ATE317846T1 - Phosphoramidat-prodrugs - Google Patents
Phosphoramidat-prodrugsInfo
- Publication number
- ATE317846T1 ATE317846T1 AT01922862T AT01922862T ATE317846T1 AT E317846 T1 ATE317846 T1 AT E317846T1 AT 01922862 T AT01922862 T AT 01922862T AT 01922862 T AT01922862 T AT 01922862T AT E317846 T1 ATE317846 T1 AT E317846T1
- Authority
- AT
- Austria
- Prior art keywords
- compounds
- phosphoramidate
- phosphoramidate prodrugs
- functional
- peptidomimetics
- Prior art date
Links
- PTMHPRAIXMAOOB-UHFFFAOYSA-L phosphoramidate Chemical compound NP([O-])([O-])=O PTMHPRAIXMAOOB-UHFFFAOYSA-L 0.000 title 1
- 229940002612 prodrug Drugs 0.000 title 1
- 239000000651 prodrug Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 2
- 150000008298 phosphoramidates Chemical class 0.000 abstract 2
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 150000001408 amides Chemical class 0.000 abstract 1
- 150000001413 amino acids Chemical class 0.000 abstract 1
- 230000001028 anti-proliverative effect Effects 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 230000003834 intracellular effect Effects 0.000 abstract 1
- 125000003729 nucleotide group Chemical group 0.000 abstract 1
- 239000000816 peptidomimetic Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 150000003014 phosphoric acid esters Chemical class 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
- C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/06—Phosphorus compounds without P—C bonds
- C07F9/22—Amides of acids of phosphorus
- C07F9/24—Esteramides
- C07F9/2454—Esteramides the amide moiety containing a substituent or a structure which is considered as characteristic
- C07F9/2458—Esteramides the amide moiety containing a substituent or a structure which is considered as characteristic of aliphatic amines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/06—Phosphorus compounds without P—C bonds
- C07F9/22—Amides of acids of phosphorus
- C07F9/26—Amides of acids of phosphorus containing P-halide groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/655—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms
- C07F9/65515—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a five-membered ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having sulfur atoms, with or without selenium or tellurium atoms, as the only ring hetero atoms
- C07F9/655345—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having sulfur atoms, with or without selenium or tellurium atoms, as the only ring hetero atoms the sulfur atom being part of a five-membered ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Saccharide Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US19391800P | 2000-03-31 | 2000-03-31 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE317846T1 true ATE317846T1 (de) | 2006-03-15 |
Family
ID=22715556
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT01922862T ATE317846T1 (de) | 2000-03-31 | 2001-03-30 | Phosphoramidat-prodrugs |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US6903081B2 (de) |
| EP (1) | EP1268493B1 (de) |
| JP (1) | JP2004538240A (de) |
| AT (1) | ATE317846T1 (de) |
| AU (1) | AU784462B2 (de) |
| CA (1) | CA2397203A1 (de) |
| DE (1) | DE60117247D1 (de) |
| WO (1) | WO2001074827A1 (de) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU5935600A (en) | 1999-07-14 | 2001-01-30 | Richard F. Borch | Phosphoramide compounds |
| ATE317846T1 (de) * | 2000-03-31 | 2006-03-15 | Purdue Research Foundation | Phosphoramidat-prodrugs |
| US8707406B2 (en) * | 2002-07-26 | 2014-04-22 | Sierra Wireless, Inc. | Always-on virtual private network access |
| ZA200507752B (en) * | 2003-03-28 | 2007-01-31 | Threshold Pharmaceuticals Inc | Compositions and methods for treating cancer |
| US7504389B2 (en) * | 2004-11-15 | 2009-03-17 | Ceptyr, Inc. | Protein tyrosine phosphatase inhibitors and methods of use thereof |
| US8399428B2 (en) * | 2004-12-09 | 2013-03-19 | Regents Of The University Of Minnesota | Nucleosides with antiviral and anticancer activity |
| WO2006099313A2 (en) * | 2005-03-14 | 2006-09-21 | Purdue Research Foundation | Phosphate conjugates of prenylation inhibitors |
| CA2613312C (en) | 2005-06-29 | 2014-10-14 | Threshold Pharmaceuticals, Inc. | Phosphoramidate alkylator prodrugs |
| CA2618335C (en) | 2005-08-15 | 2015-03-31 | F.Hoffmann-La Roche Ag | Antiviral phosphoramidates of 4'-substituted pronucleotides |
| US8197545B2 (en) | 2005-10-27 | 2012-06-12 | Depuy Spine, Inc. | Nucleus augmentation delivery device and technique |
| EP2114157B1 (de) * | 2006-12-26 | 2021-05-26 | ImmunoGenesis, Inc. | Phosphoramidatalkylator-prodrug für die krebstherapie |
| US20090118031A1 (en) * | 2007-11-01 | 2009-05-07 | Qualizza Gregory K | Shaft Structure with Configurable Bending Profile |
| WO2015137983A1 (en) | 2014-03-14 | 2015-09-17 | Alltech, Inc. | Compositions of selenoorganic compounds and methods of use thereof |
| WO2017048252A1 (en) | 2015-09-15 | 2017-03-23 | Alltech, Inc. | Compositions of selenoorganic compounds and methods of use thereof |
| US11447764B2 (en) * | 2017-02-13 | 2022-09-20 | The Regents Of The University Of California | Site-specific generation of phosphorylated tyrosines in proteins |
Family Cites Families (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3303189A (en) * | 1965-03-11 | 1967-02-07 | Smith Kline French Lab | 2, 1-benzothiazine-2, 2-dioxides |
| US5011846A (en) * | 1988-02-23 | 1991-04-30 | Merrell Dow Pharmaceuticals Inc. | Medicament compositions derived from quinolizine and quinolizinone and methods of use thereof |
| US5106855A (en) * | 1989-12-20 | 1992-04-21 | Merrell Dow Pharmaceuticals Inc. | Method for the treatment of glaucoma |
| US5153192A (en) * | 1990-04-09 | 1992-10-06 | Alcon Laboratories, Inc. | Thiophene sulfonamides useful as carbonic anhydrase inhibitors |
| US5233031A (en) * | 1991-09-23 | 1993-08-03 | University Of Rochester | Phosphoramidate analogs of 2'-deoxyuridine |
| GB9216380D0 (en) * | 1992-07-31 | 1992-09-16 | Glaxo Group Ltd | Medicaments |
| US5290781A (en) * | 1993-01-05 | 1994-03-01 | Iolab Corporation | Ketaneserinol as an agent to reduce intraocular pressure |
| US5344929A (en) * | 1993-02-18 | 1994-09-06 | Alcon Laboratories, Inc. | Preparation of carbonic anhydrase inhibitors |
| US5306727A (en) | 1993-04-30 | 1994-04-26 | Research Corporation Technologies, Inc. | Phosphoramidates useful as antitumor agents |
| TW270114B (de) * | 1993-10-22 | 1996-02-11 | Hoffmann La Roche | |
| TW334423B (en) * | 1993-10-22 | 1998-06-21 | Hoffmann La Roche | Tricyclic 1-aminoethylpyrrole-derivatives |
| US5874429A (en) * | 1993-12-24 | 1999-02-23 | Suntory Limited | Benzothiazine derivative |
| US5538966A (en) * | 1994-01-21 | 1996-07-23 | Alcon Laboratories, Inc. | Carbonic anhydrase inhibitors |
| US5538974A (en) * | 1994-01-27 | 1996-07-23 | Senju Pharamceutical Co., Ltd. | Ophthalmic composition for lowering intraocular pressure |
| US5652272A (en) * | 1994-03-18 | 1997-07-29 | Senju Pharmaceutical Co., Ltd. | Ophthalmic preparations for reducing intraocular pressure |
| AU2084995A (en) * | 1994-03-31 | 1995-10-23 | Nippon Chemiphar Co. Ltd. | Alkylenediamine derivative |
| TW403738B (en) * | 1994-08-12 | 2000-09-01 | Hoffmann La Roche | Tricyclic pyrazole derivatives |
| US5470973A (en) * | 1994-10-03 | 1995-11-28 | Alcon Laboratories, Inc. | Synthesis of sulfonamide intermediates |
| JP3232365B2 (ja) * | 1995-02-20 | 2001-11-26 | トキコ株式会社 | ディスクブレーキ |
| US5880134A (en) * | 1996-03-20 | 1999-03-09 | Eli Lilly And Company | Method for using ergoline compounds to effect physiological and pathological functions at the 5-HT7 receptor |
| JPH11193289A (ja) * | 1997-12-26 | 1999-07-21 | Suntory Ltd | ピロールスルホンアミド誘導体 |
| DE1071701T1 (de) * | 1998-04-14 | 2001-08-23 | Arena Pharmaceuticals, Inc. | Non-endogene, konstitutiv aktivierte humane serotonin-rezeptoren und kleine molekülmodulatoren davon |
| TR200100754T2 (tr) * | 1998-09-18 | 2001-10-22 | Alcon Laboratories, Inc. | Glausomanın tedavi edilmesi için serotonerjik 5HT2. |
| US6660870B1 (en) * | 2000-03-17 | 2003-12-09 | Alcon, Inc. | 2-acylaminobenzimidazole derivatives for treating glaucoma |
| US6806285B1 (en) * | 2000-03-17 | 2004-10-19 | Alcon, Inc. | 5-Hydroxyl indole derivatives for treating glaucoma |
| ATE317846T1 (de) * | 2000-03-31 | 2006-03-15 | Purdue Research Foundation | Phosphoramidat-prodrugs |
| BR0210241A (pt) * | 2001-06-01 | 2004-08-10 | Alcon Inc | Piranoindazóis e seu uso no tratamento de glaucoma |
| US6884816B2 (en) * | 2001-08-31 | 2005-04-26 | Alcon, Inc. | Hydroxy substituted fused naphthyl-azoles and fused indeno-azoles and their use for the treatment of glaucoma |
-
2001
- 2001-03-30 AT AT01922862T patent/ATE317846T1/de not_active IP Right Cessation
- 2001-03-30 EP EP01922862A patent/EP1268493B1/de not_active Expired - Lifetime
- 2001-03-30 JP JP2001572517A patent/JP2004538240A/ja not_active Withdrawn
- 2001-03-30 US US09/822,376 patent/US6903081B2/en not_active Expired - Fee Related
- 2001-03-30 CA CA002397203A patent/CA2397203A1/en not_active Abandoned
- 2001-03-30 AU AU49616/01A patent/AU784462B2/en not_active Ceased
- 2001-03-30 DE DE60117247T patent/DE60117247D1/de not_active Expired - Fee Related
- 2001-03-30 WO PCT/US2001/010163 patent/WO2001074827A1/en active IP Right Grant
-
2005
- 2005-02-08 US US11/053,024 patent/US7173020B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| US6903081B2 (en) | 2005-06-07 |
| US20020004594A1 (en) | 2002-01-10 |
| AU4961601A (en) | 2001-10-15 |
| EP1268493B1 (de) | 2006-02-15 |
| WO2001074827A1 (en) | 2001-10-11 |
| CA2397203A1 (en) | 2001-10-11 |
| JP2004538240A (ja) | 2004-12-24 |
| US20050171060A1 (en) | 2005-08-04 |
| EP1268493A1 (de) | 2003-01-02 |
| DE60117247D1 (de) | 2006-04-20 |
| AU784462B2 (en) | 2006-04-06 |
| US7173020B2 (en) | 2007-02-06 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DE60117247D1 (de) | Phosphoramidat-prodrugs | |
| ATE513847T1 (de) | Bioaktive peptide | |
| HUP0103318A2 (hu) | Eljárás hatóanyagok bevitelére tüdőn keresztül | |
| BR9405798A (pt) | Métodos para liberação in vivo de material biológico e composições úteis dos mesmos | |
| MXPA01008937A (es) | Nuevos profarmacos que contienen fosforo. | |
| DE69709407D1 (de) | Zytotoxischer aminozucker und verwandte zuckerderivate von indolopyrrolocarbazolen | |
| DK0960107T3 (da) | 6-Thiosubstituerede paclitaxeler | |
| HUP0002454A2 (hu) | D-Vitamin-molekularésszel rendelkező konjugátumok és ilyen konjugátumokat tartalmazó gyógyászati készítmények | |
| DK1093383T3 (da) | Lægemiddelafgivelsessystem omfattende et homeobox-peptid og et cytotoksisk eller antineoplastisk lægemiddel | |
| EP0837630A4 (de) | Prodrugs von pharmazeutika mit erhöhter bioverfügbarheit | |
| BR0111438A (pt) | Análogos de ácido barbitúrico como agentes terapeuticos | |
| AU2001264515A1 (en) | Melphalan derivatives and their use as cancer chemotherapeutic drugs | |
| MX9601994A (es) | Profarmacos de derivados de paclitaxel. | |
| IT1270618B (it) | Proteine ad attivita' antitumorale | |
| AU2002326070A1 (en) | Peyers's patch and/or m-celle targeting ligands | |
| ATE371737T1 (de) | Proteaseresistente flint-analoge | |
| TW200610526A (en) | Novel hydrophilic analogs of 4,8-dihydrobenzodithiophene-4,8-diones as anticancer agents | |
| DK1011329T3 (da) | 7-Methylthiooxomethyl- og 7-methylthiodioxomethyl-paclitaxeler | |
| BR0014831A (pt) | Droga terapêutica para lesões refratárias, compreendendo uma substância com atividade inibidora de elastase leucocitária humana | |
| DE60008415D1 (de) | Zusammensetzung die mindestens ein stickstoffmonoxid-synthase inhibitor und mindestens ein phospholipase a2 inhibitor enthält zur herstellung eines medikamentes | |
| ES2185083T3 (es) | Proteina estimulante de macrofagos para el tratamiento de patologias del sistema nervioso. | |
| SE9803271D0 (sv) | A drug for well-being | |
| DE60012996D1 (de) | Verwendung der bioaktiven fraktion aus dem urindestillat der kuh ("go mutra") zur verstärkung der wirksamkeit von anti-infektiva, anti-krebsmitteln und ernährungsmitteln | |
| ECSP951393A (es) | UTILIZACION DE 2- AMINO 4,5,7,8- TETRAHIDRO -6H-TIAZOLO [5,4-d] AZEPINAS SUSTITUIDAS EN POSICION 6 COMO MEDICAMENTOS CON EFECTO ANTIDEPRESIVO Y SU PREPARACION |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |