DE60209486D1 - Pyranoindazole und ihre verwendung in der glaukombehandlung - Google Patents

Pyranoindazole und ihre verwendung in der glaukombehandlung

Info

Publication number
DE60209486D1
DE60209486D1 DE60209486T DE60209486T DE60209486D1 DE 60209486 D1 DE60209486 D1 DE 60209486D1 DE 60209486 T DE60209486 T DE 60209486T DE 60209486 T DE60209486 T DE 60209486T DE 60209486 D1 DE60209486 D1 DE 60209486D1
Authority
DE
Germany
Prior art keywords
gluckom
pyranoindazole
treatment
gluckom treatment
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE60209486T
Other languages
English (en)
Other versions
DE60209486T2 (de
Inventor
Hwang-Hsing Chen
A May
S Severns
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Alcon Inc
Original Assignee
Alcon Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alcon Inc filed Critical Alcon Inc
Publication of DE60209486D1 publication Critical patent/DE60209486D1/de
Application granted granted Critical
Publication of DE60209486T2 publication Critical patent/DE60209486T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • C07D491/052—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being six-membered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
DE60209486T 2001-06-01 2002-05-30 Pyranoindazole und ihre verwendung in der glaukombehandlung Expired - Fee Related DE60209486T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US29542901P 2001-06-01 2001-06-01
US295429P 2001-06-01
PCT/US2002/016861 WO2002098350A2 (en) 2001-06-01 2002-05-30 Pyranoindazoles and their use for the treatment of glaucoma

Publications (2)

Publication Number Publication Date
DE60209486D1 true DE60209486D1 (de) 2006-04-27
DE60209486T2 DE60209486T2 (de) 2006-08-03

Family

ID=23137684

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60209486T Expired - Fee Related DE60209486T2 (de) 2001-06-01 2002-05-30 Pyranoindazole und ihre verwendung in der glaukombehandlung

Country Status (20)

Country Link
US (2) US6696476B2 (de)
EP (1) EP1392292B1 (de)
JP (1) JP2004535418A (de)
KR (1) KR100626255B1 (de)
CN (1) CN100384417C (de)
AR (1) AR036044A1 (de)
AT (1) ATE318821T1 (de)
AU (1) AU2002305732B2 (de)
BR (1) BR0210241A (de)
CA (1) CA2447480A1 (de)
DE (1) DE60209486T2 (de)
DK (1) DK1392292T3 (de)
ES (1) ES2258631T3 (de)
HK (1) HK1061212A1 (de)
MX (1) MXPA03010807A (de)
PL (1) PL366636A1 (de)
PT (1) PT1392292E (de)
RU (1) RU2273641C2 (de)
WO (1) WO2002098350A2 (de)
ZA (1) ZA200309034B (de)

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DE60117247D1 (de) * 2000-03-31 2006-04-20 Purdue Research Foundation West Lafayette Phosphoramidat-prodrugs
KR100626255B1 (ko) * 2001-06-01 2006-09-21 알콘, 인코퍼레이티드 피라노인다졸 및 녹내장의 치료를 위한 그의 용도
TW593302B (en) 2001-12-20 2004-06-21 Alcon Inc Novel benzodifuranimidazoline and benzofuranimidazoline derivatives and their use for the treatment of glaucoma
AU2002360819A1 (en) * 2001-12-28 2003-07-24 Bayer Corporation Cyclohexano- and cycloheptapyrazole derivative compounds, for use in diseases associated with the 5-ht2c receptor
AU2003262931B2 (en) * 2002-08-30 2008-06-26 Alcon, Inc. Substituted 5-chroman-5-yl-ethylamine compounds and their use for the treatment of glaucoma
BR0316775A (pt) 2002-12-13 2005-11-01 Alcon Inc Novos análogos de benzopirano e seu uso para o tratamento de glaucoma
AU2004271978B2 (en) * 2003-09-04 2009-02-05 Merck & Co., Inc. Ophthalmic compositions for treating ocular hypertension
US7476687B2 (en) 2003-11-26 2009-01-13 Alcon, Inc. Substituted furo[2,3-g]indazoles for the treatment of glaucoma
US7338972B1 (en) 2003-12-15 2008-03-04 Alcon, Inc. Substituted 1-alkylamino-1H-indazoles for the treatment of glaucoma
US7129257B1 (en) 2003-12-15 2006-10-31 Alcon, Inc. Pyrazolo[3,4- e]benzoxazoles for the treatment of glaucoma
US6989445B2 (en) 2003-12-15 2006-01-24 Alcon, Inc. Substituted [1,4]oxazino[2,3-g]indazoles for the treatment of glaucoma
JP5173190B2 (ja) 2004-08-25 2013-03-27 武田薬品工業株式会社 腹圧性尿失禁の予防・治療剤及びそのスクリーニング方法
US20060073172A1 (en) * 2004-10-01 2006-04-06 Schneider L W Stabilized ophthalmic solution for the treatment of glaucoma and lowering intraocular pressure
US7425572B2 (en) 2004-12-08 2008-09-16 Alcon, Inc. Use of dioxindoindazoles and dioxoloindazoles for treating glaucoma
TW200744567A (en) * 2005-09-23 2007-12-16 Alcon Inc Phenylethylamine analogs and their use for treating glaucoma
EP2727585A1 (de) 2006-05-16 2014-05-07 Takeda Pharmaceutical Company Limited In-vivo Screening-Methode
US20070293475A1 (en) * 2006-06-20 2007-12-20 Alcon Manufacturing Ltd. Aryl and heteroaryl tetrahydrobenzazepine derivatives and their use for treating glaucoma
US20090247552A1 (en) * 2006-07-31 2009-10-01 Shirou Sawa Aqueous liquid preparation containing amide compound
WO2008016989A1 (en) * 2006-08-01 2008-02-07 Alcon Research, Ltd. Process for preparing pyranoindazole serotonergic receptor agonists
US20080033184A1 (en) * 2006-08-01 2008-02-07 Alcon Manufacturing, Ltd. Intermediates and methods for serotonergic agonist synthesis
US20080058533A1 (en) * 2006-08-31 2008-03-06 Alcon, Inc. Pyranoindazole cyclic carbonates and methods of use
US20100266504A1 (en) 2007-11-15 2010-10-21 Takahiro Matsumoto Condensed pyridine derivative and use thereof
WO2011071136A1 (ja) 2009-12-11 2011-06-16 アステラス製薬株式会社 線維筋痛症治療剤
EP3266819B1 (de) * 2015-03-05 2019-02-20 Bridgestone Corporation Kautschukzusammensetzung, herstellungsverfahren für dienpolymer und reifen
TW201815766A (zh) * 2016-09-22 2018-05-01 美商普雷辛肯公司 用於ｉｄｏ及ｔｄｏ調節之化合物及方法以及其適應症
US20210052600A1 (en) 2017-12-27 2021-02-25 Takeda Pharmaceutical Company Limited Therapeutic agents for stress urinary incontinence and incotinence of feces
JP2021518367A (ja) 2018-03-20 2021-08-02 プレキシコン インコーポレーテッドＰｌｅｘｘｉｋｏｎ Ｉｎｃ． Ｉｄｏおよびｔｄｏ調節のための化合物および方法、ならびにそれらのための兆候

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FR2534580A1 (fr) 1982-10-13 1984-04-20 Synthelabo Derives de phenyl-1 piperidino-2 propanol, leur preparation, et medicaments qui les contiennent
US5151444B1 (en) 1987-09-18 1999-07-06 R Tech Ueno Ltd Ocular hypotensive agents
US5296504A (en) 1988-09-06 1994-03-22 Kabi Pharmacia Prostaglandin derivatives for the treatment of glaucoma or ocular hypertension
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US5578612A (en) 1990-10-15 1996-11-26 Pfizer Inc. Indole derivatives
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US5922773A (en) 1992-12-04 1999-07-13 The Children's Medical Center Corp. Glaucoma treatment
US5510383A (en) 1993-08-03 1996-04-23 Alcon Laboratories, Inc. Use of cloprostenol, fluprostenol and their salts and esters to treat glaucoma and ocular hypertension
TW270114B (de) 1993-10-22 1996-02-11 Hoffmann La Roche
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US5874477A (en) 1994-08-12 1999-02-23 The University Of Hawaii Method of treatment for malaria utilizing serotonin receptor ligands
TW403738B (en) 1994-08-12 2000-09-01 Hoffmann La Roche Tricyclic pyrazole derivatives
US5998467A (en) 1995-10-25 1999-12-07 Mitsubishi Chemical Corporation Medicine for oculopathy
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JP3560986B2 (ja) 1997-01-13 2004-09-02 山之内製薬株式会社 ５―ｈｔ２ｃ受容体作用薬及びアミノアルキルインダゾール誘導体
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ATE310566T1 (de) 1998-09-18 2005-12-15 Alcon Mfg Ltd 5ht2-agoniste zur behandlung des glaukoms
CN1240701C (zh) 1998-12-17 2006-02-08 惠氏公司 用作5HT2C激动剂的2,3,4,4a－四氢－1H－吡嗪并(1,2－a)喹喔啉－5(6H)酮衍生物
GB9902047D0 (en) 1999-01-29 1999-03-17 Cerebrus Ltd Chemical compounds XI
US6713471B1 (en) 1999-06-15 2004-03-30 Bristol-Myers Squibb Pharma Company Substituted heterocycle fused gamma-carbolines
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EP1268439A1 (de) 2000-03-17 2003-01-02 Alcon Inc. 5-hydroxyindazolderivate zur behandlung von glaukom
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KR100626255B1 (ko) * 2001-06-01 2006-09-21 알콘, 인코퍼레이티드 피라노인다졸 및 녹내장의 치료를 위한 그의 용도

Also Published As

Publication number Publication date
JP2004535418A (ja) 2004-11-25
ZA200309034B (en) 2004-07-16
ES2258631T3 (es) 2006-09-01
CN100384417C (zh) 2008-04-30
WO2002098350A2 (en) 2002-12-12
PL366636A1 (en) 2005-02-07
EP1392292A2 (de) 2004-03-03
US6881749B2 (en) 2005-04-19
ATE318821T1 (de) 2006-03-15
DK1392292T3 (da) 2006-05-29
WO2002098350A3 (en) 2003-02-27
US6696476B2 (en) 2004-02-24
CN1592619A (zh) 2005-03-09
KR20040010669A (ko) 2004-01-31
RU2273641C2 (ru) 2006-04-10
US20030171418A1 (en) 2003-09-11
EP1392292A4 (de) 2004-08-11
DE60209486T2 (de) 2006-08-03
CA2447480A1 (en) 2002-12-12
BR0210241A (pt) 2004-08-10
AR036044A1 (es) 2004-08-04
MXPA03010807A (es) 2004-11-22
KR100626255B1 (ko) 2006-09-21
RU2003137825A (ru) 2005-04-20
PT1392292E (pt) 2006-05-31
US20040106609A1 (en) 2004-06-03
EP1392292B1 (de) 2006-03-01
HK1061212A1 (en) 2004-09-10
AU2002305732B2 (en) 2007-02-01

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee