WO2002066025A3 - Wirkstoffkombination aus dem racemat des tramadols und dem (+)-o-desmethyltramadol - Google Patents
Wirkstoffkombination aus dem racemat des tramadols und dem (+)-o-desmethyltramadol Download PDFInfo
- Publication number
- WO2002066025A3 WO2002066025A3 PCT/EP2002/001762 EP0201762W WO02066025A3 WO 2002066025 A3 WO2002066025 A3 WO 2002066025A3 EP 0201762 W EP0201762 W EP 0201762W WO 02066025 A3 WO02066025 A3 WO 02066025A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- combination
- active ingredients
- desmethyltramadol
- tramadol
- racemate
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5084—Mixtures of one or more drugs in different galenical forms, at least one of which being granules, microcapsules or (coated) microparticles according to A61K9/16 or A61K9/50, e.g. for obtaining a specific release pattern or for combining different drugs
Landscapes
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
Abstract
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AU2002250977A AU2002250977A1 (en) | 2001-02-21 | 2002-02-20 | Combination of active ingredients consisting of the racemate of tramadol and of (+)-o-desmethyltramadol |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE10108123.5 | 2001-02-21 | ||
DE10108123A DE10108123A1 (de) | 2001-02-21 | 2001-02-21 | Wirkstoffkombination |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2002066025A2 WO2002066025A2 (de) | 2002-08-29 |
WO2002066025A3 true WO2002066025A3 (de) | 2003-04-24 |
Family
ID=7674848
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/EP2002/001762 WO2002066025A2 (de) | 2001-02-21 | 2002-02-20 | Wirkstoffkombination aus dem racemat des tramadols und dem (+)-o-desmethyltramadol |
Country Status (3)
Country | Link |
---|---|
AU (1) | AU2002250977A1 (de) |
DE (1) | DE10108123A1 (de) |
WO (1) | WO2002066025A2 (de) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE10225315A1 (de) * | 2002-06-06 | 2003-12-24 | Gruenenthal Gmbh | Wirkstoffsalze und Ester von 1-Dimethylamino-3-(3-methoxy-phenyl)-2-methyl- pentan-3-ol und 3-(3-Dimethylamino-1-ethyl-1-hydroxy-2-methyl- propyl)-phenol |
DE102006006532B4 (de) * | 2006-02-10 | 2007-11-08 | Biogenerics Pharma Gmbh | Pharmazeutische Zubereitung |
EP2022778A1 (de) * | 2007-08-07 | 2009-02-11 | Laboratorios del Dr. Esteve S.A. | Kristalline Form von (R,R)-Tramadol-(S)-Naproxensalz |
US10702485B2 (en) * | 2011-07-09 | 2020-07-07 | Syntrix Biosystems Inc. | Compositions and methods for overcoming resistance to tramadol |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE19601744A1 (de) * | 1996-01-19 | 1997-07-31 | Gruenenthal Gmbh | Verfahren zur Herstellung der Enantiomeren von O-Demethyltramadol |
DE19712398A1 (de) * | 1997-03-25 | 1998-10-01 | Gruenenthal Gmbh | Orale Anwendung von (+)-0-Demethyltramadol als Schmerzmittel |
-
2001
- 2001-02-21 DE DE10108123A patent/DE10108123A1/de not_active Withdrawn
-
2002
- 2002-02-20 WO PCT/EP2002/001762 patent/WO2002066025A2/de not_active Application Discontinuation
- 2002-02-20 AU AU2002250977A patent/AU2002250977A1/en not_active Abandoned
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE19601744A1 (de) * | 1996-01-19 | 1997-07-31 | Gruenenthal Gmbh | Verfahren zur Herstellung der Enantiomeren von O-Demethyltramadol |
DE19712398A1 (de) * | 1997-03-25 | 1998-10-01 | Gruenenthal Gmbh | Orale Anwendung von (+)-0-Demethyltramadol als Schmerzmittel |
Non-Patent Citations (3)
Title |
---|
GROND S ET AL: "ANALGESIC EFFICACY AND SAFETY OF TRAMADOL ENANTIOMERS IN COMPARISON WITH THE RACEMATE: A RANDOMISED, DOUBLE-BLIND STUDY WITH GYNAECOLOGICAL PATIENTS USING INTRAVENOUS PATIENT-CONTROLLED ANALGESIA", PAIN, ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, NL, vol. 62, no. 3, September 1995 (1995-09-01), pages 313 - 320, XP000891573, ISSN: 0304-3959 * |
RAFFA R B: "A NOVEL APPROACH TO THE PARMACOLOGY OF ANALGESICS", AMERICAN JOURNAL OF MEDICINE, XX, XX, vol. 101, 1996, pages 40S - 46S, XP000920591, ISSN: 0002-9343 * |
SINDRUP S H ET AL: "THE EFFECT OF TRAMADOL IN PAINFUL POLYNEUROPATHY IN RELATION TO SERUM DRUG AND METABOLIC LEVELS", CLINICAL PHARMACOLOGY & THERAPEUTICS, MOSBY-YEAR BOOK, ST LOUIS, MO, US, vol. 66, no. 6, 1999, pages 636, XP000909291, ISSN: 0009-9236 * |
Also Published As
Publication number | Publication date |
---|---|
WO2002066025A2 (de) | 2002-08-29 |
DE10108123A1 (de) | 2002-10-02 |
AU2002250977A1 (en) | 2002-09-04 |
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