ECSP066647A - Derivados de triazol como antagonistas de vasopresina - Google Patents

Derivados de triazol como antagonistas de vasopresina

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Publication number
ECSP066647A
ECSP066647A EC2006006647A ECSP066647A ECSP066647A EC SP066647 A ECSP066647 A EC SP066647A EC 2006006647 A EC2006006647 A EC 2006006647A EC SP066647 A ECSP066647 A EC SP066647A EC SP066647 A ECSP066647 A EC SP066647A
Authority
EC
Ecuador
Prior art keywords
saturated
optionally substituted
heterocyclic ring
ring
number chosen
Prior art date
Application number
EC2006006647A
Other languages
English (en)
Inventor
Patrick Stephen Johnson
Thomas Ryckmans
Lee Richard Roberts
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0329693A external-priority patent/GB0329693D0/en
Priority claimed from GB0408789A external-priority patent/GB0408789D0/en
Application filed by Pfizer filed Critical Pfizer
Publication of ECSP066647A publication Critical patent/ECSP066647A/es

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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
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    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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Abstract

Un compuesto de la fórmula (I) consta gráfico o derivados del mismo aceptables farmacéuticamente, en el que:X representa -[CH2]a-R ó -[CH2]a-O-[CH2]b-R; a representa un número elegido entre 0 y 6; b representa un número elegido entre 0 y 6; R representa H, CF3 o Het; Het representa un anillo heterocíclico de 5 ó 6 miembros, saturado, parcialmente saturado o aromático;Y representa uno o más sustituyentes elegidos independientemente entre -[O]c-[CH2]d-R1, que pueden ser iguales o diferentes en cada aparición; c en cada aparición representa independientemente un número elegido entre 0 ó 1; d en cada aparición representa independientemente un número elegido entre 0 y 6; R1 en cada aparición representa independientemente H, halo, CF3, CN o Het1; Het1 en cada aparición representa independientemente un anillo heterocíclico insaturado de 5 ó 6 miembros;V representa un enlace directo ó -O-;el anillo A representa un anillo heterocíclico saturado de 5 a 7 miembros, o un grupo fenileno;Q representa un enlace directo ó -N(R2)-; R2 representa hidrógeno o alquilo C1-C6;Z representa -[O]e-[CH2]f-R3, un anillo de fenilo (opcionalmente fusionado con un anillo de benceno o Het2, y además siendo el grupo en su conjunto opcionalmente sustituido), o Het3 (opcionalmente fusionado con un anillo de benceno o Het4, y además siendo el grupo en su conjunto un grupo opcionalmente sustituido); R3 representa alquilo C1-C6 (opcionalmente sustituido), cicloalquilo C3-C6, cicloalquenilo C3-C6, fenilo (opcionalmente sustituido), Het5 ó NR4R5; e representa un número elegido entre 0 ó 1; f representa un número elegido entre 0 y 6; Het2 y Het5 representan independientemente anillos heterocíclicos saturados, parcialmente saturados o aromáticos, de 5 ó 6 miembros; Het3 representa un anillo heterocíclico saturado, parcialmente saturado o aromático, de 4 a 6 miembros; Het4 representa un anillo heterocíclico aromático de 6 miembros, opcionalmente sustituido; R4 y R5 representan independientemente alquilo C1-C6, alquiloxi C1-C6, cicloalquilo C3-C8 (opcionalmente fusionado con cicloalquilo C3-C8), Het6 ó hidrógeno; Het6 representa un anillo heterocíclico saturado, parcialmente saturado o aromático de 5 ó 6 miembros opcionalmente sustituido;son útiles para tratar un trastorno para el cual está indicado un antagonista de V1a, en particular la dismenorrea.
EC2006006647A 2003-12-22 2006-06-15 Derivados de triazol como antagonistas de vasopresina ECSP066647A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB0329693A GB0329693D0 (en) 2003-12-22 2003-12-22 Compounds useful in therapy
GB0408789A GB0408789D0 (en) 2004-04-20 2004-04-20 Triazole derivatives

Publications (1)

Publication Number Publication Date
ECSP066647A true ECSP066647A (es) 2006-10-25

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EC2006006647A ECSP066647A (es) 2003-12-22 2006-06-15 Derivados de triazol como antagonistas de vasopresina

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EP (1) EP1701959A1 (es)
JP (1) JP4698604B2 (es)
KR (1) KR100854872B1 (es)
AP (1) AP2331A (es)
AR (1) AR047340A1 (es)
AU (1) AU2004309164B2 (es)
BR (1) BRPI0417267A (es)
CA (1) CA2551038C (es)
CR (1) CR8481A (es)
DO (1) DOP2004001062A (es)
EA (1) EA010132B1 (es)
EC (1) ECSP066647A (es)
GE (1) GEP20084571B (es)
HK (1) HK1095822A1 (es)
IL (1) IL176349A (es)
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NL (1) NL1027833C2 (es)
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PA (1) PA8620501A1 (es)
PE (1) PE20051051A1 (es)
TW (1) TWI287541B (es)
UY (1) UY28693A1 (es)
WO (1) WO2005063754A1 (es)

Families Citing this family (52)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4101852B2 (ja) 2004-05-26 2008-06-18 エーザイ・アール・アンド・ディー・マネジメント株式会社 シンナミド化合物
AU2005286648A1 (en) 2004-09-20 2006-03-30 Xenon Pharmaceuticals Inc. Heterocyclic derivatives and their use as stearoyl-CoA desaturase inhibitors
CA2580787A1 (en) 2004-09-20 2006-03-30 Xenon Pharmaceuticals Inc. Heterocyclic derivatives for the treatment of diseases mediated by stearoyl-coa desaturase enzymes
TW200626138A (en) 2004-09-20 2006-08-01 Xenon Pharmaceuticals Inc Heterocyclic derivatives and their use as therapeutic agents
CN101083992A (zh) 2004-09-20 2007-12-05 泽农医药公司 抑制人硬脂酰CoA去饱和酶的哒嗪衍生物
AR051092A1 (es) * 2004-09-20 2006-12-20 Xenon Pharmaceuticals Inc Derivados heterociclicos y su uso como inhibidores de la estearoil-coa
EP2269610A3 (en) 2004-09-20 2011-03-09 Xenon Pharmaceuticals Inc. Heterocyclic derivatives and their use as stearoyl-coa desaturase inhibitors
MX2007003327A (es) 2004-09-20 2007-06-05 Xenon Pharmaceuticals Inc Derivados heterociclicos, y su uso como mediadores de estearoil-coa desaturasa.
CA2580119A1 (en) 2004-10-26 2006-05-04 Eisai R & D Management Co., Ltd. Amorphous object of cinnamide compound
AP2007004047A0 (en) 2005-01-20 2007-06-30 Pfizer Ltd Substituted triazole derivatives as oxtocin antagonists
CA2618646A1 (en) 2005-06-03 2007-11-15 Xenon Pharmaceuticals Inc. Aminothiazole derivatives as human stearoyl-coa desaturase inhibitors
CA2616937A1 (en) * 2005-07-29 2007-02-08 F. Hoffman-La Roche Ag Indol-3-yl-carbonyl-piperidin and piperazin derivatives
TWI370130B (en) 2005-11-24 2012-08-11 Eisai R&D Man Co Ltd Two cyclic cinnamide compound
TWI378091B (en) 2006-03-09 2012-12-01 Eisai R&D Man Co Ltd Multi-cyclic cinnamide derivatives
WO2008013622A2 (en) 2006-07-27 2008-01-31 E. I. Du Pont De Nemours And Company Fungicidal azocyclic amides
US9090604B2 (en) 2006-07-27 2015-07-28 E I Du Pont De Nemours And Company Fungicidal azocyclic amides
US7737141B2 (en) 2006-07-28 2010-06-15 Eisai R&D Management Co., Ltd. Prodrug of cinnamide compound
CA2670671A1 (en) * 2006-12-07 2008-06-12 F. Hoffmann-La Roche Ag Spiro-piperidine derivatives
CA2670674A1 (en) 2006-12-07 2008-06-12 F. Hoffmann-La Roche Ag Spiro-piperidine derivatives as via receptor antagonists
JP2010513385A (ja) * 2006-12-22 2010-04-30 エフ．ホフマン−ラ ロシュ アーゲー スピロ−ピペリジン誘導体
BRPI0720827A2 (pt) * 2006-12-29 2014-03-04 Hoffmann La Roche Derivados de azaspiro
CL2008000582A1 (es) 2007-02-28 2008-06-27 Eisai R&D Man Co Ltd Compuestos ciclicos derivados de oximorfolina condensados; farmacos que comprenden a dichos compuestos; y su uso para tratar enfermedad de alzheimer, demencia senil, sindrome de down o amiloidosis.
US7935815B2 (en) 2007-08-31 2011-05-03 Eisai R&D Management Co., Ltd. Imidazoyl pyridine compounds and salts thereof
TW200916469A (en) 2007-08-31 2009-04-16 Eisai R & Amp D Man Co Ltd Multi-cyclic compounds
WO2010051245A1 (en) 2008-11-03 2010-05-06 Merck Sharp & Dohme Corp. Benzimidazole and aza-benzimidazole carboxamides
NZ608729A (en) 2010-10-01 2014-08-29 Taisho Pharmaceutical Co Ltd 1,2,4-triazolone derivative
EP2970104B1 (en) 2013-03-14 2019-04-24 Zeno Royalties & Milestones, LLC Bicyclic analgesic compounds
JP6542794B2 (ja) 2013-12-12 2019-07-10 ゼノ ロイアルティー アンド マイルストーンズ リミテッド ライアビリティー カンパニー 二環式アルキル化合物、および合成
CA2942144C (en) 2014-03-07 2023-08-22 Kalyra Pharmaceuticals, Inc. Propellane derivates and synthesis
CN106999451B (zh) * 2014-09-17 2021-04-02 里科瑞尔姆Ip控股有限责任公司 双环化合物
ES2712886T3 (es) 2014-09-24 2019-05-16 Bayer Pharma AG Derivados de piridobenzazepina y piridobenzazocina que inhiben el factor XIa
SG11201703199UA (en) * 2014-11-03 2017-05-30 Bayer Pharma AG Hydroxyalkyl-substituted phenyltriazole derivatives and uses thereof
RU2637101C2 (ru) * 2016-01-11 2017-11-29 Федеральное государственное бюджетное научное учреждение "Федеральный исследовательский центр вирусологии и микробиологии" (ФГБНУ ФИЦВиМ) Устройство для определения аспирированной дозы аэрозолей
EP3419626A1 (en) * 2016-02-23 2019-01-02 Servicio Andaluz De Salud Piperazine derivatives as antiviral agents with increased therapeutic activity
US10525041B2 (en) 2016-05-03 2020-01-07 Bayer Pharma Aktiengesellschaft Fluoroalkyl-substituted aryltriazole derivatives and uses thereof
EP3452470B1 (en) 2016-05-03 2020-03-18 Bayer Pharma Aktiengesellschaft Amide-substituted phenyltriazole derivatives and uses thereof
EP3452472A1 (en) 2016-05-03 2019-03-13 Bayer Aktiengesellschaft Hydroxyalkyl-substituted heteroaryltriazole derivatives and uses thereof
US9988367B2 (en) * 2016-05-03 2018-06-05 Bayer Pharma Aktiengesellschaft Amide-substituted pyridinyltriazole derivatives and uses thereof
WO2017191105A1 (en) 2016-05-03 2017-11-09 Bayer Pharma Aktiengesellschaft Amide-substituted aryltriazole derivatives and uses thereof
WO2017191115A1 (en) 2016-05-03 2017-11-09 Bayer Pharma Aktiengesellschaft Oxoalkyl-substituted phenyltriazole derivatives and uses thereof
US11178872B2 (en) 2016-05-09 2021-11-23 Nippon Soda Co., Ltd. Cyclic amine compound and pest control agent
US10927098B2 (en) 2016-10-20 2021-02-23 Bayer Pharma Aktiengesellschaft Hydroxyalkyl-substituted triazole derivatives and uses thereof
BR112019024155A2 (pt) 2017-05-15 2020-06-02 Recurium Ip Holdings, Llc Compostos analgésicos
US11149023B2 (en) 2017-10-24 2021-10-19 Bayer Pharma Aktiengesellschaft Substituted triazole derivatives and uses thereof
WO2019081302A1 (en) 2017-10-24 2019-05-02 Bayer Pharma Aktiengesellschaft SUBSTITUTED TRIAZOLE DERIVATIVES AND USES THEREOF
CA3079770A1 (en) 2017-10-24 2019-05-02 Bayer Pharma Aktiengesellschaft Amine substituted triazole derivatives and uses thereof
LT3700913T (lt) 2017-10-24 2022-01-25 Bayer Aktiengesellschaft Pakeistojo triazolo darinių provaistai ir jų naudojimas
CA3079771A1 (en) 2017-10-24 2019-05-02 Bayer Pharma Aktiengesellschaft Substituted triazole derivatives and uses thereof
WO2019081307A1 (en) 2017-10-24 2019-05-02 Bayer Aktiengesellschaft SUBSTITUTED TRIAZOLE DERIVATIVES AND USES THEREOF
WO2019081291A1 (en) 2017-10-24 2019-05-02 Bayer Aktiengesellschaft PRODRUGS OF SUBSTITUTED TRIAZOLE DERIVATIVES AND USES THEREOF
TW201938171A (zh) 2017-12-15 2019-10-01 匈牙利商羅特格登公司 作為血管升壓素Ｖ１ａ受體拮抗劑之三環化合物
HU231206B1 (hu) 2017-12-15 2021-10-28 Richter Gedeon Nyrt. Triazolobenzazepinek

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4481360A (en) * 1983-08-26 1984-11-06 The Upjohn Company 4H-1,2,4-Triazol-3-yl compounds
AU2000223275A1 (en) * 2000-02-08 2001-08-20 Yamanouchi Pharmaceutical Co..Ltd. Novel triazole derivatives
BR0110961A (pt) * 2000-05-19 2004-06-29 Merck Patent Gmbh Derivados de triazol

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