PL1969004T3 - Kompozycje zawierające acylowaną insulinę i cynk oraz sposób wytwarzania tych kompozycji - Google Patents
Kompozycje zawierające acylowaną insulinę i cynk oraz sposób wytwarzania tych kompozycjiInfo
- Publication number
- PL1969004T3 PL1969004T3 PL06841562T PL06841562T PL1969004T3 PL 1969004 T3 PL1969004 T3 PL 1969004T3 PL 06841562 T PL06841562 T PL 06841562T PL 06841562 T PL06841562 T PL 06841562T PL 1969004 T3 PL1969004 T3 PL 1969004T3
- Authority
- PL
- Poland
- Prior art keywords
- compositions
- insulin
- zinc
- making
- acylated insulin
- Prior art date
Links
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical class N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 title abstract 8
- 239000000203 mixture Substances 0.000 title abstract 3
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 title abstract 2
- 238000004519 manufacturing process Methods 0.000 title 1
- 239000011701 zinc Substances 0.000 title 1
- 229910052725 zinc Inorganic materials 0.000 title 1
- 102000004877 Insulin Human genes 0.000 abstract 2
- 108090001061 Insulin Proteins 0.000 abstract 2
- 229940125396 insulin Drugs 0.000 abstract 2
- 101000976075 Homo sapiens Insulin Proteins 0.000 abstract 1
- 229940123452 Rapid-acting insulin Drugs 0.000 abstract 1
- 108010026951 Short-Acting Insulin Proteins 0.000 abstract 1
- PBGKTOXHQIOBKM-FHFVDXKLSA-N insulin (human) Chemical compound C([C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@H]1CSSC[C@H]2C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@H](C(=O)N[C@H](C(N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC=3C=CC(O)=CC=3)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=3C=CC(O)=CC=3)C(=O)N[C@@H](CSSC[C@H](NC(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=3C=CC(O)=CC=3)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=3NC=NC=3)NC(=O)[C@H](CO)NC(=O)CNC1=O)C(=O)NCC(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)O)C(O)=O)C(=O)N[C@@H](CC(N)=O)C(O)=O)=O)CSSC[C@@H](C(N2)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C(C)C)NC(=O)[C@@H](NC(=O)CN)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](NC(=O)[C@@H](N)CC=1C=CC=CC=1)C(C)C)C1=CN=CN1 PBGKTOXHQIOBKM-FHFVDXKLSA-N 0.000 abstract 1
- 239000004026 insulin derivative Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/52—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an inorganic compound, e.g. an inorganic ion that is complexed with the active ingredient
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/28—Insulins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/62—Insulins
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Epidemiology (AREA)
- Toxicology (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Immunology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Inorganic Chemistry (AREA)
- Emergency Medicine (AREA)
- Hematology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Obesity (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP05113021 | 2005-12-28 | ||
| PCT/EP2006/070104 WO2007074133A2 (en) | 2005-12-28 | 2006-12-21 | Compositions comprising an acylated insulin and zinc and method of making the said compositions |
| EP06841562A EP1969004B1 (en) | 2005-12-28 | 2006-12-21 | Compositions comprising an acylated insulin and zinc and method of making the said compositions |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL1969004T3 true PL1969004T3 (pl) | 2012-01-31 |
Family
ID=36888823
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL06841562T PL1969004T3 (pl) | 2005-12-28 | 2006-12-21 | Kompozycje zawierające acylowaną insulinę i cynk oraz sposób wytwarzania tych kompozycji |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US20090074882A1 (OSRAM) |
| EP (2) | EP2505593A1 (OSRAM) |
| JP (3) | JP4808785B2 (OSRAM) |
| CN (1) | CN101389650B (OSRAM) |
| AT (1) | ATE519780T1 (OSRAM) |
| DK (1) | DK1969004T3 (OSRAM) |
| ES (1) | ES2371361T3 (OSRAM) |
| PL (1) | PL1969004T3 (OSRAM) |
| PT (1) | PT1969004E (OSRAM) |
| WO (1) | WO2007074133A2 (OSRAM) |
Families Citing this family (46)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2107069B1 (en) | 2003-08-05 | 2013-01-16 | Novo Nordisk A/S | Novel insulin derivatives |
| WO2006051103A2 (en) * | 2004-11-12 | 2006-05-18 | Novo Nordisk A/S | Stable formulations of peptides |
| EP1846447B1 (en) | 2005-02-02 | 2013-08-21 | Novo Nordisk A/S | Insulin derivatives |
| EP2256130B1 (en) | 2005-02-02 | 2013-09-25 | Novo Nordisk A/S | Novel insulin derivatives |
| EP2505593A1 (en) | 2005-12-28 | 2012-10-03 | Novo Nordisk A/S | Compositions comprising an acylated insulin and zinc and method of making the said compositions |
| DE602007009496D1 (de) * | 2006-02-27 | 2010-11-11 | Novo Nordisk As | Insulinderivate |
| MX2008014061A (es) * | 2006-05-09 | 2008-11-14 | Novo Nordisk As | Derivado de insulina. |
| EP2024390B1 (en) * | 2006-05-09 | 2015-08-19 | Novo Nordisk A/S | Insulin derivative |
| EP2074141B1 (en) | 2006-09-22 | 2016-08-10 | Novo Nordisk A/S | Protease resistant insulin analogues |
| WO2008132224A2 (en) | 2007-04-30 | 2008-11-06 | Novo Nordisk A/S | Method for drying a protein composition, a dried protein composition and a pharmaceutical composition comprising the dried protein |
| CN101677947B (zh) * | 2007-06-13 | 2013-07-17 | 诺沃-诺迪斯克有限公司 | 包含胰岛素衍生物的药物制剂 |
| CN101932601B (zh) * | 2007-11-08 | 2016-08-03 | 诺沃-诺迪斯克有限公司 | 胰岛素衍生物 |
| CA2705821A1 (en) | 2007-11-16 | 2009-05-22 | Novo Nordisk A/S | Pharmaceutical compositions containing insulin and an insulinotropic peptide |
| CN101970477B (zh) | 2008-03-14 | 2014-12-31 | 诺沃-诺迪斯克有限公司 | 蛋白酶稳定的胰岛素类似物 |
| PT2910570T (pt) | 2008-03-18 | 2017-01-24 | Novo Nordisk As | Análogos de insulina acilados, estabilizados contra proteases |
| AU2009309623B9 (en) | 2008-10-30 | 2014-10-02 | Novo Nordisk A/S | Treating diabetes melitus using insulin injections with less than daily injection frequency |
| US10842951B2 (en) | 2010-01-12 | 2020-11-24 | Aerami Therapeutics, Inc. | Liquid insulin formulations and methods relating thereto |
| US9180261B2 (en) | 2010-01-12 | 2015-11-10 | Dance Biopharm Inc. | Preservative free insulin formulations and systems and methods for aerosolizing |
| US20130143803A1 (en) | 2010-05-10 | 2013-06-06 | Novo Nordisk A/S | Process for the Preparation of Insulin-Zinc Complexes |
| EP2632478B1 (en) | 2010-10-27 | 2019-07-24 | Novo Nordisk A/S | Treating diabetes melitus using insulin injections administered with varying injection intervals |
| RU2013123515A (ru) | 2010-10-27 | 2014-12-10 | Ново Нордиск А/С | Лечение сахарного диабета с помощью инъекций инсулина, вводимых с различными интервалами |
| EP2651432A1 (en) | 2010-12-14 | 2013-10-23 | Novo Nordisk A/S | Fast-acting insulin in combination with long-acting insulin |
| MX342922B (es) * | 2011-02-01 | 2016-10-19 | Novo Nordisk As | Purificacion de insulina. |
| CN102675452B (zh) | 2011-03-17 | 2015-09-16 | 重庆富进生物医药有限公司 | 具持续降血糖和受体高结合的人胰岛素及类似物的偶联物 |
| BR112014025132A2 (pt) | 2012-04-11 | 2017-07-11 | Novo Nordisk As | formulações de insulina |
| US9884094B2 (en) | 2012-05-01 | 2018-02-06 | Novo Nordisk A/S | Method of treating diabetes mellitus |
| US20150297573A1 (en) | 2012-10-24 | 2015-10-22 | INSERM (Institut National de la Santé et de la Recherche Médicale) | TPL2 KINASE INHIBITORS FOR PREVENTING OR TREATING DIABETES AND FOR PROMOTING Beta-CELL SURVIVAL |
| KR102367083B1 (ko) | 2012-11-13 | 2022-02-24 | 아도시아 | 치환된 음이온성 화합물을 포함하는 속효성 인슐린 제형 |
| JP6755175B2 (ja) * | 2013-03-20 | 2020-09-16 | ノヴォ ノルディスク アー／エス | インスリン投薬レジメン |
| WO2014177623A1 (en) | 2013-04-30 | 2014-11-06 | Novo Nordisk A/S | Novel administration regime |
| PT3055325T (pt) | 2013-10-07 | 2018-04-06 | Novo Nordisk As | Novo derivado de um análogo de insulina |
| SG11201604708VA (en) * | 2014-01-09 | 2016-07-28 | Sanofi Sa | Stabilized glycerol free pharmaceutical formulations of insulin analogues and/or insulin derivatives |
| AR099569A1 (es) | 2014-02-28 | 2016-08-03 | Novo Nordisk As | Derivados de insulina y los usos médicos de estos |
| ES2630106T3 (es) | 2014-10-07 | 2017-08-18 | Cyprumed Gmbh | Formulaciones farmacéuticas para la administración oral de fármacos peptídicos o proteicos |
| CN107530372A (zh) * | 2015-02-25 | 2018-01-02 | 当斯生物制药有限公司 | 液体胰岛素制剂及与其相关的方法 |
| US10426818B2 (en) | 2015-03-24 | 2019-10-01 | Inserm (Institut National De La Sante Et De La Recherche Medicale) | Method and pharmaceutical composition for use in the treatment of diabetes |
| US10815287B2 (en) | 2016-08-02 | 2020-10-27 | Jiangsu Hengrui Medicine Co., Ltd. | Acylated derivative of human insulin or analogue thereof |
| PT3554534T (pt) * | 2016-12-16 | 2021-11-05 | Novo Nordisk As | Composições farmacêuticas contendo insulina |
| TWI740099B (zh) * | 2018-02-01 | 2021-09-21 | 大陸商江蘇恒瑞醫藥股份有限公司 | 含人胰島素類似物的醯化衍生物的藥物組合物及其製備方法 |
| TWI742377B (zh) | 2018-05-24 | 2021-10-11 | 大陸商江蘇恒瑞醫藥股份有限公司 | 一種重組人胰島素或其類似物的前驅物的製備方法 |
| US10335464B1 (en) | 2018-06-26 | 2019-07-02 | Novo Nordisk A/S | Device for titrating basal insulin |
| US12343383B2 (en) | 2019-07-12 | 2025-07-01 | Novo Nordisk A/S | High concentration insulin formulation |
| WO2021185304A1 (zh) * | 2020-03-18 | 2021-09-23 | 东莞市东阳光生物药研发有限公司 | 制备长脂肪链二酸衍生物的方法及其应用 |
| CN116583531A (zh) * | 2020-11-27 | 2023-08-11 | 江苏恒瑞医药股份有限公司 | 一种制备胰岛素或其类似物的酰化衍生物的方法 |
| AU2022300061A1 (en) * | 2021-06-25 | 2024-02-01 | Gan & Lee Pharmaceuticals Co., Ltd. | Acylated insulin-containing pharmaceutical composition |
| CN113896784B (zh) * | 2021-10-18 | 2024-04-16 | 合肥天麦生物科技发展有限公司 | 一种胰岛素结晶的制备方法及其产品 |
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-
2006
- 2006-12-21 EP EP11156145A patent/EP2505593A1/en not_active Withdrawn
- 2006-12-21 PT PT06841562T patent/PT1969004E/pt unknown
- 2006-12-21 JP JP2008547953A patent/JP4808785B2/ja active Active
- 2006-12-21 DK DK06841562.9T patent/DK1969004T3/da active
- 2006-12-21 WO PCT/EP2006/070104 patent/WO2007074133A2/en not_active Ceased
- 2006-12-21 US US12/096,476 patent/US20090074882A1/en not_active Abandoned
- 2006-12-21 EP EP06841562A patent/EP1969004B1/en active Active
- 2006-12-21 PL PL06841562T patent/PL1969004T3/pl unknown
- 2006-12-21 AT AT06841562T patent/ATE519780T1/de active
- 2006-12-21 CN CN2006800535166A patent/CN101389650B/zh not_active Ceased
- 2006-12-21 ES ES06841562T patent/ES2371361T3/es active Active
-
2010
- 2010-08-02 JP JP2010174030A patent/JP5026567B2/ja active Active
-
2011
- 2011-01-19 JP JP2011008924A patent/JP2011121963A/ja not_active Withdrawn
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2014
- 2014-07-16 US US14/332,906 patent/US11167035B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| DK1969004T3 (da) | 2011-11-28 |
| US20090074882A1 (en) | 2009-03-19 |
| PT1969004E (pt) | 2011-11-25 |
| CN101389650B (zh) | 2012-10-10 |
| ES2371361T3 (es) | 2011-12-30 |
| US11167035B2 (en) | 2021-11-09 |
| EP1969004A2 (en) | 2008-09-17 |
| JP2009522231A (ja) | 2009-06-11 |
| EP1969004B1 (en) | 2011-08-10 |
| WO2007074133A2 (en) | 2007-07-05 |
| ATE519780T1 (de) | 2011-08-15 |
| WO2007074133A3 (en) | 2007-10-11 |
| JP2011006428A (ja) | 2011-01-13 |
| EP2505593A1 (en) | 2012-10-03 |
| JP5026567B2 (ja) | 2012-09-12 |
| CN101389650A (zh) | 2009-03-18 |
| JP2011121963A (ja) | 2011-06-23 |
| US20140328943A1 (en) | 2014-11-06 |
| JP4808785B2 (ja) | 2011-11-02 |
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