PE20030065A1 - Metodos para administrar anticuerpos anti-tnfalfa - Google Patents
Metodos para administrar anticuerpos anti-tnfalfaInfo
- Publication number
- PE20030065A1 PE20030065A1 PE2002000478A PE2002000478A PE20030065A1 PE 20030065 A1 PE20030065 A1 PE 20030065A1 PE 2002000478 A PE2002000478 A PE 2002000478A PE 2002000478 A PE2002000478 A PE 2002000478A PE 20030065 A1 PE20030065 A1 PE 20030065A1
- Authority
- PE
- Peru
- Prior art keywords
- antigen
- tnfo
- refers
- antibody
- recombining
- Prior art date
Links
- 150000001413 amino acids Chemical group 0.000 abstract 1
- 239000000427 antigen Substances 0.000 abstract 1
- 102000036639 antigens Human genes 0.000 abstract 1
- 108091007433 antigens Proteins 0.000 abstract 1
- 231100000135 cytotoxicity Toxicity 0.000 abstract 1
- 238000000338 in vitro Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
- C07K16/241—Tumor Necrosis Factors
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- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
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- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
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- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
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Abstract
SE REFIERE AL USO DE UNA COMPOSICION QUE CONTIENE UN ANTICUERPO ANTI-TNFO O UNA PORCION DE UNION A ANTIGENO DEL MISMO QUE SE DISOCIA CON UNA CONSTANTE DE VELOCIDAD Koff DE 5 x 10 -4 s-1. LA PORCION DE UNION A ANTIGENO DEL MISMO NEUTRALIZA LA CITOXICIDAD CAUSADA POR EL TNFO HUMANO EN UN ENSAYO COMUN IN VITRO L929 CON UNA IC50 DE 1x10 -9 M O MENOS Y ES UN ANTICUERPO RECOMBINANTE O UNA PORCION RECOMBINANTE DE UNION A ANTIGENO DEL MISMO. SE REFIERE TAMBIEN A COMPOSICIONES FARMACEUTICAS QUE SE USAN EN UN REGIMEN DE DOSIFICACION CADA DOS SEMANAS PARA INHIBIR LA ACTIVIDAD DE TNFO EN UN SUJETO DONDE DICHO ANTICUERPO TIENE LAS SIGUIENTES CARACTERISTICAS: a) SE DISOCIA DEL TNFO HUMANO CON UNA CONSTANTE DE VELOCIDAD Koff DE 1 x 10 -3 s-1; b) TIENE UN DOMINIO DE CADENA LIVIANA CDR3 QUE COMPRENDE LA SECUENCIA SEQ ID N° 3 Y C) TIENE UN DOMINIO DE CADENA PESADA CDR3 QUE COMPRENDE LA SECUENCIA DE AMINOACIDOS DE SEQ ID N° 4
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US29696101P | 2001-06-08 | 2001-06-08 |
Publications (1)
Publication Number | Publication Date |
---|---|
PE20030065A1 true PE20030065A1 (es) | 2003-02-12 |
Family
ID=23144283
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2016001292A PE20160999A1 (es) | 2001-06-08 | 2002-06-07 | Metodos para administrar anticuerpos anti-tnf-alfa |
PE2002000478A PE20030065A1 (es) | 2001-06-08 | 2002-06-07 | Metodos para administrar anticuerpos anti-tnfalfa |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2016001292A PE20160999A1 (es) | 2001-06-08 | 2002-06-07 | Metodos para administrar anticuerpos anti-tnf-alfa |
Country Status (33)
Country | Link |
---|---|
US (16) | US8889135B2 (es) |
EP (6) | EP1406656B1 (es) |
JP (7) | JP2005517629A (es) |
KR (8) | KR101497363B1 (es) |
CN (5) | CN101574520A (es) |
AR (3) | AR034429A1 (es) |
AU (1) | AU2002314922C1 (es) |
BG (2) | BG66459B1 (es) |
BR (1) | BR0206289A (es) |
CA (3) | CA2385745C (es) |
CL (1) | CL2012000856A1 (es) |
CY (1) | CY1120540T1 (es) |
CZ (1) | CZ309160B6 (es) |
DK (2) | DK1406656T3 (es) |
EC (1) | ECSP034867A (es) |
ES (2) | ES2612436T3 (es) |
HK (1) | HK1065471A1 (es) |
HU (1) | HU230947B1 (es) |
IL (4) | IL158831A0 (es) |
LT (1) | LT2940044T (es) |
MX (2) | MXPA03011316A (es) |
NO (2) | NO334490B1 (es) |
NZ (6) | NZ573478A (es) |
PE (2) | PE20160999A1 (es) |
PH (3) | PH12013500297A1 (es) |
PL (4) | PL217702B1 (es) |
PT (2) | PT1406656E (es) |
SA (1) | SA02230384B1 (es) |
SI (2) | SI2940044T1 (es) |
SK (1) | SK288509B6 (es) |
TW (1) | TWI473622B (es) |
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