PE20120126A1 - Nuevas bencenosulfonamidas como bloqueadores de canales de calcio - Google Patents
Nuevas bencenosulfonamidas como bloqueadores de canales de calcioInfo
- Publication number
- PE20120126A1 PE20120126A1 PE2011001348A PE2011001348A PE20120126A1 PE 20120126 A1 PE20120126 A1 PE 20120126A1 PE 2011001348 A PE2011001348 A PE 2011001348A PE 2011001348 A PE2011001348 A PE 2011001348A PE 20120126 A1 PE20120126 A1 PE 20120126A1
- Authority
- PE
- Peru
- Prior art keywords
- benzenosulphonamides
- calcium channel
- channel blockers
- benzenosulfonamide
- ylcarbonyl
- Prior art date
Links
- 229940127291 Calcium channel antagonist Drugs 0.000 title abstract 2
- 239000000480 calcium channel blocker Substances 0.000 title abstract 2
- -1 PYRROLIDINYL Chemical class 0.000 abstract 4
- 150000001875 compounds Chemical class 0.000 abstract 4
- 208000019901 Anxiety disease Diseases 0.000 abstract 1
- WZKSXHQDXQKIQJ-UHFFFAOYSA-N F[C](F)F Chemical group F[C](F)F WZKSXHQDXQKIQJ-UHFFFAOYSA-N 0.000 abstract 1
- CIUQDSCDWFSTQR-UHFFFAOYSA-N [C]1=CC=CC=C1 Chemical compound [C]1=CC=CC=C1 CIUQDSCDWFSTQR-UHFFFAOYSA-N 0.000 abstract 1
- 230000036506 anxiety Effects 0.000 abstract 1
- 206010015037 epilepsy Diseases 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
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- A—HUMAN NECESSITIES
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- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/10—Drugs for disorders of the urinary system of the bladder
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
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- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/56—Nitrogen atoms
- C07D211/58—Nitrogen atoms attached in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Psychiatry (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pain & Pain Management (AREA)
- Addiction (AREA)
- Urology & Nephrology (AREA)
- Reproductive Health (AREA)
- Endocrinology (AREA)
- Diabetes (AREA)
- Pulmonology (AREA)
- Dermatology (AREA)
- Gynecology & Obstetrics (AREA)
- Hospice & Palliative Care (AREA)
- Immunology (AREA)
- Hematology (AREA)
- Psychology (AREA)
- Rheumatology (AREA)
- Emergency Medicine (AREA)
- Vascular Medicine (AREA)
- Pregnancy & Childbirth (AREA)
- Obesity (AREA)
- Epidemiology (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US14489909P | 2009-01-15 | 2009-01-15 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20120126A1 true PE20120126A1 (es) | 2012-03-18 |
Family
ID=41796157
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2011001348A PE20120126A1 (es) | 2009-01-15 | 2010-01-14 | Nuevas bencenosulfonamidas como bloqueadores de canales de calcio |
Country Status (22)
| Country | Link |
|---|---|
| US (3) | US8101614B2 (enExample) |
| EP (1) | EP2382191B1 (enExample) |
| JP (1) | JP5619773B2 (enExample) |
| KR (1) | KR20110110299A (enExample) |
| CN (1) | CN102282131B (enExample) |
| AR (1) | AR077440A1 (enExample) |
| AU (1) | AU2010204753A1 (enExample) |
| BR (1) | BRPI1005675A2 (enExample) |
| CA (1) | CA2747752A1 (enExample) |
| CL (1) | CL2011001714A1 (enExample) |
| CO (1) | CO6400194A2 (enExample) |
| DO (1) | DOP2011000217A (enExample) |
| ES (1) | ES2527467T3 (enExample) |
| IL (1) | IL213500A0 (enExample) |
| MX (1) | MX337190B (enExample) |
| PE (1) | PE20120126A1 (enExample) |
| RU (1) | RU2011134052A (enExample) |
| SG (1) | SG172308A1 (enExample) |
| TW (1) | TW201028421A (enExample) |
| UY (1) | UY32384A (enExample) |
| WO (1) | WO2010083264A1 (enExample) |
| ZA (1) | ZA201104715B (enExample) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8420823B2 (en) | 2008-04-24 | 2013-04-16 | Msd K.K. | Long-chain fatty acyl elongase inhibitor comprising arylsulfonyl derivative as active ingredient |
| TW201028421A (en) * | 2009-01-15 | 2010-08-01 | Abbott Lab | Novel benzenesulfonamides as calcium channel blockers |
| WO2013040520A1 (en) * | 2011-09-15 | 2013-03-21 | Taipei Medical University | Use of indolyl and indolinyl hydroxamates for treating heart failure of neuronal injury |
| US8669255B2 (en) | 2011-09-29 | 2014-03-11 | Abbvie Inc. | Substituted octahydropyrrolo[1,2-a]pyrazines as calcium channel blockers |
| UY34349A (es) | 2011-09-29 | 2013-04-05 | Abb Vie Inc | OCTAHIDROPIRROLO[1,2-a]PIRAZINA SULFONAMIDAS SUSTITUIDAS COMO BLOQUEADORES DE CANALES DE CALCIO |
| US20130178477A1 (en) * | 2012-01-05 | 2013-07-11 | Abbvie Inc. | Methods of treating diabetic neuropathy using benzenesulfonamides |
| US9029361B2 (en) | 2012-12-12 | 2015-05-12 | Abbvie Inc. | Agents for treating pain and uses thereof |
| MX2016003082A (es) | 2013-09-10 | 2016-09-13 | Univ Texas | Terapia que se dirige a proteinas polipopsis adenomatosa coli (apc) truncadas. |
| US9700549B2 (en) | 2013-10-03 | 2017-07-11 | David Wise | Compositions and methods for treating pelvic pain and other conditions |
| US10082496B2 (en) | 2014-09-10 | 2018-09-25 | Board Of Regents Of The University Of Texas System | Targeting emopamil binding protein (EBP) with small molecules that induce an abnormal feedback response by lowering endogenous cholesterol biosynthesis |
| WO2017070680A1 (en) | 2015-10-22 | 2017-04-27 | Cavion Llc | Methods for treating angelman syndrome and related disorders |
| CN110545806A (zh) | 2017-02-15 | 2019-12-06 | 卡维昂公司 | 钙通道抑制剂 |
| AU2018260699B2 (en) | 2017-04-26 | 2022-04-28 | Cavion, Inc. | Methods for improving memory and cognition and for treating memory and cognitive disorders |
| AU2019207491A1 (en) | 2018-01-10 | 2020-07-30 | Cura Therapeutics, Llc | Pharmaceutical compositions comprising phenylsulfonamides, and their therapeutic applications |
| EP3841096A4 (en) | 2018-08-24 | 2022-05-18 | Sunshine Lake Pharma Co., Ltd. | PYRIDINYLMETHYLENEPIPERIDEINDIVATES AND THEIR USES |
| IL300798B2 (en) | 2018-10-03 | 2025-09-01 | Cavion Inc | Treatment of skeletal tremor with (r)–2-(4–isopropylphenyl)–n-(1-(5-(2,2,2–trifluoroethoxy)pyridin-2-yl)ethyl)acetamide |
| AR116898A1 (es) * | 2018-10-30 | 2021-06-23 | H Lundbeck As | DERIVADOS DE ARILSULFONILPIRROLCARBOXAMIDA COMO ACTIVADORES DE CANALES DE POTASIO Kv3 |
| AU2020311404A1 (en) * | 2019-07-11 | 2022-03-03 | Cura Therapeutics, Llc | Sulfone compounds and pharmaceutical compositions thereof, and their therapeutic applications for the treatment of neurodegenerative diseases |
| JP2022540253A (ja) | 2019-07-11 | 2022-09-14 | プラクシス プレシジョン メディシンズ， インコーポレイテッド | Ｔ型カルシウムチャネル調節因子の製剤およびその使用方法 |
| WO2025255502A1 (en) | 2024-06-07 | 2025-12-11 | Cavion, Inc. | PYRIDYL AMIDE Cav3 CHANNEL MODULATORS |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2000059882A1 (en) | 1999-04-07 | 2000-10-12 | Gray Lloyd S | Anticancer calcium channel blockers |
| TW200503994A (en) * | 2003-01-24 | 2005-02-01 | Novartis Ag | Organic compounds |
| US7223754B2 (en) | 2003-03-10 | 2007-05-29 | Dynogen Pharmaceuticals, Inc. | Thiazolidinone, oxazolidinone, and imidazolone derivatives for treating lower urinary tract and related disorders |
| DE602004027171D1 (de) * | 2003-04-11 | 2010-06-24 | High Point Pharmaceuticals Llc | Verbindungen mit Aktivität an der 11Beta-Hydroxasteroiddehydrogenase |
| CA2527170A1 (en) * | 2003-04-15 | 2004-10-28 | Astrazeneca Ab | Therapeutic compounds |
| WO2006105127A2 (en) * | 2005-03-31 | 2006-10-05 | Takeda San Diego, Inc. | Hydroxysteroid dehydrogenase inhibitors |
| WO2007052843A1 (ja) * | 2005-11-04 | 2007-05-10 | Takeda Pharmaceutical Company Limited | 複素環アミド化合物およびその用途 |
| CA2666275A1 (en) * | 2006-10-13 | 2008-04-17 | Neuromed Pharmaceuticals Ltd. | Cyclopropyl-piperazine compounds as calcium channel blockers |
| JP5622568B2 (ja) * | 2007-06-03 | 2014-11-12 | バンダービルト ユニバーシティ | ベンズアミドｍＧｌｕＲ５の正のアロステリック調節因子ならびにその作製および使用方法 |
| US8420823B2 (en) | 2008-04-24 | 2013-04-16 | Msd K.K. | Long-chain fatty acyl elongase inhibitor comprising arylsulfonyl derivative as active ingredient |
| TW201028421A (en) * | 2009-01-15 | 2010-08-01 | Abbott Lab | Novel benzenesulfonamides as calcium channel blockers |
-
2009
- 2009-12-31 TW TW098146447A patent/TW201028421A/zh unknown
-
2010
- 2010-01-14 RU RU2011134052/04A patent/RU2011134052A/ru not_active Application Discontinuation
- 2010-01-14 WO PCT/US2010/020964 patent/WO2010083264A1/en not_active Ceased
- 2010-01-14 BR BRPI1005675A patent/BRPI1005675A2/pt not_active IP Right Cessation
- 2010-01-14 MX MX2011007496A patent/MX337190B/es active IP Right Grant
- 2010-01-14 PE PE2011001348A patent/PE20120126A1/es not_active Application Discontinuation
- 2010-01-14 JP JP2011546319A patent/JP5619773B2/ja not_active Expired - Fee Related
- 2010-01-14 AU AU2010204753A patent/AU2010204753A1/en not_active Abandoned
- 2010-01-14 CA CA2747752A patent/CA2747752A1/en active Pending
- 2010-01-14 US US12/687,465 patent/US8101614B2/en not_active Expired - Fee Related
- 2010-01-14 KR KR1020117018567A patent/KR20110110299A/ko not_active Withdrawn
- 2010-01-14 CN CN201080004675.3A patent/CN102282131B/zh not_active Expired - Fee Related
- 2010-01-14 EP EP10701070.4A patent/EP2382191B1/en active Active
- 2010-01-14 ES ES10701070.4T patent/ES2527467T3/es active Active
- 2010-01-14 SG SG2011045564A patent/SG172308A1/en unknown
- 2010-01-15 UY UY0001032384A patent/UY32384A/es not_active Application Discontinuation
- 2010-01-15 AR ARP100100091A patent/AR077440A1/es not_active Application Discontinuation
-
2011
- 2011-06-12 IL IL213500A patent/IL213500A0/en unknown
- 2011-06-24 ZA ZA2011/04715A patent/ZA201104715B/en unknown
- 2011-07-07 DO DO2011000217A patent/DOP2011000217A/es unknown
- 2011-07-14 CL CL2011001714A patent/CL2011001714A1/es unknown
- 2011-08-02 CO CO11097206A patent/CO6400194A2/es not_active Application Discontinuation
- 2011-12-12 US US13/323,029 patent/US8404719B2/en active Active
-
2013
- 2013-02-04 US US13/758,615 patent/US8741899B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| WO2010083264A1 (en) | 2010-07-22 |
| ES2527467T3 (es) | 2015-01-26 |
| CN102282131B (zh) | 2015-08-26 |
| MX337190B (es) | 2016-02-16 |
| US20100197693A1 (en) | 2010-08-05 |
| RU2011134052A (ru) | 2013-02-20 |
| UY32384A (es) | 2010-08-31 |
| CN102282131A (zh) | 2011-12-14 |
| MX2011007496A (es) | 2011-08-04 |
| US8101614B2 (en) | 2012-01-24 |
| IL213500A0 (en) | 2011-07-31 |
| JP2012515209A (ja) | 2012-07-05 |
| TW201028421A (en) | 2010-08-01 |
| US8741899B2 (en) | 2014-06-03 |
| BRPI1005675A2 (pt) | 2017-06-13 |
| CO6400194A2 (es) | 2012-03-15 |
| AU2010204753A1 (en) | 2011-08-11 |
| EP2382191B1 (en) | 2014-11-12 |
| DOP2011000217A (es) | 2011-07-31 |
| JP5619773B2 (ja) | 2014-11-05 |
| CL2011001714A1 (es) | 2011-11-11 |
| AR077440A1 (es) | 2011-08-31 |
| US20130210827A1 (en) | 2013-08-15 |
| ZA201104715B (en) | 2014-01-29 |
| SG172308A1 (en) | 2011-07-28 |
| CA2747752A1 (en) | 2010-07-22 |
| US20120083499A1 (en) | 2012-04-05 |
| EP2382191A1 (en) | 2011-11-02 |
| US8404719B2 (en) | 2013-03-26 |
| KR20110110299A (ko) | 2011-10-06 |
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| FD | Application declared void or lapsed |