MX355015B - Uso de hidroxamatos de indolilo e indolinilo para tratar insuficiencia cardiaca o lesión neuronal. - Google Patents

Uso de hidroxamatos de indolilo e indolinilo para tratar insuficiencia cardiaca o lesión neuronal.

Info

Publication number
MX355015B
MX355015B MX2014003256A MX2014003256A MX355015B MX 355015 B MX355015 B MX 355015B MX 2014003256 A MX2014003256 A MX 2014003256A MX 2014003256 A MX2014003256 A MX 2014003256A MX 355015 B MX355015 B MX 355015B
Authority
MX
Mexico
Prior art keywords
indolyl
heart failure
neuronal injury
treating heart
hydroxamates
Prior art date
Application number
MX2014003256A
Other languages
English (en)
Other versions
MX2014003256A (es
Inventor
Chen Yi-Jen
Hung Kuo-Sheng
Kao Yu-Hsun
Liou Jing-Ping
Shan Pei-Wen
Original Assignee
Univ Taipei Medical
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Taipei Medical filed Critical Univ Taipei Medical
Publication of MX2014003256A publication Critical patent/MX2014003256A/es
Publication of MX355015B publication Critical patent/MX355015B/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Epidemiology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

El uso novedoso de moléculas pequeñas, particularmente hidroxamatos de indolilo e indolinilo, se da a conocer en este documento. Los hidroxamatos de indolilo e indolinilo son útiles como compuestos de partida para elaborar un medicamento o una composición farmacéutica para tratar a un paciente que adolece de insuficiencia cardiaca o lesión neuronal.
MX2014003256A 2011-09-15 2012-09-15 Uso de hidroxamatos de indolilo e indolinilo para tratar insuficiencia cardiaca o lesión neuronal. MX355015B (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161534902P 2011-09-15 2011-09-15
US201161537589P 2011-09-22 2011-09-22
PCT/US2012/055664 WO2013040520A1 (en) 2011-09-15 2012-09-15 Use of indolyl and indolinyl hydroxamates for treating heart failure of neuronal injury

Publications (2)

Publication Number Publication Date
MX2014003256A MX2014003256A (es) 2014-09-15
MX355015B true MX355015B (es) 2018-04-02

Family

ID=47883813

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2014003256A MX355015B (es) 2011-09-15 2012-09-15 Uso de hidroxamatos de indolilo e indolinilo para tratar insuficiencia cardiaca o lesión neuronal.

Country Status (11)

Country Link
US (1) US9296692B2 (es)
EP (1) EP2763673B1 (es)
JP (1) JP6180417B2 (es)
KR (1) KR20140091522A (es)
CN (1) CN104080451B (es)
AU (1) AU2012308243B2 (es)
CA (1) CA2848877A1 (es)
MX (1) MX355015B (es)
RU (1) RU2615767C2 (es)
TW (1) TWI464147B (es)
WO (1) WO2013040520A1 (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2931345A1 (en) 2013-11-24 2015-05-28 Taipei Medical University Use of indolyl and idolinyl hydroxamates for treating neurodegenerative disorders or cognitive deficits
ES2965877T3 (es) * 2015-10-27 2024-04-17 Univ Taipei Medical Derivados de indolina para el tratamiento y/o la prevención de enfermedades fibróticas
CN107141247B (zh) * 2017-06-02 2020-03-20 烟台大学 抗心脏衰竭化合物、其制备方法及应用
RU2673481C1 (ru) * 2017-12-11 2018-11-27 Федеральное государственное бюджетное образовательное учреждение высшего образования "Юго-Западный государственный университет" (ЮЗГУ) Способ комплексной терапии при сочетанной ишемии центральной гемодинамической системы, нижних конечностей, сердца и головного мозга
EP4019806A4 (en) 2019-08-22 2023-04-19 Harmonic Drive Systems Inc. ONE SHAFT GEAR DEVICE
WO2025238446A1 (en) 2024-05-17 2025-11-20 3M Innovative Properties Company Coating comprising methyl methacrylate copolymer with silicon-oxygen groups and articles

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JP2881688B2 (ja) * 1995-09-27 1999-04-12 小野薬品工業株式会社 スルホンアミド誘導体
GB9805520D0 (en) * 1998-03-17 1998-05-13 Zeneca Ltd Chemical compounds
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JP2001233875A (ja) * 1999-10-12 2001-08-28 Takeda Chem Ind Ltd ピリミジン−５−カルボキサミド化合物、その製造法およびその用途
JP2002371059A (ja) * 2000-05-16 2002-12-26 Takeda Chem Ind Ltd メラニン凝集ホルモン拮抗剤
EP1491541B1 (en) * 2001-03-30 2007-01-24 Pfizer Products Inc. Pyridazinone aldose reductase inhibitors
EP1753421B1 (en) * 2004-04-20 2012-08-01 Amgen Inc. Arylsulfonamides and uses as hydroxysteroid dehydrogenase
CN101052640B (zh) * 2004-09-03 2011-05-11 默克雪兰诺有限公司 吡啶亚甲基唑烷酮类及其作为磷酸肌醇抑制剂的用途
WO2006038594A1 (ja) * 2004-10-04 2006-04-13 Ono Pharmaceutical Co., Ltd. Ｎ型カルシウムチャネル阻害薬
WO2006101456A1 (en) * 2005-03-21 2006-09-28 S*Bio Pte Ltd Bicyclic heterocycles hydroxamate compounds useful as histone deacetylase (hdac) inhibitors
WO2006117165A2 (en) * 2005-05-02 2006-11-09 Friedrich-Alexander-Universität Erlangen-Nürnberg Means and methods for the treatment of head injuries and stroke
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Also Published As

Publication number Publication date
CN104080451A (zh) 2014-10-01
JP2014526518A (ja) 2014-10-06
AU2012308243A8 (en) 2014-05-22
TWI464147B (zh) 2014-12-11
RU2014114860A (ru) 2015-10-20
CN104080451B (zh) 2016-08-24
AU2012308243A1 (en) 2014-04-17
EP2763673A1 (en) 2014-08-13
KR20140091522A (ko) 2014-07-21
RU2615767C2 (ru) 2017-04-11
EP2763673B1 (en) 2018-08-01
CA2848877A1 (en) 2013-03-21
US9296692B2 (en) 2016-03-29
TW201313679A (zh) 2013-04-01
JP6180417B2 (ja) 2017-08-16
US20150065552A1 (en) 2015-03-05
MX2014003256A (es) 2014-09-15
WO2013040520A1 (en) 2013-03-21
AU2012308243B2 (en) 2017-09-14
EP2763673A4 (en) 2015-05-06

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