MX341001B - Anticuerpos anti-tnf-alfa para uso en terapia. - Google Patents
Anticuerpos anti-tnf-alfa para uso en terapia.Info
- Publication number
- MX341001B MX341001B MX2011001809A MX2011001809A MX341001B MX 341001 B MX341001 B MX 341001B MX 2011001809 A MX2011001809 A MX 2011001809A MX 2011001809 A MX2011001809 A MX 2011001809A MX 341001 B MX341001 B MX 341001B
- Authority
- MX
- Mexico
- Prior art keywords
- htnfα
- antibody
- methods
- antibodies
- less
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 2
- 230000000694 effects Effects 0.000 abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 abstract 2
- 101000611183 Homo sapiens Tumor necrosis factor Proteins 0.000 abstract 1
- FBOZXECLQNJBKD-ZDUSSCGKSA-N L-methotrexate Chemical compound C=1N=C2N=C(N)N=C(N)C2=NC=1CN(C)C1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 FBOZXECLQNJBKD-ZDUSSCGKSA-N 0.000 abstract 1
- 108060008682 Tumor Necrosis Factor Proteins 0.000 abstract 1
- 102000000852 Tumor Necrosis Factor-alpha Human genes 0.000 abstract 1
- 239000000427 antigen Substances 0.000 abstract 1
- 102000036639 antigens Human genes 0.000 abstract 1
- 108091007433 antigens Proteins 0.000 abstract 1
- 230000001627 detrimental effect Effects 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 208000035475 disorder Diseases 0.000 abstract 1
- 238000010494 dissociation reaction Methods 0.000 abstract 1
- 230000005593 dissociations Effects 0.000 abstract 1
- 102000057041 human TNF Human genes 0.000 abstract 1
- 238000000338 in vitro Methods 0.000 abstract 1
- 238000001727 in vivo Methods 0.000 abstract 1
- 229960000485 methotrexate Drugs 0.000 abstract 1
- 238000007920 subcutaneous administration Methods 0.000 abstract 1
Classifications
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- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
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- C—CHEMISTRY; METALLURGY
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- C07K—PEPTIDES
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
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- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
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Abstract
La presente invención se refiere a un anticuerpo anti-TNF? humano, aislado, para uso en tratamiento de artritis reumatoide moderada a severa en un sujeto humano, en donde el anticuerpo es para ser administrable al sujeto humano en un régimen de dosis bisemanal de 40 mg cada 14 días, en donde el anticuerpo tiene una región variable de cadena ligera (LCVR) que comprende la secuencia de aminoácido de SEQ ID NO: 1, y una región variable de cadena pesada (HCVR) que comprende la secuencia de aminoácido de SEQ ID NO: 2, tiene una región constante de cadena pesada IgG1 y tiene una región constante de cadena ligera kappa, y en donde el anticuerpo es para ser administrable en combinación con metotrexato.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US29696101P | 2001-06-08 | 2001-06-08 |
Publications (1)
Publication Number | Publication Date |
---|---|
MX341001B true MX341001B (es) | 2016-08-03 |
Family
ID=23144283
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MXPA03011316A MXPA03011316A (es) | 2001-06-08 | 2002-06-05 | Metodos para administrar anticuerpod anti-tnfa. |
MX2011001809A MX341001B (es) | 2001-06-08 | 2003-12-08 | Anticuerpos anti-tnf-alfa para uso en terapia. |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MXPA03011316A MXPA03011316A (es) | 2001-06-08 | 2002-06-05 | Metodos para administrar anticuerpod anti-tnfa. |
Country Status (33)
Country | Link |
---|---|
US (16) | US8889135B2 (es) |
EP (6) | EP3190124A1 (es) |
JP (7) | JP2005517629A (es) |
KR (8) | KR20160096222A (es) |
CN (5) | CN1638796A (es) |
AR (3) | AR034429A1 (es) |
AU (1) | AU2002314922C1 (es) |
BG (2) | BG66459B1 (es) |
BR (1) | BR0206289A (es) |
CA (3) | CA2868614A1 (es) |
CL (1) | CL2012000856A1 (es) |
CY (1) | CY1120540T1 (es) |
CZ (1) | CZ309160B6 (es) |
DK (2) | DK2940044T3 (es) |
EC (1) | ECSP034867A (es) |
ES (2) | ES2612436T3 (es) |
HK (1) | HK1065471A1 (es) |
HU (1) | HU230947B1 (es) |
IL (4) | IL158831A0 (es) |
LT (1) | LT2940044T (es) |
MX (2) | MXPA03011316A (es) |
NO (2) | NO334490B1 (es) |
NZ (6) | NZ545649A (es) |
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