WO2013038200A3 - Neurodevelopmental disorders - Google Patents
Neurodevelopmental disorders Download PDFInfo
- Publication number
- WO2013038200A3 WO2013038200A3 PCT/GB2012/052278 GB2012052278W WO2013038200A3 WO 2013038200 A3 WO2013038200 A3 WO 2013038200A3 GB 2012052278 W GB2012052278 W GB 2012052278W WO 2013038200 A3 WO2013038200 A3 WO 2013038200A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- neurodevelopmental disorders
- methods
- disorders
- ameliorating
- medicaments
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/34—Tobacco-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/36—Opioid-abuse
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- C07D491/056—Ortho-condensed systems with two or more oxygen atoms as ring hetero atoms in the oxygen-containing ring
Abstract
The invention provides pharmaceutical compositions, medicaments and methods for use in preventing, ameliorating or treating neurodevelopmental disorders. The invention extends to novel synthetic methods for preparing active agents useful in the treatment of neurodevelopmental disorders.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB1115977.9 | 2011-09-15 | ||
GB1115977.9A GB2503187A (en) | 2011-09-15 | 2011-09-15 | Composition for use in the treatment of neurodevelopmental disorders |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2013038200A2 WO2013038200A2 (en) | 2013-03-21 |
WO2013038200A3 true WO2013038200A3 (en) | 2013-06-27 |
Family
ID=44908638
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/GB2012/052278 WO2013038200A2 (en) | 2011-09-15 | 2012-09-14 | Neurodevelopmental disorders |
Country Status (2)
Country | Link |
---|---|
GB (1) | GB2503187A (en) |
WO (1) | WO2013038200A2 (en) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
HUE055000T2 (en) | 2015-02-27 | 2021-10-28 | Dechra Ltd | Stimulation of appetite, management of weight loss, and treatment of anorexia in dogs and cats |
WO2017083739A1 (en) | 2015-11-13 | 2017-05-18 | The Trustees Of Columbia University In The City Of New York | A method for predicting a subject's response to valproic acid therapy |
WO2020065090A2 (en) * | 2018-09-28 | 2020-04-02 | Medizinische Hochschule Hannover (Mhh) | Treatment of dementia-associated tauopathies |
Citations (6)
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GB2201414A (en) * | 1984-04-24 | 1988-09-01 | Glaxo Group Ltd | 1, 4-Benzodioxane-2,3-dimethanols |
WO1994008579A1 (en) * | 1992-10-08 | 1994-04-28 | New York University | β-AGONIST, α1-AGONIST, AND/OR α2-ANTAGONIST TREATMENT OF NEURODEGENERATIVE DISEASES AND CENTRAL NERVOUS SYSTEM TRAUMA |
WO2001055132A1 (en) * | 2000-01-28 | 2001-08-02 | Novartis Ag | 1,3-disubstituted pyrrolidines as alpha-2-adrenoceptor antagonists |
WO2003082866A1 (en) * | 2002-04-03 | 2003-10-09 | Orion Corporation | Polycyclic compounds as potent alpha2-adrenoceptor antagonists |
WO2004011031A1 (en) * | 2002-07-29 | 2004-02-05 | Potomac, Pharma, Llc. | Antipsychotic combination therapies and compositions of an alpha-2 adrenergic receptor antagonist and an atypical antipsychotic neuroleptic |
WO2008019431A1 (en) * | 2006-08-14 | 2008-02-21 | Brc Operations Pty Limited | Method and compositions for simultaneously regulating memory and mood |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3760089A (en) | 1972-04-27 | 1973-09-18 | Westinghouse Electric Corp | Electrical bushing assembly having resilient means enclosed within sealing means |
GB8526209D0 (en) | 1985-10-23 | 1985-11-27 | Glaxo Group Ltd | Chemical process |
GB8828032D0 (en) * | 1988-12-01 | 1989-01-05 | Glaxo Group Ltd | Medicaments |
GB8911166D0 (en) * | 1989-05-16 | 1989-07-05 | Glaxo Group Ltd | Medicaments |
GB2244431A (en) * | 1990-05-31 | 1991-12-04 | Farmos Oy | Treatment of age related memory impairment and other cognitive disorders |
GB9012469D0 (en) * | 1990-06-05 | 1990-07-25 | Glaxo Group Ltd | Medicaments |
GB9119466D0 (en) | 1991-09-12 | 1991-10-23 | Glaxo Group Ltd | Chemical compounds |
WO2007148185A2 (en) | 2006-06-21 | 2007-12-27 | Pfizer Products Inc. | Substituted 3 -amino- pyrrolidino-4 -lactams as dpp inhibitors |
-
2011
- 2011-09-15 GB GB1115977.9A patent/GB2503187A/en not_active Withdrawn
-
2012
- 2012-09-14 WO PCT/GB2012/052278 patent/WO2013038200A2/en active Application Filing
Patent Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
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GB2201414A (en) * | 1984-04-24 | 1988-09-01 | Glaxo Group Ltd | 1, 4-Benzodioxane-2,3-dimethanols |
WO1994008579A1 (en) * | 1992-10-08 | 1994-04-28 | New York University | β-AGONIST, α1-AGONIST, AND/OR α2-ANTAGONIST TREATMENT OF NEURODEGENERATIVE DISEASES AND CENTRAL NERVOUS SYSTEM TRAUMA |
WO2001055132A1 (en) * | 2000-01-28 | 2001-08-02 | Novartis Ag | 1,3-disubstituted pyrrolidines as alpha-2-adrenoceptor antagonists |
WO2003082866A1 (en) * | 2002-04-03 | 2003-10-09 | Orion Corporation | Polycyclic compounds as potent alpha2-adrenoceptor antagonists |
WO2004011031A1 (en) * | 2002-07-29 | 2004-02-05 | Potomac, Pharma, Llc. | Antipsychotic combination therapies and compositions of an alpha-2 adrenergic receptor antagonist and an atypical antipsychotic neuroleptic |
WO2008019431A1 (en) * | 2006-08-14 | 2008-02-21 | Brc Operations Pty Limited | Method and compositions for simultaneously regulating memory and mood |
Non-Patent Citations (6)
Title |
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GIAKOUMAKI STELLA G ET AL: "Improvement of Prepulse Inhibition and Executive Function by the COMT Inhibitor Tolcapone Depends on COMT Val(158)Met Polymorphism", NEUROPSYCHOPHARMACOLOGY, vol. 33, no. 13, December 2008 (2008-12-01), pages 3058 - 3068, XP002688113, ISSN: 0893-133X * |
GIBBS A A ET AL: "Deletion variant of +/-2b-adrenergic receptor gene moderates the effect of COMT val<158>met polymorphism on episodic memory performance", EUROPEAN NEUROPSYCHOPHARMACOLOGY, ELSEVIER SCIENCE PUBLISHERS BV, AMSTERDAM, NL, vol. 20, no. 4, 1 April 2010 (2010-04-01), pages 272 - 275, XP026930262, ISSN: 0924-977X, [retrieved on 20100127], DOI: 10.1016/J.EURONEURO.2009.12.007 * |
KOHLI UTKARSH ET AL: "Effects of variation in the human alpha2A- and alpha2C-adrenoceptor genes on cognitive tasks and pain perception.", EUROPEAN JOURNAL OF PAIN (LONDON, ENGLAND) FEB 2010, vol. 14, no. 2, February 2010 (2010-02-01), pages 154 - 159, XP002688114, ISSN: 1532-2149 * |
SAHAKIAN B J ET AL: "Selective enhancement of executive function by idazoxan in a patient with dementia of the frontal lobe type.", JOURNAL OF NEUROLOGY, NEUROSURGERY, AND PSYCHIATRY JAN 1994, vol. 57, no. 1, January 1994 (1994-01-01), pages 120 - 121, XP002688112, ISSN: 0022-3050 * |
SCULLION G A ET AL: "Chronic treatment with the-adrenoceptor antagonist fluparoxan prevents age-related deficits in spatial working memory in APPPS1 transgenic mice without altering -amyloid plaque load or astrocytosis", NEUROPHARMACOLOGY, PERGAMON PRESS, OXFORD, GB, vol. 60, no. 2, 3 September 2010 (2010-09-03), pages 223 - 234, XP028365576, ISSN: 0028-3908, [retrieved on 20100917], DOI: 10.1016/J.NEUROPHARM.2010.09.002 * |
WEICKERT T W ET AL: "Catechol-O-methyltransferase val<108/158>met genotype predicts working memory response to antipsychotic medications", BIOLOGICAL PSYCHIATRY, ELSEVIER SCIENCE, NEW YORK, NY, US, vol. 56, no. 9, 1 November 2004 (2004-11-01), pages 677 - 682, XP004619801, ISSN: 0006-3223, DOI: 10.1016/J.BIOPSYCH.2004.08.012 * |
Also Published As
Publication number | Publication date |
---|---|
WO2013038200A2 (en) | 2013-03-21 |
GB201115977D0 (en) | 2011-10-26 |
GB2503187A (en) | 2013-12-25 |
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