EA200802012A1 - Фармацевтические препараты в форме раствора для дозирующих ингаляторов под давлением - Google Patents
Фармацевтические препараты в форме раствора для дозирующих ингаляторов под давлениемInfo
- Publication number
- EA200802012A1 EA200802012A1 EA200802012A EA200802012A EA200802012A1 EA 200802012 A1 EA200802012 A1 EA 200802012A1 EA 200802012 A EA200802012 A EA 200802012A EA 200802012 A EA200802012 A EA 200802012A EA 200802012 A1 EA200802012 A1 EA 200802012A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- solution
- under pressure
- pharmaceutical preparations
- active drug
- drug substances
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
- A61K9/008—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy comprising drug dissolved or suspended in liquid propellant for inhalation via a pressurized metered dose inhaler [MDI]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A61K31/138—Aryloxyalkylamines, e.g. propranolol, tamoxifen, phenoxybenzamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
- A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4704—2-Quinolinones, e.g. carbostyril
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
- A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/12—Aerosols; Foams
- A61K9/124—Aerosols; Foams characterised by the propellant
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Abstract
Изобретение относится к применению препарата в форме раствора для дозирующих ингаляторов под давлением, способных обеспечить доставку терапевтических доз двух или более активных лекарственных веществ в легкое, для изготовления лекарственного средства для предупреждения или лечения тяжелого бронхолегочного заболевания, где все активные лекарственные вещества полностью растворены в препарате, а также два или более активных лекарственных вещества доставляются, по существу, с одинаковым распределением частиц по размерам.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US11/408,026 US20060257324A1 (en) | 2000-05-22 | 2006-04-21 | Pharmaceutical solution formulations for pressurised metered dose inhalers |
PCT/EP2007/003420 WO2007121913A2 (en) | 2006-04-21 | 2007-04-19 | Pharmaceutical solution formulations for pressurised metered dose inhalers |
Publications (2)
Publication Number | Publication Date |
---|---|
EA200802012A1 true EA200802012A1 (ru) | 2009-04-28 |
EA016262B1 EA016262B1 (ru) | 2012-03-30 |
Family
ID=38230023
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA200802012A EA016262B1 (ru) | 2006-04-21 | 2007-04-19 | Фармацевтические препараты в форме раствора для дозирующих ингаляторов под давлением |
Country Status (21)
Country | Link |
---|---|
US (4) | US20060257324A1 (ru) |
EP (1) | EP2010190B1 (ru) |
JP (1) | JP5289306B2 (ru) |
KR (1) | KR101311662B1 (ru) |
CN (4) | CN106074359A (ru) |
AU (1) | AU2007241336C1 (ru) |
BR (1) | BRPI0709510A2 (ru) |
CA (1) | CA2649556C (ru) |
CY (1) | CY1114215T1 (ru) |
DK (1) | DK2010190T3 (ru) |
EA (1) | EA016262B1 (ru) |
ES (1) | ES2424753T3 (ru) |
HR (1) | HRP20130835T1 (ru) |
ME (1) | ME02342B (ru) |
MX (1) | MX2008013460A (ru) |
PL (1) | PL2010190T3 (ru) |
PT (1) | PT2010190E (ru) |
RS (1) | RS52940B (ru) |
SI (1) | SI2010190T1 (ru) |
WO (1) | WO2007121913A2 (ru) |
ZA (1) | ZA200808965B (ru) |
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US20060257324A1 (en) * | 2000-05-22 | 2006-11-16 | Chiesi Farmaceutici S.P.A. | Pharmaceutical solution formulations for pressurised metered dose inhalers |
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GB0323684D0 (en) | 2003-10-09 | 2003-11-12 | Jagotec Ag | Improvements in or relating to organic compounds |
MXPA06013189A (es) * | 2004-05-13 | 2007-02-14 | Chiesi Farma Spa | Productos medicinales de formulacion en aerosol que tienen estabilidad quimica mejorada. |
GB0501956D0 (en) * | 2005-01-31 | 2005-03-09 | Arrow Internat | Nebulizer formulation |
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US20100291221A1 (en) * | 2009-05-15 | 2010-11-18 | Robert Owen Cook | Method of administering dose-sparing amounts of formoterol fumarate-budesonide combination particles by inhalation |
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GB0918149D0 (en) * | 2009-10-16 | 2009-12-02 | Jagotec Ag | Improved medicinal aerosol formulation |
GB0918150D0 (en) * | 2009-10-16 | 2009-12-02 | Jagotec Ag | Improved formulations |
EA021917B1 (ru) * | 2009-12-23 | 2015-09-30 | КЬЕЗИ ФАРМАЧЕУТИЧИ С.п.А. | Комбинированная терапия астмы и copd |
EP2515856B1 (en) * | 2009-12-23 | 2014-04-02 | Chiesi Farmaceutici S.p.A. | Aerosol Formulation for COPD |
CA2785349C (en) * | 2009-12-23 | 2018-07-03 | Chiesi Farmaceutici S.P.A. | Combination therapy for copd |
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RU2568882C2 (ru) * | 2010-07-16 | 2015-11-20 | Сипла Лимитед | Фармацевтические композиции |
GB201200525D0 (en) * | 2011-12-19 | 2012-02-29 | Teva Branded Pharmaceutical Prod R & D Inc | An inhalable medicament |
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US10034866B2 (en) | 2014-06-19 | 2018-07-31 | Teva Branded Pharmaceutical Products R&D, Inc. | Inhalable medicament comprising tiotropium |
GB201515310D0 (en) * | 2015-08-27 | 2015-10-14 | Jagotec Ag | Pharmaceutical composition |
BR122020022602B1 (pt) | 2015-12-04 | 2024-03-05 | Mexichem Fluor S.A. De C.V. | Composição farmacêutica |
BR112019005133A2 (pt) | 2016-09-19 | 2019-06-04 | Mexichem Fluor Sa De Cv | composição farmacêutica, recipiente vedado, inalador de dose medida, e, métodos para tratar um paciente sofrendo ou susceptível de sofrer de um distúrbio respiratório, para melhorar a estabilidade de uma composição farmacêutica, para melhoria do desempenho de dispersão em aerossol de uma composição farmacêutica e para reduzir o potencial de aquecimento global de uma composição farmacêutica. |
MX2019003099A (es) | 2016-09-19 | 2019-06-10 | Mexichem Fluor Sa De Cv | Composicion farmaceutica. |
ES2891579T3 (es) | 2016-09-19 | 2022-01-28 | Mexichem Fluor Sa De Cv | Composición farmacéutica |
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IL265349B2 (en) * | 2016-09-19 | 2023-03-01 | Mexichem Fluor Sa De Cv | Pharmaceutical composition |
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-
2006
- 2006-04-21 US US11/408,026 patent/US20060257324A1/en not_active Abandoned
-
2007
- 2007-04-19 KR KR1020087018846A patent/KR101311662B1/ko active IP Right Grant
- 2007-04-19 BR BRPI0709510-4A patent/BRPI0709510A2/pt not_active Application Discontinuation
- 2007-04-19 MX MX2008013460A patent/MX2008013460A/es active IP Right Grant
- 2007-04-19 CN CN201610483860.4A patent/CN106074359A/zh active Pending
- 2007-04-19 WO PCT/EP2007/003420 patent/WO2007121913A2/en active Application Filing
- 2007-04-19 CA CA2649556A patent/CA2649556C/en active Active
- 2007-04-19 DK DK07724357.4T patent/DK2010190T3/da active
- 2007-04-19 JP JP2009505773A patent/JP5289306B2/ja active Active
- 2007-04-19 CN CNA2007800069518A patent/CN101389341A/zh active Pending
- 2007-04-19 PL PL07724357T patent/PL2010190T3/pl unknown
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2008
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