SI1335728T1 - Medicament compositions based on tiotropium salts and on salmeterol salts - Google Patents

Medicament compositions based on tiotropium salts and on salmeterol salts

Info

Publication number
SI1335728T1
SI1335728T1 SI200130347T SI200130347T SI1335728T1 SI 1335728 T1 SI1335728 T1 SI 1335728T1 SI 200130347 T SI200130347 T SI 200130347T SI 200130347 T SI200130347 T SI 200130347T SI 1335728 T1 SI1335728 T1 SI 1335728T1
Authority
SI
Slovenia
Prior art keywords
salts
salmeterol
tiotropium
compositions based
medicament compositions
Prior art date
Application number
SI200130347T
Other languages
English (en)
Inventor
Christel Schmelzer
Juergen Nagel
Original Assignee
Boehringer Ingelheim Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Pharma filed Critical Boehringer Ingelheim Pharma
Publication of SI1335728T1 publication Critical patent/SI1335728T1/xx

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/468-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, cocaine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/007Pulmonary tract; Aromatherapy
    • A61K9/0073Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0078Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a nebulizer such as a jet nebulizer, ultrasonic nebulizer, e.g. in the form of aqueous drug solutions or dispersions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/13Amines
    • A61K31/135Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/137Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/439Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/007Pulmonary tract; Aromatherapy
    • A61K9/0073Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0075Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/007Pulmonary tract; Aromatherapy
    • A61K9/0073Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/008Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy comprising drug dissolved or suspended in liquid propellant for inhalation via a pressurized metered dose inhaler [MDI]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/06Antiasthmatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/08Antiallergic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Pulmonology (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Otolaryngology (AREA)
  • Emergency Medicine (AREA)
  • Dispersion Chemistry (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
SI200130347T 2000-11-13 2001-11-09 Medicament compositions based on tiotropium salts and on salmeterol salts SI1335728T1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10056104A DE10056104A1 (de) 2000-11-13 2000-11-13 Neue Arzneimittelkompositionen auf der Basis von Tiotropiumsalzen und Salzen des Salmeterols
PCT/EP2001/012962 WO2002038154A1 (de) 2000-11-13 2001-11-09 Neue arzneimittelkompositionen auf der basis von tiotropiumsalzen und salzen des salmeterols

Publications (1)

Publication Number Publication Date
SI1335728T1 true SI1335728T1 (en) 2005-08-31

Family

ID=7663071

Family Applications (2)

Application Number Title Priority Date Filing Date
SI200130347T SI1335728T1 (en) 2000-11-13 2001-11-09 Medicament compositions based on tiotropium salts and on salmeterol salts
SI200130751T SI1514546T1 (sl) 2000-11-13 2001-11-09 Sestavki zdravil na osnovi tiotropijevih soli in salmeterolnih soli

Family Applications After (1)

Application Number Title Priority Date Filing Date
SI200130751T SI1514546T1 (sl) 2000-11-13 2001-11-09 Sestavki zdravil na osnovi tiotropijevih soli in salmeterolnih soli

Country Status (32)

Country Link
EP (3) EP1514546B1 (xx)
JP (2) JP4282322B2 (xx)
KR (2) KR100940752B1 (xx)
CN (1) CN1678318A (xx)
AT (2) ATE291428T1 (xx)
AU (3) AU2002227910B2 (xx)
BG (1) BG107781A (xx)
BR (1) BR0115226A (xx)
CA (1) CA2429012A1 (xx)
CY (1) CY1106774T1 (xx)
CZ (1) CZ20031444A3 (xx)
DE (3) DE10056104A1 (xx)
DK (2) DK1514546T3 (xx)
EA (1) EA007904B1 (xx)
EC (1) ECSP034571A (xx)
EE (1) EE200300228A (xx)
ES (2) ES2287629T3 (xx)
HR (1) HRP20030378A2 (xx)
HU (1) HUP0301447A3 (xx)
IL (2) IL155718A0 (xx)
MX (1) MXPA03004164A (xx)
NO (1) NO20032111L (xx)
NZ (1) NZ526400A (xx)
PL (1) PL205330B1 (xx)
PT (2) PT1514546E (xx)
RS (2) RS50286B (xx)
SG (1) SG167657A1 (xx)
SI (2) SI1335728T1 (xx)
SK (2) SK286939B6 (xx)
UA (1) UA74853C2 (xx)
WO (1) WO2002038154A1 (xx)
ZA (1) ZA200302921B (xx)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2165768B1 (es) 1999-07-14 2003-04-01 Almirall Prodesfarma Sa Nuevos derivados de quinuclidina y composiciones farmaceuticas que los contienen.
US7214687B2 (en) 1999-07-14 2007-05-08 Almirall Ag Quinuclidine derivatives and medicinal compositions containing the same
EP1231894B1 (en) * 1999-11-23 2005-01-12 Glaxo Group Limited Pharmaceutical formulations of salmeterol
JP2005504076A (ja) * 2001-09-14 2005-02-10 ベーリンガー インゲルハイム ファルマ ゲゼルシャフト ミット ベシュレンクテル ハフツング ウント コンパニー コマンディトゲゼルシャフト 新規な吸入用医薬組成物
US7244415B2 (en) 2002-03-28 2007-07-17 Boehringer Ingelheim Pharma Gmbh & Co. Kg HFA suspension formulations of an anhydrate
DE10214263A1 (de) * 2002-03-28 2003-10-16 Boehringer Ingelheim Pharma HFA-Suspensionsformulierungen enthaltend ein Anticholinergikum
US7311894B2 (en) 2002-03-28 2007-12-25 Boehringer Ingelheim Pharma Gmbh & Co. Kg HFA suspension formulations containing an anticholinergic
US7250426B2 (en) 2002-11-29 2007-07-31 Boehringer Ingelheim Pharma Gmbh & Co Kg Tiotropium-containing pharmaceutical combination for inhalation
DE10256080A1 (de) * 2002-11-29 2004-06-17 Boehringer Ingelheim Pharma Gmbh & Co. Kg Tiotropiumhaltige Arzneimittelkombination für die Inhalation
KR20050085650A (ko) * 2002-12-16 2005-08-29 베링거 잉겔하임 파르마 게엠베하 운트 코 카게 타이오트로피움 함유 hfc 용액 제형
DE10351663A1 (de) * 2002-12-20 2004-07-01 Boehringer Ingelheim Pharma Gmbh & Co. Kg Pulverförmige Arzneimittel enthaltend ein Tiotropiumsalz und Salmeterolxinafoat
DE10345065A1 (de) * 2003-09-26 2005-04-14 Boehringer Ingelheim Pharma Gmbh & Co. Kg Aerosolformulierung für die Inhalation enthaltend ein Anticholinergikum
ATE478071T1 (de) * 2003-11-03 2010-09-15 Boehringer Ingelheim Int Verfahren zur herstellung neuer tiotropiumsalze
PT1682541E (pt) 2003-11-03 2010-04-14 Boehringer Ingelheim Int Processo para a preparação de sais de tiotrópio
ES2317245T3 (es) * 2004-05-31 2009-04-16 Laboratorios Almirall, S.A. Combinaciones que comprenden agentes antimuscarinicos y agonistas beta-adrenergicos.
ES2257152B1 (es) 2004-05-31 2007-07-01 Laboratorios Almirall S.A. Combinaciones que comprenden agentes antimuscarinicos y agonistas beta-adrenergicos.
CN101166738B (zh) 2005-05-02 2011-06-01 贝林格尔·英格海姆国际有限公司 噻托溴铵的新晶型
WO2007017437A1 (en) * 2005-08-06 2007-02-15 Boehringer Ingelheim International Gmbh Method for the treatment of dyspnea comprising combined administration of tiotropium salts and salts of salmeterol
ES2298049B1 (es) 2006-07-21 2009-10-20 Laboratorios Almirall S.A. Procedimiento para fabricar bromuro de 3(r)-(2-hidroxi-2,2-ditien-2-ilacetoxi)-1-(3-fenoxipropil)-1-azoniabiciclo (2.2.2) octano.
EP2100598A1 (en) 2008-03-13 2009-09-16 Laboratorios Almirall, S.A. Inhalation composition containing aclidinium for treatment of asthma and chronic obstructive pulmonary disease
EP2100599A1 (en) 2008-03-13 2009-09-16 Laboratorios Almirall, S.A. Inhalation composition containing aclidinium for treatment of asthma and chronic obstructive pulmonary disease
US20120220557A1 (en) * 2011-02-17 2012-08-30 Chiesi Farmaceutici S.P.A. Liquid propellant-free formulation comprising an antimuscarinic drug
EP2510928A1 (en) 2011-04-15 2012-10-17 Almirall, S.A. Aclidinium for use in improving the quality of sleep in respiratory patients
JP6335798B2 (ja) * 2012-02-28 2018-05-30 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 新規噴射剤含有チオトロピウム製剤
WO2015065222A1 (ru) * 2013-10-28 2015-05-07 Шолекс Девелопмент Гмбх Фармацевтический ингаляционный препарат для лечения бронхиальной астмы и хронической обструктивной болезни легких, содержащий в качестве активного вещества микронизированный тиотропия бромид, и способ его получения
TW201835041A (zh) 2017-02-17 2018-10-01 印度商托仁特生技有限公司 具β-腎上腺素促效劑及抗蕈毒活性化合物
WO2019142214A1 (en) * 2018-01-19 2019-07-25 Cipla Limited Pharmaceutical composition comprising tiotropium for inhalation
CN116173025A (zh) * 2018-07-26 2023-05-30 四川海思科制药有限公司 一种含格隆铵盐及茚达特罗盐的气雾剂药物组合物及其制备方法与应用
CN116196298A (zh) * 2018-07-26 2023-06-02 四川海思科制药有限公司 一种含格隆铵盐的气雾剂药物组合物及其制备方法与应用
US11642372B2 (en) 2020-05-01 2023-05-09 Tygrus, LLC Therapeutic material with low pH and low toxicity active against at least one pathogen for addressing patients with respiratory illnesses
US11826382B2 (en) 2020-05-01 2023-11-28 Tygrus, LLC Therapeutic material with low pH and low toxicity active against at least one pathogen for addressing patients with respiratory illnesses
WO2022119661A1 (en) * 2020-12-04 2022-06-09 Tygrus, LLC THERAPEUTIC MATERIAL WITH LOW pH AND LOW TOXICITY ACTIVE AGAINST AT LEAST ONE PATHOGEN FOR ADDRESSING PATIENTS WITH RESPIRATORY ILLNESSES

Family Cites Families (6)

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Publication number Priority date Publication date Assignee Title
ATE283033T1 (de) * 1998-07-24 2004-12-15 Jago Res Ag Medizinische aerosolformulierungen
DE19835346A1 (de) * 1998-08-05 2000-02-10 Boehringer Ingelheim Pharma Zweiteilige Kapsel zur Aufnahme von pharmazeutischen Zubereitungen für Pulverinhalatoren
DE19847970A1 (de) * 1998-10-17 2000-04-20 Boehringer Ingelheim Pharma Lagerfähige Wirkstoff-Formulierung
DE19847971A1 (de) * 1998-10-17 1999-09-02 Schiering Verfahren und Einrichtung zur Verhinderung von Filterbränden (Staubfilter)
DE19921693A1 (de) * 1999-05-12 2000-11-16 Boehringer Ingelheim Pharma Neuartige Arzneimittelkompositionen auf der Basis von anticholinergisch wirksamen Verbindungen und ß-Mimetika
DE19961300A1 (de) * 1999-12-18 2001-06-21 Asta Medica Ag Vorratssystem für Arzneimittel in Pulverform und damit ausgestatteter Inhalator

Also Published As

Publication number Publication date
BR0115226A (pt) 2003-10-07
JP4282322B2 (ja) 2009-06-17
EP1514546A1 (de) 2005-03-16
YU35503A (sh) 2006-05-25
ATE362761T1 (de) 2007-06-15
MXPA03004164A (es) 2005-08-16
HUP0301447A3 (en) 2007-10-29
PL365989A1 (en) 2005-01-24
SG167657A1 (en) 2011-01-28
ATE291428T1 (de) 2005-04-15
NO20032111D0 (no) 2003-05-12
AU2791002A (en) 2002-05-21
DK1514546T3 (da) 2007-09-24
PL205330B1 (pl) 2010-04-30
SK286939B6 (sk) 2009-07-06
ES2287629T3 (es) 2007-12-16
KR100940752B1 (ko) 2010-02-11
NO20032111L (no) 2003-07-08
JP2005068163A (ja) 2005-03-17
CN1678318A (zh) 2005-10-05
DE10056104A1 (de) 2002-05-23
DE50105729D1 (de) 2005-04-28
BG107781A (bg) 2004-06-30
WO2002038154A1 (de) 2002-05-16
EP1808174A1 (de) 2007-07-18
JP2004513146A (ja) 2004-04-30
HRP20030378A2 (en) 2005-04-30
CY1106774T1 (el) 2012-05-23
DE50112535D1 (de) 2007-07-05
IL155718A (en) 2010-06-30
KR100886094B1 (ko) 2009-02-27
PT1335728E (pt) 2005-05-31
HUP0301447A2 (hu) 2003-10-28
UA74853C2 (en) 2006-02-15
ECSP034571A (es) 2003-06-25
AU2007202303A1 (en) 2007-06-14
EP1335728B1 (de) 2005-03-23
DK1335728T3 (da) 2005-04-18
RS50286B (sr) 2009-09-08
ES2240549T3 (es) 2005-10-16
JP4282594B2 (ja) 2009-06-24
EP1335728A1 (de) 2003-08-20
AU2002227910B2 (en) 2007-03-01
CA2429012A1 (en) 2002-05-16
SK7412003A3 (en) 2003-10-07
KR20080079701A (ko) 2008-09-01
NZ526400A (en) 2005-09-30
CZ20031444A3 (cs) 2003-08-13
RS20090105A (xx) 2009-07-15
SI1514546T1 (sl) 2007-10-31
KR20030065509A (ko) 2003-08-06
EE200300228A (et) 2003-10-15
PT1514546E (pt) 2007-06-15
SK286950B6 (sk) 2009-08-06
EP1514546B1 (de) 2007-05-23
AU2007202303B2 (en) 2010-01-21
ZA200302921B (en) 2004-04-19
IL155718A0 (en) 2003-11-23
EA200300503A1 (ru) 2004-12-30
EA007904B1 (ru) 2007-02-27

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