PE20140571A1 - Uso de 2,3-dihidroimidazo[1,2-c]quinazolinas sustituidas - Google Patents

Uso de 2,3-dihidroimidazo[1,2-c]quinazolinas sustituidas

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Publication number
PE20140571A1
PE20140571A1 PE2013002187A PE2013002187A PE20140571A1 PE 20140571 A1 PE20140571 A1 PE 20140571A1 PE 2013002187 A PE2013002187 A PE 2013002187A PE 2013002187 A PE2013002187 A PE 2013002187A PE 20140571 A1 PE20140571 A1 PE 20140571A1
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PE
Peru
Prior art keywords
dihydroimidazo
quinazolin
alkyl
quinazolines
compounds
Prior art date
Application number
PE2013002187A
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English (en)
Inventor
Ningshu Liu
Claudia Schneider
Original Assignee
Bayer Ip Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=45894478&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PE20140571(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Bayer Ip Gmbh filed Critical Bayer Ip Gmbh
Publication of PE20140571A1 publication Critical patent/PE20140571A1/es

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/436—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/63—Compounds containing para-N-benzenesulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonyl hydrazide
    • A61K31/635—Compounds containing para-N-benzenesulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonyl hydrazide having a heterocyclic ring, e.g. sulfadiazine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57407—Specifically defined cancers
    • G01N33/57415—Specifically defined cancers of breast

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Pathology (AREA)
  • Analytical Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Physics & Mathematics (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hospice & Palliative Care (AREA)
  • Oncology (AREA)
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  • General Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
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  • Biophysics (AREA)
  • General Engineering & Computer Science (AREA)
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Abstract

SE REFIERE A COMPUESTOS DERIVADOS DE 2,3-DIHIDROIMIDAZO[1,2-c]QUINAZOLINAS DE FORMULA (I) DONDE R1 ES -(CH2)n-(CHR4)-(CH2)m-N(R5)(R5'), EN DONDE R4 ES H, HIDROXI O ALCOXI; R5 Y R5' SON CADA UNO H, ALQUILO, CICLOALQUILALQUILO, ALCOXIALQUILO, ENTRE OTROS; n ES DE 1 A 4; m ES DE 0 A 4; R2 ES HETEROARILO OPCIONALMENTE SUSTITUIDO CON R6, DONDE R6 ES HALOGENO, ALQUILO, ARILO, ENTRE OTROS; R3 ES ALQUILO O CICLOALQUILO. SON COMPUESTOS PREFERIDOS: N-[7-METOXI-8-(3-MORFOLIN-4-ILPROPOXI)-2,3-DIHIDROIMIDAZO[1,2-c]QUINAZOLIN-5-IL]PIRIMIDIN-5-CARBOXAMIDA; N-(8-{3-[(2R,6S)-2,6-DIMETILMORFOLIN-4-IL]PROPOXI}-7-METOXI-2,3-DIHIDROIMIDAZO[1,2-c]QUINAZOLIN-5-IL)NICOTINAMIDA; N-(8-{3-[(2R,6S)-2,6-DIMETILMORFOLIN-4-IL]PROPOXI}-7-METOXI-2,3-DIHIDROIMIDAZO[1,2-c]QUINAZOLIN-5-IL)-2,4-DIMETIL-1,3-TIAZOL-5-CARBOXAMIDA; ENTRE OTROS. TAMBIEN SE REFIERE A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON UTILES EN EL TRATAMIENTO DE CANCER DE MAMA
PE2013002187A 2011-04-05 2012-03-29 Uso de 2,3-dihidroimidazo[1,2-c]quinazolinas sustituidas PE20140571A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP11161142 2011-04-05

Publications (1)

Publication Number Publication Date
PE20140571A1 true PE20140571A1 (es) 2014-05-19

Family

ID=45894478

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2013002187A PE20140571A1 (es) 2011-04-05 2012-03-29 Uso de 2,3-dihidroimidazo[1,2-c]quinazolinas sustituidas

Country Status (28)

Country Link
US (1) US10202385B2 (es)
EP (1) EP2694069A1 (es)
JP (1) JP6013446B2 (es)
KR (1) KR102006033B1 (es)
CN (1) CN103608018B (es)
AP (1) AP3751A (es)
AR (1) AR088730A1 (es)
AU (2) AU2012238887A1 (es)
BR (1) BR112013025517A2 (es)
CA (1) CA2832120C (es)
CL (1) CL2013002869A1 (es)
CU (1) CU24349B1 (es)
DO (1) DOP2013000224A (es)
EA (1) EA027670B1 (es)
EC (1) ECSP13013007A (es)
GT (1) GT201300235A (es)
IL (1) IL228435A0 (es)
JO (1) JO3733B1 (es)
MA (1) MA35015B1 (es)
MX (1) MX2013011582A (es)
MY (1) MY169532A (es)
PE (1) PE20140571A1 (es)
SG (1) SG193577A1 (es)
TN (1) TN2013000402A1 (es)
TW (1) TWI639599B (es)
UA (1) UA114177C2 (es)
UY (1) UY33984A (es)
WO (1) WO2012136549A1 (es)

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CN103608018B (zh) 2017-06-30
GT201300235A (es) 2014-08-27
AP2013007147A0 (en) 2013-09-30
CA2832120C (en) 2020-10-27
MY169532A (en) 2019-04-22
AU2017203474A1 (en) 2017-06-08
NZ615502A (en) 2016-03-31
TN2013000402A1 (en) 2015-03-30
CU20130134A7 (es) 2014-01-29
UA114177C2 (uk) 2017-05-10
WO2012136549A1 (en) 2012-10-11
CA2832120A1 (en) 2012-10-11
DOP2013000224A (es) 2013-11-15
JP6013446B2 (ja) 2016-10-25
JP2014514297A (ja) 2014-06-19
AU2012238887A1 (en) 2013-10-10
BR112013025517A2 (pt) 2016-12-27
US10202385B2 (en) 2019-02-12
SG193577A1 (en) 2013-10-30
IL228435A0 (en) 2013-12-31
CU24349B1 (es) 2018-06-05
AP3751A (en) 2016-07-31
UY33984A (es) 2012-10-31
TWI639599B (zh) 2018-11-01
EA027670B1 (ru) 2017-08-31
TW201245202A (en) 2012-11-16
EA201301106A1 (ru) 2014-03-31
MA35015B1 (fr) 2014-04-03
AR088730A1 (es) 2014-07-02
KR102006033B1 (ko) 2019-07-31
CL2013002869A1 (es) 2014-07-18
AU2017203474B2 (en) 2019-03-21
CN103608018A (zh) 2014-02-26
EP2694069A1 (en) 2014-02-12
ECSP13013007A (es) 2013-12-31
JO3733B1 (ar) 2021-01-31
US20140243295A1 (en) 2014-08-28
KR20140025427A (ko) 2014-03-04
MX2013011582A (es) 2014-05-01

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