DE60117247D1 - Phosphoramidat-prodrugs - Google Patents
Phosphoramidat-prodrugsInfo
- Publication number
- DE60117247D1 DE60117247D1 DE60117247T DE60117247T DE60117247D1 DE 60117247 D1 DE60117247 D1 DE 60117247D1 DE 60117247 T DE60117247 T DE 60117247T DE 60117247 T DE60117247 T DE 60117247T DE 60117247 D1 DE60117247 D1 DE 60117247D1
- Authority
- DE
- Germany
- Prior art keywords
- compounds
- phosphoramidate
- phosphoramidate prodrugs
- functional
- peptidomimetics
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- PTMHPRAIXMAOOB-UHFFFAOYSA-L phosphoramidate Chemical compound NP([O-])([O-])=O PTMHPRAIXMAOOB-UHFFFAOYSA-L 0.000 title 1
- 229940002612 prodrug Drugs 0.000 title 1
- 239000000651 prodrug Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 2
- 150000008298 phosphoramidates Chemical class 0.000 abstract 2
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 150000001408 amides Chemical class 0.000 abstract 1
- 150000001413 amino acids Chemical class 0.000 abstract 1
- 230000001028 anti-proliverative effect Effects 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 230000003834 intracellular effect Effects 0.000 abstract 1
- 125000003729 nucleotide group Chemical group 0.000 abstract 1
- 239000000816 peptidomimetic Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 150000003014 phosphoric acid esters Chemical class 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
- C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/06—Phosphorus compounds without P—C bonds
- C07F9/22—Amides of acids of phosphorus
- C07F9/24—Esteramides
- C07F9/2454—Esteramides the amide moiety containing a substituent or a structure which is considered as characteristic
- C07F9/2458—Esteramides the amide moiety containing a substituent or a structure which is considered as characteristic of aliphatic amines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/06—Phosphorus compounds without P—C bonds
- C07F9/22—Amides of acids of phosphorus
- C07F9/26—Amides of acids of phosphorus containing P-halide groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/655—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms
- C07F9/65515—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a five-membered ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having sulfur atoms, with or without selenium or tellurium atoms, as the only ring hetero atoms
- C07F9/655345—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having sulfur atoms, with or without selenium or tellurium atoms, as the only ring hetero atoms the sulfur atom being part of a five-membered ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Biotechnology (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Genetics & Genomics (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Saccharide Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US19391800P | 2000-03-31 | 2000-03-31 | |
PCT/US2001/010163 WO2001074827A1 (en) | 2000-03-31 | 2001-03-30 | Phosphoramidate prodrugs |
Publications (1)
Publication Number | Publication Date |
---|---|
DE60117247D1 true DE60117247D1 (de) | 2006-04-20 |
Family
ID=22715556
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE60117247T Expired - Fee Related DE60117247D1 (de) | 2000-03-31 | 2001-03-30 | Phosphoramidat-prodrugs |
Country Status (8)
Country | Link |
---|---|
US (2) | US6903081B2 (de) |
EP (1) | EP1268493B1 (de) |
JP (1) | JP2004538240A (de) |
AT (1) | ATE317846T1 (de) |
AU (1) | AU784462B2 (de) |
CA (1) | CA2397203A1 (de) |
DE (1) | DE60117247D1 (de) |
WO (1) | WO2001074827A1 (de) |
Families Citing this family (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU5935600A (en) | 1999-07-14 | 2001-01-30 | Richard F. Borch | Phosphoramide compounds |
DE60117247D1 (de) * | 2000-03-31 | 2006-04-20 | Purdue Research Foundation West Lafayette | Phosphoramidat-prodrugs |
US8707406B2 (en) * | 2002-07-26 | 2014-04-22 | Sierra Wireless, Inc. | Always-on virtual private network access |
ZA200507752B (en) * | 2003-03-28 | 2007-01-31 | Threshold Pharmaceuticals Inc | Compositions and methods for treating cancer |
WO2006055525A2 (en) * | 2004-11-15 | 2006-05-26 | Ceptyr, Inc. | Protein tyrosine phosphatase inhibitors and methods of use thereof |
JP2008523082A (ja) * | 2004-12-09 | 2008-07-03 | リージェンツ オブ ザ ユニバーシティ オブ ミネソタ | 抗菌活性および抗癌活性を有するヌクレオチド |
WO2006099313A2 (en) * | 2005-03-14 | 2006-09-21 | Purdue Research Foundation | Phosphate conjugates of prenylation inhibitors |
US8003625B2 (en) | 2005-06-29 | 2011-08-23 | Threshold Pharmaceuticals, Inc. | Phosphoramidate alkylator prodrugs |
CA2618335C (en) * | 2005-08-15 | 2015-03-31 | F.Hoffmann-La Roche Ag | Antiviral phosphoramidates of 4'-substituted pronucleotides |
US8197545B2 (en) | 2005-10-27 | 2012-06-12 | Depuy Spine, Inc. | Nucleus augmentation delivery device and technique |
EP2114157B1 (de) * | 2006-12-26 | 2021-05-26 | ImmunoGenesis, Inc. | Phosphoramidatalkylator-prodrug für die krebstherapie |
US20090118031A1 (en) * | 2007-11-01 | 2009-05-07 | Qualizza Gregory K | Shaft Structure with Configurable Bending Profile |
CN106456658A (zh) | 2014-03-14 | 2017-02-22 | 全技术公司 | 硒有机化合物的组合物和其使用方法 |
WO2017048252A1 (en) | 2015-09-15 | 2017-03-23 | Alltech, Inc. | Compositions of selenoorganic compounds and methods of use thereof |
US11447764B2 (en) * | 2017-02-13 | 2022-09-20 | The Regents Of The University Of California | Site-specific generation of phosphorylated tyrosines in proteins |
Family Cites Families (28)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3303189A (en) * | 1965-03-11 | 1967-02-07 | Smith Kline French Lab | 2, 1-benzothiazine-2, 2-dioxides |
US5011846A (en) * | 1988-02-23 | 1991-04-30 | Merrell Dow Pharmaceuticals Inc. | Medicament compositions derived from quinolizine and quinolizinone and methods of use thereof |
US5106855A (en) * | 1989-12-20 | 1992-04-21 | Merrell Dow Pharmaceuticals Inc. | Method for the treatment of glaucoma |
US5153192A (en) * | 1990-04-09 | 1992-10-06 | Alcon Laboratories, Inc. | Thiophene sulfonamides useful as carbonic anhydrase inhibitors |
US5233031A (en) * | 1991-09-23 | 1993-08-03 | University Of Rochester | Phosphoramidate analogs of 2'-deoxyuridine |
GB9216380D0 (en) * | 1992-07-31 | 1992-09-16 | Glaxo Group Ltd | Medicaments |
US5290781A (en) * | 1993-01-05 | 1994-03-01 | Iolab Corporation | Ketaneserinol as an agent to reduce intraocular pressure |
US5344929A (en) * | 1993-02-18 | 1994-09-06 | Alcon Laboratories, Inc. | Preparation of carbonic anhydrase inhibitors |
US5306727A (en) * | 1993-04-30 | 1994-04-26 | Research Corporation Technologies, Inc. | Phosphoramidates useful as antitumor agents |
TW334423B (en) * | 1993-10-22 | 1998-06-21 | Hoffmann La Roche | Tricyclic 1-aminoethylpyrrole-derivatives |
TW270114B (de) * | 1993-10-22 | 1996-02-11 | Hoffmann La Roche | |
US5874429A (en) * | 1993-12-24 | 1999-02-23 | Suntory Limited | Benzothiazine derivative |
US5538966A (en) * | 1994-01-21 | 1996-07-23 | Alcon Laboratories, Inc. | Carbonic anhydrase inhibitors |
US5538974A (en) * | 1994-01-27 | 1996-07-23 | Senju Pharamceutical Co., Ltd. | Ophthalmic composition for lowering intraocular pressure |
ES2116681T3 (es) * | 1994-03-18 | 1998-07-16 | Senju Pharma Co | Preparaciones oftalmicas para reducir la presion intraocular. |
US5773437A (en) * | 1994-03-31 | 1998-06-30 | Nippon Chemiphar Co., Ltd. | Alkylenediamine derivatives |
TW403738B (en) * | 1994-08-12 | 2000-09-01 | Hoffmann La Roche | Tricyclic pyrazole derivatives |
US5470973A (en) * | 1994-10-03 | 1995-11-28 | Alcon Laboratories, Inc. | Synthesis of sulfonamide intermediates |
JP3232365B2 (ja) * | 1995-02-20 | 2001-11-26 | トキコ株式会社 | ディスクブレーキ |
US5880134A (en) * | 1996-03-20 | 1999-03-09 | Eli Lilly And Company | Method for using ergoline compounds to effect physiological and pathological functions at the 5-HT7 receptor |
JPH11193289A (ja) * | 1997-12-26 | 1999-07-21 | Suntory Ltd | ピロールスルホンアミド誘導体 |
AU764766B2 (en) * | 1998-04-14 | 2003-08-28 | Arena Pharmaceuticals, Inc. | Non-endogenous, constitutively activated human serotonin receptors and small molecule modulators thereof |
BR9913800A (pt) * | 1998-09-18 | 2001-05-29 | Alcon Lab Inc | Método para tratar glaucoma, e, composição para tratar glaucoma |
US6806285B1 (en) * | 2000-03-17 | 2004-10-19 | Alcon, Inc. | 5-Hydroxyl indole derivatives for treating glaucoma |
WO2001070705A1 (en) * | 2000-03-17 | 2001-09-27 | Alcon, Inc. | 2-acylaminobenzimidazole derivatives for treating glaucoma |
DE60117247D1 (de) * | 2000-03-31 | 2006-04-20 | Purdue Research Foundation West Lafayette | Phosphoramidat-prodrugs |
JP2004535418A (ja) * | 2001-06-01 | 2004-11-25 | アルコン,インコーポレイテッド | ピラノインダゾールおよび緑内障治療への使用 |
US6884816B2 (en) * | 2001-08-31 | 2005-04-26 | Alcon, Inc. | Hydroxy substituted fused naphthyl-azoles and fused indeno-azoles and their use for the treatment of glaucoma |
-
2001
- 2001-03-30 DE DE60117247T patent/DE60117247D1/de not_active Expired - Fee Related
- 2001-03-30 JP JP2001572517A patent/JP2004538240A/ja not_active Withdrawn
- 2001-03-30 WO PCT/US2001/010163 patent/WO2001074827A1/en active IP Right Grant
- 2001-03-30 CA CA002397203A patent/CA2397203A1/en not_active Abandoned
- 2001-03-30 AT AT01922862T patent/ATE317846T1/de not_active IP Right Cessation
- 2001-03-30 AU AU49616/01A patent/AU784462B2/en not_active Ceased
- 2001-03-30 US US09/822,376 patent/US6903081B2/en not_active Expired - Fee Related
- 2001-03-30 EP EP01922862A patent/EP1268493B1/de not_active Expired - Lifetime
-
2005
- 2005-02-08 US US11/053,024 patent/US7173020B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
AU4961601A (en) | 2001-10-15 |
CA2397203A1 (en) | 2001-10-11 |
ATE317846T1 (de) | 2006-03-15 |
US7173020B2 (en) | 2007-02-06 |
EP1268493B1 (de) | 2006-02-15 |
US20020004594A1 (en) | 2002-01-10 |
US6903081B2 (en) | 2005-06-07 |
EP1268493A1 (de) | 2003-01-02 |
AU784462B2 (en) | 2006-04-06 |
WO2001074827A1 (en) | 2001-10-11 |
JP2004538240A (ja) | 2004-12-24 |
US20050171060A1 (en) | 2005-08-04 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8339 | Ceased/non-payment of the annual fee |