MX355015B - Uso de hidroxamatos de indolilo e indolinilo para tratar insuficiencia cardiaca o lesión neuronal. - Google Patents

Uso de hidroxamatos de indolilo e indolinilo para tratar insuficiencia cardiaca o lesión neuronal.

Info

Publication number
MX355015B
MX355015B MX2014003256A MX2014003256A MX355015B MX 355015 B MX355015 B MX 355015B MX 2014003256 A MX2014003256 A MX 2014003256A MX 2014003256 A MX2014003256 A MX 2014003256A MX 355015 B MX355015 B MX 355015B
Authority
MX
Mexico
Prior art keywords
indolyl
heart failure
neuronal injury
treating heart
hydroxamates
Prior art date
Application number
MX2014003256A
Other languages
English (en)
Other versions
MX2014003256A (es
Inventor
Chen Yi-Jen
Hung Kuo-Sheng
Kao Yu-Hsun
Liou Jing-Ping
Shan Pei-Wen
Original Assignee
Univ Taipei Medical
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Taipei Medical filed Critical Univ Taipei Medical
Publication of MX2014003256A publication Critical patent/MX2014003256A/es
Publication of MX355015B publication Critical patent/MX355015B/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Epidemiology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

El uso novedoso de moléculas pequeñas, particularmente hidroxamatos de indolilo e indolinilo, se da a conocer en este documento. Los hidroxamatos de indolilo e indolinilo son útiles como compuestos de partida para elaborar un medicamento o una composición farmacéutica para tratar a un paciente que adolece de insuficiencia cardiaca o lesión neuronal.
MX2014003256A 2011-09-15 2012-09-15 Uso de hidroxamatos de indolilo e indolinilo para tratar insuficiencia cardiaca o lesión neuronal. MX355015B (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161534902P 2011-09-15 2011-09-15
US201161537589P 2011-09-22 2011-09-22
PCT/US2012/055664 WO2013040520A1 (en) 2011-09-15 2012-09-15 Use of indolyl and indolinyl hydroxamates for treating heart failure of neuronal injury

Publications (2)

Publication Number Publication Date
MX2014003256A MX2014003256A (es) 2014-09-15
MX355015B true MX355015B (es) 2018-04-02

Family

ID=47883813

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2014003256A MX355015B (es) 2011-09-15 2012-09-15 Uso de hidroxamatos de indolilo e indolinilo para tratar insuficiencia cardiaca o lesión neuronal.

Country Status (11)

Country Link
US (1) US9296692B2 (es)
EP (1) EP2763673B1 (es)
JP (1) JP6180417B2 (es)
KR (1) KR20140091522A (es)
CN (1) CN104080451B (es)
AU (1) AU2012308243B2 (es)
CA (1) CA2848877A1 (es)
MX (1) MX355015B (es)
RU (1) RU2615767C2 (es)
TW (1) TWI464147B (es)
WO (1) WO2013040520A1 (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3096753A4 (en) * 2013-11-24 2017-07-05 Taipei Medical University Use of indolyl and idolinyl hydroxamates for treating neurodegenerative disorders or cognitive deficits
JP7302120B2 (ja) * 2015-10-27 2023-07-04 タイペイ メディカル ユニバーシティ 線維症疾患の治療及び／又は予防用インドリン誘導体
CN107141247B (zh) * 2017-06-02 2020-03-20 烟台大学 抗心脏衰竭化合物、其制备方法及应用
RU2673481C1 (ru) * 2017-12-11 2018-11-27 Федеральное государственное бюджетное образовательное учреждение высшего образования "Юго-Западный государственный университет" (ЮЗГУ) Способ комплексной терапии при сочетанной ишемии центральной гемодинамической системы, нижних конечностей, сердца и головного мозга
US20220364635A1 (en) 2019-08-22 2022-11-17 Harmonic Drive Systems Inc. Unit-type strain wave gearing

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US5175164A (en) * 1991-06-05 1992-12-29 Merck & Co., Inc. Angiotensin ii antagonists incorporating a substituted indole or dihydroindole
JP2881688B2 (ja) * 1995-09-27 1999-04-12 小野薬品工業株式会社 スルホンアミド誘導体
GB9805520D0 (en) * 1998-03-17 1998-05-13 Zeneca Ltd Chemical compounds
DK1088819T3 (da) * 1999-09-30 2005-09-12 Pfizer Prod Inc 6-azauracilderivater som thyroidreceptorligander
JP2001233875A (ja) * 1999-10-12 2001-08-28 Takeda Chem Ind Ltd ピリミジン−５−カルボキサミド化合物、その製造法およびその用途
JP2002371059A (ja) * 2000-05-16 2002-12-26 Takeda Chem Ind Ltd メラニン凝集ホルモン拮抗剤
CA2442476A1 (en) * 2001-03-30 2002-10-10 Pfizer Products Inc. Pyridazinone aldose reductase inhibitors
WO2005118538A2 (en) * 2004-04-20 2005-12-15 Amgen, Inc. Arylsulfonamides and uses as hydroxysteroid dehydrogenase
KR101229647B1 (ko) * 2004-09-03 2013-02-05 메르크 세로노 에스.에이. 피리딘 메틸렌 아조리디논 및 포스포이노시타이드 저해제의용도
WO2006038594A1 (ja) * 2004-10-04 2006-04-13 Ono Pharmaceutical Co., Ltd. Ｎ型カルシウムチャネル阻害薬
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Also Published As

Publication number Publication date
CN104080451B (zh) 2016-08-24
CA2848877A1 (en) 2013-03-21
EP2763673A1 (en) 2014-08-13
JP6180417B2 (ja) 2017-08-16
AU2012308243B2 (en) 2017-09-14
TW201313679A (zh) 2013-04-01
RU2014114860A (ru) 2015-10-20
US20150065552A1 (en) 2015-03-05
WO2013040520A1 (en) 2013-03-21
US9296692B2 (en) 2016-03-29
EP2763673B1 (en) 2018-08-01
MX2014003256A (es) 2014-09-15
RU2615767C2 (ru) 2017-04-11
AU2012308243A1 (en) 2014-04-17
JP2014526518A (ja) 2014-10-06
CN104080451A (zh) 2014-10-01
AU2012308243A8 (en) 2014-05-22
TWI464147B (zh) 2014-12-11
EP2763673A4 (en) 2015-05-06
KR20140091522A (ko) 2014-07-21

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