MX2011007496A - Nuevas bencensulfonamidas como bloqueadores del canal de calcio. - Google Patents

Nuevas bencensulfonamidas como bloqueadores del canal de calcio.

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Publication number
MX2011007496A
MX2011007496A MX2011007496A MX2011007496A MX2011007496A MX 2011007496 A MX2011007496 A MX 2011007496A MX 2011007496 A MX2011007496 A MX 2011007496A MX 2011007496 A MX2011007496 A MX 2011007496A MX 2011007496 A MX2011007496 A MX 2011007496A
Authority
MX
Mexico
Prior art keywords
calcium channel
benzenesulfonamides
novel
channel blockers
formula
Prior art date
Application number
MX2011007496A
Other languages
English (en)
Other versions
MX337190B (es
Inventor
Michael F Jarvis
Andrew O Stewart
Qingwei Zhang
Zhiren Xia
Victoria E Scott
Original Assignee
Abbott Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=41796157&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MX2011007496(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Abbott Lab filed Critical Abbott Lab
Publication of MX2011007496A publication Critical patent/MX2011007496A/es
Publication of MX337190B publication Critical patent/MX337190B/es

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    • C07—ORGANIC CHEMISTRY
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    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
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    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D471/04—Ortho-condensed systems

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  • Neurology (AREA)
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  • Psychiatry (AREA)
  • Addiction (AREA)
  • Pain & Pain Management (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Reproductive Health (AREA)
  • Endocrinology (AREA)
  • Pulmonology (AREA)
  • Diabetes (AREA)
  • Gynecology & Obstetrics (AREA)
  • Hospice & Palliative Care (AREA)
  • Dermatology (AREA)
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Abstract

La presente solicitud se relaciona con inhibidores del canal de calcio que comprenden compuestos de fórmula (I), fórmula (II), fórmula (III), o fórmula (IV), en donde L1, R1, R2, R3, R4, R5, R6, R7 y RC son como se define en la especificación. La presente solicitud también se relaciona con composiciones que comprenden tales compuestos, y métodos para tratar condiciones y trastornos que utilizan tales compuestos y composiciones.
MX2011007496A 2009-01-15 2010-01-14 Nuevas bencensulfonamidas como bloqueadores del canal de calcio. MX337190B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US14489909P 2009-01-15 2009-01-15
PCT/US2010/020964 WO2010083264A1 (en) 2009-01-15 2010-01-14 Novel benzenesulfonamides as calcium channel blockers

Publications (2)

Publication Number Publication Date
MX2011007496A true MX2011007496A (es) 2011-08-04
MX337190B MX337190B (es) 2016-02-16

Family

ID=41796157

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2011007496A MX337190B (es) 2009-01-15 2010-01-14 Nuevas bencensulfonamidas como bloqueadores del canal de calcio.

Country Status (22)

Country Link
US (3) US8101614B2 (es)
EP (1) EP2382191B1 (es)
JP (1) JP5619773B2 (es)
KR (1) KR20110110299A (es)
CN (1) CN102282131B (es)
AR (1) AR077440A1 (es)
AU (1) AU2010204753A1 (es)
BR (1) BRPI1005675A2 (es)
CA (1) CA2747752A1 (es)
CL (1) CL2011001714A1 (es)
CO (1) CO6400194A2 (es)
DO (1) DOP2011000217A (es)
ES (1) ES2527467T3 (es)
IL (1) IL213500A0 (es)
MX (1) MX337190B (es)
PE (1) PE20120126A1 (es)
RU (1) RU2011134052A (es)
SG (1) SG172308A1 (es)
TW (1) TW201028421A (es)
UY (1) UY32384A (es)
WO (1) WO2010083264A1 (es)
ZA (1) ZA201104715B (es)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2722075C (en) 2008-04-24 2015-11-24 Banyu Pharmaceutical Co., Ltd. Long-chain fatty acyl elongase inhibitor comprising arylsulfonyl derivative as active ingredient
TW201028421A (en) * 2009-01-15 2010-08-01 Abbott Lab Novel benzenesulfonamides as calcium channel blockers
MX355015B (es) * 2011-09-15 2018-04-02 Univ Taipei Medical Uso de hidroxamatos de indolilo e indolinilo para tratar insuficiencia cardiaca o lesión neuronal.
WO2013049164A1 (en) 2011-09-29 2013-04-04 Abbvie Inc. SUBSTITUTED OCTAHYDROPYRROLO[1,2-a]PYRAZINES AS CALCIUM CHANNEL BLOCKERS
AR088064A1 (es) 2011-09-29 2014-05-07 Abbvie Inc Octahidropirrolo[1,2-a]pirazina sulfonamidas sustituidas como bloqueadores de canales de calcio
US20130178477A1 (en) * 2012-01-05 2013-07-11 Abbvie Inc. Methods of treating diabetic neuropathy using benzenesulfonamides
CN105008361A (zh) * 2012-12-12 2015-10-28 艾伯维公司 作为钙通道阻滞剂用于治疗疼痛的的二氮杂*衍生物
SG11201601850YA (en) * 2013-09-10 2016-04-28 Univ Texas Therapeutics targeting truncated adenomatous polyposis coli (apc) proteins
WO2015051336A1 (en) 2013-10-03 2015-04-09 David Wise Compositions and methods for treating pelvic pain and other conditions
US10082496B2 (en) 2014-09-10 2018-09-25 Board Of Regents Of The University Of Texas System Targeting emopamil binding protein (EBP) with small molecules that induce an abnormal feedback response by lowering endogenous cholesterol biosynthesis
FI3364993T3 (fi) 2015-10-22 2023-01-13 Menetelmiä angelmanin oireyhtymän hoitamiseksi
JP7134178B2 (ja) 2017-02-15 2022-09-09 カビオン・インコーポレイテッド カルシウムチャネル阻害剤
WO2018200850A1 (en) 2017-04-26 2018-11-01 Cavion, Inc. Methods for improving memory and cognition and for treating memory and cognitive disorders
CA3087856A1 (en) 2018-01-10 2019-07-18 Cura Therapeutics, Llc Pharmaceutical compositions comprising phenylsulfonamides, and their therapeutic applications
AU2019323450A1 (en) 2018-08-24 2021-02-11 Sunshine Lake Pharma Co., Ltd. Pyridinylmethylenepiperidine derivatives and uses thereof
CA3115235A1 (en) 2018-10-03 2020-04-09 Cavion, Inc. Treating essential tremor using (r)-2-(4-isopropylphenyl)-n-(1-(5-(2,2,2-trifluoroethoxy)pyridin-2-yl)ethyl)acetamide
AR116898A1 (es) * 2018-10-30 2021-06-23 H Lundbeck As DERIVADOS DE ARILSULFONILPIRROLCARBOXAMIDA COMO ACTIVADORES DE CANALES DE POTASIO Kv3
CA3146157A1 (en) * 2019-07-11 2021-01-14 Cura Therapeutics, Llc Sulfone compounds and pharmaceutical compositions thereof, and their therapeutic applications for the treatment of neurodegenerative diseases
WO2021007487A1 (en) 2019-07-11 2021-01-14 Praxis Precision Medicines, Inc. Formulations of t-type calcium channel modulators and methods of use thereof

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4932994B2 (ja) 1999-04-07 2012-05-16 ユニバーシテイ・オブ・バージニア・パテント・フアウンデーシヨン 抗癌性カルシウムチャンネル遮断薬
TW200503994A (en) * 2003-01-24 2005-02-01 Novartis Ag Organic compounds
WO2004089470A2 (en) * 2003-04-11 2004-10-21 Novo Nordisk A/S New amide derivatives and pharmaceutical use thereof
US7223754B2 (en) 2003-03-10 2007-05-29 Dynogen Pharmaceuticals, Inc. Thiazolidinone, oxazolidinone, and imidazolone derivatives for treating lower urinary tract and related disorders
JP2006523707A (ja) * 2003-04-15 2006-10-19 アストラゼネカ アクツィエボラーグ 治療化合物
EP1866298A2 (en) * 2005-03-31 2007-12-19 Takeda San Diego, Inc. Hydroxysteroid dehydrogenase inhibitors
WO2007052843A1 (ja) * 2005-11-04 2007-05-10 Takeda Pharmaceutical Company Limited 複素環アミド化合物およびその用途
WO2008043183A1 (en) * 2006-10-13 2008-04-17 Neuromed Pharmaceuticals Ltd. Cyclopropyl-piperazine compounds as calcium channel blockers
NZ581817A (en) * 2007-06-03 2012-05-25 Univ Vanderbilt Benzamide mglur5 positive allosteric modulators and methods of making and using same
CA2722075C (en) 2008-04-24 2015-11-24 Banyu Pharmaceutical Co., Ltd. Long-chain fatty acyl elongase inhibitor comprising arylsulfonyl derivative as active ingredient
TW201028421A (en) * 2009-01-15 2010-08-01 Abbott Lab Novel benzenesulfonamides as calcium channel blockers

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EP2382191A1 (en) 2011-11-02
JP2012515209A (ja) 2012-07-05
AU2010204753A1 (en) 2011-08-11
KR20110110299A (ko) 2011-10-06
CO6400194A2 (es) 2012-03-15
US8741899B2 (en) 2014-06-03
SG172308A1 (en) 2011-07-28
US8404719B2 (en) 2013-03-26
TW201028421A (en) 2010-08-01
US20130210827A1 (en) 2013-08-15
RU2011134052A (ru) 2013-02-20
JP5619773B2 (ja) 2014-11-05
DOP2011000217A (es) 2011-07-31
WO2010083264A1 (en) 2010-07-22
CA2747752A1 (en) 2010-07-22
US8101614B2 (en) 2012-01-24
US20120083499A1 (en) 2012-04-05
CL2011001714A1 (es) 2011-11-11
CN102282131A (zh) 2011-12-14
MX337190B (es) 2016-02-16
UY32384A (es) 2010-08-31
IL213500A0 (en) 2011-07-31
ZA201104715B (en) 2014-01-29
PE20120126A1 (es) 2012-03-18
US20100197693A1 (en) 2010-08-05
BRPI1005675A2 (pt) 2017-06-13
AR077440A1 (es) 2011-08-31
EP2382191B1 (en) 2014-11-12
ES2527467T3 (es) 2015-01-26
CN102282131B (zh) 2015-08-26

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