ATE317846T1 - Phosphoramidat-prodrugs - Google Patents

Phosphoramidat-prodrugs

Info

Publication number
ATE317846T1
ATE317846T1 AT01922862T AT01922862T ATE317846T1 AT E317846 T1 ATE317846 T1 AT E317846T1 AT 01922862 T AT01922862 T AT 01922862T AT 01922862 T AT01922862 T AT 01922862T AT E317846 T1 ATE317846 T1 AT E317846T1
Authority
AT
Austria
Prior art keywords
compounds
phosphoramidate
phosphoramidate prodrugs
functional
peptidomimetics
Prior art date
Application number
AT01922862T
Other languages
English (en)
Inventor
Richard F Borch
Sandra C Tobias
Hugo Garrido-Hernandez
Original Assignee
Purdue Research Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Purdue Research Foundation filed Critical Purdue Research Foundation
Application granted granted Critical
Publication of ATE317846T1 publication Critical patent/ATE317846T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/22—Amides of acids of phosphorus
    • C07F9/24—Esteramides
    • C07F9/2454—Esteramides the amide moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/2458—Esteramides the amide moiety containing a substituent or a structure which is considered as characteristic of aliphatic amines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/22—Amides of acids of phosphorus
    • C07F9/26—Amides of acids of phosphorus containing P-halide groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/655—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms
    • C07F9/65515—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a five-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having sulfur atoms, with or without selenium or tellurium atoms, as the only ring hetero atoms
    • C07F9/655345—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having sulfur atoms, with or without selenium or tellurium atoms, as the only ring hetero atoms the sulfur atom being part of a five-membered ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biotechnology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Genetics & Genomics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Saccharide Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
AT01922862T 2000-03-31 2001-03-30 Phosphoramidat-prodrugs ATE317846T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US19391800P 2000-03-31 2000-03-31

Publications (1)

Publication Number Publication Date
ATE317846T1 true ATE317846T1 (de) 2006-03-15

Family

ID=22715556

Family Applications (1)

Application Number Title Priority Date Filing Date
AT01922862T ATE317846T1 (de) 2000-03-31 2001-03-30 Phosphoramidat-prodrugs

Country Status (8)

Country Link
US (2) US6903081B2 (de)
EP (1) EP1268493B1 (de)
JP (1) JP2004538240A (de)
AT (1) ATE317846T1 (de)
AU (1) AU784462B2 (de)
CA (1) CA2397203A1 (de)
DE (1) DE60117247D1 (de)
WO (1) WO2001074827A1 (de)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU5935600A (en) 1999-07-14 2001-01-30 Richard F. Borch Phosphoramide compounds
EP1268493B1 (de) * 2000-03-31 2006-02-15 Purdue Research Foundation Phosphoramidat-prodrugs
US8707406B2 (en) * 2002-07-26 2014-04-22 Sierra Wireless, Inc. Always-on virtual private network access
ZA200507752B (en) * 2003-03-28 2007-01-31 Threshold Pharmaceuticals Inc Compositions and methods for treating cancer
CA2586363A1 (en) * 2004-11-15 2006-05-26 Ceptyr, Inc. Protein tyrosine phosphatase inhibitors and methods of use thereof
US8399428B2 (en) * 2004-12-09 2013-03-19 Regents Of The University Of Minnesota Nucleosides with antiviral and anticancer activity
WO2006099313A2 (en) * 2005-03-14 2006-09-21 Purdue Research Foundation Phosphate conjugates of prenylation inhibitors
CA2613312C (en) 2005-06-29 2014-10-14 Threshold Pharmaceuticals, Inc. Phosphoramidate alkylator prodrugs
JP2009504704A (ja) * 2005-08-15 2009-02-05 エフ．ホフマン−ラ ロシュ アーゲー 抗ウイルス４′−置換プロヌクレオチドホスホルアミダート
US8197545B2 (en) 2005-10-27 2012-06-12 Depuy Spine, Inc. Nucleus augmentation delivery device and technique
JP5357049B2 (ja) * 2006-12-26 2013-12-04 スレッシュオールド ファーマシューティカルズ， インコーポレイテッド 癌の治療のためのフォスフォルアミデートアルキル化剤プロドラッグ
US20090118031A1 (en) * 2007-11-01 2009-05-07 Qualizza Gregory K Shaft Structure with Configurable Bending Profile
JP6313479B2 (ja) 2014-03-14 2018-04-18 オールテック，インク． 有機セレン化合物の組成物およびその使用方法
WO2017048252A1 (en) 2015-09-15 2017-03-23 Alltech, Inc. Compositions of selenoorganic compounds and methods of use thereof
WO2018148754A1 (en) * 2017-02-13 2018-08-16 The Regents Of The University Of California Site-specific generation of phosphorylated tyrosines in proteins

Family Cites Families (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3303189A (en) * 1965-03-11 1967-02-07 Smith Kline French Lab 2, 1-benzothiazine-2, 2-dioxides
US5011846A (en) * 1988-02-23 1991-04-30 Merrell Dow Pharmaceuticals Inc. Medicament compositions derived from quinolizine and quinolizinone and methods of use thereof
US5106855A (en) * 1989-12-20 1992-04-21 Merrell Dow Pharmaceuticals Inc. Method for the treatment of glaucoma
US5153192A (en) * 1990-04-09 1992-10-06 Alcon Laboratories, Inc. Thiophene sulfonamides useful as carbonic anhydrase inhibitors
US5233031A (en) * 1991-09-23 1993-08-03 University Of Rochester Phosphoramidate analogs of 2'-deoxyuridine
GB9216380D0 (en) * 1992-07-31 1992-09-16 Glaxo Group Ltd Medicaments
US5290781A (en) * 1993-01-05 1994-03-01 Iolab Corporation Ketaneserinol as an agent to reduce intraocular pressure
US5344929A (en) * 1993-02-18 1994-09-06 Alcon Laboratories, Inc. Preparation of carbonic anhydrase inhibitors
US5306727A (en) * 1993-04-30 1994-04-26 Research Corporation Technologies, Inc. Phosphoramidates useful as antitumor agents
TW270114B (de) * 1993-10-22 1996-02-11 Hoffmann La Roche
TW334423B (en) * 1993-10-22 1998-06-21 Hoffmann La Roche Tricyclic 1-aminoethylpyrrole-derivatives
US5874429A (en) * 1993-12-24 1999-02-23 Suntory Limited Benzothiazine derivative
US5538966A (en) * 1994-01-21 1996-07-23 Alcon Laboratories, Inc. Carbonic anhydrase inhibitors
US5538974A (en) * 1994-01-27 1996-07-23 Senju Pharamceutical Co., Ltd. Ophthalmic composition for lowering intraocular pressure
ES2116681T3 (es) * 1994-03-18 1998-07-16 Senju Pharma Co Preparaciones oftalmicas para reducir la presion intraocular.
CN1148853A (zh) * 1994-03-31 1997-04-30 日本化学医药株式会社 亚烷基二胺衍生物
TW403738B (en) * 1994-08-12 2000-09-01 Hoffmann La Roche Tricyclic pyrazole derivatives
US5470973A (en) * 1994-10-03 1995-11-28 Alcon Laboratories, Inc. Synthesis of sulfonamide intermediates
JP3232365B2 (ja) * 1995-02-20 2001-11-26 トキコ株式会社 ディスクブレーキ
US5880134A (en) * 1996-03-20 1999-03-09 Eli Lilly And Company Method for using ergoline compounds to effect physiological and pathological functions at the 5-HT7 receptor
JPH11193289A (ja) * 1997-12-26 1999-07-21 Suntory Ltd ピロールスルホンアミド誘導体
CA2325559A1 (en) * 1998-04-14 1999-10-21 Arena Pharmaceuticals, Inc. Non-endogenous, constitutively activated human serotonin receptors and small molecule modulators thereof
BR9913800A (pt) * 1998-09-18 2001-05-29 Alcon Lab Inc Método para tratar glaucoma, e, composição para tratar glaucoma
WO2001070705A1 (en) * 2000-03-17 2001-09-27 Alcon, Inc. 2-acylaminobenzimidazole derivatives for treating glaucoma
US6806285B1 (en) * 2000-03-17 2004-10-19 Alcon, Inc. 5-Hydroxyl indole derivatives for treating glaucoma
EP1268493B1 (de) * 2000-03-31 2006-02-15 Purdue Research Foundation Phosphoramidat-prodrugs
CA2447480A1 (en) * 2001-06-01 2002-12-12 Alcon, Inc. Pyranoindazoles and their use for the treatment of glaucoma
US6884816B2 (en) * 2001-08-31 2005-04-26 Alcon, Inc. Hydroxy substituted fused naphthyl-azoles and fused indeno-azoles and their use for the treatment of glaucoma

Also Published As

Publication number Publication date
DE60117247D1 (de) 2006-04-20
AU4961601A (en) 2001-10-15
EP1268493A1 (de) 2003-01-02
AU784462B2 (en) 2006-04-06
US7173020B2 (en) 2007-02-06
EP1268493B1 (de) 2006-02-15
US20020004594A1 (en) 2002-01-10
CA2397203A1 (en) 2001-10-11
WO2001074827A1 (en) 2001-10-11
US20050171060A1 (en) 2005-08-04
JP2004538240A (ja) 2004-12-24
US6903081B2 (en) 2005-06-07

Similar Documents

Publication Publication Date Title
DE60117247D1 (de) Phosphoramidat-prodrugs
ATE513847T1 (de) Bioaktive peptide
HUP0103318A2 (hu) Eljárás hatóanyagok bevitelére tüdőn keresztül
BR9405798A (pt) Métodos para liberação in vivo de material biológico e composições úteis dos mesmos
MXPA01008937A (es) Nuevos profarmacos que contienen fosforo.
DE69709407D1 (de) Zytotoxischer aminozucker und verwandte zuckerderivate von indolopyrrolocarbazolen
DK0960107T3 (da) 6-Thiosubstituerede paclitaxeler
HUP0002454A2 (hu) D-Vitamin-molekularésszel rendelkező konjugátumok és ilyen konjugátumokat tartalmazó gyógyászati készítmények
DK1093383T3 (da) Lægemiddelafgivelsessystem omfattende et homeobox-peptid og et cytotoksisk eller antineoplastisk lægemiddel
EP0837630A4 (de) Prodrugs von pharmazeutika mit erhöhter bioverfügbarheit
HU9601846D0 (en) Use of 2-hydroxy-5-phenylazobenzoic acid derivatives as colon cancer chemopreventative and chemotherapeutic agents
BR0111438A (pt) Análogos de ácido barbitúrico como agentes terapeuticos
AU2001264515A1 (en) Melphalan derivatives and their use as cancer chemotherapeutic drugs
MX9601994A (es) Profarmacos de derivados de paclitaxel.
IT1270618B (it) Proteine ad attivita' antitumorale
AU2002326070A1 (en) Peyers's patch and/or m-celle targeting ligands
ATE371737T1 (de) Proteaseresistente flint-analoge
TW200610526A (en) Novel hydrophilic analogs of 4,8-dihydrobenzodithiophene-4,8-diones as anticancer agents
DK1011329T3 (da) 7-Methylthiooxomethyl- og 7-methylthiodioxomethyl-paclitaxeler
BR0014831A (pt) Droga terapêutica para lesões refratárias, compreendendo uma substância com atividade inibidora de elastase leucocitária humana
DE60008415D1 (de) Zusammensetzung die mindestens ein stickstoffmonoxid-synthase inhibitor und mindestens ein phospholipase a2 inhibitor enthält zur herstellung eines medikamentes
ES2185083T3 (es) Proteina estimulante de macrofagos para el tratamiento de patologias del sistema nervioso.
ATE273014T1 (de) VERWENDUNG DER BIOAKTIVEN FRAKTION AUS DEM URINDESTILLAT DER KUH (ßGO MUTRAß) ZUR VERSTÄRKUNG DER WIRKSAMKEIT VON ANTI-INFEKTIVA, ANTI-KREBSMITTELN UND ERNÄHRUNGSMITTELN
SE9803271D0 (sv) A drug for well-being
ECSP951393A (es) UTILIZACION DE 2- AMINO 4,5,7,8- TETRAHIDRO -6H-TIAZOLO [5,4-d] AZEPINAS SUSTITUIDAS EN POSICION 6 COMO MEDICAMENTOS CON EFECTO ANTIDEPRESIVO Y SU PREPARACION

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties