ECSP034891A - Derivados de benzoxazepina y su uso como estimula_ dores de receptores ampa - Google Patents
Derivados de benzoxazepina y su uso como estimula_ dores de receptores ampaInfo
- Publication number
- ECSP034891A ECSP034891A EC2003004891A ECSP034891A ECSP034891A EC SP034891 A ECSP034891 A EC SP034891A EC 2003004891 A EC2003004891 A EC 2003004891A EC SP034891 A ECSP034891 A EC SP034891A EC SP034891 A ECSP034891 A EC SP034891A
- Authority
- EC
- Ecuador
- Prior art keywords
- alkyl
- derivatives
- alkyloxy
- independently
- halogen
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D515/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D515/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D515/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
- A61P25/12—Antiepileptics; Anticonvulsants for grand-mal
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/36—Opioid-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Psychiatry (AREA)
- Addiction (AREA)
- Pain & Pain Management (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Hospice & Palliative Care (AREA)
- Gynecology & Obstetrics (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
La presente invención se refiere a un derivado de benzoxazepina que tiene la fórmula general I, en la cual X representa CO o SO2; R1, R2, R3 y R4 son independientemente seleccionados desde H, (C 1-4) alquilo, (C 1-4) alquiloxi, (C 1-4)alquiloxi(C 1-4)alquilo, CF3, halógeno, nitro, ciano, NR8R9, NR8COR10, y CONR8R9; R5, R6 y R7 son independientemente H o (C 1-4)alquilo; R8 y R9 son independientemente H o (C 1-4)alquilo; o R8 y R9 forman junto con el átomo de nitrógeno al cual están unidos al anillo heterocíclico saturado membrado 5- o 6-, conteniendo opcionalmente un hetero átomo adicional seleccionado desde O, S, o NR11; R10 es (C 1-4)alquilo; R11 es (C 1-4)alquilo; A representa el residuo de un anillo heterocíclico saturado membrado 4-7, opcionalmente conteniendo un átomo de oxígeno, el anillo siendo opcionalmente sustituido con sustituyentes 1-3 seleccionados desde (C 1-4)alquilo, (C 1-4)alquiloxi, hidroxi, halógeno u oxo; o una sal farmacéuticamente aceptable del mismo. LA invención también e refiere a composiciones farmacéuticas que comprenden dichos derivados, y el uso de estos derivados de benzoxazepina en el tratamiento de enfermedades neurológicas y desórdenes psiquiátricos los cuales responden al aumento de las respuestas sinápticas intermediadas por los receptores AMPA en el sistema nervioso central.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP01202215 | 2001-06-11 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ECSP034891A true ECSP034891A (es) | 2004-01-28 |
Family
ID=8180450
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EC2003004891A ECSP034891A (es) | 2001-06-11 | 2003-12-11 | Derivados de benzoxazepina y su uso como estimula_ dores de receptores ampa |
Country Status (29)
| Country | Link |
|---|---|
| US (2) | US7307073B2 (es) |
| EP (1) | EP1399450B1 (es) |
| JP (1) | JP4435561B2 (es) |
| KR (1) | KR100863255B1 (es) |
| CN (1) | CN1257908C (es) |
| AR (1) | AR036092A1 (es) |
| AT (1) | ATE389659T1 (es) |
| AU (1) | AU2002314144B2 (es) |
| BR (1) | BR0210222A (es) |
| CA (1) | CA2450274C (es) |
| CO (1) | CO5550447A2 (es) |
| CZ (1) | CZ300052B6 (es) |
| DE (1) | DE60225689T2 (es) |
| EC (1) | ECSP034891A (es) |
| ES (1) | ES2301651T3 (es) |
| HR (1) | HRP20031007A2 (es) |
| HU (1) | HUP0400154A3 (es) |
| IL (2) | IL158905A0 (es) |
| IS (1) | IS2526B (es) |
| MX (1) | MXPA03011563A (es) |
| NO (1) | NO328705B1 (es) |
| NZ (1) | NZ529670A (es) |
| PE (1) | PE20030097A1 (es) |
| PL (1) | PL366721A1 (es) |
| RU (1) | RU2279434C2 (es) |
| SK (1) | SK287150B6 (es) |
| TW (1) | TWI232863B (es) |
| WO (1) | WO2002100865A1 (es) |
| ZA (1) | ZA200309382B (es) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7345036B2 (en) | 2001-06-14 | 2008-03-18 | N.V. Organon | (Pyrido/thieno)—[f]—oxazepine-5-one derivatives |
| WO2010054336A2 (en) * | 2008-11-10 | 2010-05-14 | The Regents Of The University Of California | Therapeutic uses of ampa receptor modulators for treatment of motor dysfunction |
| DK2483278T3 (da) * | 2009-09-28 | 2014-01-13 | Hoffmann La Roche | Benzoxazepin pi3k-inhibitorforbindelser og deres anvendelse i behandlingen af cancer |
| FR2964969B1 (fr) | 2010-09-16 | 2012-08-24 | Servier Lab | Nouveaux derives dihydrobenzoxathiazepines, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| EP3008167A4 (en) | 2013-06-13 | 2017-06-07 | VeroScience LLC | Compositions and methods for treating metabolic disorders |
| WO2018009256A1 (en) | 2016-03-29 | 2018-01-11 | Respirerx Pharmaceuticals, Inc. | Compositions and methods for treating attention deficit disorders |
| US10821103B2 (en) | 2016-11-07 | 2020-11-03 | Arbutus Biopharma Corporation | Substituted pyridinone-containing trycyclic compounds, and methods using same |
| WO2019177937A1 (en) | 2018-03-12 | 2019-09-19 | Arbutus Biopharma, Inc. | Substituted 2-pyridone tricyclic compounds, analogues thereof, and methods using same |
| KR20200142529A (ko) | 2018-04-12 | 2020-12-22 | 아뷰터스 바이오파마 코포레이션 | 치환된 피리디논-함유 트리사이클릭 화합물의 제조 방법 |
| AU2019382521B2 (en) | 2018-11-22 | 2023-11-16 | Fujian Akeylink Biotechnology Co., Ltd. | Crystal form of hepatitis B surface antigen inhibitor |
| EP4121072A1 (en) * | 2020-03-20 | 2023-01-25 | Amathus Therapeutics, Inc. | Cyclic sulfonamide derivatives as trap1 modulators and uses thereof |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1238719A (es) | 1968-11-01 | 1971-07-07 | ||
| CA2138533C (en) | 1992-07-24 | 2009-04-14 | Gary S. Lynch | Drugs that enhance synaptic responses mediated by ampa receptors |
| CN1168140A (zh) | 1995-01-06 | 1997-12-17 | 弗·哈夫曼-拉罗切有限公司 | 羟甲基咪唑并二氮杂䓬及其酯 |
| US5650409A (en) * | 1995-06-02 | 1997-07-22 | Cortex Pharmaceuticals, Inc. | Benzoyl piperidines/pyrrolidines for enhancing synaptic response |
| US5736543A (en) * | 1996-04-03 | 1998-04-07 | The Regents Of The University Of California | Benzoxazines for enhancing synaptic response |
| DE69831446T2 (de) | 1997-06-09 | 2006-06-14 | Pfizer Prod Inc | Chinazolin-4-on AMPA Antagonisten |
| US5985871A (en) | 1997-12-24 | 1999-11-16 | Cortex Pharmaceuticals, Inc. | Benzoxazine compounds for enhancing synaptic response |
| CA2320354A1 (en) * | 1998-02-18 | 1999-08-26 | Neurosearch A/S | Novel compounds and their use as positive ampa receptor modulators |
| US6124278A (en) | 1998-04-03 | 2000-09-26 | The Regents Of The University Of California | Acylbenzoxazines for enhancing synaptic response |
-
2002
- 2002-05-31 TW TW091111746A patent/TWI232863B/zh not_active IP Right Cessation
- 2002-06-05 WO PCT/EP2002/006185 patent/WO2002100865A1/en not_active Ceased
- 2002-06-05 JP JP2003503632A patent/JP4435561B2/ja not_active Expired - Lifetime
- 2002-06-05 SK SK1518-2003A patent/SK287150B6/sk not_active IP Right Cessation
- 2002-06-05 KR KR1020037016150A patent/KR100863255B1/ko not_active Expired - Fee Related
- 2002-06-05 CN CNB028116410A patent/CN1257908C/zh not_active Expired - Lifetime
- 2002-06-05 CZ CZ20033376A patent/CZ300052B6/cs not_active IP Right Cessation
- 2002-06-05 HU HU0400154A patent/HUP0400154A3/hu unknown
- 2002-06-05 US US10/480,623 patent/US7307073B2/en not_active Expired - Lifetime
- 2002-06-05 DE DE60225689T patent/DE60225689T2/de not_active Expired - Lifetime
- 2002-06-05 MX MXPA03011563A patent/MXPA03011563A/es active IP Right Grant
- 2002-06-05 IL IL15890502A patent/IL158905A0/xx unknown
- 2002-06-05 HR HR20031007A patent/HRP20031007A2/xx not_active Application Discontinuation
- 2002-06-05 RU RU2004100310/04A patent/RU2279434C2/ru not_active IP Right Cessation
- 2002-06-05 PL PL02366721A patent/PL366721A1/xx not_active IP Right Cessation
- 2002-06-05 AT AT02740691T patent/ATE389659T1/de active
- 2002-06-05 EP EP02740691A patent/EP1399450B1/en not_active Expired - Lifetime
- 2002-06-05 CA CA2450274A patent/CA2450274C/en not_active Expired - Lifetime
- 2002-06-05 NZ NZ529670A patent/NZ529670A/en unknown
- 2002-06-05 BR BR0210222-6A patent/BR0210222A/pt not_active Application Discontinuation
- 2002-06-05 AU AU2002314144A patent/AU2002314144B2/en not_active Expired
- 2002-06-05 ES ES02740691T patent/ES2301651T3/es not_active Expired - Lifetime
- 2002-06-10 PE PE2002000495A patent/PE20030097A1/es not_active Application Discontinuation
- 2002-06-10 AR ARP020102171A patent/AR036092A1/es unknown
-
2003
- 2003-11-13 IS IS7036A patent/IS2526B/is unknown
- 2003-11-17 IL IL158905A patent/IL158905A/en not_active IP Right Cessation
- 2003-12-02 ZA ZA200309382A patent/ZA200309382B/en unknown
- 2003-12-04 CO CO03107046A patent/CO5550447A2/es not_active Application Discontinuation
- 2003-12-10 NO NO20035486A patent/NO328705B1/no not_active IP Right Cessation
- 2003-12-11 EC EC2003004891A patent/ECSP034891A/es unknown
-
2007
- 2007-10-25 US US11/924,451 patent/US7504390B2/en not_active Expired - Lifetime
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