AR012952A1 - Derivado de pirazol triciclico y composicion farmaceutica que lo incluye - Google Patents

Derivado de pirazol triciclico y composicion farmaceutica que lo incluye

Info

Publication number
AR012952A1
AR012952A1 ARP980102731A ARP980102731A AR012952A1 AR 012952 A1 AR012952 A1 AR 012952A1 AR P980102731 A ARP980102731 A AR P980102731A AR P980102731 A ARP980102731 A AR P980102731A AR 012952 A1 AR012952 A1 AR 012952A1
Authority
AR
Argentina
Prior art keywords
group
atom
derivative
straight
disorders
Prior art date
Application number
ARP980102731A
Other languages
English (en)
Original Assignee
Astellas Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astellas Pharma Inc filed Critical Astellas Pharma Inc
Publication of AR012952A1 publication Critical patent/AR012952A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Gynecology & Obstetrics (AREA)
  • Psychiatry (AREA)
  • Anesthesiology (AREA)
  • Pain & Pain Management (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Un derivado de pirazol tricíclico representado por la formula general (I), o una sal farmacéuticamente aceptable del mismo, que muestra fuerte afinidady selectividad por el receptor 5-HT(2c) y es util para el tratamiento de enfermedades del sistema nervioso central (por ej., desordenes sexuales,desordenes de la alimentacion, ansiedad, depresion, desordenes del sueno y lo similar). Dicho derivado se incluye en composiciones farmacéuticas. Cadasímbolo de la formula anterior significa losiguiente: Anillo Het: un anillo heterocíclico no saturado de cinco miembros que contiene 1 a 3 heteroátomosseleccionado cada uno del grupo formado por un átomo de nitrogeno, un átomo de oxígeno y un átomo de azufre, A: un grupo alquileno inferior recto oramificado,y R: un átomo de hidrogeno, un grupo alquilo inferior, un átomo de halogeno, un grupo hidroxilo o un grupo alcoxi inferior. El término inferiorsignifica una cadena de carbono recta o ramificada que tiene 1 a 6 átomos de carbono.
ARP980102731A 1997-06-13 1998-06-10 Derivado de pirazol triciclico y composicion farmaceutica que lo incluye AR012952A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP15725597 1997-06-13

Publications (1)

Publication Number Publication Date
AR012952A1 true AR012952A1 (es) 2000-11-22

Family

ID=15645662

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP980102731A AR012952A1 (es) 1997-06-13 1998-06-10 Derivado de pirazol triciclico y composicion farmaceutica que lo incluye

Country Status (18)

Country Link
US (1) US6245796B1 (es)
EP (1) EP0990650B8 (es)
JP (1) JP3410478B2 (es)
KR (1) KR19990006912A (es)
CN (1) CN1097054C (es)
AR (1) AR012952A1 (es)
AT (1) ATE302192T1 (es)
AU (2) AU727654B2 (es)
BR (1) BR9802005A (es)
CA (1) CA2291651A1 (es)
DE (1) DE69831236T2 (es)
ES (1) ES2246535T3 (es)
HU (1) HUP9801340A1 (es)
ID (1) ID23173A (es)
PL (1) PL326777A1 (es)
RU (1) RU2191176C2 (es)
TW (1) TW502024B (es)
WO (1) WO1998056768A1 (es)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7138393B2 (en) 1998-07-24 2006-11-21 Wyeth Biologically active vasopressin agonist metabolites
EP1102755B1 (en) 1998-08-07 2006-01-04 Chiron Corporation Substituted isoxazole derivatives as estrogen receptor modulators
GB9819019D0 (en) * 1998-09-01 1998-10-28 Cerebrus Ltd Chemical compounds II
EP1112106B1 (en) 1998-09-18 2005-11-23 Alcon Manufacturing Ltd. Serotonergic 5ht2 agonists for treating glaucoma
GB9918965D0 (en) 1999-08-11 1999-10-13 Cerebrus Ltd Chemical compounds xxi
WO2001083487A1 (fr) * 2000-04-28 2001-11-08 Yamanouchi Pharmaceutical Co., Ltd. Derive de froindazole
DE10055093A1 (de) * 2000-11-07 2002-05-16 Agfa Gevaert Ag Cyaninfarbstoff
AU1529402A (en) 2000-11-20 2002-05-27 Biovitrum Ab Piperazinylpyrazines compounds as antagonists of serotonin 5-ht2 receptor
SE0004245D0 (sv) 2000-11-20 2000-11-20 Pharmacia Ab Novel compounds and their use
DK1392292T3 (da) 2001-06-01 2006-05-29 Alcon Inc Pyranoindazoler og deres anvendelse til behandling af glaukom
JP2004532887A (ja) 2001-06-01 2004-10-28 アルコン，インコーポレイテッド 新規な融合インダゾールおよびインドールおよび緑内障治療へのこれらの使用
AU2002360819A1 (en) * 2001-12-28 2003-07-24 Bayer Corporation Cyclohexano- and cycloheptapyrazole derivative compounds, for use in diseases associated with the 5-ht2c receptor
BR0311970A (pt) 2002-06-19 2005-03-29 Biovitrum Ab Novos compostos, seu uso e preparação
JP2006511556A (ja) 2002-12-13 2006-04-06 アルコン，インコーポレイテッド 新規のベンゾピラン類似体及び緑内障の治療のためのそれらの使用
CL2004000826A1 (es) 2003-04-25 2005-03-04 Pfizer Uso de un agonista para el receptor 5-ht2c para preparar un medicamento util en el tratamiento de la incontinencia urinaria provocada por estres, con la condicion de que el agonista no sea 1-[6-cloro-5-(trifluorometil)-2-piridinil]piperazina (org-129
WO2005053688A1 (en) * 2003-11-26 2005-06-16 Alcon, Inc. Substituted furo[2,3-g] indazoles for the treatment of glaucoma
WO2005058911A2 (en) * 2003-12-15 2005-06-30 Alcon, Inc. Substituted [1,4]oxazino[2,3-g]indazoles for the treatment of glaucoma
US7129257B1 (en) * 2003-12-15 2006-10-31 Alcon, Inc. Pyrazolo[3,4- e]benzoxazoles for the treatment of glaucoma
JP4960235B2 (ja) * 2004-09-03 2012-06-27 アサーシス， インク． セロトニン受容体調節剤としての三環ヘテロアリールのピペラジン化合物、ピロリジン化合物およびアゼチジン化合物
US7691888B2 (en) * 2004-10-07 2010-04-06 Boehringer Ingelheim International Gmbh Thiazolyl-dihydro-indazole
TW201118073A (en) * 2009-10-30 2011-06-01 Merck Sharp & Dohme Hexahydrocyclopentyl [F] indazole pyridyl ethanols and derivatives thereof as selective glucocorticoid receptor modulators
WO2011071136A1 (ja) 2009-12-11 2011-06-16 アステラス製薬株式会社 線維筋痛症治療剤
WO2012030953A1 (en) 2010-09-01 2012-03-08 Arena Pharmaceuticals, Inc. 5-ht2c receptor agonists in the treatment of disorders ameliorated by reduction of norepinephrine level
WO2013040321A1 (en) * 2011-09-15 2013-03-21 University Of Kansas Kappa opioid receptor effectors and uses thereof
US8853207B2 (en) 2012-04-12 2014-10-07 Development Center For Biotechnology Heterocyclic pyrazole compounds, method for preparing the same and use thereof
WO2015066344A1 (en) 2013-11-01 2015-05-07 Arena Pharmaceuticals, Inc. 5-ht2c receptor agonists and compositions and methods of use
CA3164963A1 (en) 2019-12-19 2021-06-24 Bayer Aktiengesellschaft Furoindazole derivatives
EP4298102A1 (en) 2021-02-23 2024-01-03 Bayer Aktiengesellschaft Furoindazole derivatives as gpr84 antagonists
WO2022229061A1 (en) 2021-04-29 2022-11-03 Bayer Aktiengesellschaft Furoindazole derivatives as antagonists or inhibitors of gpr84
WO2024083705A1 (en) 2022-10-18 2024-04-25 Bayer Aktiengesellschaft Furoindazole derivatives for the treatment of pain

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5637984B2 (es) 1974-01-31 1981-09-03
TW334423B (en) * 1993-10-22 1998-06-21 Hoffmann La Roche Tricyclic 1-aminoethylpyrrole-derivatives
TW270114B (es) 1993-10-22 1996-02-11 Hoffmann La Roche
GB9326192D0 (en) * 1993-12-22 1994-02-23 Glaxo Group Ltd Chemical compounds
US5756496A (en) * 1994-05-28 1998-05-26 Smithkline Beecham P.L.C. Amide derivatives having 5HT1D-antagonist activity
TW403738B (en) 1994-08-12 2000-09-01 Hoffmann La Roche Tricyclic pyrazole derivatives

Also Published As

Publication number Publication date
TW502024B (en) 2002-09-11
PL326777A1 (en) 1998-12-21
JP3410478B2 (ja) 2003-05-26
AU7674098A (en) 1998-12-30
EP0990650B1 (en) 2005-08-17
AU6989398A (en) 1998-12-17
HUP9801340A1 (hu) 1999-11-29
EP0990650A4 (en) 2002-02-13
HU9801340D0 (en) 1998-08-28
ES2246535T3 (es) 2006-02-16
ID23173A (id) 2000-03-23
KR19990006912A (ko) 1999-01-25
EP0990650A1 (en) 2000-04-05
AU727654B2 (en) 2000-12-21
ATE302192T1 (de) 2005-09-15
CN1097054C (zh) 2002-12-25
CN1203234A (zh) 1998-12-30
DE69831236D1 (de) 2005-09-22
CA2291651A1 (en) 1998-12-17
EP0990650B8 (en) 2005-10-19
WO1998056768A1 (fr) 1998-12-17
RU2191176C2 (ru) 2002-10-20
DE69831236T2 (de) 2006-04-13
US6245796B1 (en) 2001-06-12
BR9802005A (pt) 2000-03-21

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