PE20140163A1 - Composiciones terapeuticas que comprenden rilpivirina hcl y tenofovir disoproxil fumarato - Google Patents

Composiciones terapeuticas que comprenden rilpivirina hcl y tenofovir disoproxil fumarato

Info

Publication number
PE20140163A1
PE20140163A1 PE2013001214A PE2013001214A PE20140163A1 PE 20140163 A1 PE20140163 A1 PE 20140163A1 PE 2013001214 A PE2013001214 A PE 2013001214A PE 2013001214 A PE2013001214 A PE 2013001214A PE 20140163 A1 PE20140163 A1 PE 20140163A1
Authority
PE
Peru
Prior art keywords
rilpivirin
hcl
therapeutic compositions
compositions including
tenofovir disoproxil
Prior art date
Application number
PE2013001214A
Other languages
English (en)
Inventor
Reza Oliyai
Lauren Wiser
Mark M Menning
Original Assignee
Gilead Sciences Inc
Janssen Randd Ireland
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=45094284&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PE20140163(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Gilead Sciences Inc, Janssen Randd Ireland filed Critical Gilead Sciences Inc
Publication of PE20140163A1 publication Critical patent/PE20140163A1/es

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/2072Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2086Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
    • A61K9/209Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat containing drug in at least two layers or in the core and in at least one outer layer
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/513Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/66Phosphorus compounds
    • A61K31/675Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • A61P31/18Antivirals for RNA viruses for HIV

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Molecular Biology (AREA)
  • AIDS & HIV (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

SE REFIERE A UNA COMPOSICION FARMACEUTICA EN FORMA DE COMPRIMIDO MULTICAPA CUYAS CAPAS COMPRENDEN: A) LA PRIMERA CAPA ES UN RECUBRIMIENTO DE PELICULA POLIMERICA QUE CONTIENE i) RILPIVIRINA HCl EN UNA CANTIDAD DE 27,5 � 1,4 MG, Y ii) EXCIPIENTES TALES COMO CROSCARMELOSA SODICA, POLISORBATO 20, CELULOSA MICROCRISTALINA, ENTRE OTROS; Y B) LA SEGUNDA CAPA CONTIENE i) TENOFOVIR DISOPROXIL FUMARATO EN UNA CANTIDAD DE 300 � 15 MG, ii) EMTRICITABINA EN UNA CANTIDAD DE 200 � 10 MG, Y iii) EXCIPIENTES TALES COMO MONOHIDRATO DE LACTOSA, CROSCARMELOSA SODICA, CELULOSA MICROCRISTALINA, ENTRE OTROS. DICHA COMPOSICION ES UTIL EN EL TRATAMIENTO DE VIH
PE2013001214A 2010-11-19 2011-11-18 Composiciones terapeuticas que comprenden rilpivirina hcl y tenofovir disoproxil fumarato PE20140163A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US41560010P 2010-11-19 2010-11-19

Publications (1)

Publication Number Publication Date
PE20140163A1 true PE20140163A1 (es) 2014-02-08

Family

ID=45094284

Family Applications (3)

Application Number Title Priority Date Filing Date
PE2013001214A PE20140163A1 (es) 2010-11-19 2011-11-18 Composiciones terapeuticas que comprenden rilpivirina hcl y tenofovir disoproxil fumarato
PE2016002828A PE20170521A1 (es) 2010-11-19 2011-11-18 Combinacion farmaceutica que comprende rilpivirina hcl, tenofovir disoproxil fumarato y emtricitabina
PE2021000720A PE20211657A1 (es) 2010-11-19 2011-11-18 Composiciones terapeuticas que comprenden rilpivirina hcl y tenofovir disoproxil fumarato

Family Applications After (2)

Application Number Title Priority Date Filing Date
PE2016002828A PE20170521A1 (es) 2010-11-19 2011-11-18 Combinacion farmaceutica que comprende rilpivirina hcl, tenofovir disoproxil fumarato y emtricitabina
PE2021000720A PE20211657A1 (es) 2010-11-19 2011-11-18 Composiciones terapeuticas que comprenden rilpivirina hcl y tenofovir disoproxil fumarato

Country Status (35)

Country Link
US (1) US10857102B2 (es)
EP (2) EP2640362B2 (es)
JP (2) JP2014500261A (es)
KR (1) KR101923103B1 (es)
CN (2) CN106511357A (es)
AP (1) AP3816A (es)
AR (2) AR084500A1 (es)
AU (3) AU2011329642B2 (es)
BR (1) BR112013012245B1 (es)
CA (1) CA2818097C (es)
CL (1) CL2013001402A1 (es)
CO (1) CO6761300A2 (es)
CR (1) CR20130293A (es)
DK (1) DK2640362T4 (es)
EA (2) EA201691695A1 (es)
EC (2) ECSP13012700A (es)
ES (1) ES2524408T5 (es)
HK (2) HK1190064A1 (es)
HR (1) HRP20140946T1 (es)
IL (1) IL226300B (es)
MA (1) MA34735B1 (es)
ME (1) ME01980B (es)
MX (1) MX347512B (es)
MY (1) MY185604A (es)
NZ (1) NZ610729A (es)
PE (3) PE20140163A1 (es)
PL (1) PL2640362T5 (es)
PT (1) PT2640362E (es)
RS (1) RS53691B1 (es)
SG (3) SG10201912527XA (es)
SM (1) SMT201400150B (es)
TW (1) TWI556840B (es)
UA (1) UA114075C2 (es)
WO (1) WO2012068535A1 (es)
ZA (1) ZA201304481B (es)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2004206821C1 (en) 2003-01-14 2009-10-01 Gilead Sciences, Inc. Compositions and methods for combination antiviral therapy
TWI471145B (zh) 2005-06-13 2015-02-01 Bristol Myers Squibb & Gilead Sciences Llc 單一式藥學劑量型
PL2640362T5 (pl) 2010-11-19 2022-05-02 Gilead Sciences, Inc. Kompozycje terapeutyczne zawierające hcl rylpiwiryny i fumaran dizoproksylu tenofowiru
AR087546A1 (es) 2011-08-16 2014-04-03 Gilead Sciences Inc Hemifumarato de tenofovir alafenamida
CA2779052A1 (en) * 2012-05-31 2013-11-30 Pharmascience Inc. Pharmaceutical composition of entecavir and process of manufacturing
MD4736C1 (ro) 2012-12-21 2021-07-31 Gilead Sciences, Inc. Compus policiclic de carbamoilpiridonă şi utilizarea farmaceutică a acestuia
EP2832351A1 (en) * 2013-07-29 2015-02-04 Sanovel Ilac Sanayi ve Ticaret A.S. Multilayer Tablet Formulations Comprising Tenofovir and Entecavir
CZ2013985A3 (cs) * 2013-12-09 2015-06-17 Zentiva, K.S. Stabilní farmaceutická kompozice obsahující tenofovir disoproxil fumarát
WO2015152433A1 (en) * 2014-03-31 2015-10-08 Hanmi Pharm. Co., Ltd. Amorphous solid dispersion comprising paclitaxel, tablet comprising the same, and method for preparing the same
KR20230130175A (ko) 2014-12-26 2023-09-11 에모리 유니버시티 N4-하이드록시시티딘, 이와 관련된 유도체 및 이의 항 바이러스적 용도
US9839212B2 (en) 2015-04-16 2017-12-12 Bio-Lab, Inc. Multicomponent and multilayer compacted tablets
CA2921336A1 (en) * 2015-06-30 2016-12-30 Gilead Sciences, Inc. Pharmaceutical formulations
KR20170003063A (ko) * 2015-06-30 2017-01-09 한미약품 주식회사 테노포비어 디소프록실 함유 경구용 고형제제 및 그 제조방법
BR102016026127A2 (pt) * 2015-11-09 2017-05-16 Gilead Sciences Inc composições terapêuticas para o tratamento do vírus da imunodeficiência humana
JP2019513754A (ja) * 2016-04-08 2019-05-30 塩野義製薬株式会社 安定化した固形製剤
TR201617448A2 (tr) * 2016-11-29 2018-06-21 Arven Ilac Sanayi Ve Ticaret Anonim Sirketi Tenofovi̇r ve emtri̇si̇tabi̇n i̇çeren kati oral farmasöti̇k bi̇leşi̇mler
US10561614B2 (en) * 2017-01-27 2020-02-18 Steerlife India Private Limited Tenofovir granules
WO2019003150A2 (en) * 2017-06-30 2019-01-03 Viiv Healthcare Company ASSOCIATION, USES AND THERAPEUTIC DIAGRAMS
AU2018378832B9 (en) 2017-12-07 2021-05-27 Emory University N4-hydroxycytidine and derivatives and anti-viral uses related thereto
WO2021001508A1 (en) * 2019-07-03 2021-01-07 Janssen Sciences Ireland Unlimited Company Methods of treating hiv in pediatric patients with rilpivirine
CN112137981A (zh) * 2020-11-02 2020-12-29 成都晶富医药科技有限公司 富马酸丙酚替诺福韦片及其制备工艺

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL100965A (en) 1991-02-22 1999-12-31 Univ Emory 2 - Hydroxymethyl - 5 -) 5 - Fluorocytocin - 1 - Eyal (- 1, 3 - Oxathiolane, its resolution and pharmaceuticals containing it
JO3429B1 (ar) 2001-08-13 2019-10-20 Janssen Pharmaceutica Nv مشتقات برميدينات مثبطة فيروس الايدز
MY169670A (en) 2003-09-03 2019-05-08 Tibotec Pharm Ltd Combinations of a pyrimidine containing nnrti with rt inhibitors
US20030124186A1 (en) 2001-11-27 2003-07-03 Hussain Munir A. Efavirenz tablet formulation having unique biopharmaceutical characteristics
AU2004206821C1 (en) 2003-01-14 2009-10-01 Gilead Sciences, Inc. Compositions and methods for combination antiviral therapy
WO2006024668A1 (en) 2004-09-02 2006-03-09 Janssen Pharmaceutica N.V. Hydrochloride of 4-[[4-[[4-(2-cyanoethenyl)-2,6-dimethylphenyl]amino]-2-pyrimidinyl] amino]benzonitrile
ATE508748T1 (de) 2004-09-02 2011-05-15 Janssen Pharmaceutica Nv Salz von 4-ää4-ää4-(2-cyanoethenyl)-2,6- dimethylphenylüaminoü-2- pyrimidinylüaminoübenzonitril.
TWI471145B (zh) * 2005-06-13 2015-02-01 Bristol Myers Squibb & Gilead Sciences Llc 單一式藥學劑量型
TWI375560B (en) * 2005-06-13 2012-11-01 Gilead Sciences Inc Composition comprising dry granulated emtricitabine and tenofovir df and method for making the same
WO2007047371A2 (en) 2005-10-14 2007-04-26 Microdose Technologies, Inc. Pharmaceutical packaging of an oral dosage combination
US20080317852A1 (en) 2005-12-14 2008-12-25 Amar Lulla Pharmaceutical Combination
EA019893B1 (ru) * 2007-02-23 2014-07-30 Джилид Сайэнс, Инк. Фармацевтическая композиция и способ лечения вич-инфекции
WO2008140461A1 (en) 2007-05-16 2008-11-20 Fmc Corporation Solid form
US20080286344A1 (en) 2007-05-16 2008-11-20 Olivia Darmuzey Solid form
EP2160394A1 (en) 2007-05-22 2010-03-10 Ultimorphix Technologies B.v. Tenofovir disoproxil hemi-fumaric acid co-crystal
WO2009037449A1 (en) 2007-09-18 2009-03-26 Cipla Limited Solid pharmaceutical compositions comprising one or more herpes virus inhibitors and one or more reverse transcriptase inhibitors
WO2009106960A2 (en) 2008-02-27 2009-09-03 Aurobindo Pharma Limited Stable compositions of lamivudine, tenofovir and efavirenz
MX2010011963A (es) 2008-05-02 2010-12-06 Gilead Sciences Inc Uso de particulas trasportadoras solidas para mejorar la capacidad de procesamiento de un agente farmaceutico.
KR101738325B1 (ko) 2009-02-06 2017-05-19 길리애드 사이언시즈, 인코포레이티드 조합 요법용 정제
PT2480552T (pt) 2009-09-21 2017-02-14 Gilead Sciences Inc Análogos de carba-nucleósidos 2¿ -fluoro substituídos para tratamento antiviral
WO2011077100A1 (en) 2009-12-24 2011-06-30 Cipla Limited Antiretroviral composition
PL2640362T5 (pl) 2010-11-19 2022-05-02 Gilead Sciences, Inc. Kompozycje terapeutyczne zawierające hcl rylpiwiryny i fumaran dizoproksylu tenofowiru

Also Published As

Publication number Publication date
AU2011329642B2 (en) 2016-08-11
ZA201304481B (en) 2022-03-30
AU2016208417B2 (en) 2018-04-05
UA114075C2 (xx) 2017-04-25
MX2013005669A (es) 2013-11-04
AU2018202635A1 (en) 2018-05-10
DK2640362T3 (en) 2014-12-01
AU2016208417A1 (en) 2016-08-18
CN103491948A (zh) 2014-01-01
AP3816A (en) 2016-09-30
SMT201400150B (it) 2015-01-15
AR084500A1 (es) 2013-05-22
SG10201912527XA (en) 2020-02-27
ECSP13012700A (es) 2013-08-30
CA2818097A1 (en) 2012-05-24
EP2826466A1 (en) 2015-01-21
TWI556840B (zh) 2016-11-11
PE20211657A1 (es) 2021-08-24
EA025852B1 (ru) 2017-02-28
CL2013001402A1 (es) 2013-12-27
HRP20140946T1 (hr) 2015-02-13
RS53691B1 (en) 2015-04-30
CO6761300A2 (es) 2013-09-30
IL226300B (en) 2019-05-30
AU2011329642A1 (en) 2013-05-02
DK2640362T4 (da) 2022-03-07
ECSP19078196A (es) 2019-11-30
EA201390651A1 (ru) 2013-11-29
ES2524408T5 (es) 2022-04-25
MA34735B1 (fr) 2013-12-03
MX347512B (es) 2017-04-28
MY185604A (en) 2021-05-25
SG10201509521WA (en) 2015-12-30
ES2524408T3 (es) 2014-12-09
KR20140037799A (ko) 2014-03-27
SG190333A1 (en) 2013-06-28
CR20130293A (es) 2013-10-03
PL2640362T5 (pl) 2022-05-02
BR112013012245B1 (pt) 2022-09-27
CN106511357A (zh) 2017-03-22
EP2640362B2 (en) 2021-12-01
US20130243857A1 (en) 2013-09-19
AR123409A2 (es) 2022-11-30
JP6138851B2 (ja) 2017-05-31
ME01980B (me) 2015-05-20
CN103491948B (zh) 2016-11-02
JP2014500261A (ja) 2014-01-09
PE20170521A1 (es) 2017-05-27
PL2640362T3 (pl) 2015-03-31
JP2015131853A (ja) 2015-07-23
CA2818097C (en) 2019-07-30
BR112013012245A2 (pt) 2016-08-09
EP2640362B1 (en) 2014-09-10
HK1206592A1 (en) 2016-01-15
US10857102B2 (en) 2020-12-08
AP2013006931A0 (en) 2013-06-30
WO2012068535A1 (en) 2012-05-24
NZ610729A (en) 2015-10-30
KR101923103B1 (ko) 2018-11-28
TW201238612A (en) 2012-10-01
HK1190064A1 (en) 2014-06-27
EP2640362A1 (en) 2013-09-25
PT2640362E (pt) 2014-11-28
EA201691695A1 (ru) 2017-11-30

Similar Documents

Publication Publication Date Title
PE20140163A1 (es) Composiciones terapeuticas que comprenden rilpivirina hcl y tenofovir disoproxil fumarato
GT201300309A (es) Liberación modificada de 4-metil-3-[[4-(3-piridinil)-2- pirimidinil]-amino]-n-[5-(4-metil -1h-imidazol-1-il)-3-(trifluoro-metil)-fenil]-benzamida solubilizada utilizando ácidos orgánicos
EA201690102A1 (ru) Фармацевтическая композиция, содержащая диметилфумарат, для введения в низкой суточной дозе
CR20140019A (es) Procedimiento para la fabricación de una composición farmacéutica en forma de tabletas de liberación prolongada conteniendo pirfenidona y su aplicación en la regresión de la insuficiencia real crónica, contractura capsular mamaria y ...
ES2916604T1 (es) Ensayos de detección de nrf2 y métodos y composiciones relacionados
EA201291247A1 (ru) ФАРМАЦЕВТИЧЕСКИЙ СОСТАВ В ФОРМЕ ДВУХСЛОЙНЫХ ТАБЛЕТОК, СОДЕРЖАЩИХ ИНГИБИТОР HMG-CoA РЕДУКТАЗЫ И ИРБЕСАРТАН
BR112012024139A2 (pt) formulações farmacêuticas de camada dupla contendo agonistas e antagonistas de opióide.
BR112013006597A2 (pt) tablete para desintegração oral em múltiplas camadas, e a fabricação do mesmo
RU2015102772A (ru) Бензодиазелипы для мелкоклеточного рака легкого
EA201690679A1 (ru) Стабильная фармацевтическая композиция, содержащая амлодипин и валсартан
JP2015508082A5 (es)
ES2720869T3 (es) Composiciones farmacéuticas de sevelámero
MX2010007281A (es) Composiciones farmaceuticas de amlodipina y valsartan.
PE20110943A1 (es) Formulacion oral solida de alisquireno
MX2016007682A (es) Composicion farmaceutica que comprende ivabradina amorfa.
PE20120956A1 (es) Composicion farmaceutica que contiene buprenorfina y nalmefeno
CL2013003176A1 (es) Formulacion farmaceutica oral de liberacion sostenida que comprende dos tabletas que contienen 1000 mg de paracetamol, el cual esta presente en una capa de liberacion sostenida y otra de liberacion inmediata, en una proporcion de paracetamol por capa de 80-90 %: 10-20 %, donde la dosis unitaria comprende 2000 mg de paracetamol.
AR083095A1 (es) Cocristal de aprepitant l-prolina y composicion farmaceutica
EA201390014A1 (ru) Таблетка длительного высвобождения, содержащая тримебутин
EA201270269A1 (ru) Фармацевтическая таблетка, содержащая розувастатин кальция
PE20110925A1 (es) Formulacion galenica que comprende alisquireno y proceso para su preparacion mediante granulacion de extrusion fundida
PH12014502609B1 (en) Multilayer coating form of orally administered pharmaceutical composition containing omega-3 fatty acid or alkyl ester thereof and statin based drug
PE20150935A1 (es) Formulacion de comprimido compuesto de dos capas que comprende atorvastatina, irbesartan y carbonato de magnesio
ATE546133T1 (de) Orale dosierform mit trisubstituierten glycerin- verbindungen
CL2008003584A1 (es) Uso de la 10-[(3r)-1-azabiciclo]oct-3-ilmetil]-10-h-fenotiazina, o una de sus sales farmaceuticamente aceptables para la preparación de un medicamento util para prevenir o tratar la bronconeumopatia obstructiva.

Legal Events

Date Code Title Description
FC Refusal