ES2527467T3 - Nuevas bencenosulfonamidas como bloqueantes de canales de calcio - Google Patents
Nuevas bencenosulfonamidas como bloqueantes de canales de calcio Download PDFInfo
- Publication number
- ES2527467T3 ES2527467T3 ES10701070.4T ES10701070T ES2527467T3 ES 2527467 T3 ES2527467 T3 ES 2527467T3 ES 10701070 T ES10701070 T ES 10701070T ES 2527467 T3 ES2527467 T3 ES 2527467T3
- Authority
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- Spain
- Prior art keywords
- alkyl
- nrc
- heteroaryl
- aryl
- alkoxy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 229940127291 Calcium channel antagonist Drugs 0.000 title 1
- 150000008331 benzenesulfonamides Chemical class 0.000 title 1
- 239000000480 calcium channel blocker Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract description 3
- 125000000217 alkyl group Chemical group 0.000 abstract 6
- 125000003118 aryl group Chemical group 0.000 abstract 4
- 125000001072 heteroaryl group Chemical group 0.000 abstract 4
- 125000003545 alkoxy group Chemical group 0.000 abstract 3
- 229910052736 halogen Inorganic materials 0.000 abstract 3
- 150000002367 halogens Chemical class 0.000 abstract 3
- 229910052739 hydrogen Inorganic materials 0.000 abstract 3
- 239000001257 hydrogen Substances 0.000 abstract 3
- 125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 3
- 125000003725 azepanyl group Chemical group 0.000 abstract 2
- 125000002393 azetidinyl group Chemical group 0.000 abstract 2
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 2
- 125000001188 haloalkyl group Chemical group 0.000 abstract 2
- 125000002757 morpholinyl group Chemical group 0.000 abstract 2
- 125000003386 piperidinyl group Chemical group 0.000 abstract 2
- 125000000719 pyrrolidinyl group Chemical group 0.000 abstract 2
- 125000001424 substituent group Chemical group 0.000 abstract 2
- 125000004568 thiomorpholinyl group Chemical group 0.000 abstract 2
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 125000002768 hydroxyalkyl group Chemical group 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 101150093826 par1 gene Proteins 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 101000932804 Homo sapiens Voltage-dependent T-type calcium channel subunit alpha-1H Proteins 0.000 description 3
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 description 2
- 102000054636 human CACNA1H Human genes 0.000 description 2
- 239000005557 antagonist Substances 0.000 description 1
- 231100000673 dose–response relationship Toxicity 0.000 description 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/10—Drugs for disorders of the urinary system of the bladder
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
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- A—HUMAN NECESSITIES
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- A61P25/08—Antiepileptics; Anticonvulsants
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- A—HUMAN NECESSITIES
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- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P25/36—Opioid-abuse
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- A—HUMAN NECESSITIES
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- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- A—HUMAN NECESSITIES
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- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/56—Nitrogen atoms
- C07D211/58—Nitrogen atoms attached in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Psychiatry (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pain & Pain Management (AREA)
- Urology & Nephrology (AREA)
- Addiction (AREA)
- Reproductive Health (AREA)
- Endocrinology (AREA)
- Diabetes (AREA)
- Pulmonology (AREA)
- Gynecology & Obstetrics (AREA)
- Hospice & Palliative Care (AREA)
- Dermatology (AREA)
- Rheumatology (AREA)
- Vascular Medicine (AREA)
- Pregnancy & Childbirth (AREA)
- Psychology (AREA)
- Obesity (AREA)
- Emergency Medicine (AREA)
- Immunology (AREA)
- Hematology (AREA)
- Epidemiology (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US14489909P | 2009-01-15 | 2009-01-15 | |
| US144899P | 2009-01-15 | ||
| PCT/US2010/020964 WO2010083264A1 (en) | 2009-01-15 | 2010-01-14 | Novel benzenesulfonamides as calcium channel blockers |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2527467T3 true ES2527467T3 (es) | 2015-01-26 |
Family
ID=41796157
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES10701070.4T Active ES2527467T3 (es) | 2009-01-15 | 2010-01-14 | Nuevas bencenosulfonamidas como bloqueantes de canales de calcio |
Country Status (22)
| Country | Link |
|---|---|
| US (3) | US8101614B2 (enExample) |
| EP (1) | EP2382191B1 (enExample) |
| JP (1) | JP5619773B2 (enExample) |
| KR (1) | KR20110110299A (enExample) |
| CN (1) | CN102282131B (enExample) |
| AR (1) | AR077440A1 (enExample) |
| AU (1) | AU2010204753A1 (enExample) |
| BR (1) | BRPI1005675A2 (enExample) |
| CA (1) | CA2747752A1 (enExample) |
| CL (1) | CL2011001714A1 (enExample) |
| CO (1) | CO6400194A2 (enExample) |
| DO (1) | DOP2011000217A (enExample) |
| ES (1) | ES2527467T3 (enExample) |
| IL (1) | IL213500A0 (enExample) |
| MX (1) | MX337190B (enExample) |
| PE (1) | PE20120126A1 (enExample) |
| RU (1) | RU2011134052A (enExample) |
| SG (1) | SG172308A1 (enExample) |
| TW (1) | TW201028421A (enExample) |
| UY (1) | UY32384A (enExample) |
| WO (1) | WO2010083264A1 (enExample) |
| ZA (1) | ZA201104715B (enExample) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104352492B (zh) | 2008-04-24 | 2017-12-05 | Msd K.K.公司 | 以芳基磺酰基衍生物作为有效成分的长链脂肪酸延长酶抑制剂 |
| TW201028421A (en) * | 2009-01-15 | 2010-08-01 | Abbott Lab | Novel benzenesulfonamides as calcium channel blockers |
| AU2012308243B2 (en) * | 2011-09-15 | 2017-09-14 | Taipei Medical University | Use of indolyl and indolinyl hydroxamates for treating heart failure of neuronal injury |
| UY34349A (es) | 2011-09-29 | 2013-04-05 | Abb Vie Inc | OCTAHIDROPIRROLO[1,2-a]PIRAZINA SULFONAMIDAS SUSTITUIDAS COMO BLOQUEADORES DE CANALES DE CALCIO |
| WO2013049164A1 (en) | 2011-09-29 | 2013-04-04 | Abbvie Inc. | SUBSTITUTED OCTAHYDROPYRROLO[1,2-a]PYRAZINES AS CALCIUM CHANNEL BLOCKERS |
| US20130178477A1 (en) * | 2012-01-05 | 2013-07-11 | Abbvie Inc. | Methods of treating diabetic neuropathy using benzenesulfonamides |
| AU2013359533A1 (en) * | 2012-12-12 | 2015-05-28 | Abbvie, Inc. | Diazepine derivatives useful as calcium channel blockers in the treatment of pain |
| RU2727516C2 (ru) | 2013-09-10 | 2020-07-22 | Борд Оф Риджентс Оф Дзе Юниверсити Оф Техас Систем | Терапевтические средства, нацеленные на укороченные белки аденоматозного полипоза толстого кишечника (арс) |
| WO2015051336A1 (en) | 2013-10-03 | 2015-04-09 | David Wise | Compositions and methods for treating pelvic pain and other conditions |
| US10082496B2 (en) | 2014-09-10 | 2018-09-25 | Board Of Regents Of The University Of Texas System | Targeting emopamil binding protein (EBP) with small molecules that induce an abnormal feedback response by lowering endogenous cholesterol biosynthesis |
| EP3364993B1 (en) | 2015-10-22 | 2022-11-09 | Cavion, Inc. | Methods for treating angelman syndrome |
| CN110545806A (zh) | 2017-02-15 | 2019-12-06 | 卡维昂公司 | 钙通道抑制剂 |
| EP3615521A4 (en) | 2017-04-26 | 2021-02-17 | Cavion, Inc. | METHODS FOR IMPROVING MEMORY AND COGNITION AND TREATING MEMORY AND COGNITIVE DISORDERS |
| AU2019207491A1 (en) | 2018-01-10 | 2020-07-30 | Cura Therapeutics, Llc | Pharmaceutical compositions comprising phenylsulfonamides, and their therapeutic applications |
| US11858910B2 (en) | 2018-08-24 | 2024-01-02 | Sunshine Lake Pharma Co., Ltd. | Pyridinylmethylenepiperidine derivatives and uses thereof |
| JP7480131B2 (ja) | 2018-10-03 | 2024-05-09 | カビオン・インコーポレイテッド | （ｒ）－２－（４－イソプロピルフェニル）－ｎ－（１－（５－（２，２，２－トリフルオロエトキシ）ピリジン－２－イル）エチル）アセトアミドを使用した本態性振戦の処置 |
| US20200131156A1 (en) * | 2018-10-30 | 2020-04-30 | H. Lundbeck A/S | ARYLSULFONYLPYROLECARBOXAMIDE DERIVATIVES AS Kv3 POTASSIUM CHANNEL ACTIVATORS |
| WO2021007478A1 (en) * | 2019-07-11 | 2021-01-14 | Cura Therapeutics, Llc | Sulfone compounds and pharmaceutical compositions thereof, and their therapeutic applications for the treatment of neurodegenerative diseases |
| WO2021007487A1 (en) | 2019-07-11 | 2021-01-14 | Praxis Precision Medicines, Inc. | Formulations of t-type calcium channel modulators and methods of use thereof |
| CN117229257B (zh) * | 2022-06-06 | 2026-01-30 | 中国药科大学 | 间氨磺酰苯甲酰胺类化合物及制法、药物组合物和应用 |
| WO2025255502A1 (en) | 2024-06-07 | 2025-12-11 | Cavion, Inc. | PYRIDYL AMIDE Cav3 CHANNEL MODULATORS |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE269848T1 (de) | 1999-04-07 | 2004-07-15 | Univ Virginia | Calciumkanalblocker als antikrebsmittel |
| TW200503994A (en) | 2003-01-24 | 2005-02-01 | Novartis Ag | Organic compounds |
| US7223754B2 (en) | 2003-03-10 | 2007-05-29 | Dynogen Pharmaceuticals, Inc. | Thiazolidinone, oxazolidinone, and imidazolone derivatives for treating lower urinary tract and related disorders |
| DE602004027171D1 (de) * | 2003-04-11 | 2010-06-24 | High Point Pharmaceuticals Llc | Verbindungen mit Aktivität an der 11Beta-Hydroxasteroiddehydrogenase |
| JP2006523707A (ja) * | 2003-04-15 | 2006-10-19 | アストラゼネカ アクツィエボラーグ | 治療化合物 |
| WO2006105127A2 (en) * | 2005-03-31 | 2006-10-05 | Takeda San Diego, Inc. | Hydroxysteroid dehydrogenase inhibitors |
| WO2007052843A1 (ja) * | 2005-11-04 | 2007-05-10 | Takeda Pharmaceutical Company Limited | 複素環アミド化合物およびその用途 |
| EP2074105A4 (en) * | 2006-10-13 | 2010-10-06 | Neuromed Pharmaceuticals Ltd | CYCLOPROPYL-PIPERAZINE COMPOUNDS AS CALCIUM INHIBITORS |
| KR20100033981A (ko) * | 2007-06-03 | 2010-03-31 | 벤더르빌트 유니버시티 | 벤즈아미드 대사성 글루타민산염 수용체5 양성 알로스테릭 조절자 및 이의 제조 및 사용방법 |
| CN104352492B (zh) | 2008-04-24 | 2017-12-05 | Msd K.K.公司 | 以芳基磺酰基衍生物作为有效成分的长链脂肪酸延长酶抑制剂 |
| TW201028421A (en) * | 2009-01-15 | 2010-08-01 | Abbott Lab | Novel benzenesulfonamides as calcium channel blockers |
-
2009
- 2009-12-31 TW TW098146447A patent/TW201028421A/zh unknown
-
2010
- 2010-01-14 MX MX2011007496A patent/MX337190B/es active IP Right Grant
- 2010-01-14 BR BRPI1005675A patent/BRPI1005675A2/pt not_active IP Right Cessation
- 2010-01-14 CN CN201080004675.3A patent/CN102282131B/zh not_active Expired - Fee Related
- 2010-01-14 CA CA2747752A patent/CA2747752A1/en active Pending
- 2010-01-14 US US12/687,465 patent/US8101614B2/en not_active Expired - Fee Related
- 2010-01-14 SG SG2011045564A patent/SG172308A1/en unknown
- 2010-01-14 EP EP10701070.4A patent/EP2382191B1/en active Active
- 2010-01-14 ES ES10701070.4T patent/ES2527467T3/es active Active
- 2010-01-14 PE PE2011001348A patent/PE20120126A1/es not_active Application Discontinuation
- 2010-01-14 JP JP2011546319A patent/JP5619773B2/ja not_active Expired - Fee Related
- 2010-01-14 KR KR1020117018567A patent/KR20110110299A/ko not_active Withdrawn
- 2010-01-14 WO PCT/US2010/020964 patent/WO2010083264A1/en not_active Ceased
- 2010-01-14 RU RU2011134052/04A patent/RU2011134052A/ru not_active Application Discontinuation
- 2010-01-14 AU AU2010204753A patent/AU2010204753A1/en not_active Abandoned
- 2010-01-15 UY UY0001032384A patent/UY32384A/es not_active Application Discontinuation
- 2010-01-15 AR ARP100100091A patent/AR077440A1/es not_active Application Discontinuation
-
2011
- 2011-06-12 IL IL213500A patent/IL213500A0/en unknown
- 2011-06-24 ZA ZA2011/04715A patent/ZA201104715B/en unknown
- 2011-07-07 DO DO2011000217A patent/DOP2011000217A/es unknown
- 2011-07-14 CL CL2011001714A patent/CL2011001714A1/es unknown
- 2011-08-02 CO CO11097206A patent/CO6400194A2/es not_active Application Discontinuation
- 2011-12-12 US US13/323,029 patent/US8404719B2/en active Active
-
2013
- 2013-02-04 US US13/758,615 patent/US8741899B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| UY32384A (es) | 2010-08-31 |
| JP5619773B2 (ja) | 2014-11-05 |
| US8741899B2 (en) | 2014-06-03 |
| AU2010204753A1 (en) | 2011-08-11 |
| BRPI1005675A2 (pt) | 2017-06-13 |
| JP2012515209A (ja) | 2012-07-05 |
| WO2010083264A1 (en) | 2010-07-22 |
| EP2382191A1 (en) | 2011-11-02 |
| MX337190B (es) | 2016-02-16 |
| TW201028421A (en) | 2010-08-01 |
| US20100197693A1 (en) | 2010-08-05 |
| US8101614B2 (en) | 2012-01-24 |
| PE20120126A1 (es) | 2012-03-18 |
| MX2011007496A (es) | 2011-08-04 |
| US20120083499A1 (en) | 2012-04-05 |
| SG172308A1 (en) | 2011-07-28 |
| RU2011134052A (ru) | 2013-02-20 |
| US20130210827A1 (en) | 2013-08-15 |
| KR20110110299A (ko) | 2011-10-06 |
| ZA201104715B (en) | 2014-01-29 |
| DOP2011000217A (es) | 2011-07-31 |
| CA2747752A1 (en) | 2010-07-22 |
| EP2382191B1 (en) | 2014-11-12 |
| CO6400194A2 (es) | 2012-03-15 |
| US8404719B2 (en) | 2013-03-26 |
| CL2011001714A1 (es) | 2011-11-11 |
| CN102282131A (zh) | 2011-12-14 |
| CN102282131B (zh) | 2015-08-26 |
| AR077440A1 (es) | 2011-08-31 |
| IL213500A0 (en) | 2011-07-31 |
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