PL2182949T3 - (2S,3R)-N-(2-((3-Pirydynylo)metylo)- 1-azabicyklo[2.2.2]okt-3-ylo)benzofurano-2-karboksyamid, nowe postacie soli, oraz sposoby ich stosowania - Google Patents

(2S,3R)-N-(2-((3-Pirydynylo)metylo)- 1-azabicyklo[2.2.2]okt-3-ylo)benzofurano-2-karboksyamid, nowe postacie soli, oraz sposoby ich stosowania

Info

Publication number
PL2182949T3
PL2182949T3 PL08782584T PL08782584T PL2182949T3 PL 2182949 T3 PL2182949 T3 PL 2182949T3 PL 08782584 T PL08782584 T PL 08782584T PL 08782584 T PL08782584 T PL 08782584T PL 2182949 T3 PL2182949 T3 PL 2182949T3
Authority
PL
Poland
Prior art keywords
azabicyclo
benzofuran
pyridinyl
carboxamide
oct
Prior art date
Application number
PL08782584T
Other languages
English (en)
Polish (pl)
Inventor
Merouane Bencherif
Lisa Benson
Gary Maurice Dull
Nikolai Fedorov
Gregory J Gatto
John Genus
Kristen G Jordan
Jacob Mathew
Anatoly A Mazurov
Lan Miao
Julio A Munoz
Inigo Pfeiffer
Sondra Pfeiffer
Teresa Y Phillips
Original Assignee
Targacept Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=39945177&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PL2182949(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Targacept Inc filed Critical Targacept Inc
Publication of PL2182949T3 publication Critical patent/PL2182949T3/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers
PL08782584T 2007-08-02 2008-08-01 (2S,3R)-N-(2-((3-Pirydynylo)metylo)- 1-azabicyklo[2.2.2]okt-3-ylo)benzofurano-2-karboksyamid, nowe postacie soli, oraz sposoby ich stosowania PL2182949T3 (pl)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US95361007P 2007-08-02 2007-08-02
US95361407P 2007-08-02 2007-08-02
US95361307P 2007-08-02 2007-08-02
US97165407P 2007-09-12 2007-09-12
EP08782584A EP2182949B1 (en) 2007-08-02 2008-08-01 (2s,3r)-n-(2-((3-pyridinyl)methyl)-1-azabicyclo[2.2.2]oct-3-yl)benzofuran-2-carboxamide, novel salt forms, and methods of use thereof
PCT/US2008/071872 WO2009018505A1 (en) 2007-08-02 2008-08-01 (2s,3r)-n-(2-((3-pyridinyl)methyl)-1-azabicyclo[2.2.2]oct-3-yl)benzofuran-2-carboxamide, novel salt forms, and methods of use thereof

Publications (1)

Publication Number Publication Date
PL2182949T3 true PL2182949T3 (pl) 2013-06-28

Family

ID=39945177

Family Applications (1)

Application Number Title Priority Date Filing Date
PL08782584T PL2182949T3 (pl) 2007-08-02 2008-08-01 (2S,3R)-N-(2-((3-Pirydynylo)metylo)- 1-azabicyklo[2.2.2]okt-3-ylo)benzofurano-2-karboksyamid, nowe postacie soli, oraz sposoby ich stosowania

Country Status (35)

Country Link
US (6) US7981906B2 (zh)
EP (6) EP2185152A2 (zh)
JP (4) JP2010535252A (zh)
KR (2) KR20100051684A (zh)
CN (4) CN103172628A (zh)
AR (1) AR067775A1 (zh)
AU (3) AU2008283807B2 (zh)
BR (2) BRPI0815009A2 (zh)
CA (2) CA2694510A1 (zh)
CL (3) CL2008002271A1 (zh)
CO (2) CO6260081A2 (zh)
CY (1) CY1113561T1 (zh)
DK (2) DK2431037T3 (zh)
EC (2) ECSP10010007A (zh)
ES (3) ES2611139T3 (zh)
HK (1) HK1140968A1 (zh)
HR (1) HRP20130286T1 (zh)
HU (1) HUE030387T2 (zh)
IL (1) IL218976A0 (zh)
ME (1) ME01508B (zh)
MX (3) MX346451B (zh)
MY (1) MY148002A (zh)
NO (2) NO20100078L (zh)
NZ (2) NZ582828A (zh)
PE (3) PE20121821A1 (zh)
PL (1) PL2182949T3 (zh)
PT (1) PT2182949E (zh)
RS (1) RS52743B (zh)
RU (2) RU2012140182A (zh)
SA (2) SA08290475B1 (zh)
SI (1) SI2182949T1 (zh)
TW (3) TW201402117A (zh)
UY (1) UY31265A (zh)
WO (2) WO2009018505A1 (zh)
ZA (1) ZA201000719B (zh)

Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6953855B2 (en) * 1998-12-11 2005-10-11 Targacept, Inc. 3-substituted-2(arylalkyl)-1-azabicycloalkanes and methods of use thereof
DE10164139A1 (de) 2001-12-27 2003-07-10 Bayer Ag 2-Heteroarylcarbonsäureamide
US8314119B2 (en) 2006-11-06 2012-11-20 Abbvie Inc. Azaadamantane derivatives and methods of use
SA08290475B1 (ar) * 2007-08-02 2013-06-22 Targacept Inc (2s، 3r)-n-(2-((3-بيردينيل)ميثيل)-1-آزا بيسيكلو[2، 2، 2]أوكت-3-يل)بنزو فيوران-2-كربوكساميد، وصور أملاحه الجديدة وطرق استخدامه
EP2647373A1 (en) * 2008-05-12 2013-10-09 Targacept, Inc. Methods for preventing the development of retinopathy by the oral administration of exo-S-mecamylamine.
TW201031664A (en) 2009-01-26 2010-09-01 Targacept Inc Preparation and therapeutic applications of (2S,3R)-N-2-((3-pyridinyl)methyl)-1-azabicyclo[2.2.2]oct-3-yl)-3,5-difluorobenzamide
JO3250B1 (ar) 2009-09-22 2018-09-16 Novartis Ag إستعمال منشطات مستقبل نيكوتينيك أسيتيل كولين ألفا 7
ES2746850T3 (es) 2010-05-17 2020-03-09 Forum Pharmaceuticals Inc Formulaciones farmacéuticas que comprenden formas cristalinas de clorhidrato de (R)-7-cloro-N-(quinuclidin-3-il)benzo(b)tiofeno-2-carboxamida monohidratado
CN103260619A (zh) * 2010-07-26 2013-08-21 英维沃医药有限公司 利用某些α-7烟酸受体激动剂与乙酰胆碱酯酶抑制剂的组合治疗认知障碍
SG188307A1 (en) 2010-09-23 2013-04-30 Abbvie Inc Monohydrate of an azaadamantane derivative
JP2014502996A (ja) * 2011-01-18 2014-02-06 ターガセプト，インコーポレイテッド 統合失調症における認知障害の治療
JP2014503568A (ja) 2011-01-27 2014-02-13 ノバルティス アーゲー ニコチン酸アセチルコリン受容体α７活性化因子の使用
KR20140018286A (ko) 2011-03-18 2014-02-12 노파르티스 아게 파킨슨병에서의 도파민 유발 이상운동증에서 사용하기 위한 알파 7 니코틴성 아세틸콜린 수용체 활성화제 및 mGluR5 길항제의 조합물
CA2830511C (en) 2011-03-18 2021-09-14 Alkermes Pharma Ireland Limited Pharmaceutical compositions comprising aripiprazole lauroxil and sorbitan laurate
WO2012129262A1 (en) * 2011-03-23 2012-09-27 Targacept, Inc. Treatment of attention deficit/hyperactivity disease
AU2012276651A1 (en) 2011-06-30 2014-02-06 Toray Industries, Inc. Antipruritic agent
TW201311698A (zh) * 2011-08-22 2013-03-16 Targacept Inc 作為神經元菸鹼乙醯膽鹼受體配位體之１，４－二氮雜雙環［３．２．２］壬烷
EP2768507B1 (en) 2011-10-20 2019-12-11 Novartis AG Biomarkers predictive of responsiveness to alpha 7 nicotinic acetylcholine receptor activator treatment
US9993556B2 (en) * 2012-03-19 2018-06-12 Alkermes Pharma Ireland Limited Pharmaceutical compositions comprising fatty glycerol esters
US9999670B2 (en) 2012-03-19 2018-06-19 Alkermes Pharma Ireland Limited Pharmaceutical compositions comprising benzyl alcohol
CA2867121C (en) 2012-03-19 2021-05-25 Alkermes Pharma Ireland Limited Pharmaceutical compositions comprising fatty acid esters
MX358512B (es) 2012-05-08 2018-08-24 Forum Pharmaceuticals Inc Uso de (r)-7cloro-n-(quinuclidin-3-il) benzo[b] tiofeno-2-carboxamida o una sal farmacéuticamente aceptable de la misma para preparar una composición farmacéutica en el tratamiento de una disfunción cognitiva.
EP3718536A1 (en) 2012-09-19 2020-10-07 Alkermes Pharma Ireland Limited Pharmaceutical compositions having improved storage stability
JP6114951B2 (ja) 2012-12-11 2017-04-19 ノバルティス アーゲー アルファ７ニコチン性アセチルコリン受容体アクチベーターによる処置に対する応答性を予測するバイオマーカー
US20150313884A1 (en) 2013-01-15 2015-11-05 Novartis Ag Use of alpha 7 nicotinic acetylcholine receptor agonists
CN105246485B (zh) 2013-01-15 2019-03-15 诺华有限公司 α7烟碱型乙酰胆碱受体激动剂的应用
CN105263495B (zh) 2013-01-15 2019-05-14 诺华有限公司 α7烟碱型乙酰胆碱受体激动剂的应用
MX362819B (es) 2013-01-15 2019-02-18 Novartis Ag Uso de agonistas del receptor nicotinico de acetilcolina alfa 7 para el tratamiento de la narcolepsia.
WO2014153424A1 (en) * 2013-03-19 2014-09-25 La Jolla Institute For Allergy And Immunology Reducing diabetes in patients receiving hmg-coa reductase inhibitors (statins)
MA39495A (fr) 2014-03-20 2015-09-24 Alkermes Pharma Ireland Ltd Formulations d'aripiprazole présentant des vitesses d'injection plus élevées
CN106659765B (zh) 2014-04-04 2021-08-13 德玛医药 二脱水半乳糖醇及其类似物或衍生物用于治疗非小细胞肺癌和卵巢癌的用途
CN104288771B (zh) * 2014-09-30 2017-03-15 郑州大学第五附属医院 α7nAChR激动剂的新用途
EP3291813A4 (en) 2015-05-06 2019-01-02 The Regents of The University of California K-ras modulators
US9724340B2 (en) 2015-07-31 2017-08-08 Attenua, Inc. Antitussive compositions and methods
US10282666B1 (en) 2015-11-10 2019-05-07 Google Llc Coherency detection and information management system
RU2675111C2 (ru) * 2017-03-31 2018-12-17 Федеральное государственное бюджетное научное учреждение "Научно-исследовательский институт фундаментальной и клинической иммунологии" Способ стимуляции нейрогенеза в гиппокампе
SG11201909570PA (en) 2017-04-20 2019-11-28 Univ California K-ras modulators
EP3761983A1 (en) 2018-03-05 2021-01-13 Alkermes Pharma Ireland Limited Aripiprazole dosing strategy

Family Cites Families (108)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4203990A (en) 1979-04-30 1980-05-20 G. D. Searle & Co. Anti-diarrheal 2-substituted quinuclidines
EP0353189B1 (de) 1988-07-28 1994-01-12 Ciba-Geigy Ag Kupfer- und Nickeldihalogenidkomplexe, Verfahren zu deren Herstellung und deren Verwendung
US4922901A (en) 1988-09-08 1990-05-08 R. J. Reynolds Tobacco Company Drug delivery articles utilizing electrical energy
EP0402056A3 (en) 1989-06-06 1991-09-04 Beecham Group p.l.c. Azabicyclic compounds, process for their preparation and pharmaceutical compositions containing them
EP0412798A3 (en) 1989-08-08 1992-07-01 Merck Sharp & Dohme Ltd. Substituted pyridines, their preparation, formulations and use in dementia
IN173570B (zh) 1989-11-23 1994-06-04 Pfizer
DK40890D0 (da) 1990-02-16 1990-02-16 Ferrosan As Substituerede urinstofforbindelser, deres fremstilling og anvendelse
EP0492903A1 (en) 1990-12-21 1992-07-01 MERCK SHARP & DOHME LTD. Substituted pyrazines, pyrimidines and pyridazines for use in the treatment of glaucoma
ES2153357T3 (es) 1991-03-01 2001-03-01 Univ Florida Uso de analogos nicotinicos para el tratamiento de enfermedades degenerativas del sistema nervioso.
US5212188A (en) 1992-03-02 1993-05-18 R. J. Reynolds Tabacco Company Method for treatment of neurodegenerative diseases
US5276043A (en) 1992-04-10 1994-01-04 R. J. Reynolds Tobacco Company Method for treatment of neurodegenerative diseases
CA2142610C (en) 1992-08-31 2003-09-16 William R. Kem Anabaseine derivatives useful in the treatment of degenerative diseases of the nervous system
US5977144A (en) 1992-08-31 1999-11-02 University Of Florida Methods of use and compositions for benzylidene- and cinnamylidene-anabaseines
IL107184A (en) 1992-10-09 1997-08-14 Abbott Lab Heterocyclic ether compounds that enhance cognitive function
US5852041A (en) 1993-04-07 1998-12-22 Sibia Neurosciences, Inc. Substituted pyridines useful as modulators of acethylcholine receptors
IL109451A0 (en) * 1993-04-29 1994-07-31 Zeneca Ltd Heterocyclic derivatives
WO1995003306A1 (en) 1993-07-22 1995-02-02 E.I. Du Pont De Nemours And Company Arthropodicidal azacyclic heterocycles
US5493026A (en) 1993-10-25 1996-02-20 Organix, Inc. Substituted 2-carboxyalkyl-3-(fluorophenyl)-8-(3-halopropen-2-yl) nortropanes and their use as imaging for agents for neurodegenerative disorders
US5510355A (en) 1994-09-06 1996-04-23 Bencherif; Merouane Depolarizing skeletal muscle relaxants
US5998404A (en) 1994-10-24 1999-12-07 Eli Lilly And Company Heterocyclic compounds and their use
US5824692A (en) 1995-01-06 1998-10-20 Lippiello; Patrick Michael Pharmaceutical compositions for prevention and treatment of central nervous system disorders
US5616707A (en) 1995-01-06 1997-04-01 Crooks; Peter A. Compounds which are useful for prevention and treatment of central nervous system disorders
US5597919A (en) 1995-01-06 1997-01-28 Dull; Gary M. Pyrimidinyl or Pyridinyl alkenyl amine compounds
US5604231A (en) 1995-01-06 1997-02-18 Smith; Carr J. Pharmaceutical compositions for prevention and treatment of ulcerative colitis
US5859004A (en) 1995-02-17 1999-01-12 Novo Nordisk A/S Use of heterocyclic compounds for the treatment of conditions caused by malfunctioning of the nicotinic cholinergic system
US5585388A (en) 1995-04-07 1996-12-17 Sibia Neurosciences, Inc. Substituted pyridines useful as modulators of acetylcholine receptors
US5583140A (en) 1995-05-17 1996-12-10 Bencherif; Merouane Pharmaceutical compositions for the treatment of central nervous system disorders
IL118279A (en) 1995-06-07 2006-10-05 Abbott Lab Compounds 3 - Pyridyloxy (or Thio) Alkyl Heterocyclic Pharmaceutical Compositions Containing Them and Their Uses for Preparing Drugs to Control Synaptic Chemical Transmission
EP0842172A1 (en) 1995-06-29 1998-05-20 Novo Nordisk A/S Novel substituted azacyclic or azabicyclic compounds
EP0853621A1 (en) 1995-09-22 1998-07-22 Novo Nordisk A/S Novel substituted azacyclic or azabicyclic compounds
US5712270A (en) 1995-11-06 1998-01-27 American Home Products Corporation 2-arylamidothiazole derivatives with CNS activity
US5616716A (en) 1996-01-06 1997-04-01 Dull; Gary M. (3-(5-ethoxypyridin)yl)-alkenyl 1 amine compounds
SE9600683D0 (sv) 1996-02-23 1996-02-23 Astra Ab Azabicyclic esters of carbamic acids useful in therapy
US5663356A (en) 1996-04-23 1997-09-02 Ruecroft; Graham Method for preparation of aryl substituted alefinic secondary amino compounds
US5726189A (en) 1996-05-03 1998-03-10 The United States Of America, Represented By The Secretary, Department Of Health And Human Services Method for imaging nicotinic acetylcholinergic receptors in the brain using radiolabeled pyridyl-7-azabicyclo 2.2.1!heptanes
ZA9711092B (en) 1996-12-11 1999-07-22 Smithkline Beecham Corp Novel compounds.
US5861423A (en) 1997-02-21 1999-01-19 Caldwell; William Scott Pharmaceutical compositions incorporating aryl substituted olefinic amine compounds
US5811442A (en) 1997-02-21 1998-09-22 Bencherif; Merouane Pharmaceutical compositions for the treatment of conditions associated with decreased blood flow
JP4447663B2 (ja) 1997-05-30 2010-04-07 ニューロサーチ、アクティーゼルスカブ ニコチン性ａｃｈレセプターに於けるコリン作動性リガンドとしての８−アザビシクロ（３．２．１）オクト−２−エン及びオクタン誘導体
AR013184A1 (es) * 1997-07-18 2000-12-13 Astrazeneca Ab Aminas heterociclicas espiroazobiciclicas, composicion farmaceutica, uso de dichas aminas para preparar medicamentos y metodo de tratamiento o profilaxis
BR9907172A (pt) 1998-04-02 2000-10-10 Reynolds Tobacco Co R Derivados de azatriciclo[3.3.1.1] decano e composições farmacêuticas contendo-os
US5952339A (en) 1998-04-02 1999-09-14 Bencherif; Merouane Pharmaceutical compositions and methods of using nicotinic antagonists for treating a condition or disorder characterized by alteration in normal neurotransmitter release
ATE255888T1 (de) 1998-06-01 2003-12-15 Ortho Mcneil Pharm Inc Tetrahydronaphtalene verbindungen und deren verwendung zur behandlung von neurodegenerativen krankheiten
US6310043B1 (en) 1998-08-07 2001-10-30 Governors Of The University Of Alberta Treatment of bacterial infections
GB9821503D0 (en) 1998-10-02 1998-11-25 Novartis Ag Organic compounds
US6953855B2 (en) * 1998-12-11 2005-10-11 Targacept, Inc. 3-substituted-2(arylalkyl)-1-azabicycloalkanes and methods of use thereof
US6432975B1 (en) 1998-12-11 2002-08-13 Targacept, Inc. Pharmaceutical compositions and methods for use
US6734215B2 (en) 1998-12-16 2004-05-11 University Of South Florida Exo-S-mecamylamine formulation and use in treatment
SE9900100D0 (sv) 1999-01-15 1999-01-15 Astra Ab New compounds
FR2791678B1 (fr) 1999-03-30 2001-05-04 Synthelabo Derives de 1,4-diazabicyclo [3.2.2] nonane-4-carboxylates et -carboxamides, leur preparation et leur application en therapeutique
SE9904176D0 (sv) 1999-11-18 1999-11-18 Astra Ab New use
SE0000540D0 (sv) 2000-02-18 2000-02-18 Astrazeneca Ab New compounds
GB0010955D0 (en) 2000-05-05 2000-06-28 Novartis Ag Organic compounds
KR100751981B1 (ko) 2000-06-27 2007-08-28 라보라토리오스 살바트, 에스.에이. 아릴알킬아민으로부터 유도된 카바메이트
US6486172B2 (en) 2000-08-18 2002-11-26 Pharmacia & Upjohn Company Quinuclidine-substituted aryl compounds for treatment of disease
US6492386B2 (en) 2000-08-18 2002-12-10 Pharmacia & Upjohn Company Quinuclidine-substituted aryl compounds for treatment of disease
AU2001282874A1 (en) 2000-08-18 2002-03-04 Pharmacia And Upjohn Company Quinuclidine-substituted aryl moieties for treatment of disease (nicotinic acetylcholine receptor ligands)
JP2004506734A (ja) 2000-08-21 2004-03-04 ファルマシア・アンド・アップジョン・カンパニー 疾患治療用のキヌクリド置換ヘテロアリール部分
WO2002015662A2 (en) 2000-08-21 2002-02-28 Pharmacia & Upjohn Company Quinuclidine-substituted heteroaryl moieties for treatment of disease (nicotinic acetylcholine receptor antagonists
AU2001282875A1 (en) * 2000-08-21 2002-03-04 Pharmacia And Upjohn Company Quinuclidine-substituted heteroaryl moieties for treatment of disease
CA2441896A1 (en) 2000-12-22 2002-07-04 Almirall Prodesfarma Ag Quinuclidine carbamate derivatives and their use as m3 antagonists
US20020086871A1 (en) 2000-12-29 2002-07-04 O'neill Brian Thomas Pharmaceutical composition for the treatment of CNS and other disorders
CN1294136C (zh) 2001-06-01 2007-01-10 阿斯特拉曾尼卡有限公司 用于治疗的烟碱乙酰胆碱受体新型配体
US6569865B2 (en) * 2001-06-01 2003-05-27 Astrazeneca Ab Spiro 1-azabicyclo[2.2.2]octane-3,2′(3′h)-furo[2,3-b]pyridine
AR036040A1 (es) * 2001-06-12 2004-08-04 Upjohn Co Compuestos de heteroarilo multiciclicos sustituidos con quinuclidinas y composiciones farmaceuticas que los contienen
WO2003011837A1 (en) 2001-08-01 2003-02-13 Merck & Co., Inc. Tyrosine kinase inhibitors
WO2003018586A1 (en) 2001-08-24 2003-03-06 Pharmacia & Upjohn Company Substituted-aryl 7-aza[2.2.1]bicycloheptanes for the treatment of disease
US6562816B2 (en) 2001-08-24 2003-05-13 Pharmacia & Upjohn Company Substituted-heteroaryl-7-aza[2.2.1]bicycloheptanes for the treatment of disease
CA2460075A1 (en) 2001-09-12 2003-03-20 Donn Gregory Wishka Substituted 7-aza[2.2.1] bicycloheptanes for the treatment of diseases
CA2476681A1 (en) 2002-02-19 2003-08-28 Bruce N. Rogers Fused bicyclic-n-bridged-heteroaromatic carboxamides for the treatment of disease
AU2003214936A1 (en) 2002-02-20 2003-09-09 Pharmacia And Upjohn Company Azabicyclic compounds with alfa7 nicotinic acetylcholine receptor activity
JP4511196B2 (ja) 2002-04-18 2010-07-28 アストラゼネカ・アクチエボラーグ チエニル化合物
DE60328010D1 (de) 2002-04-18 2009-07-30 Astrazeneca Ab Heterocyclische verbindungen
CA2482311C (en) 2002-04-18 2009-12-08 Astrazeneca Ab Furyl compounds
WO2004013137A1 (en) 2002-08-01 2004-02-12 Pharmacia & Upjohn Company Llc 1h-pyrazole and 1h-pyrrole-azabicyclic compounds with alfa-7 nachr activity
RU2323217C2 (ru) 2002-08-14 2008-04-27 Ньюросерч А/С Новые хинуклидиновые производные и их применение
SE0202430D0 (sv) 2002-08-14 2002-08-14 Astrazeneca Ab New Compounds
SE0202465D0 (sv) 2002-08-14 2002-08-14 Astrazeneca Ab New compounds
EP1531820A1 (en) 2002-08-30 2005-05-25 Memory Pharmaceuticals Corporation Anabaseine derivatives useful in the treatment of neurodegenerative diseases
RU2391341C2 (ru) 2002-09-25 2010-06-10 Мемори Фармасьютиклз Корпорейшн Индазолы, бензотиазолы, бензоизотиазолы, их получение и применение
AU2003269413A1 (en) 2002-11-01 2004-05-25 Pharmacia & Upjohn Company Llc Nicotinic acetylcholine agonists in the treatment of glaucoma and retinal neuropathy
AU2003269401A1 (en) 2002-11-01 2004-05-25 Pharmacia & Upjohn Company Llc Compounds having both alpha7 nachr agonist and 5ht antagonist activity for treatment of cns diseases
ES2293086T3 (es) 2002-12-06 2008-03-16 The Feinstein Institute For Medical Research Inhibicion de la inflamacion usando agonistas colinergicos de union al receptor alfa 7.
EA200500783A1 (ru) 2002-12-11 2005-12-29 ФАРМАЦИЯ ЭНД АПДЖОН КОМПАНИ ЭлЭлСи Комбинация для лечения синдрома дефицита внимания с гиперактивностью
EP1572205A2 (en) 2002-12-11 2005-09-14 Pharmacia & Upjohn Company LLC Treatment of diseases with combinations of alpha 7 nicotinic acetylcholine receptor agonists and other compounds
US6917746B2 (en) 2002-12-17 2005-07-12 3M Innovative Properties Company Apparatus and method for creating a fiber optic circuit
US6777617B2 (en) 2002-12-30 2004-08-17 3M Innovative Properties Company Telecommunications terminal
US7678788B2 (en) 2003-02-27 2010-03-16 Neurosearch A/S Diazabicyclic aryl derivatives
BRPI0412382A (pt) 2003-07-08 2006-09-19 Astrazeneca Ab composto , método para a verificação de novos compostos medicinais que se ligam a e modulam a atividade, por agonismo , agonismo parcial, ou antagonismo, do receptor de acetilcolina nicotìnico alfa7, método de tratamento ou profilaxia de uma doença ou condição humana, método para tratamento de jetlag, induzindo interrupção de fumar, vìcio em nicotina, abstinência, dor, e para colite ulcerativa, composição farmacêutica, e, método de tratamento ou prevenção de uma condição ou distúrbio que surge da disfunção de neurotransmissão do receptor de acetilcolina nicotìnico em um mamìfero, e, uso de um composto
BRPI0414633A (pt) 2003-09-25 2006-11-07 Astrazeneca Ab composto, composição de diagnóstico, método para a doagnose de doenças ou condições, e, kit
JP4855264B2 (ja) 2003-10-21 2012-01-18 アストラゼネカ・アクチエボラーグ スピロフロピリジンアリール誘導体
US20050137398A1 (en) 2003-12-22 2005-06-23 Jianguo Ji 3-Quinuclidinyl heteroatom bridged biaryl derivatives
US7160876B2 (en) 2003-12-22 2007-01-09 Abbott Laboratories Fused bicycloheterocycle substituted quinuclidine derivatives
US20050245531A1 (en) 2003-12-22 2005-11-03 Abbott Laboratories Fused bicycloheterocycle substituted quinuclidine derivatives
US20050137203A1 (en) 2003-12-22 2005-06-23 Jianguo Ji 3-quinuclidinyl amino-substituted biaryl derivatives
US20050137217A1 (en) 2003-12-22 2005-06-23 Jianguo Ji Spirocyclic quinuclidinic ether derivatives
JP2007520527A (ja) * 2004-02-04 2007-07-26 ノイロサーチ アクティーゼルスカブ ニコチン性アセチルコリン受容体リガンドとしてのジアザ２環式アリール誘導体
CA2567977A1 (en) 2004-04-22 2006-01-05 Memory Pharmaceutical Corporation Indoles, 1h-indazoles, 1,2-benzisoxazoles, 1,2-benzoisothiazoles, and preparation and uses thereof
EP1745046B1 (en) 2004-05-07 2011-04-13 Memory Pharmaceuticals Corporation 1 h-indazoles, benzothiazoles, 1,2-benziosoxazoles, 1,2-benzoisothiazoles, and chromones and preparation and uses thereof
JP2008517032A (ja) * 2004-10-20 2008-05-22 ノイロサーチ アクティーゼルスカブ 新規なジアザ二環式アリール誘導体及びその医薬用途
JP2008524208A (ja) 2004-12-15 2008-07-10 アストラゼネカ・アクチエボラーグ ニコチン性アセチルコリン受容体リガンド
AU2005319248A1 (en) * 2004-12-22 2006-06-29 Memory Pharmaceuticals Corporation Nicotinic alpha-7 receptor ligands and preparation and uses thereof
EP1891036A4 (en) 2005-06-07 2010-08-04 Univ Florida SELECTIVE LIGANDS OF THE ALPHA 7 NICOTINIC RECEPTOR
WO2007024814A1 (en) 2005-08-22 2007-03-01 Targacept, Inc. HETEROARYL-SUBSTiTUTED DIAZATRICYCLOALKANES, METHODS FOR ITS PREPARATION AND USE THEREOF
JP2009509964A (ja) 2005-09-23 2009-03-12 メモリー・ファーマシューティカルズ・コーポレイション インダゾール類、ベンゾチアゾール類、ベンゾイソオキサゾール類、ピラゾロピリジン類、イソチアゾロピリジン類、およびそれらの製造と用途
US8316104B2 (en) * 2005-11-15 2012-11-20 California Institute Of Technology Method and apparatus for collaborative system
SA08290475B1 (ar) * 2007-08-02 2013-06-22 Targacept Inc (2s، 3r)-n-(2-((3-بيردينيل)ميثيل)-1-آزا بيسيكلو[2، 2، 2]أوكت-3-يل)بنزو فيوران-2-كربوكساميد، وصور أملاحه الجديدة وطرق استخدامه
US20110059947A1 (en) * 2008-02-13 2011-03-10 Targacept, Inc. Alpha 7 nicotinic agonists and antipsychotics

Also Published As

Publication number Publication date
JP2013231070A (ja) 2013-11-14
ES2611139T3 (es) 2017-05-05
KR20100051684A (ko) 2010-05-17
HRP20130286T1 (en) 2013-06-30
AU2008283807B2 (en) 2012-03-29
BRPI0815009A2 (pt) 2015-03-03
CN101784273A (zh) 2010-07-21
EP2465501A1 (en) 2012-06-20
ECSP10010007A (es) 2010-07-30
JP2013231071A (ja) 2013-11-14
HUE030387T2 (en) 2017-05-29
IL218976A0 (en) 2012-05-31
DK2182949T3 (da) 2013-04-02
CO6260080A2 (es) 2011-03-22
JP6106549B2 (ja) 2017-04-05
CA2694504A1 (en) 2009-02-05
SA08290475B1 (ar) 2013-06-22
EP2465501B1 (en) 2016-10-05
DK2431037T3 (en) 2017-02-13
AU2012203288A1 (en) 2012-06-21
UY31265A (es) 2009-12-14
ZA201000719B (en) 2010-11-24
AU2012203288B2 (en) 2013-08-29
CN103172628A (zh) 2013-06-26
EP2182949A1 (en) 2010-05-12
PE20090566A1 (es) 2009-05-13
AU2008283807A1 (en) 2009-02-05
CN101868237A (zh) 2010-10-20
MX346748B (es) 2017-03-29
HK1140968A1 (zh) 2010-10-29
AU2008283813A1 (en) 2009-02-05
ES2606752T3 (es) 2017-03-27
MY148002A (en) 2013-02-28
RU2012140182A (ru) 2014-03-27
TWI429435B (zh) 2014-03-11
CN101784273B (zh) 2017-01-18
US20110263859A1 (en) 2011-10-27
TW200914004A (en) 2009-04-01
CY1113561T1 (el) 2016-06-22
US7981906B2 (en) 2011-07-19
EP2185152A2 (en) 2010-05-19
NZ582828A (en) 2011-09-30
SA112330303B1 (ar) 2014-11-10
US20090048290A1 (en) 2009-02-19
ES2415107T3 (es) 2013-07-24
CN106831755A (zh) 2017-06-13
EP2431037B1 (en) 2016-11-30
US8119659B2 (en) 2012-02-21
CL2008002271A1 (es) 2008-12-19
NZ582986A (en) 2012-01-12
BRPI0814889A2 (pt) 2017-05-23
NO20100078L (no) 2010-02-26
ME01508B (me) 2014-04-20
SI2182949T1 (sl) 2013-10-30
US20150045386A1 (en) 2015-02-12
CO6260081A2 (es) 2011-03-22
EP2484363A1 (en) 2012-08-08
JP2010535251A (ja) 2010-11-18
US8541446B2 (en) 2013-09-24
RU2012140148A (ru) 2014-03-27
JP5358573B2 (ja) 2013-12-04
AR067775A1 (es) 2009-10-21
EP2182949B1 (en) 2013-01-02
PE20121821A1 (es) 2013-01-23
WO2009018511A3 (en) 2009-04-23
EP2431037A1 (en) 2012-03-21
CA2694510A1 (en) 2009-02-05
US20110124678A1 (en) 2011-05-26
JP2010535252A (ja) 2010-11-18
US8846715B2 (en) 2014-09-30
EP2409703A1 (en) 2012-01-25
WO2009018511A2 (en) 2009-02-05
MX2010001293A (es) 2011-02-25
MX346451B (es) 2017-03-17
RS52743B (en) 2013-08-30
TW201402117A (zh) 2014-01-16
US20140024673A1 (en) 2014-01-23
US20120129885A1 (en) 2012-05-24
PT2182949E (pt) 2013-02-14
JP5852611B2 (ja) 2016-02-03
CL2013002226A1 (es) 2013-11-15
CL2013002227A1 (es) 2013-11-08
ECSP10010008A (es) 2010-04-30
NO20100077L (no) 2010-02-26
CA2694504C (en) 2014-01-07
TW201402116A (zh) 2014-01-16
WO2009018505A1 (en) 2009-02-05
PE20121820A1 (es) 2013-01-23
KR20100063043A (ko) 2010-06-10

Similar Documents

Publication Publication Date Title
IL218976A0 (en) (2s,3r) - n - (2 - ((3 - pyridinyl) methyl) - 1 - azabicyclo [2.2.2] oct - 3 - yl) benzofuran - 2 - carboxamide, novel salt forms, and methods of use thereof
ZA200804030B (en) Improved process for the preparation of 4-(benzimidazolylmethylamino)benzamides and the salts thereof
IL192242A0 (en) Improved process for the preparation of the salts of 4-(benzimidazolylmethylamino)-benzamides
ZA200803527B (en) Crystals of laquinimod sodium, and process for the manufacture thereof
NO343929B3 (no) 1-[2-(2,4-dimetylfenylsulfanyl-fenyl]-piperazin som en forbindelse med kombinert serotoninreopptak, 5-HT3- og 5HT1A-aktivitet for behandlingen av kognitiv smerte
DK2389378T3 (da) Fremgangsmåde og terapeutisk anvendelse af (2s,3r)-n-2-((3-pyridinyl)methyl)-1-azabicyclo[2.2.2]oct-3-yl)-3,5-difluorbenzamid
RS52256B2 (sr) Terapeutske upotrebe jedinjenja sa kombinovanim sert, 5-ht3 i 5-ht1a aktivnostima
EP2103214A4 (en) FLOOR OR SEED TREATMENT AGENT CONTAINING A CHINOLINE COMPOUND OR A SALT THEREOF AS ACTIVE SUBSTANCE OR METHOD FOR COMBATING PLANT DISEASES USING THE AGENT
PL378587A1 (pl) Sposób wytwarzania (S)-(-)-2-amino-6-n-propyloamino-4,5,6,7-tetrahydrobenzotiazolu i/lub jego soli
EP2401263A4 (en) SUBSTITUTED AZOL DERIVATIVES, PHARMACEUTICAL COMPOSITION WITH THE DERIVATIVES AND METHOD FOR THE TREATMENT OF MORBUS PARKINSON THEREWITH
SI1954251T1 (sl) Sestavek s počasnim sproščanjem, ki ima kot aktivno učinkovino Fe sol, postopek njegove priprave in uporabe
EP2036909A4 (en) SPIROCYCLOPIPERAZINE QUATERNARY AMMONIUM SALT TYPE COMPOUNDS, PREPARATION METHODS AND USES THEREOF
WO2008051539A3 (en) Processes for preparing palonosetron salts
IL199239A0 (en) Processes for the preparation of 3-(4-(2,4-difluorobenzyloxy)-3-bromo-6-
EP1950198A4 (en) PROCESS FOR PRODUCING BENZYLOXYPYRROLIDINE DERIVATIVE AND PROCESS FOR PRODUCING OPTICALLY ACTIVE HYDROCHLORIDE SALT POWDER OF OPTICALLY ACTIVE BENZYLOXYPYRROLIDINE DERIVATIVE
ZA201000754B (en) (2S,3R)-N-(2-((3-pyridinyl)methyl)-1-azabicyclo[2.2.2]oct-3-yl)benzofuran-2-carboxamide, novel salt forms, and methods of use thereof
IL203377A (en) Methods for Manufacturing (S2, R3) –N – 2) - ((3– Pyridinyl) Methyl) –1 – Azabicyclo [2.2.2] Oct – 3 –Il) Benzoforan - 2 - Carboxamide, Stereoisomeric Enrichment and Intermediates for Methods
FR2897614B1 (fr) Forme cristalline du chlorhydrate de la besipirdine, procedes de preparation et utilisations
IL197013A0 (en) Heterocyclyl pyridyl sulfonamide derivatives, their manufacture and use as pharmaceutical agents
IL200952A0 (en) Substituted sulphonamides, process for their preparation, pharmaceutical composition comprising thereof and their use
WO2008005955A8 (en) Synthesis of heterocyclic compounds