ATE310566T1 - 5ht2-agoniste zur behandlung des glaukoms - Google Patents

5ht2-agoniste zur behandlung des glaukoms

Info

Publication number
ATE310566T1
ATE310566T1 AT99948085T AT99948085T ATE310566T1 AT E310566 T1 ATE310566 T1 AT E310566T1 AT 99948085 T AT99948085 T AT 99948085T AT 99948085 T AT99948085 T AT 99948085T AT E310566 T1 ATE310566 T1 AT E310566T1
Authority
AT
Austria
Prior art keywords
agonits
glaucoma
treatment
Prior art date
Application number
AT99948085T
Other languages
English (en)
Inventor
Jesse A May
Thomas R Dean
Najam A Sharif
Mark R Hellberg
Original Assignee
Alcon Mfg Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alcon Mfg Ltd filed Critical Alcon Mfg Ltd
Application granted granted Critical
Publication of ATE310566T1 publication Critical patent/ATE310566T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A61K31/4045—Indole-alkylamines; Amides thereof, e.g. serotonin, melatonin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Ophthalmology & Optometry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
AT99948085T 1998-09-18 1999-09-03 5ht2-agoniste zur behandlung des glaukoms ATE310566T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10106798P 1998-09-18 1998-09-18
PCT/US1999/019888 WO2000016761A2 (en) 1998-09-18 1999-09-03 Serotonergic 5ht2 agonists for treating glaucoma

Publications (1)

Publication Number Publication Date
ATE310566T1 true ATE310566T1 (de) 2005-12-15

Family

ID=22282920

Family Applications (1)

Application Number Title Priority Date Filing Date
AT99948085T ATE310566T1 (de) 1998-09-18 1999-09-03 5ht2-agoniste zur behandlung des glaukoms

Country Status (18)

Country Link
US (2) US6664286B1 (de)
EP (1) EP1112106B1 (de)
JP (1) JP2002526443A (de)
KR (1) KR20010073153A (de)
CN (1) CN1269484C (de)
AR (1) AR020442A1 (de)
AT (1) ATE310566T1 (de)
AU (1) AU755119B2 (de)
BR (1) BR9913800A (de)
CA (1) CA2344150A1 (de)
DE (1) DE69928542T2 (de)
DK (1) DK1112106T3 (de)
ES (1) ES2252978T3 (de)
HK (1) HK1038516A1 (de)
TR (1) TR200100754T2 (de)
TW (1) TWI229602B (de)
WO (1) WO2000016761A2 (de)
ZA (1) ZA200102157B (de)

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BR0017163A (pt) * 2000-03-17 2003-01-14 Alcon Inc Derivados 5-hidróxi-indazol para tratamento do glaucoma
CN1450994A (zh) * 2000-03-17 2003-10-22 爱尔康公司 用于治疗青光眼的6－羟基－吲唑衍生物
AU2001219185A1 (en) 2000-03-17 2001-10-03 Alcon, Inc. 2-acylaminobenzimidazole derivatives for treating glaucoma
AU2001216035A1 (en) * 2000-03-17 2001-10-03 Alcon Universal Ltd. 5-hydroxy indole derivatives for treating glaucoma
US7012090B1 (en) 2000-03-17 2006-03-14 Alcon, Inc. Pyranoindoles for treating glaucoma
US7005443B1 (en) * 2000-03-17 2006-02-28 Alcon, Inc. 5-Hydroxy indazole derivatives for treating glaucoma
US6956036B1 (en) 2000-03-17 2005-10-18 Alcon, Inc. 6-hydroxy-indazole derivatives for treating glaucoma
US6927233B1 (en) * 2000-03-17 2005-08-09 Alcon, Inc. 5ht2 agonists for controlling IOP and treating glaucoma
US6903081B2 (en) * 2000-03-31 2005-06-07 Purdue Research Foundation Phosphoramidates and methods therefor
WO2002098860A1 (en) 2001-06-01 2002-12-12 Alcon, Inc. Novel fused indazoles and indoles and their use for the treatment of glaucoma
CA2447479A1 (en) 2001-06-01 2002-12-12 Alcon, Inc. Novel arylaminopropane analogues and their use for the treatment of glaucoma
DE60209486T2 (de) 2001-06-01 2006-08-03 Alcon Inc. Pyranoindazole und ihre verwendung in der glaukombehandlung
US6884816B2 (en) * 2001-08-31 2005-04-26 Alcon, Inc. Hydroxy substituted fused naphthyl-azoles and fused indeno-azoles and their use for the treatment of glaucoma
TW593302B (en) 2001-12-20 2004-06-21 Alcon Inc Novel benzodifuranimidazoline and benzofuranimidazoline derivatives and their use for the treatment of glaucoma
AU2003262931B2 (en) * 2002-08-30 2008-06-26 Alcon, Inc. Substituted 5-chroman-5-yl-ethylamine compounds and their use for the treatment of glaucoma
CA2492468A1 (en) * 2002-09-24 2004-04-08 Virginia Commonwealth University .beta.-hydroxyphenylalkylamines and their use for treating glaucoma
CA2506204A1 (en) 2002-12-13 2004-07-01 Alcon, Inc. Novel benzopyran analogs and their use for the treatment of glaucoma
WO2005053688A1 (en) * 2003-11-26 2005-06-16 Alcon, Inc. Substituted furo[2,3-g] indazoles for the treatment of glaucoma
US7338972B1 (en) 2003-12-15 2008-03-04 Alcon, Inc. Substituted 1-alkylamino-1H-indazoles for the treatment of glaucoma
WO2005058911A2 (en) * 2003-12-15 2005-06-30 Alcon, Inc. Substituted [1,4]oxazino[2,3-g]indazoles for the treatment of glaucoma
US7129257B1 (en) 2003-12-15 2006-10-31 Alcon, Inc. Pyrazolo[3,4- e]benzoxazoles for the treatment of glaucoma
EP1744784A2 (de) * 2004-05-11 2007-01-24 Becton, Dickinson and Company Schmerzmittelformulierungen und verfahren zu deren anwendung
EP2400300A1 (de) 2004-08-25 2011-12-28 Takeda Pharmaceutical Company Limited Screeningverfahren von Mitteln zur Prävention/Behandlung von stressbedingter Harninkontinenz
WO2006062839A1 (en) * 2004-12-08 2006-06-15 Alcon, Inc. Use of dioxindoindazoles and dioxoloindazoles for treating glaucoma
US20060211700A1 (en) * 2005-03-21 2006-09-21 Alcon, Inc. (R)-8,9-dichloro-2,3,4,4a-tetrahydro-1H,6H-pyrazino[1,2-a]quinoxalin-5-one for controlling IOP and treating glaucoma
TW200744567A (en) * 2005-09-23 2007-12-16 Alcon Inc Phenylethylamine analogs and their use for treating glaucoma
WO2007132841A1 (ja) 2006-05-16 2007-11-22 Takeda Pharmaceutical Company Limited 縮合複素環化合物およびその用途
WO2007149728A2 (en) * 2006-06-20 2007-12-27 Alcon Research, Ltd. Aryl and heteroaryl tetrahydrobenzazepine derivatives and their use for treating glaucoma
MY167602A (en) 2007-11-01 2018-09-20 Acucela Inc Amine derivatives compounds for treating ophthalmic diseases and disorders
WO2009063992A1 (ja) 2007-11-15 2009-05-22 Takeda Pharmaceutical Company Limited 縮合ピリジン誘導体およびその用途
US9642819B2 (en) * 2008-07-10 2017-05-09 Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical Low dosage serotonin 5-HT2A receptor agonist to suppress inflammation
US8299079B2 (en) 2009-05-22 2012-10-30 Kaufman Herbert E Preparations and methods for ameliorating or reducing presbyopia
JPWO2011071136A1 (ja) 2009-12-11 2013-04-22 アステラス製薬株式会社 線維筋痛症治療剤
TW201210584A (en) 2010-08-18 2012-03-16 Alcon Res Ltd Bradykinin receptor agonists and uses thereof to treat ocular hypertension and glaucoma
GB2571696B (en) 2017-10-09 2020-05-27 Compass Pathways Ltd Large scale method for the preparation of Psilocybin and formulations of Psilocybin so produced
JPWO2019131902A1 (ja) 2017-12-27 2020-12-10 武田薬品工業株式会社 腹圧性尿失禁および便失禁の治療薬
WO2020212952A1 (en) 2019-04-17 2020-10-22 Compass Pathfinder Limited Treatment of depression and other various disorders with psilocybin
WO2024010765A1 (en) * 2022-07-05 2024-01-11 Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College Compositions for treating 5-ht2 conditions and methods of using the same

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US4659706A (en) 1985-12-20 1987-04-21 Smithkline Beckman Corporation Sulfinyl and sulfonyl substituted 3-benzazepines
US5011846A (en) 1988-02-23 1991-04-30 Merrell Dow Pharmaceuticals Inc. Medicament compositions derived from quinolizine and quinolizinone and methods of use thereof
DE69018332T2 (de) 1989-07-28 1995-10-26 Nippon Oil Co Ltd Verfahren zur kontinuierlichen Herstellung eines Polyethylenmaterials mit hoher Festigkeit und hohem Modul.
US5578612A (en) 1990-10-15 1996-11-26 Pfizer Inc. Indole derivatives
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WO1992020338A1 (en) 1991-05-10 1992-11-26 Merrell Dow Pharmaceuticals Inc. Method for the treatment of glaucoma
DE69227458T2 (de) 1991-06-21 1999-04-29 Smithkline Beecham Plc Tryptamin analoga, ihre herstellung und anwendung als 5-ht1-artige rezeptoren oder 5-ht2 rezeptor agonisten
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US5290781A (en) 1993-01-05 1994-03-01 Iolab Corporation Ketaneserinol as an agent to reduce intraocular pressure
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US5696166A (en) * 1995-10-31 1997-12-09 Yanni; John M. Compositions containing hydroxyeicosatetraenoic acid derivatives and methods of use in treating dry eye disorders
RU2167160C2 (ru) 1995-11-09 2001-05-20 Санофи-Синтелябо Производные 5-фенил-3-(пиперидин-4-ил)-1,3,4-оксадиазол-2(3н)-она, способ их получения, фармацевтическая композиция на их основе и лекарственное средство
WO1997033579A1 (en) 1996-03-13 1997-09-18 Glaxo Group Limited Medicaments comprising 5ht1-like receptor agonists with an increased absorption
DE69710258T2 (de) * 1996-06-17 2002-08-22 Mitsubishi Chem Corp Mittel zur Beschleunigung des Tränenflusses enthaltend einen Serotonin-Liganden, insbesondere Aminoalkoxybibenzyle
WO1998018458A1 (en) * 1996-10-31 1998-05-07 Alcon Laboratories, Inc. Opthalmological compositions containing serotonin 5-ht1a receptor agonist and their use in the treatment of glaucoma
ATE257470T1 (de) 1997-01-08 2004-01-15 Hoffmann La Roche Tricyclische benz(e)isoindole und benz(h)isochinoline
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Also Published As

Publication number Publication date
ES2252978T3 (es) 2006-05-16
TWI229602B (en) 2005-03-21
EP1112106B1 (de) 2005-11-23
DE69928542D1 (de) 2005-12-29
DE69928542T2 (de) 2006-03-30
CA2344150A1 (en) 2000-03-30
EP1112106A2 (de) 2001-07-04
AU755119B2 (en) 2002-12-05
TR200100754T2 (tr) 2001-10-22
US6664286B1 (en) 2003-12-16
BR9913800A (pt) 2001-05-29
WO2000016761A2 (en) 2000-03-30
AR020442A1 (es) 2002-05-15
KR20010073153A (ko) 2001-07-31
DK1112106T3 (da) 2005-12-12
AU6132699A (en) 2000-04-10
HK1038516A1 (en) 2002-03-22
CN1317979A (zh) 2001-10-17
JP2002526443A (ja) 2002-08-20
WO2000016761A3 (en) 2000-05-25
US20030203912A1 (en) 2003-10-30
CN1269484C (zh) 2006-08-16
ZA200102157B (en) 2003-03-05

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