PE20120126A1 - Nuevas bencenosulfonamidas como bloqueadores de canales de calcio - Google Patents

Nuevas bencenosulfonamidas como bloqueadores de canales de calcio

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Publication number
PE20120126A1
PE20120126A1 PE2011001348A PE2011001348A PE20120126A1 PE 20120126 A1 PE20120126 A1 PE 20120126A1 PE 2011001348 A PE2011001348 A PE 2011001348A PE 2011001348 A PE2011001348 A PE 2011001348A PE 20120126 A1 PE20120126 A1 PE 20120126A1
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PE
Peru
Prior art keywords
benzenosulphonamides
calcium channel
channel blockers
benzenosulfonamide
ylcarbonyl
Prior art date
Application number
PE2011001348A
Other languages
English (en)
Inventor
Qingwei Zhan
Andrew O Stewart
Zhiren Xia
Michael F Jarvis
Victoria E Scott
Original Assignee
Abbvie Bahamas Ltd
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Publication date
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=41796157&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PE20120126(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Abbvie Bahamas Ltd filed Critical Abbvie Bahamas Ltd
Publication of PE20120126A1 publication Critical patent/PE20120126A1/es

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    • C07ORGANIC CHEMISTRY
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    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
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    • C07ORGANIC CHEMISTRY
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    • C07D211/06Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/56Nitrogen atoms
    • C07D211/58Nitrogen atoms attached in position 4
    • CCHEMISTRY; METALLURGY
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    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems

Abstract

SE REFIERE A COMPUESTOS DERIVADOS DE BENCENOSULFONAMIDAS DE FORMULAS (I) Y (II) DONDE R1 Y R2 SON CADA UNO X E Y, EN DONDE X ES UN COMPUESTO DE FORMULA (i) O (ii) DONDE m Y n SON CADA UNO 1 O 2; G1 ES AZETIDINILO, PIRROLIDINILO, MORFOLINILO, ENTRE OTROS; Y ES NRcAr1, NRcCH(Ar1)2, ENTRE OTROS, EN DONDE Ar1 ES ARILO O HETEROARILO OPCIONALMENTE SUSTITUIDOS CON ALCOXI, ALQUILO, CN, ENTRE OTROS; Rc ES H O ALQUILO; R3, R4, R5 Y R6 SON CADA UNO H, ALCOXI, ALQUILO O HALOGENO. SON COMPUESTOS PREFERIDOS: 3-[(8aR)-HEXAHIDROPIRROLO[1,2-a]PIRAZIN-2(1H)-ILCARBONIL]-N-[4-(TRIFLUOROMETIL)FENIL]BENCENOSULFONAMIDA; N-(2-FLUOROFENIL)-3-[(8aR)-HEXAHIDROPIRROLO[1,2-a]PIRAZIN-2(1H)-ILCARBONIL]BENCENOSULFONAMIDA; N-(3-FLUOROFENIL)-3-[(8aS)-HEXAHIDROPIRROLO[1,2-a]PIRAZIN-2(1H)-ILCARBONIL]BENCENOSULFONAMIDA; ENTRE OTROS. TAMBIEN SE REFIERE A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON BLOQUEADORES DE CANALES DE CALCIO SIENDO UTILES EN EL TRATAMIENTO DEL DOLOR, EPILEPSIA, DEPRESION, ANSIEDAD, MIGRANA
PE2011001348A 2009-01-15 2010-01-14 Nuevas bencenosulfonamidas como bloqueadores de canales de calcio PE20120126A1 (es)

Applications Claiming Priority (1)

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US14489909P 2009-01-15 2009-01-15

Publications (1)

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PE20120126A1 true PE20120126A1 (es) 2012-03-18

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ID=41796157

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PE2011001348A PE20120126A1 (es) 2009-01-15 2010-01-14 Nuevas bencenosulfonamidas como bloqueadores de canales de calcio

Country Status (22)

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US (3) US8101614B2 (es)
EP (1) EP2382191B1 (es)
JP (1) JP5619773B2 (es)
KR (1) KR20110110299A (es)
CN (1) CN102282131B (es)
AR (1) AR077440A1 (es)
AU (1) AU2010204753A1 (es)
BR (1) BRPI1005675A2 (es)
CA (1) CA2747752A1 (es)
CL (1) CL2011001714A1 (es)
CO (1) CO6400194A2 (es)
DO (1) DOP2011000217A (es)
ES (1) ES2527467T3 (es)
IL (1) IL213500A0 (es)
MX (1) MX337190B (es)
PE (1) PE20120126A1 (es)
RU (1) RU2011134052A (es)
SG (1) SG172308A1 (es)
TW (1) TW201028421A (es)
UY (1) UY32384A (es)
WO (1) WO2010083264A1 (es)
ZA (1) ZA201104715B (es)

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JP5501226B2 (ja) 2008-04-24 2014-05-21 Msd株式会社 アリールスルホニル誘導体を有効成分とする長鎖脂肪酸伸長酵素阻害剤
TW201028421A (en) * 2009-01-15 2010-08-01 Abbott Lab Novel benzenesulfonamides as calcium channel blockers
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TW201028421A (en) * 2009-01-15 2010-08-01 Abbott Lab Novel benzenesulfonamides as calcium channel blockers

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EP2382191B1 (en) 2014-11-12
AR077440A1 (es) 2011-08-31
JP2012515209A (ja) 2012-07-05
RU2011134052A (ru) 2013-02-20
KR20110110299A (ko) 2011-10-06
US8101614B2 (en) 2012-01-24
MX2011007496A (es) 2011-08-04
UY32384A (es) 2010-08-31
IL213500A0 (en) 2011-07-31
US8741899B2 (en) 2014-06-03
WO2010083264A1 (en) 2010-07-22
JP5619773B2 (ja) 2014-11-05
CL2011001714A1 (es) 2011-11-11
AU2010204753A1 (en) 2011-08-11
ZA201104715B (en) 2014-01-29
CO6400194A2 (es) 2012-03-15
EP2382191A1 (en) 2011-11-02
TW201028421A (en) 2010-08-01
MX337190B (es) 2016-02-16
CN102282131B (zh) 2015-08-26
SG172308A1 (en) 2011-07-28
ES2527467T3 (es) 2015-01-26
US8404719B2 (en) 2013-03-26
US20100197693A1 (en) 2010-08-05
US20120083499A1 (en) 2012-04-05
BRPI1005675A2 (pt) 2017-06-13
CA2747752A1 (en) 2010-07-22
CN102282131A (zh) 2011-12-14
DOP2011000217A (es) 2011-07-31
US20130210827A1 (en) 2013-08-15

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