ATE471144T1 - Intranasale verabreichung von schnell wirkendem insulin - Google Patents

Intranasale verabreichung von schnell wirkendem insulin

Info

Publication number
ATE471144T1
ATE471144T1 AT06826368T AT06826368T ATE471144T1 AT E471144 T1 ATE471144 T1 AT E471144T1 AT 06826368 T AT06826368 T AT 06826368T AT 06826368 T AT06826368 T AT 06826368T AT E471144 T1 ATE471144 T1 AT E471144T1
Authority
AT
Austria
Prior art keywords
rapid
intranasal administration
acting insulin
insulin
human insulin
Prior art date
Application number
AT06826368T
Other languages
English (en)
Inventor
Steven Quay
Annemarie Cohen
Henry Costantino
Shu-Chih Chen Quay
Anthony SILENO
Mary Kleppe
Original Assignee
Mdrna Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mdrna Inc filed Critical Mdrna Inc
Application granted granted Critical
Publication of ATE471144T1 publication Critical patent/ATE471144T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/28—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0043—Nose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/40—Cyclodextrins; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
AT06826368T 2005-10-20 2006-10-20 Intranasale verabreichung von schnell wirkendem insulin ATE471144T1 (de)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US72887705P 2005-10-20 2005-10-20
US77872406P 2006-03-03 2006-03-03
US80690406P 2006-07-10 2006-07-10
US82152506P 2006-08-04 2006-08-04
US82587606P 2006-09-15 2006-09-15
PCT/US2006/041081 WO2007047948A2 (en) 2005-10-20 2006-10-20 Intranasal administration of rapid acting insulin

Publications (1)

Publication Number Publication Date
ATE471144T1 true ATE471144T1 (de) 2010-07-15

Family

ID=37898816

Family Applications (1)

Application Number Title Priority Date Filing Date
AT06826368T ATE471144T1 (de) 2005-10-20 2006-10-20 Intranasale verabreichung von schnell wirkendem insulin

Country Status (10)

Country Link
US (1) US20100210506A1 (de)
EP (1) EP1951198B1 (de)
JP (1) JP2009512709A (de)
KR (1) KR20080064171A (de)
AT (1) ATE471144T1 (de)
AU (1) AU2006304757A1 (de)
CA (1) CA2626357A1 (de)
DE (1) DE602006014990D1 (de)
IL (1) IL190838A0 (de)
WO (1) WO2007047948A2 (de)

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US20080090753A1 (en) 2004-03-12 2008-04-17 Biodel, Inc. Rapid Acting Injectable Insulin Compositions
JP4808785B2 (ja) 2005-12-28 2011-11-02 ノボ・ノルデイスク・エー／エス インスリン組成物および組成物の製造方法
KR101729986B1 (ko) 2006-09-22 2017-04-25 노보 노르디스크 에이/에스 프로테아제 내성 인슐린 유사체
WO2008132224A2 (en) 2007-04-30 2008-11-06 Novo Nordisk A/S Method for drying a protein composition, a dried protein composition and a pharmaceutical composition comprising the dried protein
US20100120660A1 (en) * 2007-04-30 2010-05-13 Per Balschmidt Highly concentrated insulin solutions and compositions
EP2164458A1 (de) * 2007-06-01 2010-03-24 Novo Nordisk A/S Stabile nichtwässrige pharmazeutische zusammensetzungen
US20110144010A1 (en) * 2007-06-01 2011-06-16 Novo Nordisk A/S Spontaneously Dispersible Preconcentrates Including a Peptide Drug in a Solid or Semisolid Carrier
WO2009112583A2 (en) 2008-03-14 2009-09-17 Novo Nordisk A/S Protease-stabilized insulin analogues
EP2910569B1 (de) 2008-03-18 2016-10-05 Novo Nordisk A/S Proteasestabilisierte, acylierte Insulinanaloga
TWI394580B (zh) * 2008-04-28 2013-05-01 Halozyme Inc 超快起作用胰島素組成物
US8895033B2 (en) * 2008-09-04 2014-11-25 Amylin Pharmaceuticals, Llc Sustained release formulations using non-aqueous carriers
US9603904B2 (en) 2008-10-30 2017-03-28 Novo Nordisk A/S Treating diabetes melitus using insulin injections with less than daily injection frequency
US9060927B2 (en) 2009-03-03 2015-06-23 Biodel Inc. Insulin formulations for rapid uptake
US20130269684A1 (en) 2012-04-16 2013-10-17 Dance Pharmaceuticals, Inc. Methods and systems for supplying aerosolization devices with liquid medicaments
US10842951B2 (en) 2010-01-12 2020-11-24 Aerami Therapeutics, Inc. Liquid insulin formulations and methods relating thereto
US8950394B2 (en) * 2010-01-12 2015-02-10 Dance Biopharm Inc. Preservative-free single dose inhaler systems
US9545488B2 (en) 2010-01-12 2017-01-17 Dance Biopharm Inc. Preservative-free single dose inhaler systems
WO2011094632A1 (en) * 2010-01-29 2011-08-04 The Uab Research Foundation Method for administration of insulin and pharmaceutical composition thereof
PT2627173E (pt) 2010-10-12 2015-07-24 Medicines Co Formulações de clevidipina em emulsão contendo agentes antimicrobianos
US8658676B2 (en) 2010-10-12 2014-02-25 The Medicines Company Clevidipine emulsion formulations containing antimicrobial agents
RU2013123515A (ru) 2010-10-27 2014-12-10 Ново Нордиск А/С Лечение сахарного диабета с помощью инъекций инсулина, вводимых с различными интервалами
WO2012065996A1 (en) * 2010-11-15 2012-05-24 Sanofi-Aventis Deutschland Gmbh PHARMACEUTICAL FORMULATION COMPRISING INSULIN GLARGINE AND MALTOSYL-ß-CYCLODEXTRIN
WO2012066086A1 (en) * 2010-11-17 2012-05-24 Sanofi-Aventis Deutschland Gmbh PHARMACEUTICAL FORMULATION COMPRISING INSULIN GLARGINE AND SULFOBUTYL ETHER 7-ß-CYCLODEXTRIN
US9993529B2 (en) 2011-06-17 2018-06-12 Halozyme, Inc. Stable formulations of a hyaluronan-degrading enzyme
NZ717728A (en) * 2011-06-17 2016-04-29 Halozyme Inc Stable formulations of a hyaluronan-degrading enzyme
EP2804621A4 (de) * 2012-01-20 2015-11-18 Univ Case Western Reserve Glutaminsäurestabilisierte insulinanaloga
EP2836508B1 (de) 2012-04-11 2016-06-29 Novo Nordisk A/S Insulinformulierungen
EP2991672A1 (de) 2013-04-30 2016-03-09 Novo Nordisk A/S Neuartiges verabreichungsschema
MX366636B (es) 2013-10-07 2019-07-17 Novo Nordisk As Nuevo derivado de un análogo de insulina.
US10471222B2 (en) 2014-07-01 2019-11-12 Dance Biopharm Inc. Aerosolization system with flow restrictor and feedback device
US11273271B2 (en) 2014-07-01 2022-03-15 Aerami Therapeutics, Inc. Aerosolization system with flow restrictor and feedback device
US10857313B2 (en) 2014-07-01 2020-12-08 Aerami Therapeutics, Inc. Liquid nebulization systems and methods
CN107530372A (zh) 2015-02-25 2018-01-02 当斯生物制药有限公司 液体胰岛素制剂及与其相关的方法
US10821156B2 (en) 2016-04-12 2020-11-03 Cell and Molecular Tissue Engineering, LLC Systems, methods and products for minimizing tissue reactions and tissue injury at an infusion site
GB201607918D0 (en) * 2016-05-06 2016-06-22 Arecor Ltd Novel formulations
RU2758367C2 (ru) 2016-12-16 2021-10-28 Ново Нордиск А/С Фармацевтические композиции, содержащие инсулин
US10335464B1 (en) 2018-06-26 2019-07-02 Novo Nordisk A/S Device for titrating basal insulin
CA3159941A1 (en) * 2019-11-08 2021-05-14 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Compositions comprising antimicrobial peptides
US11585042B2 (en) 2020-09-30 2023-02-21 Haier Us Appliance Solutions, Inc. Dryer appliance with additive dispenser

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US4179337A (en) * 1973-07-20 1979-12-18 Davis Frank F Non-immunogenic polypeptides
CA1291036C (en) * 1986-04-23 1991-10-22 Edwin I. Stoltz Nasal administration of drugs
US4789660A (en) * 1987-09-10 1988-12-06 American Home Products Corporation Insulin administration using methyl and propyl paraben
BE1006873A6 (nl) * 1993-03-26 1995-01-10 Merkus Franciscus W H M Toedieningsformulering voor nasale insuline toediening.
US20010003739A1 (en) * 1993-06-24 2001-06-14 Astrazeneca Ab Systemic administration of a therapeutic preparation
CO4750643A1 (es) * 1997-06-13 1999-03-31 Lilly Co Eli Formulacion estable de la insulina que contiene l-arginina y protamina
ES2173679T3 (es) * 1999-01-27 2002-10-16 Idea Ag Inmunizacion/transporte transnasal con vehiculos altamente adaptables.
SG135204A1 (en) * 2003-07-18 2007-09-28 Baxter Int Methods for fabrication, uses and compositions of small spherical particles prepared by controlled phase separation
EP2046284A1 (de) * 2006-08-04 2009-04-15 Nastech Pharmaceutical Company Inc. Zusammensetzungen zur intranasalen abgabe von menschlichem insulin und ihre verwendungen

Also Published As

Publication number Publication date
WO2007047948A3 (en) 2007-10-11
KR20080064171A (ko) 2008-07-08
US20100210506A1 (en) 2010-08-19
WO2007047948A2 (en) 2007-04-26
JP2009512709A (ja) 2009-03-26
AU2006304757A1 (en) 2007-04-26
IL190838A0 (en) 2008-11-03
EP1951198A2 (de) 2008-08-06
EP1951198B1 (de) 2010-06-16
CA2626357A1 (en) 2007-04-26
DE602006014990D1 (de) 2010-07-29

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