AR047340A1 - Derivados de triazol como antagonistas del receptor vi a - Google Patents

Derivados de triazol como antagonistas del receptor vi a

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Publication number
AR047340A1
AR047340A1 ARP040104826A ARP040104826A AR047340A1 AR 047340 A1 AR047340 A1 AR 047340A1 AR P040104826 A ARP040104826 A AR P040104826A AR P040104826 A ARP040104826 A AR P040104826A AR 047340 A1 AR047340 A1 AR 047340A1
Authority
AR
Argentina
Prior art keywords
saturated
optionally substituted
ring
heterocyclic ring
number chosen
Prior art date
Application number
ARP040104826A
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English (en)
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0329693A external-priority patent/GB0329693D0/en
Priority claimed from GB0408789A external-priority patent/GB0408789D0/en
Application filed by Pfizer filed Critical Pfizer
Publication of AR047340A1 publication Critical patent/AR047340A1/es

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    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
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    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
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  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
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  • Diabetes (AREA)
  • Cardiology (AREA)
  • Reproductive Health (AREA)
  • Endocrinology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pulmonology (AREA)
  • Urology & Nephrology (AREA)
  • Pain & Pain Management (AREA)
  • Gynecology & Obstetrics (AREA)
  • Hospice & Palliative Care (AREA)
  • Rheumatology (AREA)
  • Obesity (AREA)
  • Vascular Medicine (AREA)
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  • Psychiatry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Otolaryngology (AREA)
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Abstract

Un compuesto de formula (1) o derivados del mismo aceptables farmacéuticamente, en el que: X representa -[CH2]a-R o -[CH2]a-O-[CH2]b-R; a representa un numero elegido entre 0 y 6; b representa un numero elegido entre 0 y 6; R representa H, CF3 o Het; Het representa un anillo heterocíclico de 5 o 6 miembros, saturado, parcialmente saturado o aromático; Y representa uno o más sustituyentes elegidos independientemente entre -[O]c-[CH2]d-R1, que pueden ser iguales o diferentes en cada aparicion; c en cada aparicion representa independientemente un numero elegido entre 0 o 1; d en cada aparicion representa independientemente un numero elegido entre 0 y 6; R1 en cada aparicion representa independientemente H, halo, CF3, CN o Het1; Het1en cada aparicion representa independientemente un anillo heterocíclico insaturado de 5 o 6 miembros; V representa un enlace directo o -O-; el anillo A representa un anillo heterocíclico saturado de 5 a 7 miembros, o un grupo fenileno; Q representa un enlace directo o -N(R2)-; R2 representa H o alquilo C1-6; Z representa -[O]e-[CH2]f-R3, un anillo fenilo (opcionalmente fusionado con un anillo de benceno o Het2, y además siendo el grupo en su conjunto opcionalmente sustituido), o Het 3 (opcionalmente fusionado con un anillo de benceno o Het4, y además siendo el grupo en su conjunto un grupo opcionalmente sustituido); R3 representa alquilo C1-6 (opcionalmente sustituido), cicloalquilo C3-6, cicloalquenilo C3-6, fenilo (opcionalmente sustituido), Het5 o NR4R5; e representa un numero elegido entre 0 o 1; f representa un numero elegido entre 0 y 6; Het2 y Het5 representan independientemente anillos heterocíclicos saturados, parcialmente saturados o aromáticos, de 5 o 6 miembros; Het3 representa un anillo heterocíclico saturado, parcialmente saturado o aromático de 4 o 6 miembros; Het4 representa un anillo heterocíclico aromático de 6 miembros, opcionalmente sustituido; R4 y R5 representan independientemente alquilo C1-6, alquiloxi C1-6, cicloalquilo C3-8 (opcionalmente fusionado con cicloalquilo C3-8), Het6 o ; Het6 representa un anillo heterocíclico saturado, parcialmente saturado o aromático de 5 o 6 miembros opcionalmente sustituido; son utiles para tratar un trastorno para el cual está indicado un antagonista de V1a, en particular la dismenorrea.
ARP040104826A 2003-12-22 2004-12-21 Derivados de triazol como antagonistas del receptor vi a AR047340A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB0329693A GB0329693D0 (en) 2003-12-22 2003-12-22 Compounds useful in therapy
GB0408789A GB0408789D0 (en) 2004-04-20 2004-04-20 Triazole derivatives

Publications (1)

Publication Number Publication Date
AR047340A1 true AR047340A1 (es) 2006-01-18

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ARP040104826A AR047340A1 (es) 2003-12-22 2004-12-21 Derivados de triazol como antagonistas del receptor vi a

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EP (1) EP1701959A1 (es)
JP (1) JP4698604B2 (es)
KR (1) KR100854872B1 (es)
AP (1) AP2331A (es)
AR (1) AR047340A1 (es)
AU (1) AU2004309164B2 (es)
BR (1) BRPI0417267A (es)
CA (1) CA2551038C (es)
CR (1) CR8481A (es)
DO (1) DOP2004001062A (es)
EA (1) EA010132B1 (es)
EC (1) ECSP066647A (es)
GE (1) GEP20084571B (es)
HK (1) HK1095822A1 (es)
IL (1) IL176349A (es)
IS (1) IS8472A (es)
MA (1) MA28393B1 (es)
NL (1) NL1027833C2 (es)
NO (1) NO20063380L (es)
OA (1) OA13347A (es)
PA (1) PA8620501A1 (es)
PE (1) PE20051051A1 (es)
TW (1) TWI287541B (es)
UY (1) UY28693A1 (es)
WO (1) WO2005063754A1 (es)

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JP5043668B2 (ja) 2004-09-20 2012-10-10 ゼノン・ファーマシューティカルズ・インコーポレイテッド 複素環誘導体および治療薬としてのそれらの使用
MX2007003327A (es) 2004-09-20 2007-06-05 Xenon Pharmaceuticals Inc Derivados heterociclicos, y su uso como mediadores de estearoil-coa desaturasa.
TW200626154A (en) * 2004-09-20 2006-08-01 Xenon Pharmaceuticals Inc Heterocyclic derivatives and their use as therapeutic agents
JP5149009B2 (ja) 2004-09-20 2013-02-20 ゼノン・ファーマシューティカルズ・インコーポレイテッド ヒトステアロイル−ＣｏＡデサチュラーゼを阻害するためのピリダジン誘導体
MX2007003332A (es) 2004-09-20 2007-06-05 Xenon Pharmaceuticals Inc Derivados heterociclicos y su uso como inhibidores de estearoil-coa-desaturasa.
BRPI0515483A (pt) 2004-09-20 2008-07-22 Xenon Pharmaceuticals Inc derivados heterocìclicos para o tratamento de doenças mediadas por enzimas estearoil-coa desaturase
EP1804799B1 (en) 2004-09-20 2013-08-21 Xenon Pharmaceuticals Inc. Heterocyclic derivatives and their use as stearoyl-coa desaturase inhibitors
US7923563B2 (en) 2004-10-26 2011-04-12 Eisai R&D Management Co., Ltd. Amorphous object of cinnamide compound
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