BR0210222A - Derivado de benzoxazepina, composição farmacêutica, uso de um derivado de benzoxazepina, e, método para tratar uma doença neurológica ou distúrbio psiquiátrico - Google Patents
Derivado de benzoxazepina, composição farmacêutica, uso de um derivado de benzoxazepina, e, método para tratar uma doença neurológica ou distúrbio psiquiátricoInfo
- Publication number
- BR0210222A BR0210222A BR0210222-6A BR0210222A BR0210222A BR 0210222 A BR0210222 A BR 0210222A BR 0210222 A BR0210222 A BR 0210222A BR 0210222 A BR0210222 A BR 0210222A
- Authority
- BR
- Brazil
- Prior art keywords
- alkyl
- derivative
- benzoxazepine
- independently
- benzoxazepine derivative
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D515/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D515/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D515/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
- A61P25/12—Antiepileptics; Anticonvulsants for grand-mal
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/36—Opioid-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Psychiatry (AREA)
- Addiction (AREA)
- Pain & Pain Management (AREA)
- Endocrinology (AREA)
- Hospice & Palliative Care (AREA)
- Heart & Thoracic Surgery (AREA)
- Gynecology & Obstetrics (AREA)
- Cardiology (AREA)
- Reproductive Health (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
"DERIVADO DE BENZOXAZEPINA, COMPOSIçãO FARMACêUTICA, USO DE UM DERIVADO DE BENZOXAZEPINA, E, MéTODO PARA TRATAR UMA DOENçA NEUROLóGICA OU DISTúRBIO PSIQUIáTRICO". A presente ivenção diz respeito a derivado de benzoxazepina tendo a fórmula geral I, em que X representa CO ou SO~ 2~; R^ 1^, R^ 2^, R^ 3^ e R^ 4^ são independentemente selecionados de H, alquila C~ 1-4~, alquilóxi C~ 1-4~, alquilóxi C~ 1-4ãlquila C~ 1-4~, halogênio, nitro, ciano, NR^ 8^R^ 9^, NR^ 8^COR^ 10^ e CONR^ 8^R^ 9^, R^ 5^, R^ 6^ e R^ 7^ são independentemente H ou alquila C~ 1-4~; R^ 8^ e R^ 9^ são independentemente H ou alquila C~ 1-4~; ou R^ 8^ e R^ 9^ formam juntamente com o átomo de nitrogênio a que eles são ligados, um anel heterocíclico saturado de 5 ou 6 membros, opcionalmente contendo um outro heteroátomo selecionado de O, S ou NR^ 11^; R^ 10^ é alquila C~ 1-4~; R^ 11^ é alquila C~ 1-4~; A representa o resíduo de um anel heterocíclico saturado de 4 a 7 membros, opcionalmente contendo um átomo de oxigênio, o anel sendo opcionalmente substituído por 1 a 3 substituintes selecionados de alquila C~ 1-4~, alquilóxi C~ 1-4~, hidróxi, halogênio e oxo; ou um sal destes farmaceuticamente aceitável. A invenção também diz respeito a composições farmacêuticas que compreendem referidos derivados, e ao uso destes derivados de benzoxazepina no tratamento de doenças neurológicas e distúrbios psiquiátricos que sejam responsivos à intensificação das respostas sinápticas mediadas pelos receptores AMPA no sistema nervoso central.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP01202215 | 2001-06-11 | ||
| PCT/EP2002/006185 WO2002100865A1 (en) | 2001-06-11 | 2002-06-05 | Benzoxazepine derivatives and their use as ampa receptor stimulators |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR0210222A true BR0210222A (pt) | 2004-04-13 |
Family
ID=8180450
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR0210222-6A BR0210222A (pt) | 2001-06-11 | 2002-06-05 | Derivado de benzoxazepina, composição farmacêutica, uso de um derivado de benzoxazepina, e, método para tratar uma doença neurológica ou distúrbio psiquiátrico |
Country Status (30)
| Country | Link |
|---|---|
| US (2) | US7307073B2 (pt) |
| EP (1) | EP1399450B1 (pt) |
| JP (1) | JP4435561B2 (pt) |
| KR (1) | KR100863255B1 (pt) |
| CN (1) | CN1257908C (pt) |
| AR (1) | AR036092A1 (pt) |
| AT (1) | ATE389659T1 (pt) |
| AU (1) | AU2002314144B2 (pt) |
| BR (1) | BR0210222A (pt) |
| CA (1) | CA2450274C (pt) |
| CO (1) | CO5550447A2 (pt) |
| CZ (1) | CZ300052B6 (pt) |
| DE (1) | DE60225689T2 (pt) |
| EC (1) | ECSP034891A (pt) |
| ES (1) | ES2301651T3 (pt) |
| HK (1) | HK1061858A1 (pt) |
| HR (1) | HRP20031007A2 (pt) |
| HU (1) | HUP0400154A3 (pt) |
| IL (2) | IL158905A0 (pt) |
| IS (1) | IS2526B (pt) |
| MX (1) | MXPA03011563A (pt) |
| NO (1) | NO328705B1 (pt) |
| NZ (1) | NZ529670A (pt) |
| PE (1) | PE20030097A1 (pt) |
| PL (1) | PL366721A1 (pt) |
| RU (1) | RU2279434C2 (pt) |
| SK (1) | SK287150B6 (pt) |
| TW (1) | TWI232863B (pt) |
| WO (1) | WO2002100865A1 (pt) |
| ZA (1) | ZA200309382B (pt) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2002102808A2 (en) | 2001-06-14 | 2002-12-27 | Akzo Nobel N.V. | (PYRIDO/THIENO)-[f]-OXAZEPIN-5-ONE DERIVATIVES AS POSITIVE MODULATORS OF THE AMPA RECEPTOR |
| WO2010054336A2 (en) * | 2008-11-10 | 2010-05-14 | The Regents Of The University Of California | Therapeutic uses of ampa receptor modulators for treatment of motor dysfunction |
| JP5540101B2 (ja) * | 2009-09-28 | 2014-07-02 | エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト | ベンゾオキサゼピンｐｉ３ｋ阻害剤化合物及び使用方法 |
| FR2964969B1 (fr) | 2010-09-16 | 2012-08-24 | Servier Lab | Nouveaux derives dihydrobenzoxathiazepines, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| CA2915405A1 (en) | 2013-06-13 | 2014-12-18 | Veroscience Llc | Compositions and methods for treating metabolic disorders |
| CN110114071B (zh) | 2016-11-07 | 2023-07-04 | 爱彼特生物制药公司 | 含有取代的吡啶酮的三环化合物以及使用其的方法 |
| WO2019177937A1 (en) | 2018-03-12 | 2019-09-19 | Arbutus Biopharma, Inc. | Substituted 2-pyridone tricyclic compounds, analogues thereof, and methods using same |
| CA3096687A1 (en) | 2018-04-12 | 2019-10-17 | Arbutus Biopharma Corporation | Methods for preparing substituted pyridinone-containing tricyclic compounds |
| KR102606946B1 (ko) | 2018-11-22 | 2023-11-29 | 푸지엔 에이키링크 바이오테크놀로지 컴퍼니 리미티드 | B형 간염 표면 항원 억제제의 결정형 |
| WO2021188911A1 (en) * | 2020-03-20 | 2021-09-23 | Amathus Therapeutics, Inc. | Cyclic sulfonamide derivatives as trap1 modulators and uses thereof |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1238719A (pt) | 1968-11-01 | 1971-07-07 | ||
| ES2210060T3 (es) | 1992-07-24 | 2004-07-01 | The Regents Of The University Of California | Farmacos que aumentan las respuestas sinapticas mediadas por receptores ampa. |
| PT801651E (pt) | 1995-01-06 | 2001-12-28 | Hoffmann La Roche | Hidroximetil-imidazodiazepinas e seus esteres |
| US5650409A (en) | 1995-06-02 | 1997-07-22 | Cortex Pharmaceuticals, Inc. | Benzoyl piperidines/pyrrolidines for enhancing synaptic response |
| US5736543A (en) * | 1996-04-03 | 1998-04-07 | The Regents Of The University Of California | Benzoxazines for enhancing synaptic response |
| ES2245015T3 (es) | 1997-06-09 | 2005-12-16 | Pfizer Products Inc. | Quinazolin-4-onas como antagonistas de ampa. |
| US5985871A (en) * | 1997-12-24 | 1999-11-16 | Cortex Pharmaceuticals, Inc. | Benzoxazine compounds for enhancing synaptic response |
| PL342843A1 (en) * | 1998-02-18 | 2001-07-16 | Neurosearch As | Novel compounds and their use as positive ampa receptor modulators |
| US6124278A (en) | 1998-04-03 | 2000-09-26 | The Regents Of The University Of California | Acylbenzoxazines for enhancing synaptic response |
-
2002
- 2002-05-31 TW TW091111746A patent/TWI232863B/zh not_active IP Right Cessation
- 2002-06-05 AT AT02740691T patent/ATE389659T1/de active
- 2002-06-05 HU HU0400154A patent/HUP0400154A3/hu unknown
- 2002-06-05 JP JP2003503632A patent/JP4435561B2/ja not_active Expired - Lifetime
- 2002-06-05 CZ CZ20033376A patent/CZ300052B6/cs not_active IP Right Cessation
- 2002-06-05 MX MXPA03011563A patent/MXPA03011563A/es active IP Right Grant
- 2002-06-05 BR BR0210222-6A patent/BR0210222A/pt not_active Application Discontinuation
- 2002-06-05 US US10/480,623 patent/US7307073B2/en not_active Expired - Lifetime
- 2002-06-05 WO PCT/EP2002/006185 patent/WO2002100865A1/en active IP Right Grant
- 2002-06-05 EP EP02740691A patent/EP1399450B1/en not_active Expired - Lifetime
- 2002-06-05 CA CA2450274A patent/CA2450274C/en not_active Expired - Lifetime
- 2002-06-05 SK SK1518-2003A patent/SK287150B6/sk not_active IP Right Cessation
- 2002-06-05 RU RU2004100310/04A patent/RU2279434C2/ru not_active IP Right Cessation
- 2002-06-05 PL PL02366721A patent/PL366721A1/xx not_active IP Right Cessation
- 2002-06-05 KR KR1020037016150A patent/KR100863255B1/ko not_active IP Right Cessation
- 2002-06-05 NZ NZ529670A patent/NZ529670A/en unknown
- 2002-06-05 CN CNB028116410A patent/CN1257908C/zh not_active Expired - Lifetime
- 2002-06-05 ES ES02740691T patent/ES2301651T3/es not_active Expired - Lifetime
- 2002-06-05 AU AU2002314144A patent/AU2002314144B2/en not_active Expired
- 2002-06-05 DE DE60225689T patent/DE60225689T2/de not_active Expired - Lifetime
- 2002-06-05 IL IL15890502A patent/IL158905A0/xx unknown
- 2002-06-10 PE PE2002000495A patent/PE20030097A1/es not_active Application Discontinuation
- 2002-06-10 AR ARP020102171A patent/AR036092A1/es unknown
-
2003
- 2003-11-13 IS IS7036A patent/IS2526B/is unknown
- 2003-11-17 IL IL158905A patent/IL158905A/en not_active IP Right Cessation
- 2003-12-02 ZA ZA200309382A patent/ZA200309382B/en unknown
- 2003-12-04 CO CO03107046A patent/CO5550447A2/es not_active Application Discontinuation
- 2003-12-04 HR HR20031007A patent/HRP20031007A2/xx not_active Application Discontinuation
- 2003-12-10 NO NO20035486A patent/NO328705B1/no not_active IP Right Cessation
- 2003-12-11 EC EC2003004891A patent/ECSP034891A/es unknown
-
2004
- 2004-07-07 HK HK04104926A patent/HK1061858A1/xx not_active IP Right Cessation
-
2007
- 2007-10-25 US US11/924,451 patent/US7504390B2/en not_active Expired - Lifetime
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| B07A | Application suspended after technical examination (opinion) [chapter 7.1 patent gazette] | ||
| B09B | Patent application refused [chapter 9.2 patent gazette] | ||
| B09B | Patent application refused [chapter 9.2 patent gazette] |
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