AU2791002A - Novel medicament compositions based on tiotropium salts and on salmeterol salts - Google Patents

Novel medicament compositions based on tiotropium salts and on salmeterol salts

Info

Publication number
AU2791002A
AU2791002A AU2791002A AU2791002A AU2791002A AU 2791002 A AU2791002 A AU 2791002A AU 2791002 A AU2791002 A AU 2791002A AU 2791002 A AU2791002 A AU 2791002A AU 2791002 A AU2791002 A AU 2791002A
Authority
AU
Australia
Prior art keywords
salts
salmeterol
tiotropium
compositions based
medicament compositions
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
AU2791002A
Inventor
Christel Schmelzer
Juergen Nagel
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
BOEHRINGER INGELHEIM PHARMA
Boehringer Ingelheim Pharma GmbH and Co KG
Original Assignee
BOEHRINGER INGELHEIM PHARMA
Boehringer Ingelheim Pharma GmbH and Co KG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by BOEHRINGER INGELHEIM PHARMA, Boehringer Ingelheim Pharma GmbH and Co KG filed Critical BOEHRINGER INGELHEIM PHARMA
Publication of AU2791002A publication Critical patent/AU2791002A/en
Pending legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/468-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, cocaine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/007Pulmonary tract; Aromatherapy
    • A61K9/0073Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0078Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a nebulizer such as a jet nebulizer, ultrasonic nebulizer, e.g. in the form of aqueous drug solutions or dispersions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/13Amines
    • A61K31/135Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/137Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/439Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/007Pulmonary tract; Aromatherapy
    • A61K9/0073Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0075Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/007Pulmonary tract; Aromatherapy
    • A61K9/0073Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/008Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy comprising drug dissolved or suspended in liquid propellant for inhalation via a pressurized metered dose inhaler [MDI]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/06Antiasthmatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/08Antiallergic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pulmonology (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Otolaryngology (AREA)
  • Emergency Medicine (AREA)
  • Dispersion Chemistry (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Drug compositions containing one or more tiotropium salts and one or more salmeterol salts, are new. Drug compositions containing one or more tiotropium salts and one or more salmeterol salts, are new. The salts can be present in the form of enantiomers, enantiomer mixtures or racemates as well as in the form of solvates or hydrates. The compositions may also contain a pharmaceutical adjuvant. ACTIVITY : Antiasthmatic. MECHANISM OF ACTION : Anticholinergic; beta -mimetic.
AU2791002A 2000-11-13 2001-11-09 Novel medicament compositions based on tiotropium salts and on salmeterol salts Pending AU2791002A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10056104A DE10056104A1 (en) 2000-11-13 2000-11-13 Drug compositions useful for treatment of respiratory diseases, especially asthma and chronic obstructive pulmonary disease comprises tiotropium salts and salmeterol salts
PCT/EP2001/012962 WO2002038154A1 (en) 2000-11-13 2001-11-09 Novel medicament compositions based on tiotropium salts and on salmeterol salts

Publications (1)

Publication Number Publication Date
AU2791002A true AU2791002A (en) 2002-05-21

Family

ID=7663071

Family Applications (3)

Application Number Title Priority Date Filing Date
AU2791002A Pending AU2791002A (en) 2000-11-13 2001-11-09 Novel medicament compositions based on tiotropium salts and on salmeterol salts
AU2002227910A Ceased AU2002227910B2 (en) 2000-11-13 2001-11-09 Novel medicament compositions based on tiotropium salts and on salmeterol salts
AU2007202303A Ceased AU2007202303B2 (en) 2000-11-13 2007-05-22 Novel medicament compositions based on tiotropium salts and on salmeterol salts

Family Applications After (2)

Application Number Title Priority Date Filing Date
AU2002227910A Ceased AU2002227910B2 (en) 2000-11-13 2001-11-09 Novel medicament compositions based on tiotropium salts and on salmeterol salts
AU2007202303A Ceased AU2007202303B2 (en) 2000-11-13 2007-05-22 Novel medicament compositions based on tiotropium salts and on salmeterol salts

Country Status (32)

Country Link
EP (3) EP1808174A1 (en)
JP (2) JP4282322B2 (en)
KR (2) KR100886094B1 (en)
CN (1) CN1678318A (en)
AT (2) ATE362761T1 (en)
AU (3) AU2791002A (en)
BG (1) BG107781A (en)
BR (1) BR0115226A (en)
CA (1) CA2429012A1 (en)
CY (1) CY1106774T1 (en)
CZ (1) CZ20031444A3 (en)
DE (3) DE10056104A1 (en)
DK (2) DK1514546T3 (en)
EA (1) EA007904B1 (en)
EC (1) ECSP034571A (en)
EE (1) EE200300228A (en)
ES (2) ES2240549T3 (en)
HR (1) HRP20030378A2 (en)
HU (1) HUP0301447A3 (en)
IL (2) IL155718A0 (en)
MX (1) MXPA03004164A (en)
NO (1) NO20032111L (en)
NZ (1) NZ526400A (en)
PL (1) PL205330B1 (en)
PT (2) PT1514546E (en)
RS (2) RS50286B (en)
SG (1) SG167657A1 (en)
SI (2) SI1514546T1 (en)
SK (2) SK286950B6 (en)
UA (1) UA74853C2 (en)
WO (1) WO2002038154A1 (en)
ZA (1) ZA200302921B (en)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2165768B1 (en) 1999-07-14 2003-04-01 Almirall Prodesfarma Sa NEW DERIVATIVES OF QUINUCLIDINE AND PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THEM.
US7214687B2 (en) 1999-07-14 2007-05-08 Almirall Ag Quinuclidine derivatives and medicinal compositions containing the same
WO2001037805A1 (en) * 1999-11-23 2001-05-31 Glaxo Group Limited Pharmaceutical formulations of salmeterol
CA2459493C (en) * 2001-09-14 2011-08-02 Boehringer Ingelheim Pharma Gmbh & Co. Kg New pharmaceutical compositions for inhalation
DE10214263A1 (en) * 2002-03-28 2003-10-16 Boehringer Ingelheim Pharma HFA suspension formulations containing an anticholinergic
US7244415B2 (en) 2002-03-28 2007-07-17 Boehringer Ingelheim Pharma Gmbh & Co. Kg HFA suspension formulations of an anhydrate
US7311894B2 (en) 2002-03-28 2007-12-25 Boehringer Ingelheim Pharma Gmbh & Co. Kg HFA suspension formulations containing an anticholinergic
DE10256080A1 (en) * 2002-11-29 2004-06-17 Boehringer Ingelheim Pharma Gmbh & Co. Kg Combination medicinal product for inhalation containing tiotropium
US7250426B2 (en) 2002-11-29 2007-07-31 Boehringer Ingelheim Pharma Gmbh & Co Kg Tiotropium-containing pharmaceutical combination for inhalation
CA2510043A1 (en) * 2002-12-16 2004-07-01 Boehringer Ingelheim Pharma Gmbh & Co. Kg Tiotropium containing hfc solution formulations
DE10351663A1 (en) * 2002-12-20 2004-07-01 Boehringer Ingelheim Pharma Gmbh & Co. Kg Stable, accurately dosable inhalable powder medicament for treating asthma or chronic obstructive pulmonary disease, containing tiotropium, specific form of salmeterol xinafoate and auxiliary
DE10345065A1 (en) * 2003-09-26 2005-04-14 Boehringer Ingelheim Pharma Gmbh & Co. Kg Aerosol formulation for inhalation containing an anticholinergic
UY28589A1 (en) * 2003-11-03 2005-06-30 Boehringer Ingelheim Int NEW TIOTROPE SALTS, PROCEDURES FOR PREPARATION, AS WELL AS MEDICINAL FORMULATIONS CONTAINING THEM
PT1682541E (en) 2003-11-03 2010-04-14 Boehringer Ingelheim Int Method for producing tiotropium salts
DE602005018969D1 (en) * 2004-05-31 2010-03-04 Almirall Sa Compositions with antimuscarinic agents and corticosteroids
ES2257152B1 (en) * 2004-05-31 2007-07-01 Laboratorios Almirall S.A. COMBINATIONS THAT INCLUDE ANTIMUSCARINIC AGENTS AND BETA-ADRENERGIC AGONISTS.
ES2393794T3 (en) 2005-05-02 2012-12-28 Boehringer Ingelheim International Gmbh New crystalline forms of tiotropium bromide
CA2617897A1 (en) * 2005-08-06 2007-02-15 Boehringer Ingelheim International Gmbh Method for the treatment of dyspnea comprising combined administration of tiotropium salts and salts of salmeterol
ES2298049B1 (en) 2006-07-21 2009-10-20 Laboratorios Almirall S.A. PROCEDURE FOR MANUFACTURING BROMIDE OF 3 (R) - (2-HIDROXI-2,2-DITIEN-2-ILACETOXI) -1- (3-PHENOXIPROPIL) -1-AZONIABICICLO (2.2.2) OCTANO.
EP2100599A1 (en) 2008-03-13 2009-09-16 Laboratorios Almirall, S.A. Inhalation composition containing aclidinium for treatment of asthma and chronic obstructive pulmonary disease
EP2100598A1 (en) 2008-03-13 2009-09-16 Laboratorios Almirall, S.A. Inhalation composition containing aclidinium for treatment of asthma and chronic obstructive pulmonary disease
US20120220557A1 (en) * 2011-02-17 2012-08-30 Chiesi Farmaceutici S.P.A. Liquid propellant-free formulation comprising an antimuscarinic drug
EP2510928A1 (en) 2011-04-15 2012-10-17 Almirall, S.A. Aclidinium for use in improving the quality of sleep in respiratory patients
WO2013127738A1 (en) * 2012-02-28 2013-09-06 Boehringer Ingelheim International Gmbh Novel propellant-gas-containing tiotropium formulation
WO2015065222A1 (en) * 2013-10-28 2015-05-07 Шолекс Девелопмент Гмбх Pharmaceutical inhaled drug with micronized tiotropium bromide as active ingredient for the treatment of bronchial asthma and chronic obstructive pulmonary disease and method for producing same
TW201835041A (en) 2017-02-17 2018-10-01 印度商托仁特生技有限公司 Compounds with Beta-Adrenergic Agonist and Antimuscarinic Activity
WO2019142214A1 (en) * 2018-01-19 2019-07-25 Cipla Limited Pharmaceutical composition comprising tiotropium for inhalation
WO2020019952A1 (en) * 2018-07-26 2020-01-30 四川海思科制药有限公司 Aerosol pharmaceutical composition containing glycopyrrolate salt and indacaterol salt, preparation method therefor, and uses thereof
CN116196298A (en) * 2018-07-26 2023-06-02 四川海思科制药有限公司 Aerosol pharmaceutical composition containing glycopyrronium salt and preparation method and application thereof
US11826382B2 (en) 2020-05-01 2023-11-28 Tygrus, LLC Therapeutic material with low pH and low toxicity active against at least one pathogen for addressing patients with respiratory illnesses
US11642372B2 (en) 2020-05-01 2023-05-09 Tygrus, LLC Therapeutic material with low pH and low toxicity active against at least one pathogen for addressing patients with respiratory illnesses
WO2022119661A1 (en) * 2020-12-04 2022-06-09 Tygrus, LLC THERAPEUTIC MATERIAL WITH LOW pH AND LOW TOXICITY ACTIVE AGAINST AT LEAST ONE PATHOGEN FOR ADDRESSING PATIENTS WITH RESPIRATORY ILLNESSES

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1100465B1 (en) * 1998-07-24 2004-11-24 Jago Research Ag Medicinal aerosol formulations
DE19835346A1 (en) * 1998-08-05 2000-02-10 Boehringer Ingelheim Pharma Two-part capsule for pharmaceutical preparations for powder inhalers
DE19847971A1 (en) * 1998-10-17 1999-09-02 Schiering Filter fire occurrence prevention method
DE19847970A1 (en) * 1998-10-17 2000-04-20 Boehringer Ingelheim Pharma Stable concentrated liquid formulation of inhalable drug, e.g. formoterol or salbutamol, in solution or suspension medium, used after dilution for treatment of respiratory disorders by inhalation
DE19921693A1 (en) * 1999-05-12 2000-11-16 Boehringer Ingelheim Pharma Pharmaceutical composition for treating respiratory disorders, e.g. asthma, comprises combination of anticholinergic and beta-mimetic agents having synergistic bronchospasmolytic activity and reduced side-effects
DE19961300A1 (en) * 1999-12-18 2001-06-21 Asta Medica Ag Storage system for medicinal products in powder form and inhaler equipped with them

Also Published As

Publication number Publication date
DE10056104A1 (en) 2002-05-23
CA2429012A1 (en) 2002-05-16
DK1335728T3 (en) 2005-04-18
SK286939B6 (en) 2009-07-06
EP1514546B1 (en) 2007-05-23
SK286950B6 (en) 2009-08-06
KR100940752B1 (en) 2010-02-11
NO20032111L (en) 2003-07-08
AU2007202303B2 (en) 2010-01-21
IL155718A (en) 2010-06-30
JP2004513146A (en) 2004-04-30
SK7412003A3 (en) 2003-10-07
EP1808174A1 (en) 2007-07-18
ES2240549T3 (en) 2005-10-16
BR0115226A (en) 2003-10-07
NZ526400A (en) 2005-09-30
SI1514546T1 (en) 2007-10-31
RS20090105A (en) 2009-07-15
EP1335728A1 (en) 2003-08-20
JP2005068163A (en) 2005-03-17
KR20080079701A (en) 2008-09-01
ATE291428T1 (en) 2005-04-15
KR100886094B1 (en) 2009-02-27
JP4282322B2 (en) 2009-06-17
AU2007202303A1 (en) 2007-06-14
WO2002038154A1 (en) 2002-05-16
KR20030065509A (en) 2003-08-06
YU35503A (en) 2006-05-25
JP4282594B2 (en) 2009-06-24
SI1335728T1 (en) 2005-08-31
PL365989A1 (en) 2005-01-24
DE50112535D1 (en) 2007-07-05
EP1514546A1 (en) 2005-03-16
DE50105729D1 (en) 2005-04-28
ATE362761T1 (en) 2007-06-15
UA74853C2 (en) 2006-02-15
IL155718A0 (en) 2003-11-23
DK1514546T3 (en) 2007-09-24
EA007904B1 (en) 2007-02-27
MXPA03004164A (en) 2005-08-16
RS50286B (en) 2009-09-08
ES2287629T3 (en) 2007-12-16
ECSP034571A (en) 2003-06-25
AU2002227910B2 (en) 2007-03-01
HUP0301447A2 (en) 2003-10-28
CY1106774T1 (en) 2012-05-23
NO20032111D0 (en) 2003-05-12
HUP0301447A3 (en) 2007-10-29
PT1514546E (en) 2007-06-15
EE200300228A (en) 2003-10-15
EA200300503A1 (en) 2004-12-30
PT1335728E (en) 2005-05-31
HRP20030378A2 (en) 2005-04-30
BG107781A (en) 2004-06-30
EP1335728B1 (en) 2005-03-23
SG167657A1 (en) 2011-01-28
PL205330B1 (en) 2010-04-30
ZA200302921B (en) 2004-04-19
CZ20031444A3 (en) 2003-08-13
CN1678318A (en) 2005-10-05

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