-11-28 Tygrus, LLC Therapeutic material with low pH and low toxicity active against at least one pathogen for addressing patients with respiratory illnesses

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU748867B2 (en) * 1998-07-24 2002-06-13 Jagotec Ag Medicinal aerosol formulations
DE19835346A1 (de) * 1998-08-05 2000-02-10 Boehringer Ingelheim Pharma Zweiteilige Kapsel zur Aufnahme von pharmazeutischen Zubereitungen für Pulverinhalatoren
DE19847970A1 (de) * 1998-10-17 2000-04-20 Boehringer Ingelheim Pharma Lagerfähige Wirkstoff-Formulierung
DE19847971A1 (de) * 1998-10-17 1999-09-02 Schiering Verfahren und Einrichtung zur Verhinderung von Filterbränden (Staubfilter)
DE19921693A1 (de) * 1999-05-12 2000-11-16 Boehringer Ingelheim Pharma Neuartige Arzneimittelkompositionen auf der Basis von anticholinergisch wirksamen Verbindungen und ß-Mimetika
DE19961300A1 (de) * 1999-12-18 2001-06-21 Asta Medica Ag Vorratssystem für Arzneimittel in Pulverform und damit ausgestatteter Inhalator

Also Published As

Publication number Publication date
CA2429012A1 (en) 2002-05-16
BG107781A (bg) 2004-06-30
JP4282322B2 (ja) 2009-06-17
MXPA03004164A (es) 2005-08-16
ES2240549T3 (es) 2005-10-16
JP2004513146A (ja) 2004-04-30
SK286939B6 (sk) 2009-07-06
EP1335728A1 (de) 2003-08-20
BR0115226A (pt) 2003-10-07
SI1335728T1 (en) 2005-08-31
SG167657A1 (en) 2011-01-28
HUP0301447A2 (hu) 2003-10-28
ATE291428T1 (de) 2005-04-15
ZA200302921B (en) 2004-04-19
IL155718A (en) 2010-06-30
SK286950B6 (sk) 2009-08-06
EP1335728B1 (de) 2005-03-23
PL365989A1 (en) 2005-01-24
DE50112535D1 (de) 2007-07-05
RS50286B (sr) 2009-09-08
KR20080079701A (ko) 2008-09-01
HRP20030378A2 (en) 2005-04-30
SI1514546T1 (sl) 2007-10-31
AU2002227910B2 (en) 2007-03-01
DK1514546T3 (da) 2007-09-24
ES2287629T3 (es) 2007-12-16
EP1514546A1 (de) 2005-03-16
WO2002038154A1 (de) 2002-05-16
DE10056104A1 (de) 2002-05-23
UA74853C2 (en) 2006-02-15
PL205330B1 (pl) 2010-04-30
NZ526400A (en) 2005-09-30
IL155718A0 (en) 2003-11-23
KR100886094B1 (ko) 2009-02-27
AU2007202303B2 (en) 2010-01-21
ECSP034571A (es) 2003-06-25
AU2791002A (en) 2002-05-21
EP1514546B1 (de) 2007-05-23
EA007904B1 (ru) 2007-02-27
RS20090105A (en) 2009-07-15
AU2007202303A1 (en) 2007-06-14
ATE362761T1 (de) 2007-06-15
DK1335728T3 (da) 2005-04-18
EA200300503A1 (ru) 2004-12-30
NO20032111D0 (no) 2003-05-12
SK7412003A3 (en) 2003-10-07
NO20032111L (no) 2003-07-08
KR20030065509A (ko) 2003-08-06
YU35503A (sh) 2006-05-25
PT1514546E (pt) 2007-06-15
DE50105729D1 (de) 2005-04-28
CN1678318A (zh) 2005-10-05
JP2005068163A (ja) 2005-03-17
CY1106774T1 (el) 2012-05-23
HUP0301447A3 (en) 2007-10-29
KR100940752B1 (ko) 2010-02-11
CZ20031444A3 (cs) 2003-08-13
EP1808174A1 (de) 2007-07-18
PT1335728E (pt) 2005-05-31
JP4282594B2 (ja) 2009-06-24

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