DK1392292T3 - Pyranoindazoler og deres anvendelse til behandling af glaukom - Google Patents

Pyranoindazoler og deres anvendelse til behandling af glaukom

Info

Publication number
DK1392292T3
DK1392292T3 DK02734575T DK02734575T DK1392292T3 DK 1392292 T3 DK1392292 T3 DK 1392292T3 DK 02734575 T DK02734575 T DK 02734575T DK 02734575 T DK02734575 T DK 02734575T DK 1392292 T3 DK1392292 T3 DK 1392292T3
Authority
DK
Denmark
Prior art keywords
pyranoindazoles
glaucoma
treatment
Prior art date
Application number
DK02734575T
Other languages
English (en)
Inventor
Hwang-Hsing Chen
Bryon S Severns
Jesse A May
Original Assignee
Alcon Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alcon Inc filed Critical Alcon Inc
Application granted granted Critical
Publication of DK1392292T3 publication Critical patent/DK1392292T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • C07D491/052—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being six-membered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
DK02734575T 2001-06-01 2002-05-30 Pyranoindazoler og deres anvendelse til behandling af glaukom DK1392292T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US29542901P 2001-06-01 2001-06-01

Publications (1)

Publication Number Publication Date
DK1392292T3 true DK1392292T3 (da) 2006-05-29

Family

ID=23137684

Family Applications (1)

Application Number Title Priority Date Filing Date
DK02734575T DK1392292T3 (da) 2001-06-01 2002-05-30 Pyranoindazoler og deres anvendelse til behandling af glaukom

Country Status (20)

Country Link
US (2) US6696476B2 (da)
EP (1) EP1392292B1 (da)
JP (1) JP2004535418A (da)
KR (1) KR100626255B1 (da)
CN (1) CN100384417C (da)
AR (1) AR036044A1 (da)
AT (1) ATE318821T1 (da)
AU (1) AU2002305732B2 (da)
BR (1) BR0210241A (da)
CA (1) CA2447480A1 (da)
DE (1) DE60209486T2 (da)
DK (1) DK1392292T3 (da)
ES (1) ES2258631T3 (da)
HK (1) HK1061212A1 (da)
MX (1) MXPA03010807A (da)
PL (1) PL366636A1 (da)
PT (1) PT1392292E (da)
RU (1) RU2273641C2 (da)
WO (1) WO2002098350A2 (da)
ZA (1) ZA200309034B (da)

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ATE318821T1 (de) * 2001-06-01 2006-03-15 Alcon Inc Pyranoindazole und ihre verwendung in der glaukombehandlung
TW593302B (en) 2001-12-20 2004-06-21 Alcon Inc Novel benzodifuranimidazoline and benzofuranimidazoline derivatives and their use for the treatment of glaucoma
WO2003057213A2 (en) * 2001-12-28 2003-07-17 Bayer Pharmaceuticals Corporation Cyclohexano- and cycloheptapyrazole derivative compounds, for use in diseases associated with the 5-ht2c receptor
CA2495192A1 (en) * 2002-08-30 2004-03-11 Alcon, Inc. Substituted 5-chroman-5-yl-ethylamine compounds and their use for the treatment of glaucoma
JP2006511556A (ja) 2002-12-13 2006-04-06 アルコン，インコーポレイテッド 新規のベンゾピラン類似体及び緑内障の治療のためのそれらの使用
WO2005025568A1 (en) * 2003-09-04 2005-03-24 Merck & Co., Inc. Ophthalmic compositions for treating ocular hypertension
US7476687B2 (en) 2003-11-26 2009-01-13 Alcon, Inc. Substituted furo[2,3-g]indazoles for the treatment of glaucoma
US7129257B1 (en) 2003-12-15 2006-10-31 Alcon, Inc. Pyrazolo[3,4- e]benzoxazoles for the treatment of glaucoma
US7338972B1 (en) 2003-12-15 2008-03-04 Alcon, Inc. Substituted 1-alkylamino-1H-indazoles for the treatment of glaucoma
TW200520760A (en) 2003-12-15 2005-07-01 Alcon Inc Substituted [1,4] oxazino [2,3-g] indazoles for the treatment of glaucoma
JP5173190B2 (ja) 2004-08-25 2013-03-27 武田薬品工業株式会社 腹圧性尿失禁の予防・治療剤及びそのスクリーニング方法
US20060073172A1 (en) * 2004-10-01 2006-04-06 Schneider L W Stabilized ophthalmic solution for the treatment of glaucoma and lowering intraocular pressure
US7425572B2 (en) 2004-12-08 2008-09-16 Alcon, Inc. Use of dioxindoindazoles and dioxoloindazoles for treating glaucoma
TW200744567A (en) * 2005-09-23 2007-12-16 Alcon Inc Phenylethylamine analogs and their use for treating glaucoma
EP2018863B9 (en) 2006-05-16 2015-02-18 Takeda Pharmaceutical Company Limited Fused heterocyclic compound and use thereof
US20070293475A1 (en) * 2006-06-20 2007-12-20 Alcon Manufacturing Ltd. Aryl and heteroaryl tetrahydrobenzazepine derivatives and their use for treating glaucoma
US20090247552A1 (en) * 2006-07-31 2009-10-01 Shirou Sawa Aqueous liquid preparation containing amide compound
WO2008016993A1 (en) * 2006-08-01 2008-02-07 Alcon Research, Ltd. Intermediates and methods for serotonergic agonist synthesis
US20080033183A1 (en) * 2006-08-01 2008-02-07 Alcon Manufacturing, Ltd. Process for preparing pyranoindazole serotonergic receptor agonists
US20080058533A1 (en) * 2006-08-31 2008-03-06 Alcon, Inc. Pyranoindazole cyclic carbonates and methods of use
WO2009063992A1 (ja) 2007-11-15 2009-05-22 Takeda Pharmaceutical Company Limited 縮合ピリジン誘導体およびその用途
EP2510949A4 (en) 2009-12-11 2013-11-13 Astellas Pharma Inc THERAPEUTICS FOR FIBROMYALGIA
WO2016139960A1 (ja) * 2015-03-05 2016-09-09 株式会社ブリヂストン ゴム組成物、ジエン系重合体の製造方法及びタイヤ
TW201815766A (zh) * 2016-09-22 2018-05-01 美商普雷辛肯公司 用於ｉｄｏ及ｔｄｏ調節之化合物及方法以及其適應症
WO2019131902A1 (ja) 2017-12-27 2019-07-04 武田薬品工業株式会社 腹圧性尿失禁および便失禁の治療薬
CA3094336A1 (en) 2018-03-20 2019-09-26 Plexxikon Inc. Compounds and methods for ido and tdo modulation, and indications therefor

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NZ512765A (en) 1998-12-17 2003-10-31 Wyeth Corp 2,3,4,4A-tetrahydro-1H-pyrazino(1,2-A)quinoxalin- 5(6H)one derivatives being 5HT2C agonists
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ATE318821T1 (de) * 2001-06-01 2006-03-15 Alcon Inc Pyranoindazole und ihre verwendung in der glaukombehandlung

Also Published As

Publication number Publication date
RU2003137825A (ru) 2005-04-20
EP1392292A4 (en) 2004-08-11
AU2002305732B2 (en) 2007-02-01
EP1392292A2 (en) 2004-03-03
US6881749B2 (en) 2005-04-19
PL366636A1 (en) 2005-02-07
EP1392292B1 (en) 2006-03-01
CN100384417C (zh) 2008-04-30
HK1061212A1 (en) 2004-09-10
ES2258631T3 (es) 2006-09-01
US6696476B2 (en) 2004-02-24
ATE318821T1 (de) 2006-03-15
DE60209486D1 (de) 2006-04-27
KR100626255B1 (ko) 2006-09-21
ZA200309034B (en) 2004-07-16
JP2004535418A (ja) 2004-11-25
BR0210241A (pt) 2004-08-10
AR036044A1 (es) 2004-08-04
US20030171418A1 (en) 2003-09-11
WO2002098350A3 (en) 2003-02-27
PT1392292E (pt) 2006-05-31
CA2447480A1 (en) 2002-12-12
RU2273641C2 (ru) 2006-04-10
KR20040010669A (ko) 2004-01-31
WO2002098350A2 (en) 2002-12-12
DE60209486T2 (de) 2006-08-03
US20040106609A1 (en) 2004-06-03
CN1592619A (zh) 2005-03-09
MXPA03010807A (es) 2004-11-22

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