PE20160999A1 - Metodos para administrar anticuerpos anti-tnf-alfa - Google Patents
Metodos para administrar anticuerpos anti-tnf-alfaInfo
- Publication number
- PE20160999A1 PE20160999A1 PE2016001292A PE2016001292A PE20160999A1 PE 20160999 A1 PE20160999 A1 PE 20160999A1 PE 2016001292 A PE2016001292 A PE 2016001292A PE 2016001292 A PE2016001292 A PE 2016001292A PE 20160999 A1 PE20160999 A1 PE 20160999A1
- Authority
- PE
- Peru
- Prior art keywords
- seq
- tnf
- dosage forms
- alpha antibody
- methods
- Prior art date
Links
- 239000006203 subcutaneous dosage form Substances 0.000 abstract 3
- 150000001413 amino acids Chemical group 0.000 abstract 2
- FBOZXECLQNJBKD-ZDUSSCGKSA-N L-methotrexate Chemical compound C=1N=C2N=C(N)N=C(N)C2=NC=1CN(C)C1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 FBOZXECLQNJBKD-ZDUSSCGKSA-N 0.000 abstract 1
- 239000002552 dosage form Substances 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 239000003937 drug carrier Substances 0.000 abstract 1
- 229960000485 methotrexate Drugs 0.000 abstract 1
- 229940071643 prefilled syringe Drugs 0.000 abstract 1
- 229940124597 therapeutic agent Drugs 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
- C07K16/241—Tumor Necrosis Factors
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- A—HUMAN NECESSITIES
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
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- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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- C—CHEMISTRY; METALLURGY
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- C07K—PEPTIDES
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- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
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Abstract
Se refiere a formas de dosificacion subcutanea que comprenden 40 mg de un anticuerpo antiTNFalfa humano, dicho anticuerpo se caracteriza porque comprende: a) una region variable de cadena liviana (LCVR) cuyos dominios CDR3, CDR2 y CDR1 comprenden secuencias de aminoacidos de SEQ ID NO: 3, SEQ ID NO: 5 y SEQ ID NO: 7, respectivamente; b) una region variable de cadena pesada (HCVR) cuyos dominios CDR3, CDR2 y CDR1 comprenden secuencias de aminoacidos de SEQ ID NO: 4, SEQ ID NO: 6 y SEQ ID NO: 8, respectivamente; y al menos un vehiculo farmaceuticamente aceptable. En un aspecto, la forma de dosificacion subcutanea es una jeringa precargada que comprende dicho anticuerpo antiTNFalfa. En un aspecto preferido, el anticuerpo antiTNFalfa es D2E7. Opcionalmente, dichas formas de dosificacion comprenden un agente terapeutico adicional, preferentemente metotrexato. Tambien se refiere a kits que comprenden dichas formas de dosificacion subcutanea
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US29696101P | 2001-06-08 | 2001-06-08 |
Publications (1)
Publication Number | Publication Date |
---|---|
PE20160999A1 true PE20160999A1 (es) | 2016-10-08 |
Family
ID=23144283
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2016001292A PE20160999A1 (es) | 2001-06-08 | 2002-06-07 | Metodos para administrar anticuerpos anti-tnf-alfa |
PE2002000478A PE20030065A1 (es) | 2001-06-08 | 2002-06-07 | Metodos para administrar anticuerpos anti-tnfalfa |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2002000478A PE20030065A1 (es) | 2001-06-08 | 2002-06-07 | Metodos para administrar anticuerpos anti-tnfalfa |
Country Status (33)
Country | Link |
---|---|
US (16) | US8889135B2 (es) |
EP (6) | EP1406656B1 (es) |
JP (7) | JP2005517629A (es) |
KR (8) | KR101497363B1 (es) |
CN (5) | CN101574520A (es) |
AR (3) | AR034429A1 (es) |
AU (1) | AU2002314922C1 (es) |
BG (2) | BG66459B1 (es) |
BR (1) | BR0206289A (es) |
CA (3) | CA2385745C (es) |
CL (1) | CL2012000856A1 (es) |
CY (1) | CY1120540T1 (es) |
CZ (1) | CZ309160B6 (es) |
DK (2) | DK1406656T3 (es) |
EC (1) | ECSP034867A (es) |
ES (2) | ES2612436T3 (es) |
HK (1) | HK1065471A1 (es) |
HU (1) | HU230947B1 (es) |
IL (4) | IL158831A0 (es) |
LT (1) | LT2940044T (es) |
MX (2) | MXPA03011316A (es) |
NO (2) | NO334490B1 (es) |
NZ (6) | NZ573478A (es) |
PE (2) | PE20160999A1 (es) |
PH (3) | PH12013500297A1 (es) |
PL (4) | PL217702B1 (es) |
PT (2) | PT1406656E (es) |
SA (1) | SA02230384B1 (es) |
SI (2) | SI2940044T1 (es) |
SK (1) | SK288509B6 (es) |
TW (1) | TWI473622B (es) |
WO (1) | WO2002100330A2 (es) |
ZA (1) | ZA200308861B (es) |
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