AU2010204753A1 - Novel benzenesulfonamides as calcium channel blockers - Google Patents

Novel benzenesulfonamides as calcium channel blockers Download PDF

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Publication number
AU2010204753A1
AU2010204753A1 AU2010204753A AU2010204753A AU2010204753A1 AU 2010204753 A1 AU2010204753 A1 AU 2010204753A1 AU 2010204753 A AU2010204753 A AU 2010204753A AU 2010204753 A AU2010204753 A AU 2010204753A AU 2010204753 A1 AU2010204753 A1 AU 2010204753A1
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AU
Australia
Prior art keywords
pyrazin
hexahydropyrrolo
ylcarbonyl
benzenesulfonamide
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2010204753A
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English (en)
Inventor
Michael F. Jarvis
Victoria E. SCOTT
Andrew O. Stewart
Zhiren Xia
Qingwei Zhang
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
AbbVie Bahamas Ltd
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AbbVie Bahamas Ltd
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Filing date
Publication date
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=41796157&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AU2010204753(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by AbbVie Bahamas Ltd filed Critical AbbVie Bahamas Ltd
Publication of AU2010204753A1 publication Critical patent/AU2010204753A1/en
Assigned to ABBVIE BAHAMAS LTD reassignment ABBVIE BAHAMAS LTD Request for Assignment Assignors: ABBOTT LABORATORIES
Abandoned legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
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    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
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    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/56—Nitrogen atoms
    • C07D211/58—Nitrogen atoms attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

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  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Cardiology (AREA)
  • Psychiatry (AREA)
  • Addiction (AREA)
  • Urology & Nephrology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Reproductive Health (AREA)
  • Endocrinology (AREA)
  • Pulmonology (AREA)
  • Diabetes (AREA)
  • Dermatology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Hospice & Palliative Care (AREA)
  • Emergency Medicine (AREA)
  • Pregnancy & Childbirth (AREA)
  • Vascular Medicine (AREA)
  • Psychology (AREA)
  • Immunology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Rheumatology (AREA)
  • Epidemiology (AREA)
AU2010204753A 2009-01-15 2010-01-14 Novel benzenesulfonamides as calcium channel blockers Abandoned AU2010204753A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US14489909P 2009-01-15 2009-01-15
US61/144,899 2009-01-15
PCT/US2010/020964 WO2010083264A1 (en) 2009-01-15 2010-01-14 Novel benzenesulfonamides as calcium channel blockers

Publications (1)

Publication Number Publication Date
AU2010204753A1 true AU2010204753A1 (en) 2011-08-11

Family

ID=41796157

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2010204753A Abandoned AU2010204753A1 (en) 2009-01-15 2010-01-14 Novel benzenesulfonamides as calcium channel blockers

Country Status (22)

Country Link
US (3) US8101614B2 (enExample)
EP (1) EP2382191B1 (enExample)
JP (1) JP5619773B2 (enExample)
KR (1) KR20110110299A (enExample)
CN (1) CN102282131B (enExample)
AR (1) AR077440A1 (enExample)
AU (1) AU2010204753A1 (enExample)
BR (1) BRPI1005675A2 (enExample)
CA (1) CA2747752A1 (enExample)
CL (1) CL2011001714A1 (enExample)
CO (1) CO6400194A2 (enExample)
DO (1) DOP2011000217A (enExample)
ES (1) ES2527467T3 (enExample)
IL (1) IL213500A0 (enExample)
MX (1) MX337190B (enExample)
PE (1) PE20120126A1 (enExample)
RU (1) RU2011134052A (enExample)
SG (1) SG172308A1 (enExample)
TW (1) TW201028421A (enExample)
UY (1) UY32384A (enExample)
WO (1) WO2010083264A1 (enExample)
ZA (1) ZA201104715B (enExample)

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RU2615767C2 (ru) * 2011-09-15 2017-04-11 Тайпей Медикл Юнивесити Способ лечения сердечной недостаточности и поражения нервных клеток
US8669255B2 (en) 2011-09-29 2014-03-11 Abbvie Inc. Substituted octahydropyrrolo[1,2-a]pyrazines as calcium channel blockers
US8648074B2 (en) 2011-09-29 2014-02-11 Abbvie Inc. Substituted octahydropyrrolo[1,2-a]pyrazine sulfonamides as calcium channel blockers
US20130178477A1 (en) * 2012-01-05 2013-07-11 Abbvie Inc. Methods of treating diabetic neuropathy using benzenesulfonamides
WO2014093337A1 (en) * 2012-12-12 2014-06-19 Abbvie, Inc. Diazepine derivatives useful as calcium channel blockers in the treatment of pain
DK3044218T3 (da) * 2013-09-10 2020-07-27 Univ Texas Terapeutiske midler til targetering af trunkerede adenomatøse polyposis coli (apc)-proteiner
WO2015051336A1 (en) 2013-10-03 2015-04-09 David Wise Compositions and methods for treating pelvic pain and other conditions
US10082496B2 (en) 2014-09-10 2018-09-25 Board Of Regents Of The University Of Texas System Targeting emopamil binding protein (EBP) with small molecules that induce an abnormal feedback response by lowering endogenous cholesterol biosynthesis
ES2936400T3 (es) 2015-10-22 2023-03-16 Cavion Inc Métodos para tratar el síndrome Angelman
KR102642063B1 (ko) 2017-02-15 2024-03-04 카비온, 인코포레이티드 칼슘 채널 억제제
SG10202111885PA (en) 2017-04-26 2021-12-30 Cavion Inc Methods for improving memory and cognition and for treating memory and cognitive disorders
JP7395480B2 (ja) 2018-01-10 2023-12-11 クラ セラピューティクス， エルエルシー フェニルスルホンアミドを含む薬学的組成物、及びそれらの治療的適用
CN110437205B (zh) 2018-08-24 2022-07-08 广东东阳光药业有限公司 吡啶烯基哌啶衍生物及其用途
EP3860571A4 (en) 2018-10-03 2022-06-29 Cavion, Inc. Treating essential tremor using (r)-2-(4-isopropylphenyl)-n-(1-(5-(2,2,2-trifluoroethoxy)pyridin-2-yl)ethyl)acetamide
TW202031645A (zh) * 2018-10-30 2020-09-01 丹麥商Ｈ 朗德貝克公司 作為Kv3鉀通道激活劑之芳基磺醯基吡咯甲醯胺衍生物
WO2021007478A1 (en) * 2019-07-11 2021-01-14 Cura Therapeutics, Llc Sulfone compounds and pharmaceutical compositions thereof, and their therapeutic applications for the treatment of neurodegenerative diseases
TW202116314A (zh) 2019-07-11 2021-05-01 美商普雷西斯精密藥品公司 T型鈣離子通道調節劑之調配物及其使用方法
CN117229257A (zh) * 2022-06-06 2023-12-15 中国药科大学 间氨磺酰苯甲酰胺类化合物及制法、药物组合物和应用
WO2025255502A1 (en) 2024-06-07 2025-12-11 Cavion, Inc. PYRIDYL AMIDE Cav3 CHANNEL MODULATORS

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TW201028421A (en) * 2009-01-15 2010-08-01 Abbott Lab Novel benzenesulfonamides as calcium channel blockers

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JP5619773B2 (ja) 2014-11-05
PE20120126A1 (es) 2012-03-18
SG172308A1 (en) 2011-07-28
UY32384A (es) 2010-08-31
US8404719B2 (en) 2013-03-26
WO2010083264A1 (en) 2010-07-22
US20120083499A1 (en) 2012-04-05
US8101614B2 (en) 2012-01-24
BRPI1005675A2 (pt) 2017-06-13
EP2382191A1 (en) 2011-11-02
ZA201104715B (en) 2014-01-29
AR077440A1 (es) 2011-08-31
MX337190B (es) 2016-02-16
ES2527467T3 (es) 2015-01-26
US20130210827A1 (en) 2013-08-15
MX2011007496A (es) 2011-08-04
EP2382191B1 (en) 2014-11-12
CA2747752A1 (en) 2010-07-22
US20100197693A1 (en) 2010-08-05
CL2011001714A1 (es) 2011-11-11
CN102282131B (zh) 2015-08-26
RU2011134052A (ru) 2013-02-20
KR20110110299A (ko) 2011-10-06
TW201028421A (en) 2010-08-01
CN102282131A (zh) 2011-12-14
DOP2011000217A (es) 2011-07-31
US8741899B2 (en) 2014-06-03
CO6400194A2 (es) 2012-03-15
JP2012515209A (ja) 2012-07-05

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